All Stories

  1. TGF-β1 Signaling Impairs Metformin Action on Glycemic Control

    Article • International Journal of Molecular Sciences, February 2024, MDPI AG

    Shaodong Guo

  2. Regulation of Macronutrients in Insulin Resistance and Glucose Homeostasis during Type 2 Diabetes Mellitus

    Article • Nutrients, November 2023, MDPI AG

    Shaodong Guo

  3. Suppression of FOXO1 attenuates inflamm‐aging and improves liver function during aging

    Article • Aging Cell, August 2023, Wiley

    Shaodong Guo

  4. Reciprocal regulation of hepatic TGF-β1 and Foxo1 controls gluconeogenesis and energy expenditure

    Article • Diabetes, June 2023, American Diabetes Association

    Shaodong Guo

  5. Transcription factor Foxo1 mediates TGF-β1-induced apoptosis in hepatocytes

    Article • American Journal Of Pathology, May 2023, Elsevier

    Shaodong Guo

  6. Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets

    Article • Biomolecules, March 2022, MDPI AG

    Shaodong Guo

  7. Metformin Targets Foxo1 to Control Glucose Homeostasis

    Article • Biomolecules, June 2021, MDPI AG

    Shaodong Guo

  8. Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis

    Article • Diabetes, January 2021, American Diabetes Association

    Shaodong Guo

  9. Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1

    Article • Diabetes, November 2018, American Diabetes Association

    Shaodong Guo

  10. Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases

    Article • Mediators of Inflammation, November 2018, Hindawi Publishing Corporation

    Shaodong Guo

  11. Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis

    Article • Diabetes, September 2018, American Diabetes Association

    Shaodong Guo

  12. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

    Article • Nature Communications, July 2017, Nature

    Shaodong Guo

  13. Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus

    Article • British Journal of Pharmacology, May 2017, Wiley

    Shaodong Guo

  14. Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R

    Article • Scientific Reports, April 2017, Nature

    Shaodong Guo

  15. Insulin receptor substrate signaling controls cardiac energy metabolism and heart failure

    Article • Journal of Endocrinology, April 2017, Bioscientifica

    Shaodong Guo

  16. A structural and functional analogue of a Bowman–Birk-type protease inhibitor from Odorrana schmackeri

    Article • Bioscience Reports, March 2017, Portland Press Ltd.

    Shaodong Guo

  17. Ex Vivo Smooth Muscle Pharmacological Effects of a Novel Bradykinin-Related Peptide, and Its Analogue, from Chinese Large Odorous Frog, Odorrana livida Skin Secretions

    Article • Toxins, September 2016, MDPI AG

    Shaodong Guo

  18. Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus

    Article • Scientific Reports, May 2016, Nature

    Shaodong Guo

  19. Insulin Resistance in Obesity

    Article • January 2016, Springer Science + Business Media

    Shaodong Guo

  20. Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac FunctionNovelty and Significance

    Article • Circulation Research, November 2015, Wolters Kluwer Health

    Shaodong Guo

  21. Activation of AMPK restricts coxsackievirus B3 replication by inhibiting lipid accumulation

    Article • Journal of Molecular and Cellular Cardiology, August 2015, Elsevier

    Shaodong Guo

  22. Insulin Resistance in Obesity

    Article • January 2015, Springer Science + Business Media

    Shaodong Guo

  23. Insulin Resistance in Obesity

    Article • January 2015, Springer Science + Business Media

    Shaodong Guo

  24. Novel Mechanism of Blood Pressure Regulation By Forkhead Box Class O1–Mediated Transcriptional Control of Hepatic AngiotensinogenNovelty and Significance

    Article • Hypertension, July 2014, Wolters Kluwer Health

    Shaodong Guo

  25. Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1

    Article • Journal of Diabetes and its Complications, May 2014, Elsevier

    Shaodong Guo

  26. Elastase LasB ofPseudomonas aeruginosapromotes biofilm formation partly through rhamnolipid-mediated regulation

    Article • Canadian Journal of Microbiology, April 2014, Canadian Science Publishing

    Shaodong Guo

  27. Faculty of 1000 evaluation for Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance.

    Article • November 2013, Faculty of 1000, Ltd.

