All Stories

  1. Speeding up sustainable solution-phase peptide synthesis using T3P® as a green coupling reagent: methods and challenges
  2. Characterizing the Interactions of Dimethyl Sulfoxide with Water: A Rotational Spectroscopy Study
  3. Application of Af4-Multidetection to Liraglutide in Its Formulation: Preserving and Representing Native Aggregation
  4. Fast MacMillan’s Imidazolidinone-Catalyzed Enantioselective Synthesis of Polyfunctionalized 4-Isoxazoline Scaffolds
  5. Carbodiimide-Mediated Beckmann Rearrangement of Oxyma-B as a Side Reaction in Peptide Synthesis
  6. Benefits of a Mixed-Mode Stationary Phase to Address the Challenging Purification of an Industrially Relevant Peptide: A Proof-of-Concept Study
  7. A New Approach to Supramolecular Structure Determination in Pharmaceutical Preparation of Self-Assembling Peptides: A Case Study of Lanreotide Autogel
  8. Sustainability in peptide chemistry: current synth. & purification techn. and future challenges
  9. A translation of the twelve principles of green chemistry to guide the development of cross-coupling reactions
  10. Downstream Processing of Therapeutic Peptides by Means of Preparative Liquid Chromatography
  11. Expanding the Use of Dynamic Electrostatic Repulsion Reversed-Phase Chromatography: An Effective Elution Mode for Peptides Control and Analysis
  12. Copper(II) Lysinate and Pseudoproline Assistance in the Convergent Synthesis of the GLP-1 Receptor Agonists Liraglutide and Semaglutide
  13. Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives
  14. Palladium Catalyst Recycling for Heck‐Cassar‐Sonogashira Cross‐Coupling Reactions in Green Solvent/Base Blend
  15. Process Intensification for the Purification of Peptidomimetics: The Case of Icatibant through Multicolumn Countercurrent Solvent Gradient Purification (MCSGP)
  16. Replacing piperidine in solid phase peptide synthesis: effective Fmoc removal by alternative bases
  17. Steps towards sustainable solid phase peptide synthesis: use and recovery of N-octyl pyrrolidone
  18. Ampicillin sodium: Isolation, identification and synthesis of the last unknown impurity after 60 years of clinical use
  19. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury
  20. High–throughput enantioseparation of Nα–fluorenylmethoxycarbonyl proteinogenic amino acids through fast chiral chromatography on zwitterionic-teicoplanin stationary phases
  21. From batch to continuous chromatographic purification of a therapeutic peptide through multicolumn countercurrent solvent gradient purification
  22. Fast Heck–Cassar–Sonogashira (HCS) Reactions in Green Solvents
  23. Modeling the nonlinear behavior of a bioactive peptide in reversed-phase gradient elution chromatography
  24. Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 2
  25. Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
  26. Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization
  27. Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 1.
  28. Novel insights into the chemistry of an old medicine: A general degradative pathway for penicillins from a piperacillin/tazobactam stability study
  29. Green Solvent Mixtures for Solid-Phase Peptide Synthesis: A Dimethylformamide-Free Highly Efficient Synthesis of Pharmaceutical-Grade Peptides
  30. Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids
  31. Innovative chemical synthesis and conformational hints on the lipopeptide liraglutide
  32. Recovery of bioactive compounds from artichoke brines by nanofiltration
  33. Production of peptides as generic drugs: a patent landscape of octreotide
  34. Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2AReceptor Ligands
  35. Hypoglycemic effects of a standardized extract of salvia miltiorrhiza roots in rats
  36. ST7612AA1, a Thioacetate-ω(γ-lactam carboxamide) Derivative Selected from a Novel Generation of Oral HDAC Inhibitors
  37. Reducing effect of the Chinese medicinal herb, Salvia miltiorrhiza, on alcohol self-administration in Sardinian alcohol-preferring rats
  38. Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties
  39. Protective effect of Panax ginseng in cisplatin-induced cachexia in rats
  40. 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors
  41. Synthesis and Evaluation of New Hsp90 Inhibitors Based on a 1,4,5-Trisubstituted 1,2,3-Triazole Scaffold
  42. Biotransformation of Colchicinoids into Their Corresponding 3-O-Glucosyl Derivatives by Selected Strains of Bacillus megaterium
