All Stories

  1. Comparing the performance of electrostatic repulsion-reversed phase chromatography approaches in the resolution of complex peptide mixture: Liraglutide as case study
  2. Improving Solid-State Properties of the Side-Chain Peptide Building Blocks for the Synthesis of GLP-1 Analogs through Their Complexation with Metal Cations
  3. Mastering palladium-catalyzed cross-coupling reactions: the critical role of in situ pre-catalyst reduction design
  4. Electrochemical oxidative CF3 radical-induced lactonization and etherification of terminal and internal alkenes
  5. Replace, reduce, and reuse organic solvents in peptide downstream processing: the benefits of dimethyl carbonate over acetonitrile
  6. A Sustainable Chemo-Enzymatic Approach to the Synthesis of Liraglutide
  7. Rediscovery of an Old Named Reaction: From Micellar Catalysis to Unusual Schotten–Baumann Conditions
  8. Understanding Glucagon Aggregation: In Silico Insights and Experimental Validation
  9. Assessing the performance of new chromatographic technologies for the separation of peptide epimeric impurities: the case of Icatibant
  10. Solid phase peptide synthesis using side-chain unprotected arginine and histidine with Oxyma Pure/TBEC in green solvents
  11. Dimethyl carbonate as a green alternative to acetonitrile in reversed-phase liquid chromatography. Part II: Purification of a therapeutic peptide
  12. Dimethyl carbonate as a green alternative to acetonitrile in reversed-phase liquid chromatography. Part I: Separation of small molecules
  13. Copper-Free Heck–Cassar–Sonogashira and Suzuki–Miyaura Reactions of Aryl Chlorides: A Sustainable Approach
  14. Fast Solution-Phase and Liquid-Phase Peptide Syntheses (SolPSS and LPPS) Mediated by Biomimetic Cyclic Propylphosphonic Anhydride (T3P®)
  15. New Mechanistic Insights into the Copper-Free Heck–Cassar–Sonogashira Cross-Coupling Reaction
  16. Investigation of the GnRH antagonist degarelix isomerization in biological matrices
  17. Speeding up sustainable solution-phase peptide synthesis using T3P® as a green coupling reagent: methods and challenges
  18. From green innovations in oligopeptide to oligonucleotide sustainable synthesis: differences and synergies in TIDES chemistry
  19. Characterizing the Interactions of Dimethyl Sulfoxide with Water: A Rotational Spectroscopy Study
  20. Application of Af4-Multidetection to Liraglutide in Its Formulation: Preserving and Representing Native Aggregation
  21. Fast MacMillan’s Imidazolidinone-Catalyzed Enantioselective Synthesis of Polyfunctionalized 4-Isoxazoline Scaffolds
  22. Carbodiimide-Mediated Beckmann Rearrangement of Oxyma-B as a Side Reaction in Peptide Synthesis
  23. Benefits of a Mixed-Mode Stationary Phase to Address the Challenging Purification of an Industrially Relevant Peptide: A Proof-of-Concept Study
  24. A New Approach to Supramolecular Structure Determination in Pharmaceutical Preparation of Self-Assembling Peptides: A Case Study of Lanreotide Autogel
  25. Sustainability in peptide chemistry: current synth. & purification techn. and future challenges
  26. A translation of the twelve principles of green chemistry to guide the development of cross-coupling reactions
  27. Downstream Processing of Therapeutic Peptides by Means of Preparative Liquid Chromatography
  28. Expanding the Use of Dynamic Electrostatic Repulsion Reversed-Phase Chromatography: An Effective Elution Mode for Peptides Control and Analysis
  29. Copper(II) Lysinate and Pseudoproline Assistance in the Convergent Synthesis of the GLP-1 Receptor Agonists Liraglutide and Semaglutide
  30. Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives
  31. Palladium Catalyst Recycling for Heck‐Cassar‐Sonogashira Cross‐Coupling Reactions in Green Solvent/Base Blend
  32. Process Intensification for the Purification of Peptidomimetics: The Case of Icatibant through Multicolumn Countercurrent Solvent Gradient Purification (MCSGP)
  33. Replacing piperidine in solid phase peptide synthesis: effective Fmoc removal by alternative bases
  34. Steps towards sustainable solid phase peptide synthesis: use and recovery of N-octyl pyrrolidone
  35. Ampicillin sodium: Isolation, identification and synthesis of the last unknown impurity after 60 years of clinical use
  36. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury
  37. High–throughput enantioseparation of Nα–fluorenylmethoxycarbonyl proteinogenic amino acids through fast chiral chromatography on zwitterionic-teicoplanin stationary phases
  38. From batch to continuous chromatographic purification of a therapeutic peptide through multicolumn countercurrent solvent gradient purification
  39. Fast Heck–Cassar–Sonogashira (HCS) Reactions in Green Solvents
  40. Modeling the nonlinear behavior of a bioactive peptide in reversed-phase gradient elution chromatography
  41. Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 2
  42. Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
  43. Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization
  44. Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 1.