    Shaodong Guo

  28. Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

    Article • Journal of Endocrinology, November 2013, Bioscientifica

    Dr Shaodong Guo, Shaodong Guo

  29. Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38  MAPK During Insulin Resistance

    Article • Diabetes, October 2013, American Diabetes Association

    Shaodong Guo

  30. Sample preparation for the metabolomics investigation of poly-gamma-glutamate-producing Bacillus licheniformis by GC–MS

    Article • Journal of Microbiological Methods, July 2013, Elsevier

    Shaodong Guo

  31. Molecular basis of insulin resistance: the role of IRS and Foxo1 in the control of diabetes mellitus and its complications

    Article • Drug Discovery Today Disease Mechanisms, June 2013, Elsevier

    Shaodong Guo

  32. Hepatic Suppression ofFoxo1andFoxo3Causes Hypoglycemia and Hyperlipidemia in Mice

    Article • Endocrinology, February 2012, Endocrine Society

    Shaodong Guo

  33. Foxo1 integrates insulin signaling with mitochondrial function in the liver

    Article • Nature Medicine, October 2009, Nature

    Shaodong Guo

  34. The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

    Article • Molecular and Cellular Biology, July 2009, ASM Journals

    Shaodong Guo

  35. Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

    Article • Cell Metabolism, July 2008, Elsevier

    Shaodong Guo

  36. The Reciprocal Stability of FOXO1 and IRS2 Creates a Regulatory Circuit that Controls Insulin Signaling

    Article • Molecular Endocrinology, December 2006, Endocrine Society

    Shaodong Guo

  37. Phosphatase and Tensin Homolog Regulation of Islet Growth and Glucose Homeostasis

    Article • Journal of Biological Chemistry, September 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Shaodong Guo

  38. Forkhead Transcription Factors Inhibit Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

    Article • Journal of Biological Chemistry, June 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Shaodong Guo

  39. Identification of Calcium-modulating Cyclophilin Ligand (CAML) as Transducer of Angiotensin II-mediated Nuclear Factor of Activated T Cells (NFAT) Activation

    Article • Journal of Biological Chemistry, January 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Shaodong Guo

  40. Vascular Endothelial Growth Factor Activates PI3K/Akt/Forkhead Signaling in Endothelial Cells

    Article • Arteriosclerosis Thrombosis and Vascular Biology, December 2003, Wolters Kluwer Health

    Shaodong Guo

  41. Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Shaodong Guo

  42. Gene- and Activation-specific Mechanisms for Insulin Inhibition of Basal and Glucocorticoid-induced Insulin-like Growth Factor Binding Protein-1 and Phosphoenolpyruvate Carboxykinase Transcription

    Article • Journal of Biological Chemistry, July 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Shaodong Guo

  43. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

    Article • Biochemical Journal, May 2001, Portland Press Ltd.

    Shaodong Guo

  44. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Article • Biochemical Journal, March 2001, Portland Press Ltd.

    Shaodong Guo

  45. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Article • Biochemical Journal, March 2001, Portland Press Ltd.

    Shaodong Guo

  46. Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

    Article • Journal of Biological Chemistry, June 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Shaodong Guo

  47. Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

    Article • Journal of Biological Chemistry, June 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Shaodong Guo

  48. Expression pattern of a β2 tubulin gene in zebrafish embryos identified by whole mountin situ hybridization

    Article • Chinese Science Bulletin, November 1998, Springer Science + Business Media

    Shaodong Guo

  49. Novel gene expressed during early embryogenesis of zebrafish identified by mRNA differential display

    Article • Chinese Science Bulletin, June 1998, Springer Science + Business Media

    Shaodong Guo

  50. Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

    Article • Journal of Biological Chemistry, March 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Shaodong Guo