All Stories

  1. Drug repurposing of dopaminergic drugs to inhibit ataxin-3 aggregation
  2. Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms
  3. Quantification of surface tension effects and nucleation-and-growth rates during self-assembly of biological condensates
  4. Pathogen-specific structural features of two key players in Candida albicans morphogenetic switch
  5. Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides
  6. A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly
  7. The Repeating, Modular Architecture of the HtrA Proteases
  8. The Repeating, Modular Architecture of the HtrA Proteases
  9. interferENZY: A Web-Based Tool for Enzymatic Assay Validation and Standardized Kinetic Analysis
  10. Critical assessment of protein intrinsic disorder prediction
  11. Major Improvements in Robustness and Efficiency during the Screening of Novel Enzyme Effectors by the 3-Point Kinetics Assay
  12. MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments
  13. A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures
  14. Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions
  15. Pushing myelination: developmental regulation of myosin expression drives oligodendrocyte morphological differentiation
  16. Accurate prediction of protein beta-aggregation with generalized statistical potentials
  17. CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments
  18. DisProt: intrinsic protein disorder annotation in 2020
  19. Genetic code ambiguity modulates the activity of a C. albicans MAP kinase linked to cell wall remodeling
  20. Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity
  21. The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation
  22. Chemical Kinetic Strategies for High-Throughput Screening of Protein Aggregation Modulators
  23. Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1- O -methyltransferase specific for 3- O -methylated mannosides
  24. Molecular fingerprints for a novel glucosamine kinase family in Actinobacteria
  25. Anti-TTR Nanobodies Allow the Identification of TTR Neuritogenic Epitope Associated with TTR-Megalin Neurotrophic Activities
  26. Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws
  27. Polyglutamine expansion diseases: More than simple repeats
  28. Polyglutamine-Independent Features in Ataxin-3 Aggregation and Pathogenesis of Machado-Joseph Disease
  29. Distribution of Amyloid-Like and Oligomeric Species from Protein Aggregation Kinetics
  30. Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2
  31. Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in thePKLRgene
  32. DisProt 7.0: a major update of the database of disordered proteins
  33. Disclosing the essentiality of ribose-5-phosphate isomerase B in Trypanosomatids
  34. Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models
  35. Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity
  36. Severe neonatal jaundice due to ade novoglucose-6-phosphate dehydrogenase deficient mutation
  37. Biophysical characterization of laforin-carbohydrate interaction
  38. What a difference a cluster makes: The multifaceted roles of IscR in gene regulation and DNA recognition
  39. SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97
  40. Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides
  41. Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion
  42. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (ATP complex)
  43. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway
  44. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (AppCp complex)
  45. CRYSTAL STRUCTURE OF THE 2B PROTEIN SOLUBLE DOMAIN FROM HEPATITIS A VIRUS
  46. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway
  47. Structural Basis for Host Membrane Remodeling Induced by Protein 2B of Hepatitis A Virus
  48. Ribose 5-Phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity
  49. Ser or Leu: structural snapshots of mistranslation in Candida albicans
  50. Molecular and computational analyses of genes involved in mannose 6-phosphate independent trafficking
  51. T. potens IscR
  52. E. coli IscR-DNA complex
  53. The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium
  54. Correction: Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
  55. Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
  56. A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3
  57. The Drosophila melanogaster methuselah Gene: A Novel Gene with Ancient Functions
  58. BIOCHEMICAL AND BIOPHYSICAL CHARACTERIZATION OF RECOMBINANT YEAST PROTEASOME MATURATION FACTOR UMP1
  59. The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65
  60. Trinucleotide Repeats: A Structural Perspective
  61. Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector
  62. Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
  63. Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
  64. Genome Sequence of Mycobacterium hassiacum DSM 44199, a Rare Source of Heat-Stable Mycobacterial Proteins
  65. Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments
  66. Cloning, purification and preliminary crystallographic studies of the 2AB protein from hepatitis A virus
  67. Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease
  68. Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen
  69. Candida albicans seryl-tRNA synthetase
  70. Crystal structure of the seryl-tRNA synthetase from Candida albicans
  71. Crystal Structure of the seryl-tRNA synthetase from Candida albicans
