All Stories

  1. Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice

    Article • Frontiers in Medicine, April 2025, Frontiers

    Dr Yasuo Kizawa

  2. Dasatinib attenuates airway inflammation of asthma exacerbation in mice induced by house dust mites and dsRNA

    Article • Biochemistry and Biophysics Reports, March 2023, Elsevier

    Dr Yasuo Kizawa

  3. Anti-inflammatory Effects of a Src Inhibitor on the Murine Model of Asthma Exacerbation Induced by Ovalbumin and Lipopolysaccharide

    Article • YAKUGAKU ZASSHI, February 2023, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  4. Relationship between anti-fungal effects and lung exposure of PC945, a novel inhaled antifungal agent, in Aspergillus fumigatus infected mice

    Article • European Journal of Pharmaceutical Sciences, August 2021, Elsevier

    Dr Yasuo Kizawa

  5. Antifungal Effects of PC945, a Novel Inhaled Triazole, on Candida albicans Pulmonary Infection in Immunocompromised Mice

    Article • March 2021, Scientific Archives LLC

    Dr Yasuo Kizawa

  6. Inhibitory Effects of Dabigatran on Airway Inflammation Induced by Lipopolysaccharide in Mice

    Article • YAKUGAKU ZASSHI, January 2020, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  7. Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus

    Article • Journal of Antimicrobial Chemotherapy, July 2019, Oxford University Press (OUP)

    Dr Yasuo Kizawa, Dr Kazuhiro Ito

  8. Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection

    Article • Scientific Reports, July 2019, Springer Science + Business Media

    Dr Kazuhiro Ito, Dr Yasuo Kizawa

  9. TNF-α Decreased Corticosteroid Responsiveness in Mice Models of Airway Inflammation Induced by Double Strand RNA and/or Tobacco Smoke Exposure

    Article • YAKUGAKU ZASSHI, January 2019, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  10. The Involvement of Src in Airway Inflammation Induced by Repeated Exposure to Lipopolysaccharide in Mice

    Article • YAKUGAKU ZASSHI, January 2019, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  11. In VitroandIn VivoEfficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, onAspergillus fumigatusInfection

    Article • Antimicrobial Agents and Chemotherapy, February 2018, ASM Journals

    Professor Matthew C Fisher, Dr Yasuo Kizawa, Dr Kazuhiro Ito

  12. N 1 -Nonyl-1,4-diaminobutane ameliorates brain infarction size in photochemically induced thrombosis model mice

    Article • Neuroscience Letters, February 2018, Elsevier

    Dr Yasuo Kizawa

  13. RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation

    Article • European Respiratory Journal, October 2017, European Respiratory Society (ERS)

    Dr Yasuo Kizawa

  14. Effects of intranasally dosed posaconazole on fungal load and biomarkers in Aspergillus fumigatus infected immunocompromised mice

    Article • Mycoses, July 2017, Wiley

    Dr Kazuhiro Ito, Dr Yasuo Kizawa

  15. In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice

    Article • Antimicrobial Agents and Chemotherapy, June 2017, ASM Journals

    Dr Kazuhiro Ito, Dr Yasuo Kizawa

  16. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

    Article • Antimicrobial Agents and Chemotherapy, February 2017, ASM Journals

    Dr Kazuhiro Ito, Dr Yasuo Kizawa

  17. Effects of phosphoinositide-3-kinase inhibitors on steroid-insensitive airway inflammation in poly(I:C) and allergen challenged mice

    Article • September 2016, European Respiratory Society (ERS)

    Dr Yasuo Kizawa

  18. The combination of TNF-α neutralization and dexamethasone treatment restored the corticosteroid responsiveness in tobacco smoking mice

    Article • September 2016, European Respiratory Society (ERS)

    Dr Yasuo Kizawa

  19. LPS causes corticosteroid insensitive airway inflammation via activation of PI3Kδ.

    Article • Biochemistry and Biophysics Reports, September 2016, Elsevier

    Dr Yasuo Kizawa

  20. Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

    Article • Journal of Medicinal Chemistry, February 2016, American Chemical Society (ACS)

