All Stories

  1. Toward ovarian cancer screening with protein biomarkers using dried, self-sampled cervico-vaginal fluid

    Article • iScience, February 2024, Elsevier

    Dr Stefan Enroth

  2. Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

    Article • Nature Immunology, August 2023, Springer Science + Business Media

    Dr Stefan Enroth

  3. Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins

    Article • Forensic Science International Genetics, July 2023, Elsevier

    Dr Stefan Enroth

  4. Data-driven analysis of a validated risk score for ovarian cancer identifies clinically distinct patterns during follow-up and treatment

    Article • Communications Medicine, October 2022, Springer Science + Business Media

    Dr Stefan Enroth

  5. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

    Article • Nature Genetics, September 2022, Springer Science + Business Media

    Natalia V Rivera, Dr Stefan Enroth

  6. Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability

    Article • Nature Communications, May 2022, Springer Science + Business Media

    Dr Stefan Enroth

  7. Genetic Landscape of the ACE2 Coronavirus Receptor

    Article • Circulation, May 2022, Wolters Kluwer Health

    Dr Stefan Enroth

  8. Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer

    Article • Cancers, March 2022, MDPI AG

    Dr Stefan Enroth

  9. Transcriptome Analysis of Post-Mortem Brain Tissue Reveals Up-Regulation of the Complement Cascade in a Subgroup of Schizophrenia Patients

    Article • Genes, August 2021, MDPI AG

    Dr Stefan Enroth

  10. Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and diseases

    Article • August 2021, Cold Spring Harbor Laboratory Press

    Dr Stefan Enroth

  11. Distinct genetic regions are associated with differential population susceptibility to chemical exposures

    Article • Environment International, July 2021, Elsevier

    Dr Stefan Enroth

  12. The contribution of rare whole genome sequencing variants to plasma protein levels and to the missing heritability

    Article • June 2021, Springer Science + Business Media

    Dr Stefan Enroth

  13. Identification of Candidate Protein Biomarkers for CIN2+ Lesions from Self-Sampled, Dried Cervico–Vaginal Fluid Using LC-MS/MS

    Article • Cancers, May 2021, MDPI AG

    Dr Stefan Enroth

  14. Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

    Article • Cellular and Molecular Life Sciences, April 2021, Springer Science + Business Media

    Dr Stefan Enroth

  15. Plasma Proteins and Cancer

    Article • Cancers, March 2021, MDPI AG

    Dr Stefan Enroth

  16. Evaluation of 92 cardiovascular proteins in dried blood spots collected under field‐conditions

    Article • BioEssays, February 2021, Wiley

    Dr Stefan Enroth

  17. Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

    Article • Nature Metabolism, October 2020, Springer Science + Business Media

    Dr Stefan Enroth

  18. Temporal changes in the vaginal microbiota in self-samples and its association with persistent HPV16 infection and CIN2+

    Article • Virology Journal, October 2020, Springer Science + Business Media

    Dr Stefan Enroth

  19. Preoperative Fasting and General Anaesthesia Alter the Plasma Proteome

    Article • Cancers, August 2020, MDPI AG

    Dr Stefan Enroth

  20. Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

    Article • The Lancet Respiratory Medicine, July 2020, Elsevier

    Dr Stefan Enroth

  21. HPV viral load in self-collected vaginal fluid samples as predictor for presence of cervical intraepithelial neoplasia

    Article • Virology Journal, November 2019, Springer Science + Business Media

    Dr Stefan Enroth

  22. Improved power and precision with whole genome sequencing data in genome-wide association studies of inflammatory biomarkers

    Article • Scientific Reports, November 2019, Springer Science + Business Media

    Mathias Rask-Andersen, Dr Stefan Enroth

  23. Clinical validation of the HPVIR high-risk HPV test on cervical samples according to the international guidelines for human papillomavirus DNA test requirements for cervical cancer screening

    Article • Virology Journal, August 2019, Springer Science + Business Media

    Dr Stefan Enroth

  24. High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancer

    Article • Communications Biology, June 2019, Springer Science + Business Media

    Dr Stefan Enroth

  25. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

    Article • Nature Genetics, February 2019, Springer Science + Business Media

    Dr Stefan Enroth

  26. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

    Article • Nature Genetics, February 2019, Springer Science + Business Media

    Dr Stefan Enroth

  27. Identification of Candidate Plasma Protein Biomarkers for Cervical Cancer Using the Multiplex Proximity Extension Assay

    Article • Molecular & Cellular Proteomics, January 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Stefan Enroth

  28. Invasive cervical tumors with high and low HPV titer represent molecular subgroups with different disease etiology

    Article • Carcinogenesis, December 2018, Oxford University Press (OUP)

    Dr Stefan Enroth

  29. A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer

    Article • Clinical Proteomics, December 2018, Springer Science + Business Media

    Dr Stefan Enroth

  30. Randomised study of HPV prevalence and detection of CIN2+ in vaginal self‐sampling compared to cervical specimens collected by medical personnel

    Article • International Journal of Cancer, October 2018, Wiley

    Dr Stefan Enroth

  31. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

    Article • Nature Genetics, September 2018, Springer Science + Business Media

    Dr Cristina Menni, Dr Stefan Enroth

  32. Meta-analysis of exome array data identifies six novel genetic loci for lung function

    Article • Wellcome Open Research, August 2018, Faculty of 1000, Ltd.

