Professor Vladimir Kren

In vitro response of human ovarian cancer cells to dietary bioflavonoid isoquercitrin

• Journal of Environmental Science and Health Part B
• July 2019

Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations an...

• Oxidative Medicine and Cellular Longevity
• February 2019

Enzymatic oxidative dimerization of silymarin flavonolignans

• Journal of Molecular Catalysis B Enzymatic
• November 2014

Access to bifunctionalized biomolecular platforms using oxime ligation

• Carbohydrate Research
• July 2014

Dehydro-flavonolignans from silymarin are potent inhibitors of lipid peroxidation in is...

• Biochimica et Biophysica Acta (BBA) - Bioenergetics
• July 2014

Isoquercitrin: Pharmacology, toxicology, and metabolism

• Food and Chemical Toxicology
• June 2014

cis – trans Isomerization of silybins A and B

• Beilstein Journal of Organic Chemistry
• May 2014

Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers

• Molecules
• April 2014

Preparation of silybin phase II metabolites: Streptomyces catalyzed glucuronidation

• Journal of Molecular Catalysis B Enzymatic
• April 2014

Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Deriva...

• Molecules
• March 2014

Expression, characterization and homology modeling of a novel eukaryotic GH84 β-N-acety...

• Protein Expression and Purification
• March 2014

Biphasic Catalysis with Disaccharide Phosphorylases: Chemoenzymatic Synthesis of α-<scp...

• Organic Process Research & Development
• February 2014

Re-Evaluation of Binding Properties of Recombinant Lymphocyte Receptors NKR-P1A and CD6...

• International Journal of Molecular Sciences
• January 2014

Chemistry of silybin

• Natural Product Reports
• January 2014

Biotransformation of Silybin and its Congeners

• Current Drug Metabolism
• December 2013

LC–MS metabolic study on quercetin and taxifolin galloyl esters using human hepatocytes...

• Journal of Pharmaceutical and Biomedical Analysis
• December 2013

Recombinant α-L-rhamnosidase ofAspergillus terreusimmobilization in polyvinylalcohol hy...

• Biocatalysis and Biotransformation
• November 2013

Chemoenzymatic synthesis of α-l-rhamnosides using recombinant α-l-rhamnosidase from Asp...

• Bioresource Technology
• November 2013

Antioxidant, metal-binding and DNA-damaging properties of flavonolignans: A joint exper...

• Chemico-Biological Interactions
• October 2013

Preparative Purification and Isolation of Pyranoanthocyanins from Red Wine and Evaluati...

• Chromatographia
• August 2013

ChemInform Abstract: Enzymatic Glycosylation of Multivalent Scaffolds

• ChemInform
• August 2013

Effect of 3-<i>O</i>-Galloyl Substitution on the Electrochemical Oxidation of Quercetin...

• Electroanalysis
• June 2013

Preparation of silybin and isosilybin sulfates by sulfotransferase from Desulfitobacter...

• Journal of Molecular Catalysis B Enzymatic
• May 2013

Bioavailability of silymarin flavonolignans: drug formulations and biotransformation

• Phytochemistry Reviews
• April 2013

Anti-Cancer Efficacy of Silybin Derivatives - A Structure-Activity Relationship

• PLoS ONE
• March 2013

Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransf...

• Applied Microbiology and Biotechnology
• March 2013

Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of...

• Journal of Molecular Catalysis B Enzymatic
• March 2013

A Novel Semisynthetic Flavonoid 7-<i>O</i>-Galloyltaxifolin Upregulates Heme Oxygenase-...

• Journal of Medicinal Chemistry
• January 2013

ChemInform Abstract: Enzymatic Glycosylation of Small Molecules: Challenging Substrates...

• ChemInform
• January 2013

Enzymatic glycosylation of multivalent scaffolds

• Chemical Society Reviews
• January 2013

β‐<i>N</i>‐Acetylhexosaminidases: group‐specific inhibitors wanted

• January 2013

Preparative method for isosilybin isolation based on enzymatic kinetic resolution of si...