    Dr Yasuo Kizawa

  21. In Vivo Biomarker Analysis of Intranasally Dosed PC945, a Novel Antifungal Agent, in Aspergillus Fumigatus Infection in Immunocompromised Mice

    Article • Open Forum Infectious Diseases, January 2016, Oxford University Press (OUP)

    Dr Kazuhiro Ito, Dr Yasuo Kizawa

  22. Corticosteroid sensitivity in intractable respiratory disease


    Article • Folia Pharmacologica Japonica, January 2015, Japanese Pharmacological Society

    Dr Yasuo Kizawa

  23. Correction: Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers

    Article • PLOS One, May 2014, PLOS

    Dr Yasuo Kizawa

  24. Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers

    Article • PLOS One, February 2014, PLOS

    Dr Yasuo Kizawa

  25. Toll-like Receptor 3 Stimulation Causes Corticosteroid-Refractory Airway Neutrophilia and Hyperresponsiveness in Mice

    Article • CHEST Journal, July 2013, Elsevier

    Dr Yasuo Kizawa

  26. Antagonism of NMDA receptors by butanesulfonyl-homospermine guanidine and neuroprotective effects in in vitro and in vivo

    Article • Neuroscience Letters, January 2012, Elsevier

    Dr Yasuo Kizawa

  27. Effects Of RV1088, A Narrow Spectrum Kinase Inhibitor, On Airway Inflammation And Hyperresponsiveness In Tobacco-Smoke Exposed Mice

    Article • May 2011, American Thoracic Society

    Dr Yasuo Kizawa

  28. Superior Effects Of Combination Of PI3Kgamma And Delta; Inhibitors To Each Inhibitor Alone On Airway Inflammation In Tobacco-Smoke Exposed Mice

    Article • May 2011, American Thoracic Society

    Dr Yasuo Kizawa

  29. Effects Of RV568, A Narrow Spectrum Kinase Inhibitor, On Airway Inflammation And Hyperresponsiveness In Tobacco-Smoke Exposed Mice

    Article • May 2011, American Thoracic Society

    Dr Yasuo Kizawa

  30. Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

    Article • American Review of Respiratory Disease, October 2010, American Thoracic Society

    Dr Yasuo Kizawa

  31. Involvement Of P38MAPK Gamma On Corticosteroid Refractory Airway Inflammation Induced By Tobacco Smoke In Mice

    Article • May 2010, American Thoracic Society

    Dr Yasuo Kizawa

  32. Synthesis of Water-Soluble Polyamine Derivatives Effective as N-Methyl-D-aspartate Receptor Antagonists

    Article • Chemical and Pharmaceutical Bulletin, January 2010, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  33. Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts

    Article • Fundamental and Clinical Pharmacology, October 2009, Wiley

    Dr Yasuo Kizawa

  34. Neuroprotection by Tosyl-Polyamine Derivatives through the Inhibition of Ionotropic Glutamate Receptors

    Article • Journal of Pharmacology and Experimental Therapeutics, July 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Yasuo Kizawa

  35. Synthesis of a Novel Water-Soluble Cleft-Type Cyclophane as an N-Methyl-D-aspartate Receptor Antagonist

    Article • Chemical and Pharmaceutical Bulletin, January 2009, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  36. Synthesis of Two Novel Water-soluble Cleft-Type Cyclophanes Effective as N-Methyl-D-aspartate Receptor Antagonist

    Article • Heterocycles, January 2009, Japan Institute of Heterocyclic Chemistry

    Dr Yasuo Kizawa

  37. Differential effects of linear and cyclic polyamines on NMDA receptor activities

    Article • Neurochemistry International, July 2008, Elsevier

    Dr Yasuo Kizawa

  38. Cleft-type cyclophanes confer neuroprotection against excitatory neurotoxicity in vitro and in vivo through inhibition of NMDA receptors

    Article • Neuropharmacology, September 2007, Elsevier

    Dr Yasuo Kizawa

  39. Cyclophane and acyclic cyclophane: Novel channel blockers of N-methyl-d-aspartate receptor

    Article • Neurochemistry International, January 2007, Elsevier

    Dr Yasuo Kizawa

  40. Effects of Dexamethasone and Aminophylline on Survival of Jurkat and HL-60 Cells

    Article • Biological and Pharmaceutical Bulletin, January 2006, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  41. Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblasts+

