All Stories

  1. Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene

    Article • Acta Crystallographica Section D Structural Biology, May 2020, International Union of Crystallography

    Dr Svetlana Antonyuk

  2. The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer

    Article • IUCrJ, March 2020, International Union of Crystallography

    Dr Svetlana Antonyuk

  3. Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds

    Article • FEBS Journal, March 2019, Wiley

    Dr Svetlana Antonyuk

  4. The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM

    Article • IUCrJ, March 2019, International Union of Crystallography

    Professor Samar Hasnain, Dr Svetlana Antonyuk

  5. Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS

    Article • PLoS Biology, February 2019, PLOS

    Dr Svetlana Antonyuk

  6. Identification of a tyrosine switch in copper-haem nitrite reductases

    Article • IUCrJ, June 2018, International Union of Crystallography

    Professor Samar Hasnain, Dr Svetlana Antonyuk

  7. Structural and functional insights into the unique CBS–CP12 fusion protein family in cyanobacteria

    Article • Proceedings of the National Academy of Sciences, June 2018, Proceedings of the National Academy of Sciences

    Dr Svetlana Antonyuk

  8. The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

    Article • Nature Communications, April 2018, Springer Science + Business Media

    Dr Enrico Luchinat, Dr Svetlana Antonyuk

  9. Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system

    Article • Science Signaling, April 2018, American Association for the Advancement of Science

    Dr Svetlana Antonyuk

  10. Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme

    Article • Scientific Reports, February 2018, Springer Science + Business Media

    Dr Svetlana Antonyuk

  11. X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery

    Article • IUCrJ, February 2018, International Union of Crystallography

    stephen muench, Dr Svetlana Antonyuk

  12. Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus

    Article • Journal of Virology, January 2018, ASM Journals

    Dr Svetlana Antonyuk

  13. An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase

    Article • IUCrJ, January 2018, International Union of Crystallography

    Professor Samar Hasnain, Dr Svetlana Antonyuk

  14. Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal

    Article • IUCrJ, June 2016, International Union of Crystallography

    Dr Svetlana Antonyuk

  15. Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential

    Article • IUCrJ, June 2015, International Union of Crystallography

    Dr Matthew P Blakeley, Dr Svetlana Antonyuk

  16. Antimalarial 4(1H)-pyridones bind to the Q i site of cytochrome bc 1

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    Dr Svetlana Antonyuk

  17. Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase

    Article • Nature Communications, July 2014, Springer Science + Business Media

    Dr Svetlana Antonyuk

  18. Structure and function study of the complex that synthesizesS-adenosylmethionine

    Article • IUCrJ, June 2014, International Union of Crystallography

    Professor Samar Hasnain, Dr Svetlana Antonyuk

  19. Fingerprinting crystal structures with Raman spectroscopy

    Article • Acta Crystallographica Section D Biological Crystallography, April 2014, International Union of Crystallography

    Dr Michael A Hough, Dr Florian Sven Nico Dworkowski, Dr Svetlana Antonyuk

  20. Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

    Article • Proceedings of the National Academy of Sciences, March 2014, Proceedings of the National Academy of Sciences

    Dr Svetlana Antonyuk

  21. The structure of a purple acid phosphatase involved in plant growth and pathogen defence exhibits a novel immunoglobulin-like fold

    Article • IUCrJ, February 2014, International Union of Crystallography

    Dr Svetlana Antonyuk

  22. Transport of gabapentin by LAT1 (SLC7A5)

    Article • Biochemical Pharmacology, June 2013, Elsevier

    Dr David Dickens, Dr Svetlana Antonyuk

  23. Ligand binding and aggregation of pathogenic SOD1

    Article • Nature Communications, April 2013, Springer Science + Business Media

    Dr Svetlana Antonyuk

  24. Structure of the hypothetical DUF1811-family protein GK0453 fromGeobacillus kaustophilusHTA426

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, March 2013, International Union of Crystallography

    Dr Svetlana Antonyuk

  25. Structures of protein–protein complexes involved in electron transfer

    Article • Nature, March 2013, Springer Science + Business Media

    Dr Svetlana Antonyuk

  26. Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase

    Article • PLoS ONE, September 2012, PLOS

    Dr Michael A Hough, Dr Svetlana Antonyuk

  27. Crystal structure of D-serine dehydratase from Escherichia coli

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March 2012, Elsevier

    Dr Svetlana Antonyuk

  28. Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins

    Article • Proceedings of the National Academy of Sciences, September 2011, Proceedings of the National Academy of Sciences