  45. Novel insights into the chemistry of an old medicine: A general degradative pathway for penicillins from a piperacillin/tazobactam stability study
  46. Green Solvent Mixtures for Solid-Phase Peptide Synthesis: A Dimethylformamide-Free Highly Efficient Synthesis of Pharmaceutical-Grade Peptides
  47. Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids
  48. Innovative chemical synthesis and conformational hints on the lipopeptide liraglutide
  49. Recovery of bioactive compounds from artichoke brines by nanofiltration
  50. Production of peptides as generic drugs: a patent landscape of octreotide
  51. Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2AReceptor Ligands
  52. Hypoglycemic effects of a standardized extract of salvia miltiorrhiza roots in rats
  53. ST7612AA1, a Thioacetate-ω(γ-lactam carboxamide) Derivative Selected from a Novel Generation of Oral HDAC Inhibitors
  54. Reducing effect of the Chinese medicinal herb, Salvia miltiorrhiza, on alcohol self-administration in Sardinian alcohol-preferring rats
  55. Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties
  56. Protective effect of Panax ginseng in cisplatin-induced cachexia in rats
  57. 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors
  58. Synthesis and Evaluation of New Hsp90 Inhibitors Based on a 1,4,5-Trisubstituted 1,2,3-Triazole Scaffold
  59. Biotransformation of Colchicinoids into Their Corresponding 3-O-Glucosyl Derivatives by Selected Strains of Bacillus megaterium
  60. Development of a practical and sustainable strategy for the synthesis of ST1535 by an iron-catalyzed Kumada cross-coupling reaction
  61. Thermodynamic and kinetic investigation of monoketo-aldehyde-peroxyhemiacetal (MKA), a stereolabile degradation product of dihydroartemisinin
  62. Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors
  63. Effect of SAMITAL® in the treatment of chemotherapy-induced mucositis in adult oncohematological patients
  64. SAMITAL®: a new botanical drug for the treatment of mucositis induced by oncological therapies
  65. Synthesis and Biological Evaluation of Metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), A Potent Antagonist of the A2A Adenosine Receptor for the Treatment of Parkinson’s Disease
  66. Synthesis of (E)-8-(3-Chlorostyryl)caffeine Analogues Leading to 9-Deazaxanthine Derivatives as Dual A2A Antagonists/MAO-B Inhibitors
  67. Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties
  68. Camptothecins in tumor homing via an RGD sequence mimetic
  69. Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases
  70. Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives
  71. Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
  72. New retinoid derivatives as back-ups of Adarotene
  73. Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions
  74. Novel 3,4-Isoxazolediamides as Potent Inhibitors of Chaperone Heat Shock Protein 90
  75. Erratum to “Efficient organic monoliths prepared by γ-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry” [J. Chromatogr. A 1218 ...
  76. Identification of impurities in artemisinin, their behavior in high performance liquid chromatography and implications for the quality of derived anti-malarial drugs
  77. Derivatives of R-Aminocarnitine without Ammonium Moiety as Liver Carnitine Palmitoyltransferase I (L-CPT I) Inhibitors
  78. Efficient organic monoliths prepared by γ-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry
  79. Stereolability of Dihydroartemisinin, an Antimalarial Drug: A Comprehensive Kinetic Investigation. Part 2
  80. Oxime Amides as a Novel Zinc Binding Group in Histone Deacetylase Inhibitors: Synthesis, Biological Activity, and Computational Evaluation
  81. Stereolability of Dihydroartemisinin, an Antimalarial Drug: A Comprehensive Thermodynamic Investigation. Part 1
  82. Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity
  83. A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
  84. Direct B-Alkyl Suzuki−Miyaura Cross-Coupling of 2-Halopurines. Practical Synthesis of ST1535, a Potent Adenosine A2A Receptor Antagonist
  85. Aminocarnitine Ureidic Derivatives as Inhibitors of Carnitine Palmitoyltransferase I
  86. Stereodynamic Investigation of Labile Stereogenic Centres in Dihydroartemisinin
  87. Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System
  88. Extending the use of “Inverted Chirality Columns Approach” for enantiomeric excess determination in absence of reference samples: Application to a water-soluble camptothecin derivative
  89. 2-Azetidinones: synthesis of new bis(indolyl)butyl-β-lactams
  90. Azetidinones as Zinc-Binding Groups to Design Selective HDAC8 Inhibitors
  91. Corrigendum to “N-Hydroxy-(4-oxime)-cinnamide: A versatile scaffold for the synthesis of novel histone deacetilase (HDAC) inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 2346]
  92. Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors
  93. N-Hydroxy-(4-oxime)-cinnamide: A versatile scaffold for the synthesis of novel histone deacetilase (HDAC) inhibitors
  94. Catalysis: The pharmaceutical perspective
  95. On-column epimerization of dihydroartemisinin: An effective analytical approach to overcome the shortcomings of the International Pharmacopoeia monograph☆
  96. Novel Substituted Aminoalkylguanidines as Potential Antihyperglycemic and Food Intake-Reducing Agents
  97. E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation
  98. Synthesis and Biological Activity of Fluorinated Combretastatin Analogues
  99. Catalysis: A key technology for a green approach to pharmaceutical production
  100. ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence
  101. Combination of HPLC “Inverted Chirality Columns Approach” and MS/MS Detection for Extreme Enantiomeric Excess Determination Even in Absence of Reference Samples. Application to Camptothecin Derivatives