    Article • Fundamental and Clinical Pharmacology, December 2005, Wiley

    Dr Yasuo Kizawa

  42. Design and Synthesis of a Novel Water-Soluble NMDA Receptor Antagonist with a 1,4,7,10-Tetraazacyclododecane Group

    Article • Chemical and Pharmaceutical Bulletin, January 2005, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  43. Monoamines directly inhibit N-methyl-d-aspartate receptors expressed in Xenopus oocytes in a voltage-dependent manner

    Article • Neuroscience Letters, November 2004, Elsevier

    Dr Yasuo Kizawa

  44. Proliferative response to phenytoin and nifedipine in gingival fibroblasts cultured from humans with gingival fibromatosis

    Article • Fundamental and Clinical Pharmacology, August 2004, Wiley

    Dr Yasuo Kizawa

  45. Pharmacological properties of angiotensin II receptors in cultured rabbit gingival fibroblasts

    Article • Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, March 2004, Elsevier

    Dr Yasuo Kizawa

  46. Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture

    Article • Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, August 2002, Elsevier

    Dr Yasuo Kizawa

  47. Effects of endothelin-1 and nitric oxide on proliferation of cultured guinea pig bronchial smooth muscle cells

    Article • Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, April 2001, Elsevier

    Dr Yasuo Kizawa

  48. Involvement of angiotensin II and endothelin-1 in the development of submandibular gland hypertrophy in response to isoproterenol in rats

    Article • Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology, June 2000, Elsevier

    Dr Yasuo Kizawa

  49. Evidence for the AT1 Subtype of the Angiotensin II Receptor in the Rat Submandibular Gland.

    Article • Biological and Pharmaceutical Bulletin, January 2000, Pharmaceutical Society of Japan

    Dr Yasuo Kizawa

  50. Activation of Protein Kinase C Induces Internalization of the GABAC Receptors Expressed in Xenopus Oocytes

    Article • The Japanese Journal of Physiology, January 2000, Physiological Society of Japan

    Dr Yasuo Kizawa

  51. Antigen-induced elevation of immunoreactive endothelin-1 (ET-1) levels in ovalbumin-sensitized guinea pig airway tissue

    Article • Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology, February 1999, Elsevier

    Dr Yasuo Kizawa

  52. Consensus phosphorylation sites of human GABAC/GABAρ receptors are not critical for inhibition by protein kinase C activation

    Article • Neuroscience Letters, October 1998, Elsevier

    Dr Yasuo Kizawa

  53. β-Funaltrexamine Discriminates between Two Subtypes of μ2-Opioid Receptors in Electrically Stimulated Longitudinal Muscle of Guinea Pig Ileum

    Article • General Pharmacology The Vascular System, August 1998, Elsevier

    Dr Yasuo Kizawa

  54. Synergistic actions of pentobarbital and dihydropyridine Ca2+antagonists on guinea pig isolated thoracic aorta

    Article • Fundamental and Clinical Pharmacology, September 1997, Wiley

    Dr Yasuo Kizawa

  55. GABA θ1 receptor: inhibition by protein kinase C activators

    Article • European Journal of Pharmacology Molecular Pharmacology, November 1995, Elsevier

    Dr Yasuo Kizawa

  56. Effects of organic and inorganic Ca2+-antagonists on acetylcholine-induced contraction in molluscan (Mytilus edulis) smooth muscle

    Article • General Pharmacology The Vascular System, November 1993, Elsevier

    Dr Yasuo Kizawa

  57. Immunochemical and immunohistochemical determination of ubiquitin in molluscan (Mytilus edulis) smooth muscle

    Article • Comparative Biochemistry and Physiology Part A Physiology, October 1992, Elsevier

    Dr Yasuo Kizawa

  58. Inhibitory action of McN-A-343 on acetylcholine-induced contraction in molluscan smooth muscle

    Article • Comparative Biochemistry and Physiology Part C Comparative Pharmacology, July 1992, Elsevier

    Dr Yasuo Kizawa

  59. Possible site of action of 2-methylserotonin in inducing relaxation of acetylcholine-induced contraction in the molluscan (Mytilus edulis) smooth muscle