• Process Biochemistry
• January 2013

Ionic liquids as cosolvents for glycosylation by sucrose phosphorylase: balancing accep...

• Green Chemistry
• January 2013

Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives

• Tetrahedron Letters
• January 2013

Production of Aspergillus niger β-mannosidase in Pichia pastoris

• Protein Expression and Purification
• October 2012

Enzymatic Glycosylation of Small Molecules: Challenging Substrates Require Tailored Cat...

• Chemistry - A European Journal
• August 2012

Preparatory production of quercetin-3-β-d-glucopyranoside using alkali-tolerant thermos...

• Bioresource Technology
• July 2012

Biotransformation of flavonols and taxifolin in hepatocyte in vitro systems as determin...

• Journal of Chromatography B
• June 2012

Chemo-enzymatic modification of poly- N -acetyllactosamine (LacNAc) oligomers and N,N ...

• Beilstein Journal of Organic Chemistry
• May 2012

Recombinant α-l-rhamnosidase from Aspergillus terreus in selective trimming of rutin

• Process Biochemistry
• May 2012

Facile synthesis of nitrophenyl 2-acetamido-2-deoxy-α-D-mannopyranosides from ManNAc-ox...

• Beilstein Journal of Organic Chemistry
• March 2012

Quercetin, Quercetin Glycosides and Taxifolin Differ in their Ability to Induce AhR Act...

• Phytotherapy Research
• March 2012

Heterologous Expression and Characterization of an <i>N</i>-Acetyl-β-<scp>d</scp>-hexos...

• Journal of Agricultural and Food Chemistry
• March 2012

Sequencing, cloning and high-yield expression of a fungal β-N-acetylhexosaminidase in P...

• Protein Expression and Purification
• March 2012

Facile production of Aspergillus niger α-N-acetylgalactosaminidase in yeast

• Protein Expression and Purification
• January 2012

Flavonoid-dependent Attenuation of Mitochondrial ROS Formation is Augmented by Their Mo...

• Free Radical Biology and Medicine
• November 2011

Synthesis and Antiangiogenic Activity of New Silybin Galloyl Esters

• Journal of Medicinal Chemistry
• October 2011

Electrochemical investigation of flavonolignans and study of their interactions with DN...

• Bioelectrochemistry
• October 2011

Laboratory evolution of an epoxide hydrolase – Towards an enantioconvergent biocatalyst

• Journal of Biotechnology
• October 2011

Biodegradation of tetrabromobisphenol A by oxidases in basidiomycetous fungi and estrog...

• Bioresource Technology
• October 2011

ChemInform Abstract: Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Fal...

• ChemInform
• September 2011

Purification and characterization of heterologously expressed nitrilases from filamento...

• Applied Microbiology and Biotechnology
• September 2011

Combinatorial One-Pot Synthesis of Poly-N-acetyllactosamine Oligosaccharides with Leloi...

• Advanced Synthesis & Catalysis
• September 2011

Regioselective alcoholysis of silybin A and B acetates with lipases

• Journal of Molecular Catalysis B Enzymatic
• September 2011

Charged Hexosaminides as New Substrates for β-N-Acetylhexosaminidase-Catalyzed Synthesi...

• Advanced Synthesis & Catalysis
• August 2011

Study of electrooxidation mechanisms and antioxidant properties of flavonols and flavon...

• Planta Medica
• August 2011

Narrow-bore core-shell particles and monolithic columns in the analysis of silybin dias...

• Journal of Separation Science
• June 2011

Enzymatic characterization and molecular modeling of an evolutionarily interesting fung...

• FEBS Journal
• June 2011

Evidence for differences in regioselective and stereoselective glucuronidation of silyb...

• Xenobiotica
• April 2011

Structure of the Dimeric N-Glycosylated Form of Fungal B-N-Acetylhexosaminidase Reveale...

