All Stories

  1. Structural dissection of vaccinia G9 identifies residues essential for membrane fusion and complex assembly

    Article • Journal of Virology, August 2025, ASM Journals

    Dr Wen Chang

  2. Structural Dissection of Vaccinia G9 Identifies Residues Essential for Membrane Fusion and Complex Assembly

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Dr Wen Chang

  3. Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex

    Article • Journal of Virology, December 2023, ASM Journals

    Dr Wen Chang

  4. Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations

    Article • PLoS Pathogens, November 2023, PLOS

    Dr Wen Chang

  5. Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex

    Article • August 2023, Cold Spring Harbor Laboratory Press

    Dr Wen Chang

  6. Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Dr Wen Chang

  7. Widespread Distribution and Evolution of Poxviral Entry-Fusion Complex Proteins in Giant Viruses

    Article • Microbiology Spectrum, March 2023, ASM Journals

    Chuan Ku, Dr Wen Chang

  8. FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function againstCandida albicans

    Article • Life Science Alliance, January 2023, Life Science Alliance, LLC

    Dr Wen Chang

  9. Widespread distribution and evolution of poxviral entry-fusion complex proteins in giant viruses

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Chuan Ku, Dr Wen Chang

  10. Role of Lipid Rafts in Pathogen-Host Interaction - A Mini Review

    Article • Frontiers in Immunology, January 2022, Frontiers

    Dr Wen Chang, Dr Erik A.C. Wiemer

  11. Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters

    Article • PLOS One, September 2021, PLOS

    Dr Wen Chang

  12. Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters

    Article • August 2021, Cold Spring Harbor Laboratory Press

    Dr Wen Chang

  13. NMR assignments of vaccinia virus protein A28: an entry-fusion complex component

    Article • Biomolecular NMR Assignments, January 2021, Springer Science + Business Media

    Dr Wen Chang

  14. Experimental Evolution To Isolate Vaccinia Virus Adaptive G9 Mutants That Overcome Membrane Fusion Inhibition via the Vaccinia Virus A56/K2 Protein Complex

    Article • Journal of Virology, May 2020, ASM Journals

    Dr Wen Chang

  15. Vaccinia viral A26 protein is a fusion suppressor of mature virus and triggers membrane fusion through conformational change at low pH

    Article • PLoS Pathogens, June 2019, PLOS

    Dr Wen Chang

  16. Ionization of Submicrometer-Sized Particles by Laser-Induced Radiofrequency Plasma for Mass Spectrometric Analysis

    Article • Analytical Chemistry, October 2018, American Chemical Society (ACS)

    Dr Wen Chang

  17. Reply to “Bioinformatics Analysis of Differential Innate Immune Signaling in Macrophages by Wild-Type Vaccinia Mature Virus and a Mutant Virus with a Deletion of the A26 Protein”

    Article • Journal of Virology, November 2017, ASM Journals

    Dr Wen Chang

  18. Vaccinia virus entry pathway regulates cellular innate immune responses

    Article • Journal of Virology, June 2017, ASM Journals

    Dr Wen Chang

  19. Glycosaminoglycans-Specific Cell Targeting and Imaging Using Fluorescent Nanodiamonds Coated with Viral Envelope Proteins

    Article • Analytical Chemistry, June 2017, American Chemical Society (ACS)

    Dr Wen Chang

  20. Coherent Brightfield Microscopy Provides the Spatiotemporal Resolution To Study Early Stage Viral Infection in Live Cells

    Article • ACS Nano, January 2017, American Chemical Society (ACS)

    Dr Wen Chang

  21. Vaccini virus traffics in HeLa cells requires WASH complex

    Article • Journal of Virology, June 2015, ASM Journals

    Dr Wen Chang

  22. Vaccinia Viral Protein A27 Is Anchored to the Viral Membrane via a Cooperative Interaction with Viral Membrane Protein A17

    Article • Journal of Biological Chemistry, January 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Wenlung Chen, Dr Wen Chang

  23. Crystal Structure of Vaccinia Viral A27 Protein Reveals a Novel Structure Critical for Its Function and Complex Formation with A26 Protein