    Article • Comparative Biochemistry and Physiology Part C Comparative Pharmacology, February 1992, Elsevier

    Dr Yasuo Kizawa

  60. Effect of ageing on response to nicotine in rabbit bronchial preparation

    Article • General Pharmacology The Vascular System, January 1991, Elsevier

    Dr Yasuo Kizawa

  61. Organic Ca2+-antagonist-resistant response to FMRF-NH2 on the molluscan smooth muscle

    Article • General Pharmacology The Vascular System, January 1991, Elsevier

    Dr Yasuo Kizawa

  62. Effects of chronic nicotine treatment on nicotinic receptors in the rabbit urinary bladder

    Article • Canadian Journal of Physiology and Pharmacology, January 1990, Canadian Science Publishing

    Dr Yasuo Kizawa

  63. Effect of ageing on nicotine-induced contraction of guinea-pig bronchial preparation

    Article • General Pharmacology The Vascular System, January 1990, Elsevier

    Dr Yasuo Kizawa

  64. Substance P-containing nerves mediate nicotine-induced contractions of rabbit bronchial smooth muscle

    Article • General Pharmacology The Vascular System, January 1988, Elsevier

    Dr Yasuo Kizawa

  65. Pharmacological action of nicotine in the isolated urinary bladder from rabbit: Special reference to the chronic nicotine treatment

    Article • General Pharmacology The Vascular System, January 1988, Elsevier

    Dr Yasuo Kizawa

  66. Characterization of nicotine-induced contraction in the canine bronchus

    Article • Comparative Biochemistry and Physiology Part C Comparative Pharmacology, January 1988, Elsevier

    Dr Yasuo Kizawa

  67. Noncholinergic contractile response to nicotine in the guinea pig isolated tracheal smooth muscle

    Article • Canadian Journal of Physiology and Pharmacology, February 1987, Canadian Science Publishing

    Dr Yasuo Kizawa

  68. (±)-1-[[2-(3,4-Dimethoxphenyl) ethyl]amino]-3-(3-methylphenoxy)-2-propanol hydrochloride (bevantolol, NC-1400) as a β1-selective adrenoceptor blocker with α1-adrenoceptor blocking activity

    Article • General Pharmacology The Vascular System, January 1987, Elsevier

    Dr Yasuo Kizawa

  69. Actions of 4-(2-hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propoxy)benzeneacetamide (KF4317) and labetalol on α- and β-adrenoceptors

    Article • General Pharmacology The Vascular System, January 1986, Elsevier

    Dr Yasuo Kizawa

  70. Mechanism of action of nicotine on crab-eating monkey isolated bronchial smooth muscle

    Article • Canadian Journal of Physiology and Pharmacology, November 1985, Canadian Science Publishing

    Dr Yasuo Kizawa

  71. Possible involvement of substance P immunoreactive nerves in the mediation of nicotine-induced contractile responses in isolated guinea pig bronchus

    Article • European Journal of Pharmacology, July 1985, Elsevier

    Dr Yasuo Kizawa

  72. Tetrodotoxin-resistant response to nicotine in rabbit bronchial preparation

    Article • European Journal of Pharmacology, September 1984, Elsevier

    Dr Yasuo Kizawa

  73. Nicotinic stimulant, DMPP(1,1-dimethyl-4-phenylpiperazinium iodide) on the isolated bronchial smooth muscle preparation of guinea-pig

    Article • General Pharmacology The Vascular System, January 1984, Elsevier

    Dr Yasuo Kizawa

  74. Action of nicotine on guinea-pig isolated bronchial smooth muscle preparation

    Article • General Pharmacology The Vascular System, January 1984, Elsevier

    Dr Yasuo Kizawa

  75. A possible site of action of nicotine in the bronchial smooth muscle preparation of guinea-pig

    Article • Journal of Pharmacy and Pharmacology, October 1983, Wiley

    Dr Yasuo Kizawa

  76. A receptor reserve of the alpha-inhibitory receptor for alpha-adrenoceptor stimulants in the taenia caecum of guinea pig.

    Article • The Japanese Journal of Pharmacology, January 1980, Japanese Pharmacological Society

    Dr Yasuo Kizawa