All Stories

  1. High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways

    Article • Heliyon, January 2023, Elsevier

    Prof Takeru Nose

  2. Metal ion scavenging activity of elastin-like peptide analogues containing a cadmium ion binding sequence

    Article • Scientific Reports, February 2022, Springer Science + Business Media

    Prof Takeru Nose

  3. Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation

    Article • Bioorganic & Medicinal Chemistry, December 2021, Elsevier

    Prof Takeru Nose

  4. Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β

    Article • Journal of Biological Chemistry, November 2021, Elsevier

    Prof Takeru Nose

  5. Simple Regulation of the Self-Assembling Ability by Multimerization of Elastin-Derived Peptide (FPGVG)n Using Nitrilotriacetic Acid as a Building Block

    Article • ACS Omega, February 2021, American Chemical Society (ACS)

    Prof Takeru Nose

  6. Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding

    Article • PLoS ONE, February 2021, PLOS

    Prof Takeru Nose

  7. Mechanistic Insights into a DMSO-Perturbing Inhibitory Assay of Hyaluronidase

    Article • Biochemistry, September 2020, American Chemical Society (ACS)

    Prof Takeru Nose

  8. Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ

    Article • Chemical Research in Toxicology, February 2020, American Chemical Society (ACS)

    Prof Takeru Nose

  9. Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities

    Article • Bioorganic & Medicinal Chemistry, February 2020, Elsevier

    Prof Takeru Nose

  10. Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay

    Article • Bioorganic & Medicinal Chemistry Letters, January 2020, Elsevier

    Prof Takeru Nose

  11. Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

    Article • Toxicology and Applied Pharmacology, August 2019, Elsevier

    Prof Takeru Nose

  12. DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors

    Article • ACS Medicinal Chemistry Letters, May 2019, American Chemical Society (ACS)

    Prof Takeru Nose

  13. Importance of Receptor Conformations in Docking Calculation-Based Risk Assessment for Endocrine Disruptors against Estrogen Receptor α

    Article • ACS Omega, April 2019, American Chemical Society (ACS)

    Prof Takeru Nose

  14. Simple Cyclization of ELP: Strong Self-Aggregation Properties of Cyclo[FPGVG]n,

    Article • Biomacromolecules, June 2018, American Chemical Society (ACS)

    Prof Takeru Nose

  15. The water-soluble elastin as a functional food to exert a blood pressure-lowering effect

    Article • Current Enzyme Inhibition, March 2018, Bentham Science Publishers

    Iori Maeda, Prof Takeru Nose

  16. Stepwise mechanism of temperature-dependent coacervation of short dimer ELP

    Article • Biochemistry, February 2018, American Chemical Society (ACS)

    Prof Takeru Nose

  17. Multifunctional biological activities of water extract of housefly larvae ( Musca domestica )

    Article • PharmaNutrition, December 2017, Elsevier

    Prof Takeru Nose

  18. Role of individual disulfide bridges in the conformation and activity of spinoxin (α-KTx6.13), a potassium channel toxin from Heterometrus spinifer scorpion venom

    Article • Toxicon, November 2016, Elsevier

    Prof Takeru Nose

  19. Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning

    Article • Biochemistry, May 2016, American Chemical Society (ACS)

    Prof Takeru Nose

  20. Highly coacervatable 5-mer elastin peptide repeat-dimers developed

    Article • Journal of Peptide Science, March 2016, Wiley

    Prof Takeru Nose

  21. (WPGVG)3 exhibiting temperature‐dependent self‐assembly activity

    Article • December 2015, Wiley

    Prof Takeru Nose

  22. Design of Phenylalanine-Containing Elastin-Derived Peptides Exhibiting Highly Potent Self-Assembling Capability

    Article • Protein and Peptide Letters, August 2015, Bentham Science Publishers

    Iori Maeda, Prof Takeru Nose

  23. Potent coacervation property of Ile-containing elastin-derived peptide

    Article • Protein and Peptide Letters, June 2013, Bentham Science Publishers

    Prof Takeru Nose

  24. Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor RORγ

    Article • Toxicology Letters, July 2012, Elsevier

    Prof Takeru Nose

  25. Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol A in the human nuclear receptor estrogen-related receptor  

    Article • The Journal of Biochemistry, January 2012, Oxford University Press (OUP)

    Prof Takeru Nose

  26. Structural requirements essential for elastin coacervation: favorable spatial arrangements of valine ridges on the three-dimensional structure of elastin-derived polypeptide (VPGVG)n

    Article • Journal of Peptide Science, September 2011, Wiley

    Prof Takeru Nose

  27. Spare interactions of highly potent [Arg14,Lys15]nociceptin for cooperative induction of ORL1 receptor activation

    Article • Bioorganic & Medicinal Chemistry, December 2009, Elsevier

    Prof Takeru Nose

  28. Exploration of endocrine-disrupting chemicals on estrogen receptor α by the agonist/antagonist differential-docking screening (AADS) method: 4-(1-Adamantyl)phenol as a potent endocrine disruptor candidate