• April 2011

Dimerisation Process of Silybin-Type Flavonolignans: Insights from Theory

• ChemPhysChem
• April 2011

Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short

• CHIMIA International Journal for Chemistry
• February 2011

Dendri-RAFTs: a second generation of cyclopeptide-based glycoclusters

• Organic & Biomolecular Chemistry
• January 2011

Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with ...

• Journal of Bioenergetics and Biomembranes
• December 2010

Analysis of anthocyanin pigments in Lonicera (Caerulea) extracts using chromatographic ...

• Journal of Chromatography A
• December 2010

β-N-Acetylhexosaminidase: What's in a name…?

• Biotechnology Advances
• November 2010

Large-scale separation of silybin diastereoisomers using lipases

• Process Biochemistry
• October 2010

Genome mining for the discovery of new nitrilases in filamentous fungi

• Biotechnology Letters
• September 2010

Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles

• Bioorganic & Medicinal Chemistry Letters
• July 2010

Cardioprotective activity of dehydrosilybin is linked to its uncoupler-like behavior

• Biochimica et Biophysica Acta (BBA) - Bioenergetics
• July 2010

Effect of flavonolignans derived from silybin on mitochondrial production of reactive o...

• Biochimica et Biophysica Acta (BBA) - Bioenergetics
• July 2010

ChemInform Abstract: Enzymatic Glycosylation of Branched Symmetrical Non-Carbohydrate P...

• ChemInform
• June 2010

ChemInform Abstract: Pyridoxine as a Substrate for Screening Synthetic Potential of Gly...

• ChemInform
• June 2010

ChemInform Abstract: One-pot Enzymatic Synthesis of Sialyl T-Epitope

• ChemInform
• June 2010

ChemInform Abstract: Enzymatic Synthesis of p-Nitrophenyl β-Chitobioside.

• ChemInform
• June 2010

ChemInform Abstract: Enzymatic Preparation of Lysergol β-D-Glucuronide.

• ChemInform
• June 2010

ChemInform Abstract: Enzymatic Glycosylation Using 6-O-Acylated Sugar Donors and Accept...

• ChemInform
• May 2010

ChemInform Abstract: Selective Biotransformation of Substituted Alicyclic Nitriles by R...

• ChemInform
• May 2010

Biotransformations with nitrilases

• Current Opinion in Chemical Biology
• April 2010

ChemInform Abstract: Glycosidases in Synthesis

• ChemInform
• March 2010

Antioxidant and antiviral activities of silybin fatty acid conjugates

• European Journal of Medicinal Chemistry
• March 2010

Enzymatic Processing of Bioactive Glycosides from Natural Sources

• January 2010

Condensation reactions catalyzed by α-N-acetylgalactosaminidase fromAspergillus nigeryi...

• Biocatalysis and Biotransformation
• January 2010

Silybin Derivatives Modulate Thyroid Hormone-Mediated UcP2 Expression in Neonatal Rat C...

• Biophysical Journal
• January 2010

Chemoenzymatic preparative separation of silybins A and B

• Journal of Molecular Catalysis B Enzymatic
• December 2009

Silybin (Silibinin) Structure and Chirality

• Chromatographia
• November 2009

Fungal nitrilases as biocatalysts: Recent developments

• Biotechnology Advances
• November 2009

Glycosidases: a key to tailored carbohydrates

• Trends in Biotechnology
• April 2009

Silibinin chirality

• Journal of Photochemistry and Photobiology A Chemistry
• April 2009

Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity—role of ind...

• Free Radical Biology and Medicine
• March 2009

α-Galactosidases and their applications in biotransformations

• Biocatalysis and Biotransformation
• January 2009

Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid me...

• Biocatalysis and Biotransformation
• January 2009

Biodegradation potential of the genus Rhodococcus

• Environment International
• January 2009

Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and thei...

• Glycoconjugate Journal
• August 2008

Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silyma...