    Article • PLoS Pathogens, August 2013, PLOS

    Dr Wen Chang

  24. Structure of Vaccinia virus A27

    Article • March 2013, Protein Data Bank, Rutgers University

    Dr Wen Chang

  25. Integrin  1 Mediates Vaccinia Virus Entry through Activation of PI3K/Akt Signaling

    Article • Journal of Virology, April 2012, ASM Journals

    Dr Wen Chang

  26. The Lipid Raft-Associated Protein CD98 Is Required for Vaccinia Virus Endocytosis

    Article • Journal of Virology, February 2012, ASM Journals

    Dr Wen Chang

  27. Vaccinia Mature Virus Fusion Regulator A26 Protein Binds to A16 and G9 Proteins of the Viral Entry Fusion Complex and Dissociates from Mature Virions at Low pH

    Article • Journal of Virology, January 2012, ASM Journals

    Dr Wen Chang

  28. Imaging of Vaccinia Virus Entry into HeLa Cells

    Article • January 2012, Springer Science + Business Media

    Dr Wen Chang

  29. Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction

    Article • Nature Chemistry, June 2011, Springer Science + Business Media

    Dr Wen Chang

  30. Vaccinia Virus A25 and A26 Proteins Are Fusion Suppressors for Mature Virions and Determine Strain-Specific Virus Entry Pathways into HeLa, CHO-K1, and L Cells

    Article • Journal of Virology, June 2010, ASM Journals

    Dr Wen Chang

  31. A Turn-like Structure “KKPE” Segment Mediates the Specific Binding of Viral Protein A27 to Heparin and Heparan Sulfate on Cell Surfaces

    Article • Journal of Biological Chemistry, December 2009, Elsevier

    Dr Wen Chang

  32. Disulfide Bond Formation at the C Termini of Vaccinia Virus A26 and A27 Proteins Does Not Require Viral Redox Enzymes and Suppresses Glycosaminoglycan-Mediated Cell Fusion

    Article • Journal of Virology, April 2009, ASM Journals

    Dr Wen Chang

  33. Poxvirus Host Range Protein CP77 Contains an F-Box-Like Domain That Is Necessary To Suppress NF-κB Activation by Tumor Necrosis Factor Alpha but Is Independent of Its Host Range Function

    Article • Journal of Virology, February 2009, ASM Journals

    Dr Wen Chang

  34. Vaccinia Virus WR53.5/F14.5 Protein Is a New Component of Intracellular Mature Virus and Is Important for Calcium-Independent Cell Adhesion and Vaccinia Virus Virulence in Mice

    Article • Journal of Virology, August 2008, ASM Journals

    Dr Wen Chang

  35. A Novel Cellular Protein, VPEF, Facilitates Vaccinia Virus Penetration into HeLa Cells through Fluid Phase Endocytosis

    Article • Journal of Virology, June 2008, ASM Journals

    Dr Wen Chang

  36. Vaccinia Virus 4c (A26L) Protein on Intracellular Mature Virus Binds to the Extracellular Cellular Matrix Laminin

    Article • Journal of Virology, December 2006, ASM Journals

    Dr Wen Chang

  37. The Envelope G3L Protein Is Essential for Entry of Vaccinia Virus into Host Cells

    Article • Journal of Virology, September 2006, ASM Journals

    Dr Wen Chang

  38. A Poxvirus Host Range Protein, CP77, Binds to a Cellular Protein, HMG20A, and Regulates Its Dissociation from the Vaccinia Virus Genome in CHO-K1 Cells

    Article • Journal of Virology, August 2006, ASM Journals

    Dr Wen Chang

  39. Vaccinia Virus Proteome: Identification of Proteins in Vaccinia Virus Intracellular Mature Virion Particles

    Article • Journal of Virology, March 2006, ASM Journals

    Dr Wen Chang

  40. Laser‐Induced Acoustic Desorption Mass Spectrometry of Single Bioparticles

    Article • Angewandte Chemie, February 2006, Wiley

    Zongxiu Nie, Dr Wen Chang

  41. Effects of a Temperature Sensitivity Mutation in the J1R Protein Component of a Complex Required for Vaccinia Virus Assembly