  43. Development of a practical and sustainable strategy for the synthesis of ST1535 by an iron-catalyzed Kumada cross-coupling reaction
  44. Thermodynamic and kinetic investigation of monoketo-aldehyde-peroxyhemiacetal (MKA), a stereolabile degradation product of dihydroartemisinin
  45. Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors
  46. Effect of SAMITAL® in the treatment of chemotherapy-induced mucositis in adult oncohematological patients
  47. SAMITAL®: a new botanical drug for the treatment of mucositis induced by oncological therapies
  48. Synthesis and Biological Evaluation of Metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), A Potent Antagonist of the A2A Adenosine Receptor for the Treatment of Parkinson’s Disease
  49. Synthesis of (E)-8-(3-Chlorostyryl)caffeine Analogues Leading to 9-Deazaxanthine Derivatives as Dual A2A Antagonists/MAO-B Inhibitors
  50. Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties
  51. Camptothecins in tumor homing via an RGD sequence mimetic
  52. Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases
  53. Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives
  54. Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
  55. New retinoid derivatives as back-ups of Adarotene
  56. Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions
  57. Novel 3,4-Isoxazolediamides as Potent Inhibitors of Chaperone Heat Shock Protein 90
  58. Erratum to “Efficient organic monoliths prepared by γ-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry” [J. Chromatogr. A 1218 ...
  59. Identification of impurities in artemisinin, their behavior in high performance liquid chromatography and implications for the quality of derived anti-malarial drugs
  60. Derivatives of R-Aminocarnitine without Ammonium Moiety as Liver Carnitine Palmitoyltransferase I (L-CPT I) Inhibitors
  61. Efficient organic monoliths prepared by γ-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry
  62. Stereolability of Dihydroartemisinin, an Antimalarial Drug: A Comprehensive Kinetic Investigation. Part 2
  63. Oxime Amides as a Novel Zinc Binding Group in Histone Deacetylase Inhibitors: Synthesis, Biological Activity, and Computational Evaluation
  64. Stereolability of Dihydroartemisinin, an Antimalarial Drug: A Comprehensive Thermodynamic Investigation. Part 1
  65. Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity
  66. A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
  67. Direct B-Alkyl Suzuki−Miyaura Cross-Coupling of 2-Halopurines. Practical Synthesis of ST1535, a Potent Adenosine A2A Receptor Antagonist
  68. Aminocarnitine Ureidic Derivatives as Inhibitors of Carnitine Palmitoyltransferase I
  69. Stereodynamic Investigation of Labile Stereogenic Centres in Dihydroartemisinin
  70. Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System
  71. Extending the use of “Inverted Chirality Columns Approach” for enantiomeric excess determination in absence of reference samples: Application to a water-soluble camptothecin derivative
  72. 2-Azetidinones: synthesis of new bis(indolyl)butyl-β-lactams
  73. Azetidinones as Zinc-Binding Groups to Design Selective HDAC8 Inhibitors
  74. Corrigendum to “N-Hydroxy-(4-oxime)-cinnamide: A versatile scaffold for the synthesis of novel histone deacetilase (HDAC) inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 2346]
  75. Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors
  76. N-Hydroxy-(4-oxime)-cinnamide: A versatile scaffold for the synthesis of novel histone deacetilase (HDAC) inhibitors
  77. Catalysis: The pharmaceutical perspective
  78. On-column epimerization of dihydroartemisinin: An effective analytical approach to overcome the shortcomings of the International Pharmacopoeia monograph☆
  79. Novel Substituted Aminoalkylguanidines as Potential Antihyperglycemic and Food Intake-Reducing Agents
  80. E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation
  81. Synthesis and Biological Activity of Fluorinated Combretastatin Analogues
  82. Catalysis: A key technology for a green approach to pharmaceutical production
  83. ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence
  84. Combination of HPLC “Inverted Chirality Columns Approach” and MS/MS Detection for Extreme Enantiomeric Excess Determination Even in Absence of Reference Samples. Application to Camptothecin Derivatives