• Food and Chemical Toxicology
• March 2008

Selection and screening for enzymes of nitrile metabolism

• Journal of Biotechnology
• February 2008

Laccase-mediated dimerization of the flavonolignan silybin

• Journal of Molecular Catalysis B Enzymatic
• February 2008

Biotransformation of nitriles to amides using soluble and immobilized nitrile hydratase...

• Journal of Molecular Catalysis B Enzymatic
• February 2008

Mechanism of the Antioxidant Action of Silybin and 2,3-Dehydrosilybin Flavonolignans: A...

• The Journal of Physical Chemistry A
• January 2008

Glycoside vs. Aglycon: The Role of Glycosidic Residue in Biological Activity

• January 2008

Studies on oxidation of ergot alkaloids: oxidation and desaturation of dihydrolysergol—...

• Tetrahedron
• October 2007

Structure, Function and Dynamics of fungal β-N-Hexosaminidase

• September 2007

Structural modeling of alpha-galactosidase and alpha-galactosaminidase from Aspergillus...

• September 2007

New aldoxime-dehydrating enzymes from filamentous fungi

• Journal of Biotechnology
• September 2007

Glycosyl Azides – An Alternative Way to Disaccharides

• Advanced Synthesis & Catalysis
• June 2007

Structure of the dimeric N-glycosylated form of fungal β-N-acetylhexosaminidase reveale...

• BMC Structural Biology
• May 2007

Biotransformation of heterocyclic dinitriles by Rhodococcus erythropolis and fungal nit...

• Biotechnology Letters
• May 2007

Large Propeptides of Fungal β-<i>N</i>-Acetylhexosaminidases Are Novel Enzyme Regulator...

• Biochemistry
• February 2007

Silybin and Silymarin - New and Emerging Applications in Medicine

• Current Medicinal Chemistry
• February 2007

Induction and characterization of an unusual α-d-galactosidase from Talaromyces flavus

• Journal of Biotechnology
• January 2007

Extension of the Nef reaction to C-glycosylnitromethanes

• Carbohydrate Research
• September 2006

Cyanodeoxy-Glycosyl Derivatives as Substrates for Enzymatic Reactions

• European Journal of Organic Chemistry
• September 2006

Preparative production and separation of 2-acetamido-2-deoxymannopyranoside-containing ...

• Journal of Chromatography A
• September 2006

New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotei...

• Bioorganic & Medicinal Chemistry
• June 2006

Unique transglycosylation potential of extracellular α-d-galactosidase from Talaromyces...

• Journal of Molecular Catalysis B Enzymatic
• May 2006

β-1,4-Galactosyltransferase-catalyzed glycosylation of sugar derivatives: Modulation of...

• Journal of Molecular Catalysis B Enzymatic
• May 2006

Cyanodeoxy-Glycosyl Derivatives as Substrates for Enzymatic Reactions

• European Journal of Organic Chemistry
• April 2006

Immobilization of fungal nitrilase and bacterial amidase – two enzymes working in accord

• Biocatalysis and Biotransformation
• January 2006

Glycosyl azide—a novel substrate for enzymatic transglycosylations

• Tetrahedron Letters
• December 2005

Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and a...

• Toxicology
• November 2005

Silybin and silymarin - new effects and applications

• Biomedical Papers
• July 2005

The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis:...

• Biomedical Papers
• July 2005

Biocatalyzed Generation of Molecular Diversity: Selective Modification of the Saponin A...

• Advanced Synthesis & Catalysis
• June 2005

Combined Application of Galactose Oxidase and β-N-Acetylhexosaminidase in the Synthesis...

• Advanced Synthesis & Catalysis
• June 2005

A chemoenzymatic route to mannosamine derivatives bearing different N-acyl groups

• Journal of Biotechnology
• January 2005

Screening and characterization of β-N-acetylhexosaminidases for the synthesis of nucleo...

• Enzyme and Microbial Technology
• April 2004

Synthesis of 4-Nitrophenyl 2-Acetamido-2-deoxy-β-D-mannopyranoside and 4-Nitrophenyl 2-...