    Dr Stefan Enroth

  33. Meta-analysis of exome array data identifies six novel genetic loci for lung function

    Article • Wellcome Open Research, June 2018, Faculty of 1000, Ltd.

    Dr Stefan Enroth

  34. High throughput proteomics identifies 484 high-accuracy plasma protein biomarker signatures for ovarian cancer

    Article • June 2018, Cold Spring Harbor Laboratory Press

    Dr Stefan Enroth

  35. Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

    Article • Molecular Oncology, May 2018, Wiley

    Car-Henrik Heldin, Dr Stefan Enroth

  36. Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

    Article • Journal of Cellular Physiology, May 2018, Wiley

    Car-Henrik Heldin, Dr Stefan Enroth

  37. Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases

    Article • Scientific Reports, April 2018, Nature

    Dr Stefan Enroth

  38. A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood

    Article • Frontiers in Genetics, March 2018, Frontiers

    Dr Stefan Enroth

  39. Randomised study shows that repeated self-sampling and HPV test has more than two-fold higher detection rate of women with CIN2+ histology than Pap smear cytology

    Article • British Journal of Cancer, February 2018, Nature

    Dr Stefan Enroth

  40. Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff

    Article • Scientific Reports, February 2018, Nature

    Dr Stefan Enroth

  41. Genetic variants influencing phenotypic variance heterogeneity

    Article • Human Molecular Genetics, January 2018, Oxford University Press (OUP)

    Dr Stefan Enroth

  42. The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases

    Article • PLoS Genetics, September 2017, PLOS

    Dr Stefan Enroth, Mathias Rask-Andersen

  43. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the KidneyNovelty and Significance

    Article • Hypertension, July 2017, Wolters Kluwer Health

    Dr Cristina Menni, Dr Stefan Enroth

  44. Stability of Proteins in Dried Blood Spot Biobanks

    Article • Molecular & Cellular Proteomics, May 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Stefan Enroth

  45. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

    Article • Scientific Reports, April 2017, Nature

    Dr Stefan Enroth

  46. Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

    Article • PLoS Genetics, April 2017, PLOS

    Dr Stefan Enroth

  47. Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

    Article • Nature Genetics, February 2017, Nature

    Dr Stefan Enroth

  48. Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

    Article • International Journal of Epidemiology, January 2017, Oxford University Press (OUP)

    Dr Stefan Enroth

  49. PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c

    Article • Nucleic Acids Research, December 2016, Oxford University Press (OUP)

    Dr Stefan Enroth

  50. KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

    Article • Proceedings of the National Academy of Sciences, November 2016, Proceedings of the National Academy of Sciences

    Dr Stefan Enroth, Jari Lahti

  51. Effects of Long-Term Storage Time and Original Sampling Month on Biobank Plasma Protein Concentrations

    Article • EBioMedicine, October 2016, Elsevier

    Dr Stefan Enroth

  52. Epigenome-wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction

    Article • Human Molecular Genetics, September 2016, Oxford University Press (OUP)

    Dr Stefan Enroth

  53. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

    Article • Nature Genetics, September 2016, Nature

    Dr Stefan Enroth, Dr Cristina Menni

  54. Pooled analysis of genome-wide association studies of cervical intraepithelial neoplasia 3 (CIN3) identifies a new susceptibility locus

    Article • Oncotarget, July 2016, Impact Journals, LLC

    Dr Stefan Enroth

  55. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

    Article • PLoS Genetics, June 2016, PLOS

    Dr Stefan Enroth, Dr Cristina Menni, Jari Lahti

  56. Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target

    Article • Oncotarget, February 2016, Impact Journals, LLC

    Dr Stefan Enroth

  57. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Article • Nature Communications, January 2016, Nature

    Dr Stefan Enroth, Professor Thomas Munzel or Muenzel, Professor of medicine (epidemiology) Dag Steinar Thelle

  58. Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro CardTM

    Article • Journal of Circulating Biomarkers, January 2016, SAGE Publications

    Dr Stefan Enroth

  59. Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15

    Article • Human Molecular Genetics, December 2015, Oxford University Press (OUP)

    Dr Stefan Enroth

  60. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

    Article • Nature Communications, December 2015, Nature

    Dr Stefan Enroth

  61. Protein profiling reveals consequences of lifestyle choices on predicted biological aging

    Article • Scientific Reports, December 2015, Nature

    Dr Stefan Enroth

  62. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

    Article • PLoS Genetics, October 2015, PLOS

    Dr Stefan Enroth, Dr Cristina Menni, Dr Karina Banasik, Jari Lahti

  63. MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

    Article • Nature Communications, July 2015, Nature

    Dr Stefan Enroth

  64. Homozygous loss-of-function variants in European cosmopolitan and isolate populations

    Article • Human Molecular Genetics, July 2015, Oxford University Press (OUP)