  102. Polymorphisms and Patent, Market, and Legal Battles:  Cefdinir Case Study
  103. Cefdinir: A comparative study of anhydrous vs. monohydrate formMicrostructure and tabletting behaviour
  104. Development of a Practical High-Yield Industrial Synthesis of Pergolide Mesylate
  105. Evolution of an acylase active on cephalosporin C
  106. Blakeslea trispora Genes for Carotene Biosynthesis
  107. Biotechnological lycopene production by mated fermentation of Blakeslea trispora
  108. Natural lycopene from Blakeslea trispora: all-trans lycopene thermochemical and structural properties
  109. A New Carbanionic One-Carbon Ring Enlargement—Alkylation of Lactams.
  110. A New Carbanionic One-Carbon Ring Enlargement-Alkylation of Lactams
  111. Walter Cabri and Romano Di Fabio, From Bench to Market: The Evolution of Chemical Synthesis
  112. Palladium-catalysed reduction of 3-substituted cephems. A high yield approach to ceftizoxime synthetic intermediates
  113. Solid-phase synthesis of indoles using the palladium-catalysed coupling of alkynes with iodoaniline derivatives
  114. Preparation of diphenylmethyl esters by oxone® oxidation of benzophenone hydrazone
  115. Synthesis and cytotoxic activity of alkylidene- and alkyl-substituted camptothecins
  116. A high yield semisynthetic approach to 2′-epi-Taxol
  117. Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives
  118. A new high yield semisynthetic approach to (20s)-9-NH2-camptothecin based on a sequence of palladium-catalysed reductions
  119. The Ligand Effect in Copper(I)-Catalyzed Chemoselective Amide Carbamoylation in Cabergoline Synthesis
  120. Non-toxic ligands in samarium diiodide-mediated cyclizations
  121. Recent Developments and New Perspectives in the Heck Reaction
  122. Zinc halides-mediated nucleophilic attack of thioacid salts in non protic media. A key step in the total synthesis of penems
  123. Iron(III)–copper(II) and manganese(III)–copper(II) promoted cyclizations: a new stereoselective approach towards α-methyl substituted penicillin derivatives
  124. 1,10-Phenanthroline derivatives: a new ligand class in the Heck reaction. Mechanistic aspects
  125. Synthesis and β-lactamase inhibitory activity of 6-hydroxyethyl thiaclavulanic acid.
  126. Samarium diiodide mediated reduction of allyl halides. A new reductive approach to exomethylene cephams.
  127. Metal-catalyzed and -promoted cyclizations for the synthesis of cephalosporins: a possible DAOC/DAC synthetase biomimetic process.
  128. Cobalt-catalyzed methoxycarbonylation of naphthalene mono- and di-sulfonates to naphthalene mono- and di-esters
  129. The total synthesis of ritipenems. Construction of penem thiazoline ring by incorporation of two 2C units of glycolic acid.
  130. A Facile One-Pot Synthesis of Polyfunctionalized 2-Unsubstituted Benzo[b]furans
  131. Metal-promoted thiyl radical cyclizations in β-lactam antibiotics
  132. Palladium-catalyzed arylation of unsymmetrical olefins. Bidentate phosphine ligand controlled regioselectivity
  133. .alpha.-Regioselectivity in palladium-catalyzed arylation of acyclic enol ethers
  134. Bidentate Nitrogen Ligands in Heck Type Reactions
  135. Synthesis of 5-Alkyl Substituted Uracil Derivatives from Barbituric Acid
  136. Heck reaction on anthraquinone derivatives: ligand, solvent and salt effects
  137. Palladium-catalyzed α-arylation of vinyl butyl ether with aryl halides
  138. The stereocontrolled formation of cyclic vicinal cis-diols via a samarium diiodide pinacol coupling of dialdehydes
  139. Ligand-controlled .alpha.-regioselectivity in palladium-catalyzed arylation of butyl vinyl ether
  140. A novel synthesis of (+)-4-demethoxydaunomycinone
  141. Palladium-catalyzed reduction of aryl sulfonates. Reduction versus hydrolysis selectivity control
  142. Enzymic hydrolysis of alkyl 3,4-epoxybutyrates. A new route to (R)-(-)-carnitine chloride
  143. Enzymatic resolution of 2,3-epoxyalcohols, intermediates in the synthesis of the gypsy moth sex pheromone
  144. Lipase-catalyzed resolution of chiral 2-amino 1-alcohols