    Article • Journal of Virology, July 2005, ASM Journals

    Dr Wen Chang

  42. The Oligomeric Structure of Vaccinia Viral Envelope Protein A27L is Essential for Binding to Heparin and Heparan Sulfates on Cell Surfaces: A Structural and Functional Approach Using Site-specific Mutagenesis

    Article • Journal of Molecular Biology, June 2005, Elsevier

    Dr Wen Chang

  43. Vaccinia Virus Penetration Requires Cholesterol and Results in Specific Viral Envelope Proteins Associated with Lipid Rafts

    Article • Journal of Virology, February 2005, ASM Journals

    Dr Wen Chang

  44. The cowpox virus host range gene, CP77, affects phosphorylation of eIF2 α and vaccinia viral translation in apoptotic HeLa cells

    Article • Virology, November 2004, Elsevier

    Dr Wen Chang

  45. An External Loop Region of Domain III of Dengue Virus Type 2 Envelope Protein Is Involved in Serotype-Specific Binding to Mosquito but Not Mammalian Cells

    Article • Journal of Virology, January 2004, ASM Journals

    Dr Wen Chang

  46. Role of the Serine-Threonine Kinase PAK-1 in Myxoma Virus Replication

    Article • Journal of Virology, May 2003, ASM Journals

    Dr Wen Chang

  47. Vaccinia Virus J1R Protein: a Viral Membrane Protein That Is Essential for Virion Morphogenesis

    Article • Journal of Virology, October 2002, ASM Journals

    Dr Wen Chang

  48. Structural Analysis of the Extracellular Domain of Vaccinia Virus Envelope Protein, A27L, by NMR and CD Spectroscopy

    Article • Journal of Biological Chemistry, June 2002, Elsevier

    Dr Wen Chang

  49. Molecular Chaperone Hsp90 Is Important for Vaccinia Virus Growth in Cells

    Article • Journal of Virology, February 2002, ASM Journals

    Dr Wen Chang

  50. Vaccinia Virus Envelope H3L Protein Binds to Cell Surface Heparan Sulfate and Is Important for Intracellular Mature Virion Morphogenesis and Virus Infection In Vitro and In Vivo

    Article • Journal of Virology, April 2000, ASM Journals

    Dr Wen Chang

  51. Vaccinia Virus Envelope D8L Protein Binds to Cell Surface Chondroitin Sulfate and Mediates the Adsorption of Intracellular Mature Virions to Cells

    Article • Journal of Virology, October 1999, ASM Journals

    Dr Wen Chang

  52. Cell Surface Proteoglycans Are Necessary for A27L Protein-Mediated Cell Fusion: Identification of the N-Terminal Region of A27L Protein as the Glycosaminoglycan-Binding Domain

    Article • Journal of Virology, October 1998, ASM Journals

    Dr Wen Chang

  53. A27L Protein Mediates Vaccinia Virus Interaction with Cell Surface Heparan Sulfate

    Article • Journal of Virology, February 1998, ASM Journals

    Dr Wen Chang

  54. Apoptosis and host restriction of vaccinia virus in RK13 cells

    Article • Virus Research, December 1997, Elsevier

    Dr Wen Chang

  55. Isolation and characterization of a Chinese hamster ovary mutant cell line with altered sensitivity to vaccinia virus killing

    Article • Journal of Virology, July 1996, ASM Journals

    Dr Wen Chang

  56. Isolation of a monoclonal antibody which blocks vaccinia virus infection

    Article • Journal of Virology, January 1995, ASM Journals

    Dr Wen Chang

  57. Enrichment of Insertional Mutants Following Retrovirus Gene Trap Selection

    Article • Virology, April 1993, Elsevier

    Dr Wen Chang

  58. Characterization of vaccinia virus growth factor biosynthetic pathway with an antipeptide antiserum

    Article • Journal of Virology, March 1988, ASM Journals

    Dr Wen Chang

  59. The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.

    Article • Molecular and Cellular Biology, January 1987, ASM Journals

    Dr Wen Chang