• ChemInform
• August 2003

Enzymatic Discrimination of 2-Acetamido-2-deoxy-D-mannopyranose-Containing Disaccharide...

• Advanced Synthesis & Catalysis
• June 2003

Chemical Biology and Biomedicine of Glycosylated Natural Compounds

• ChemInform
• March 2003

Synthesis of 4-Nitrophenyl 2-Acetamido-2-deoxy-β-D-mannopyranoside and 4-Nitrophenyl 2-...

• Collection of Czechoslovak Chemical Communications
• January 2003

Selective biotransformation of substituted alicyclic nitriles by <i>Rhodococcus equi</i...

• Canadian Journal of Chemistry
• June 2002

p-NITROPHENYL 2-AZIDO-2-DEOXY-D-HEXOPYRANOSIDES AS DONORS FOR ENZYMIC GLYCOSYLATION

• April 2002

Nitrile- and Amide-converting Microbial Enzymes: Stereo-, Regio- and Chemoselectivity

• Biocatalysis and Biotransformation
• January 2002

Exploitation of a library of ?-galactosidases for the synthesis of building blocks for ...

• Biotechnology and Bioengineering
• December 2001

Glycosides in Medicine: &amp;#x201C;The Role of Glycosidic Residue in Biological Activi...

• Current Medicinal Chemistry
• September 2001

Chemical Biology and Biomedicine of Glycosylated Natural Compounds

• January 2001

Semisynthetic Dimers of Antiparkinsonic Ergot Alkaloids

• Heterocycles
• January 2001

Enzymatic Glycosylation of Lincomycin

• Bioscience Biotechnology and Biochemistry
• January 2001

Silymarin: What is in the name…? An appeal for a change of editorial policy

• Hepatology
• August 2000

Formation ofmyo-inositol phosphates byAspergillus niger 3-phytase

• Folia Microbiologica
• April 2000

Enzymatic Preparation of Lysergol β-D-Glucuronide

• Collection of Czechoslovak Chemical Communications
• January 2000

Enzymatic synthesis of iso-globotriose from partially protected lactose

• Tetrahedron Letters
• December 1999

Agroclavine Glycosylation

• Collection of Czechoslovak Chemical Communications
• January 1999

One-Pot Enzymatic Synthesis of Sialyl T-Epitope

• January 1999

Pyridoxine as a Substrate for Screening Synthetic Potential of Glycosidases

• Collection of Czechoslovak Chemical Communications
• January 1999

Enzymatic Synthesis ofP-Nitrophenyl β-Chitobioside

• Journal of Carbohydrate Chemistry
• January 1999

Unusual nonreducing sugar GlcNAcβ(1↔1)Manβ formation by β-N-acetylhexosaminidase from A...

• Tetrahedron Letters
• December 1998

Enzymatic Glycosylation of Branched Symmetrical Non-Carbohydrate Polyols

• Journal of Carbohydrate Chemistry
• November 1998

Glycosidase-Catalysed Synthesis of Ergot Alkaloid α-Glycosides

• Journal of Carbohydrate Chemistry
• August 1998

Effect ofp-Substitution of Aryl α-D-Mannosides on Inhibiting Mannose-Sensitive Adhesion...

• European Journal of Organic Chemistry
• August 1998

Glucosylation of silybin by plant cell cultures of Papaver somniferum var. setigerum

• Phytochemistry
• January 1998

Transglycosylation of Thiamin by Fungal β-N-Acetylhexosaminidases

• Bioscience Biotechnology and Biochemistry
• January 1998

β-Glucosylation of chitooligomers by galactosyltransferase

• Carbohydrate Research
• December 1997

Biotransformation of Ergot Alkaloids by Haloperoxidase fromStreptomyces aureofaciens: S...

• European Journal of Organic Chemistry
• November 1997

N -Deoxyribosides of ergot alkaloids: Synthesis and biological activity

• Tetrahedron
• March 1997

Enzymatic and chemical glycosylations of ergot alkaloids and biological aspects of new ...