  72. Crystal Structure of seryl-tRNA synthetase from Candida albicans
  73. Lysosomal multienzymatic complex-related diseases: a genetic study among Portuguese patients
  74. Purification, crystallization and preliminary X-ray diffraction analysis of the seryl-tRNA synthetase fromCandida albicans
  75. Crystal structure of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus
  76. Crystal structure of R. xylanophilus MpgS in complex with GDP-Mannose
  77. Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity
  78. Ataxin-3 Plays a Role in Mouse Myogenic Differentiation through Regulation of Integrin Subunit Levels
  79. Leech-Derived Thrombin Inhibitors: From Structures to Mechanisms to Clinical Applications
  80. Mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus
  81. Tick-derived Kunitz-type inhibitors as antihemostatic factors
  82. Nucleocytoplasmic Shuttling Activity of Ataxin-3
  83. Crystal structure of M. tuberculosis glucosyl-3-phosphoglycerate synthase
  84. Crystal structure of M. tuberculosis glucosyl-3-phosphoglycerate synthase
  85. Mycobacterium tuberculosis Glucosyl-3-Phosphoglycerate Synthase: Structure of a Key Enzyme in Methylglucose Lipopolysaccharide Biosynthesis
  86. Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase fromRubrobacter xylanophilus
  87. Molecular and structural analyses of maple syrup urine disease and identification of a founder mutation in a Portuguese Gypsy community
  88. Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase
  89. Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick
  90. Crystal Structure of a Trapped Phosphate-Intermediate in Vanadium Apochloroperoxidase Catalyzing a Dephosphorylation Reaction
  91. Thrombin-bound boophilin displays a functional and accessible reactive-site loop
  92. Crystal Structure of a Trapped Phosphate Intermediate in Vanadium Apochloroperoxidase Catalyzing a Dephosphorylation Reaction‡
  93. NEDD8: A new ataxin-3 interactor
  94. Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor
  95. Polyglutamine Expansion Diseases – the Case of Machado-Joseph Disease
  96. Towards a Structural Understanding of the Fibrillization Pathway in Machado-Joseph's Disease: Trapping Early Oligomers of Non-expanded Ataxin-3
  97. Crystal structure of transthyretin in complex with iododiflunisal
  98. Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor
  99. The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe
  100. Structure of TTR R104H: a non-amyloidogenic variant with protective clinical effects
  101. NAD+-dependent (R)-2-Hydroxyglutarate Dehydrogenase from Acidaminococcus fermentans
  102. X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis
  103. Structural basis for stereo-specific catalysis in NAD+-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans
  104. The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis
  105. TRYPANOSOMA CRUZI MACROPHAGE INFECTIVITY POTENTIATOR (TCMIP)
  106. Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helix
  107. New Insights into Thermostability of Bacterial Ferredoxins: High Resolution Crystal Structure of the Seven-Iron Ferredoxin from Thermus thermophilus
  108. New insights into the thermostability of bacterial ferredoxins: high-resolution crystal structure of the seven-iron ferredoxin from Thermus thermophilus
  109. Human biliverdin IX beta reductase: NADP complex
  110. Human biliverdin IX beta reductase: NADP/biliverdin IX alpha ternary complex
  111. Human biliverdin IX beta reductase: NADP/mesobiliverdin IV alpha ternary complex
  112. Human biliverdin IX beta reductase: NADP/Lumichrome ternary complex
  113. Human biliverdin IX beta reductase: NADP/FMN ternary complex
  114. Identification of Functionally Important Amino Acid Residues within the C2-Domain of Human Factor V Using Alanine-Scanning Mutagenesis†
  115. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V
  116. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: DIMERIC CRYSTAL FORM
  117. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: COMPLEX WITH PHENYLMERCURY
  118. Crystal structures of the membrane-binding C2 domain of human coagulation factor V
  119. Heterologous Expression of the Vanadium-containing Chloroperoxidase from Curvularia inaequalis inSaccharomyces cerevisiae and Site-directed Mutagenesis of the Active Site Residues His496, Lys353, Arg360, and Arg490
  120. RECOMBINANT APO-CHLOROPEROXIDASE FROM CURVULARIA INAEQUALIS
  121. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT R360A
  122. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT H496A
  123. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: RECOMBINANT HOLO-CHLOROPEROXIDASE
  124. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT H404A
  125. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT D292A
  126. X-ray crystal structures of active site mutants of the vanadium-containing chloroperoxidase from the fungus Curvularia inaequalis
  127. HUMAN BETA-TRYPTASE: A RING-LIKE TETRAMER WITH ACTIVE SITES FACING A CENTRAL PORE
  128. Human β-tryptase is a ring-like tetramer with active sites facing a central pore
  129. STRUCTURE OF OXIDOREDUCTASE (NADP+(A),FERREDOXIN(A))
  130. Small structural changes account for the high thermostability of 1[4Fe–4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima
  131. Structure of the Val122Ile Variant Transthyretin – a Cardiomyopathic Mutant