  85. Polymorphisms and Patent, Market, and Legal Battles:  Cefdinir Case Study
  86. Cefdinir: A comparative study of anhydrous vs. monohydrate formMicrostructure and tabletting behaviour
  87. Development of a Practical High-Yield Industrial Synthesis of Pergolide Mesylate
  88. Evolution of an acylase active on cephalosporin C
  89. Blakeslea trispora Genes for Carotene Biosynthesis
  90. Biotechnological lycopene production by mated fermentation of Blakeslea trispora
  91. Natural lycopene from Blakeslea trispora: all-trans lycopene thermochemical and structural properties
  92. A New Carbanionic One-Carbon Ring Enlargement—Alkylation of Lactams.
  93. A New Carbanionic One-Carbon Ring Enlargement-Alkylation of Lactams
  94. Walter Cabri and Romano Di Fabio, From Bench to Market: The Evolution of Chemical Synthesis
  95. Palladium-catalysed reduction of 3-substituted cephems. A high yield approach to ceftizoxime synthetic intermediates
  96. Solid-phase synthesis of indoles using the palladium-catalysed coupling of alkynes with iodoaniline derivatives
  97. Preparation of diphenylmethyl esters by oxone® oxidation of benzophenone hydrazone
  98. Synthesis and cytotoxic activity of alkylidene- and alkyl-substituted camptothecins
  99. A high yield semisynthetic approach to 2′-epi-Taxol
  100. Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives
  101. A new high yield semisynthetic approach to (20s)-9-NH2-camptothecin based on a sequence of palladium-catalysed reductions
  102. The Ligand Effect in Copper(I)-Catalyzed Chemoselective Amide Carbamoylation in Cabergoline Synthesis
  103. Non-toxic ligands in samarium diiodide-mediated cyclizations
  104. Recent Developments and New Perspectives in the Heck Reaction
  105. Zinc halides-mediated nucleophilic attack of thioacid salts in non protic media. A key step in the total synthesis of penems
  106. Iron(III)–copper(II) and manganese(III)–copper(II) promoted cyclizations: a new stereoselective approach towards α-methyl substituted penicillin derivatives
  107. 1,10-Phenanthroline derivatives: a new ligand class in the Heck reaction. Mechanistic aspects
  108. Synthesis and β-lactamase inhibitory activity of 6-hydroxyethyl thiaclavulanic acid.
  109. Samarium diiodide mediated reduction of allyl halides. A new reductive approach to exomethylene cephams.
  110. Metal-catalyzed and -promoted cyclizations for the synthesis of cephalosporins: a possible DAOC/DAC synthetase biomimetic process.
  111. Cobalt-catalyzed methoxycarbonylation of naphthalene mono- and di-sulfonates to naphthalene mono- and di-esters
  112. The total synthesis of ritipenems. Construction of penem thiazoline ring by incorporation of two 2C units of glycolic acid.
  113. A Facile One-Pot Synthesis of Polyfunctionalized 2-Unsubstituted Benzo[b]furans
  114. Metal-promoted thiyl radical cyclizations in β-lactam antibiotics
  115. Palladium-catalyzed arylation of unsymmetrical olefins. Bidentate phosphine ligand controlled regioselectivity
  116. .alpha.-Regioselectivity in palladium-catalyzed arylation of acyclic enol ethers
  117. Bidentate Nitrogen Ligands in Heck Type Reactions
  118. Synthesis of 5-Alkyl Substituted Uracil Derivatives from Barbituric Acid
  119. Heck reaction on anthraquinone derivatives: ligand, solvent and salt effects
  120. Palladium-catalyzed α-arylation of vinyl butyl ether with aryl halides
  121. The stereocontrolled formation of cyclic vicinal cis-diols via a samarium diiodide pinacol coupling of dialdehydes
  122. Ligand-controlled .alpha.-regioselectivity in palladium-catalyzed arylation of butyl vinyl ether
  123. A novel synthesis of (+)-4-demethoxydaunomycinone
  124. Palladium-catalyzed reduction of aryl sulfonates. Reduction versus hydrolysis selectivity control
  125. Enzymic hydrolysis of alkyl 3,4-epoxybutyrates. A new route to (R)-(-)-carnitine chloride
  126. Enzymatic resolution of 2,3-epoxyalcohols, intermediates in the synthesis of the gypsy moth sex pheromone
  127. Lipase-catalyzed resolution of chiral 2-amino 1-alcohols