    Article • Toxicology Letters, December 2009, Elsevier

    Prof Takeru Nose

  29. Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)14, (Arg/Lys)15]nociceptin on ORL1 receptor binding and activation

    Article • Bioorganic & Medicinal Chemistry, August 2009, Elsevier

    Prof Takeru Nose

  30. Synergistic effect of basic residues at positions 14–15 of nociceptin on binding affinity and receptor activation

    Article • Bioorganic & Medicinal Chemistry, October 2008, Elsevier

    Prof Takeru Nose

  31. Radar Chart Deviation Analysis of Prion Protein Amino Acid Composition Defines Characteristic Structural Abnormalities of the N-Terminal Octapeptide Tandem Repeat

    Article • Protein and Peptide Letters, September 2008, Bentham Science Publishers

    Prof Takeru Nose

  32. Estimation of binding potency of bisphenol A against estrogen-related receptor gamma

    Article • Protein and Peptide Letters, March 2008, Bentham Science Publishers

    Prof Takeru Nose

  33. Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

    Article • Bioorganic & Medicinal Chemistry, March 2008, Elsevier

    Prof Takeru Nose

  34. Differential receptor binding characteristics of consecutive phenylalanines in μ-opioid specific peptide ligand endomorphin-2

    Article • Bioorganic & Medicinal Chemistry, June 2007, Elsevier

    Prof Takeru Nose

  35. cDNA cloning of the housefly pigment-dispersing factor(PDF) precursor protein and its peptide comparison among the insect circadian neuropeptides

    Article • Journal of Peptide Science, January 2004, Wiley

    Prof Takeru Nose

  36. Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly,Phormia regina

    Article • Letters in Peptide Science, September 2003, Springer Science + Business Media

    Prof Takeru Nose

  37. Site-directed affinity-labeling of delta opioid receptors by SNpys-containing enkephalin and dynorphin analogues

    Article • Letters in Peptide Science, September 2003, Springer Science + Business Media

    Prof Takeru Nose

  38. Aggregation Feature of Fluorine-Substituted Benzene Rings and Intermolecular C–H···F Interaction: Crystal Structure Analyses of Mono- and Trifluoro-L-phenylalanines

    Article • Chemical and Pharmaceutical Bulletin, January 2003, Pharmaceutical Society of Japan

    Prof Takeru Nose

  39. Characterization, primary structure and molecular evolution of anticoagulant protein from Agkistrodon actus venom

    Article • Toxicon, June 2002, Elsevier

    Prof Takeru Nose

  40. Structural requirements of nociceptin antagonist Ac-RYYRIK-NH2 for receptor binding

    Article • Journal of Peptide Science, January 2002, Wiley

    Prof Takeru Nose

  41. Receptor Binding Site of Arg-Lys Triple Repeat in Nociceptin Superagonist

    Article • January 2001, Springer Science + Business Media

    Prof Takeru Nose

  42. Structural essentials of xenoestrogen dialkyl phthalates to bind to the estrogen receptors

    Article • Toxicology Letters, December 2000, Elsevier

    Prof Takeru Nose

  43. The Role of Deltorphin II Phenylalanine Residue in Binding to theδOpioid Receptor

    Article • Bulletin of the Chemical Society of Japan, November 2000, The Chemical Society of Japan

    Prof Takeru Nose

  44. Exploration of the Role of Phenylalanine in the Thrombin Receptor Tethered-Ligand Peptide by Substitution with a Series of Trifluorophenylalanines

    Article • Bulletin of the Chemical Society of Japan, November 2000, The Chemical Society of Japan

    Prof Takeru Nose

  45. Highly Potent Nociceptin Analog Containing the Arg-Lys Triple Repeat

    Article • Biochemical and Biophysical Research Communications, November 2000, Elsevier

    Prof Takeru Nose

  46. Head-to-Tail Polymerization of Coagulin, a Clottable Protein of the Horseshoe Crab

    Article • Journal of Biological Chemistry, August 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Takeru Nose

  47. Edge-to-Face CH/"" Interaction between Ligand Phe-Phenyl and Receptor Aromatic Group in the Thrombin Receptor Activation

    Article • The Journal of Biochemistry, August 2000, Oxford University Press (OUP)

    Prof Takeru Nose

  48. Synthesis of a complete set of l-difluorophenylalanines, l-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

    Article • Tetrahedron Letters, February 2000, Elsevier

    Prof Takeru Nose

  49. Effects of Substitution of Hydrophobic Amino Acids by Tryptophan on Receptor Binding and Biological Activity of Neuropeptide Nociceptin

    Article • Bulletin of the Chemical Society of Japan, August 1999, The Chemical Society of Japan

    Prof Takeru Nose

  50. Design and Synthesis of para-Fluorophenylalanine Amide Derivatives as Thrombin Receptor Antagonists

    Article • The Journal of Biochemistry, July 1999, Oxford University Press (OUP)