• January 1997

Synthesis and Antiviral Evaluation of N-β-D-Ribosides of Ergot Alkaloids

• Nucleosides and Nucleotides
• January 1997

Glycosylation of silybin

• Journal of the Chemical Society Perkin Transactions 1
• January 1997

Sterols and fatty acids in <i>Peziza muralis</i>

• Canadian Journal of Microbiology
• November 1996

Ergot alkaloid glycosides with immunomodulatory activities

• Bioorganic & Medicinal Chemistry
• June 1996

Biotransformations of γ-methyl-β-ketosulfones: stereoselectivity of 3-methyl-1-(phenyls...

• Tetrahedron Asymmetry
• May 1996

N-1-Trimethylsilyl Derivatives of Ergot Alkaloids

• Collection of Czechoslovak Chemical Communications
• January 1996

Biotransformation of Chanoclavine by <i>Euphorbia calyptrata</i> Cell Culture

• Journal of Natural Products
• January 1996

Dimerization of Lysergene by <i>Euphorbia calyptrata</i> Cell Cultures

• Journal of Natural Products
• January 1996

Biotransformations of aromatic diniitriles using Rhodococcus equi cells

• Biotechnology Letters
• November 1995

A Multienzyme System for a One-Pot Synthesis of Sialyl T-Antigen

• Angewandte Chemie International Edition
• May 1995

Ein Multienzymsystem zur Eintopfsynthese des Sialyl-T-Antigens

• Angewandte Chemie
• April 1995

Assignment of Nitrogen Stereochemistry of Agroclavine and Elymoclavine 6-N-Oxides

• Collection of Czechoslovak Chemical Communications
• January 1995

Synthesis of α-mannosylated ergot alkaloids employing α-mannosidase

• Biotechnology Letters
• July 1994

Fast atom bombardment mass spectrometry of elymoclavine glycosides

• Biological Mass Spectrometry
• February 1994

Claviceps purpurea (Ergot): Culture and Bioproduction of Ergot Alkaloids

• January 1994

Determination of Lovastatin (mevinolin) and mevinolinic acid in fermentation liquids

• Journal of Chromatography A
• February 1993

Fructosylation of ergot alkaloids by yeast invertase

• Biotechnology Letters
• September 1992

Galactose oxidase production by immobilized cells ofDactylium dendroides

• Biotechnology Techniques
• July 1992

Bioconversions of ergot alkaloids

• January 1991

Glycosylation of ergot alkaloids by free and immobilized cells of Claviceps purpurea

• Applied Microbiology and Biotechnology
• March 1990

Effect of triadimefon on lipids, sterols, and membrane fluidity in submerged cultures o...

• Pesticide Biochemistry and Physiology
• July 1989

Physiological control and process kinetics of clavine alkaloid production byClaviceps p...

• Applied Microbiology and Biotechnology
• September 1988

Physiological control and process kinetics of clavine alkaloid production byClaviceps p...

• Applied Microbiology and Biotechnology
• September 1988

Effect of clomiphene on fatty acids, sterols and membrane fluidity in clavine producing...

• Biochemical and Biophysical Research Communications
• April 1988

Physiological activity of immobilized cells of Claviceps fusiformis during long-term se...

• Applied Microbiology and Biotechnology
• June 1987

Effect of cultivation temperature, clomiphene, and nystatin on the oxidation and cycliz...

• Current Microbiology
• March 1987

High-production mutant Claviceps purpurea 59 accumulating secoclavines

• FEMS Microbiology Letters
• October 1986

Identification of fatty acids in submerged cultures of Claviceps species

• FEMS Microbiology Letters
• December 1985

Occurrence of ricinoleic acid in submerged cultures of variousClaviceps sp.

• Cellular and Molecular Life Sciences
• November 1985

Continuous cultivation ofCandida utilis yeasts growing on calcium bisulphite waste liquors

• Applied Microbiology and Biotechnology
• September 1985

Azido leaving group in enzymatic synthesis-small and efficient

Glycosidases in synthesis