    Dr Svetlana Antonyuk

  29. Monitoring and validating active site redox states in protein crystals

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, June 2011, Elsevier

    Dr Svetlana Antonyuk

  30. Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase

    Article • Biochemistry, April 2011, American Chemical Society (ACS)

    Dr Michael A Hough, Dr Svetlana Antonyuk

  31. Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket

    Article • Journal of Molecular Biology, January 2011, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  32. Structural Discovery of Small Molecule Binding Sites in Cu−Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization

    Article • Journal of Medicinal Chemistry, February 2010, American Chemical Society (ACS)

    Dr Svetlana Antonyuk

  33. Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A

    Article • Archives of Biochemistry and Biophysics, December 2009, Elsevier

    Dr Svetlana Antonyuk

  34. Structure of putative 4-amino-4-deoxychorismate lyase fromThermus thermophilusHB8

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2009, International Union of Crystallography

    Professor Nobuhisa Watanabe, Dr Svetlana Antonyuk

  35. Structure of SurE protein fromAquifex aeolicusVF5 at 1.5 Å resolution

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2009, International Union of Crystallography

    Dr Svetlana Antonyuk

  36. Structure of a putative β-phosphoglucomutase (TM1254) fromThermotoga maritima

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2009, International Union of Crystallography

    Dr Svetlana Antonyuk

  37. Structure ofD-lactate dehydrogenase fromAquifex aeolicuscomplexed with NAD+and lactic acid (or pyruvate)

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2009, International Union of Crystallography

    Dr Svetlana Antonyuk

  38. Structure of dihydrodipicolinate synthase fromMethanocaldococcus jannaschii

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2009, International Union of Crystallography

    Dr Svetlana Antonyuk

  39. Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophileMethanocaldococcus jannaschii

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2009, International Union of Crystallography

    Dr Svetlana Antonyuk, Ali Andres Malay

  40. Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) fromSulfolobus tokodaii

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2009, International Union of Crystallography

    Dr Svetlana Antonyuk

  41. The structure of an archaeal ribose-5-phosphate isomerase fromMethanocaldococcus jannaschii(MJ1603)

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2009, International Union of Crystallography

    Dr Svetlana Antonyuk

  42. The Structure of Human Extracellular Copper–Zinc Superoxide Dismutase at 1.7 Å Resolution: Insights into Heparin and Collagen Binding

    Article • Journal of Molecular Biology, May 2009, Elsevier

    Dr Svetlana Antonyuk

  43. Crystal structure of human prion protein bound to a therapeutic antibody

    Article • Proceedings of the National Academy of Sciences, February 2009, Proceedings of the National Academy of Sciences

    Dr Svetlana Antonyuk

  44. Crystallography with Online Optical and X-ray Absorption Spectroscopies Demonstrates an Ordered Mechanism in Copper Nitrite Reductase

    Article • Journal of Molecular Biology, April 2008, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  45. Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis

    Article • Journal of Biological Chemistry, March 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Svetlana Antonyuk

  46. X-ray diffraction study of the complex of the enzyme SAICAR synthase with the reaction product

    Article • Crystallography Reports, October 2006, Pleiades Publishing Ltd

    Dr Svetlana Antonyuk

  47. Insight into Catalysis of Nitrous Oxide Reductase from High-resolution Structures of Resting and Inhibitor-bound Enzyme from Achromobacter cycloclastes

    Article • Journal of Molecular Biology, September 2006, Elsevier

    Professor Gary Sawers, Dr Svetlana Antonyuk

  48. Variable Metallation of Human Superoxide Dismutase: Atomic Resolution Crystal Structures of Cu–Zn, Zn–Zn and As-isolated Wild-type Enzymes

    Article • Journal of Molecular Biology, March 2006, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  49. Atomic resolution structures of resting-state, substrate- and product-complexed Cu-nitrite reductase provide insight into catalytic mechanism

    Article • Proceedings of the National Academy of Sciences, August 2005, Proceedings of the National Academy of Sciences