    Prof Takeru Nose

  51. Exploration of Universal Cysteines in the Binding Sites of Three Opioid Receptor Subtypes by Disulfide-Bonding Affinity Labeling with Chemically Activated Thiol-Containing Dynorphin A Analogs

    Article • The Journal of Biochemistry, July 1999, Oxford University Press (OUP)

    Prof Takeru Nose

  52. A novel molecular design of thrombin receptor antagonist

    Article • Bioorganic & Medicinal Chemistry Letters, May 1999, Elsevier

    Prof Takeru Nose

  53. Design of serine protease inhibitors with conformation restricted by amino acid side-chain-side-chain CH/? interaction

    Article • Biopolymers, January 1999, Wiley

    Prof Takeru Nose

  54. Interaction Mode of the Phe-Phenyl Group of Thrombin Receptor-Tethered Ligand SFLLRNP in Receptor Activation

    Article • The Journal of Biochemistry, August 1998, Oxford University Press (OUP)

    Prof Takeru Nose

  55. The Role of Arginine in Thrombin Receptor Tethered-Ligand Peptide in Intramolecular Receptor Binding and Self-Activation

    Article • Bulletin of the Chemical Society of Japan, July 1998, The Chemical Society of Japan

    Prof Takeru Nose

  56. X-ray crystal structure of a dipeptide-chymotrypsin complex in an inhibitory interaction

    Article • European Journal of Biochemistry, July 1998, Wiley

    Prof Takeru Nose

  57. Sensitivity of Opioid Receptor-like Receptor ORL1 for Chemical Modification on Nociceptin, a Naturally Occurring Nociceptive Peptide

    Article • Journal of Biological Chemistry, September 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Takeru Nose

  58. Reversible Affinity Labeling of Opioid Receptors via Disulfide Bonding: Discriminative Labeling of   and   Subtypes by Chemically Activated Thiol-Containing Enkephalin Analogs

    Article • The Journal of Biochemistry, August 1996, Oxford University Press (OUP)

    Prof Takeru Nose

  59. Chymotrypsin Inhibition Induced by Side Chain-Side Chain Intramolecular CH/  Interaction in D-Thr-L-Phe Benzylamide

    Article • The Journal of Biochemistry, May 1996, Oxford University Press (OUP)

    Prof Takeru Nose

  60. Chymotrypsin inhibitory conformation induced by amino acid side chain–side chain intramolecular CH/π interaction

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1996, Royal Society of Chemistry

    Prof Takeru Nose

  61. Different Roles of Two Consecutive Leucine Residues in a Receptor-Tethered Ligand Peptide (SFLLRNP) in Thrombin Receptor Activation

    Article • Bulletin of the Chemical Society of Japan, September 1995, The Chemical Society of Japan

    Prof Takeru Nose

  62. Purification and characterization of a coagulant enzyme, okinaxobin II, from Trimeresurs okinavensis (himehabu snake) venom which releases fibrinopeptides A and B

    Article • Toxicon, December 1994, Elsevier

    Prof Takeru Nose

  63. Differential Roles of Two Consecutive Phenylalanine Residues in Thrombin Receptor-Tethered Ligand Peptides (SFFLRNP) in Thrombin Receptor Activation

    Article • Biochemical and Biophysical Research Communications, August 1994, Elsevier

    Prof Takeru Nose

  64. Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

    Article • Proceedings of the National Academy of Sciences, June 1994, Proceedings of the National Academy of Sciences

    Prof Takeru Nose

  65. Structural Essentials of Ser-1 in Tethered Peptide Ligand of Human Thrombin Receptor for Phosphoinositide Hydrolysis

    Article • Bulletin of the Chemical Society of Japan, June 1994, The Chemical Society of Japan

    Prof Takeru Nose

  66. Purification, sequencing and characterization of single amino acid-substituted phospholipase A2 isozymes from Trimeresurus Gramineus (green habu snake) venom

    Article • Toxicon, August 1993, Elsevier

    Prof Takeru Nose

  67. Chymotrypsin inhibitory conformation of dipeptides constructed by side chain-side chain hydrophobic interactions

    Article • Journal of Molecular Recognition, June 1993, Wiley

    Prof Takeru Nose

  68. Enhancement of Thrombin Receptor Activation by Thrombin Receptor-Derived Heptapeptide with para-Fluorophenylalanine in Place of Phenylalanine

    Article • Biochemical and Biophysical Research Communications, June 1993, Elsevier

    Prof Takeru Nose

  69. Thrombin acceptor which contains ligand.

    Article • KAGAKU TO SEIBUTSU, January 1993, Japan Society for Bioscience, Biotechnology, and Agrochemistry

    Prof Takeru Nose

  70. Importance of phenylalanine residue in the tethered peptide ligand for self-activation of the thrombin receptor

    Article • January 1993, Springer Science + Business Media

    Prof Takeru Nose

  71. Occurrence of an allosteric transition in the modification of papain withl-1-acetyl-2,3-dihydropyrrolo[2,3-b]-indole-2-carboxamide

    Article • Journal of Chromatography A, April 1992, Elsevier

    Prof Takeru Nose