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Hepatic TGF-β1 expression positively correlates with obesity and insulin resistance in mice and humans. Our studies reveal that hepatic TGF-β1→Foxo1→TGF-β1 looping could serve as a potential therapeutic target for prevention and treatment of obesity and T2D.

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This page is a summary of: Reciprocal Regulation of Hepatic TGF-β1 and Foxo1 Controls Gluconeogenesis and Energy Expenditure, Diabetes, June 2023, American Diabetes Association,
DOI: 10.2337/db23-0180.
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