    Professor Gary Sawers, Dr Svetlana Antonyuk

  50. High Resolution Structural Studies of Mutants Provide Insights into Catalysis and Electron Transfer Processes in Copper Nitrite Reductase

    Article • Journal of Molecular Biology, July 2005, Elsevier

    Professor Gary Sawers, Dr Michael A Hough, Dr Svetlana Antonyuk

  51. A high-throughput structural biology/proteomics beamline at the SRS on a new multipole wiggler

    Article • Journal of Synchrotron Radiation, June 2005, International Union of Crystallography

    Dr Michele Cianci, Professor John Richard Helliwell, Dr Svetlana Antonyuk

  52. Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg

    Article • Protein Science, May 2005, Wiley

    Dr Michael A Hough, Dr Svetlana Antonyuk

  53. Insights into Redox Partner Interactions and Substrate Binding in Nitrite Reductase from Alcaligenes xylosoxidans: Crystal Structures of the Trp138His and His313Gln Mutants,

    Article • Biochemistry, December 2004, American Chemical Society (ACS)

    Professor Gary Sawers, Dr Michael A Hough, Dr Svetlana Antonyuk

  54. Observation of an Unprecedented Cu Bis-His Site: Crystal Structure of the H129V Mutant of Nitrite Reductase

    Article • Inorganic Chemistry, November 2004, American Chemical Society (ACS)

    Professor Gary Sawers, Dr Svetlana Antonyuk

  55. Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants

    Article • Proceedings of the National Academy of Sciences, March 2004, Proceedings of the National Academy of Sciences

    Dr Michael A Hough, Dr Svetlana Antonyuk

  56. X-ray diffraction study of the complex of the enzyme SAICAR synthase with substrate analogues

    Article • Crystallography Reports, September 2003, Pleiades Publishing Ltd

    Dr Svetlana Antonyuk

  57. Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

    Article • Nature Structural & Molecular Biology, May 2003, Springer Science + Business Media

    Dr Svetlana Antonyuk

  58. The Structure of Holo and Metal-deficient Wild-type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis

    Article • Journal of Molecular Biology, May 2003, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  59. The structure of glyceraldehyde 3-phosphate dehydrogenase fromAlcaligenes xylosoxidansat 1.7 Å resolution

    Article • Acta Crystallographica Section D Biological Crystallography, April 2003, International Union of Crystallography

    Dr Svetlana Antonyuk

  60. Crystal Structures of the Met148Leu and Ser86Asp Mutants of Rusticyanin from Thiobacillus ferrooxidans: Insights into the Structural Relationship with the Cupredoxins and the Multi Copper Proteins

    Article • Journal of Molecular Biology, July 2002, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  61. Resolution improvement from `in situannealing' of copper nitrite reductase crystals

    Article • Acta Crystallographica Section D Biological Crystallography, February 2002, International Union of Crystallography

    Dr Svetlana Antonyuk

  62. Crystal Structure of Manganese Catalase from Lactobacillus plantarum

    Article • Structure, August 2001, Elsevier

    Dr Svetlana Antonyuk

  63. X-ray diffraction study of the complexes of SAICAR synthase with adenosinetriphosphate

    Article • Crystallography Reports, July 2001, Pleiades Publishing Ltd

    Dr Svetlana Antonyuk

  64. Improving the X-ray resolution by reversible flash-cooling combined with concentration screening, as exemplified with PPase

    Article • Acta Crystallographica Section D Biological Crystallography, May 2000, International Union of Crystallography

    Dr Svetlana Antonyuk

  65. Crystal structure of di-manganese catalase from Thermus Thermophilus

    Article • Crystallography Reports, January 2000, Pleiades Publishing Ltd

    Dr Svetlana Antonyuk

  66. The Oxidized (3,3) State of Manganese Catalase. Comparison of Enzymes fromThermus thermophilusandLactobacillus plantarum†

    Article • Biochemistry, July 1999, American Chemical Society (ACS)

    Dr Svetlana Antonyuk

  67. Manganese-containing catalase from Thermus thermophilus peroxide-induced redox transformation of manganese ions in presence of specific inhibitors of catalase activity

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, October 1990, Elsevier

    Dr Svetlana Antonyuk