    Dr Stefan Enroth

  65. Directional dominance on stature and cognition in diverse human populations

    Article • Nature, July 2015, Nature

    Dr Stefan Enroth, Dr Cristina Menni, Jari Lahti

  66. Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs

    Article • Cell Cycle, November 2014, Taylor & Francis

    Dr Stefan Enroth

  67. CanvasDB: a local database infrastructure for analysis of targeted- and whole genome re-sequencing projects

    Article • Database, October 2014, Oxford University Press (OUP)

    Dr Stefan Enroth

  68. Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs

    Article • Nature Communications, August 2014, Nature

    Dr Stefan Enroth

  69. Pathway analysis of cervical cancer genome-wide association study highlights the MHC region and pathways involved in response to infection

    Article • Human Molecular Genetics, June 2014, Oxford University Press (OUP)

    Dr Stefan Enroth

  70. Genome-wide association analysis identifies six new loci associated with forced vital capacity

    Article • Nature Genetics, June 2014, Nature

    Dr Stefan Enroth, David Lederer

  71. Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study

    Article • Carcinogenesis, May 2014, Oxford University Press (OUP)

    Dr Stefan Enroth

  72. Nucleosome regulatory dynamics in response to TGF 

    Article • Nucleic Acids Research, April 2014, Oxford University Press (OUP)

    Dr Stefan Enroth

  73. Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

    Article • August 2013, PLOS

    Dr Stefan Enroth

  74. Prevalence and sensitization of atopic allergy and coeliac disease in the Northern Sweden Population Health Study

    Article • International Journal of Circumpolar Health, August 2013, Co-Action Publishing

    Dr Stefan Enroth

  75. Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan

    Article • PLOS One, June 2013, PLOS

    Dr Stefan Enroth

  76. Genome-wide Association Study of Susceptibility Loci for Cervical Cancer

    Article • JNCI Journal of the National Cancer Institute, March 2013, Oxford University Press (OUP)

    Dr Stefan Enroth

  77. Identification of genetic variants influencing the human plasma proteome

    Article • Proceedings of the National Academy of Sciences, March 2013, Proceedings of the National Academy of Sciences

    Dr Stefan Enroth, Dr Magnus Palmblad

  78. Peak Finder Metaserver - a novel application for finding peaks in ChIP-seq data

    Article • BMC Bioinformatics, January 2013, Springer Science + Business Media

    Dr Stefan Enroth

  79. Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing

    Article • Development, June 2012, The Company of Biologists

    Dr Stefan Enroth

  80. Genetic Adaptation of Fatty-Acid Metabolism: A Human-Specific Haplotype Increasing the Biosynthesis of Long-Chain Omega-3 and Omega-6 Fatty Acids

    Article • The American Journal of Human Genetics, May 2012, Elsevier

    Dr Stefan Enroth

  81. Combinations of Histone Modifications Mark Exon Inclusion Levels

    Article • PLOS One, January 2012, PLOS

    Dr Stefan Enroth

  82. Visualization of Rules in Rule-Based Classifiers

    Article • January 2012, Springer Science + Business Media

    Dr Stefan Enroth

  83. A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements

    Article • Algorithms for Molecular Biology, January 2012, Springer Science + Business Media

    Dr Stefan Enroth

  84. Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

    Article • BMC Cancer, October 2011, Springer Science + Business Media

    Dr Stefan Enroth

  85. SICTIN: Rapid footprinting of massively parallel sequencing data

    Article • BioData Mining, August 2010, Springer Science + Business Media

    Dr Stefan Enroth

  86. Integrative epigenomic and genomic analysis of malignant pheochromocytoma

    Article • Experimental & Molecular Medicine, January 2010, Nature

    Dr Stefan Enroth

  87. Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

    Article • Nucleic Acids Research, October 2009, Oxford University Press (OUP)

    Dr Stefan Enroth

  88. Nucleosomes are well positioned in exons and carry characteristic histone modifications

    Article • Genome Research, August 2009, Cold Spring Harbor Laboratory Press

    Dr Stefan Enroth

  89. Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection

    Article • European Journal of Biochemistry, February 2009, Wiley

    Dr Stefan Enroth

  90. Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation

    Article • Epigenetics, February 2009, Taylor & Francis

    Dr Stefan Enroth

  91. Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

    Article • Molecular Cell, October 2008, Elsevier

    Dr Stefan Enroth

  92. Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders

    Article • Genome Research, February 2008, Cold Spring Harbor Laboratory Press

    Dr Stefan Enroth

  93. Monte Carlo feature selection for supervised classification

    Article • Bioinformatics, November 2007, Oxford University Press (OUP)

    Dr Stefan Enroth

  94. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    Article • Nature, June 2007, Nature

    Dr Stefan Enroth, Piero Carninci, Sean Davis, Jonghwan Kim

  95. Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes

    Article • Genome Research, June 2007, Cold Spring Harbor Laboratory Press

    Dr Stefan Enroth

  96. The LCB Data Warehouse

    Article • Bioinformatics, February 2006, Oxford University Press (OUP)

    Dr Stefan Enroth

  97. Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays

    Article • Human Molecular Genetics, October 2005, Oxford University Press (OUP)

    Dr Stefan Enroth