All Stories

  1. Evolutionary model of repeat insertions in Ataxin‐3 traces the origin of the polyglutamine stretch to an ancestral ubiquitin binding module
  2. Drug repurposing of dopaminergic drugs to inhibit ataxin-3 aggregation
  3. Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms
  4. Quantification of surface tension effects and nucleation-and-growth rates during self-assembly of biological condensates
  5. Pathogen-specific structural features of two key players in Candida albicans morphogenetic switch
  6. Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides
  7. A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly
  8. The Repeating, Modular Architecture of the HtrA Proteases
  9. The Repeating, Modular Architecture of the HtrA Proteases
  10. interferENZY: A Web-Based Tool for Enzymatic Assay Validation and Standardized Kinetic Analysis
  11. Critical assessment of protein intrinsic disorder prediction
  12. Major Improvements in Robustness and Efficiency during the Screening of Novel Enzyme Effectors by the 3-Point Kinetics Assay
  13. MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments
  14. A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures
  15. Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions
  16. Pushing myelination: developmental regulation of myosin expression drives oligodendrocyte morphological differentiation
  17. Accurate prediction of protein beta-aggregation with generalized statistical potentials
  18. CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments
  19. DisProt: intrinsic protein disorder annotation in 2020
  20. Genetic code ambiguity modulates the activity of a C. albicans MAP kinase linked to cell wall remodeling
  21. Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity
  22. The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation
  23. Chemical Kinetic Strategies for High-Throughput Screening of Protein Aggregation Modulators
  24. Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1- O -methyltransferase specific for 3- O -methylated mannosides
  25. Molecular fingerprints for a novel glucosamine kinase family in Actinobacteria
  26. Anti-TTR Nanobodies Allow the Identification of TTR Neuritogenic Epitope Associated with TTR-Megalin Neurotrophic Activities
  27. Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws
  28. Polyglutamine expansion diseases: More than simple repeats
  29. Polyglutamine-Independent Features in Ataxin-3 Aggregation and Pathogenesis of Machado-Joseph Disease
  30. Distribution of Amyloid-Like and Oligomeric Species from Protein Aggregation Kinetics
  31. Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2
  32. Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in thePKLRgene
  33. DisProt 7.0: a major update of the database of disordered proteins
  34. Disclosing the essentiality of ribose-5-phosphate isomerase B in Trypanosomatids
  35. Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models
  36. Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity
  37. Severe neonatal jaundice due to ade novoglucose-6-phosphate dehydrogenase deficient mutation
  38. Biophysical characterization of laforin-carbohydrate interaction
  39. What a difference a cluster makes: The multifaceted roles of IscR in gene regulation and DNA recognition
  40. SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97
  41. Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides
  42. Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion
  43. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (ATP complex)
  44. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway
  45. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (AppCp complex)
  46. CRYSTAL STRUCTURE OF THE 2B PROTEIN SOLUBLE DOMAIN FROM HEPATITIS A VIRUS
  47. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway
  48. Structural Basis for Host Membrane Remodeling Induced by Protein 2B of Hepatitis A Virus
  49. Ribose 5-Phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity
  50. Ser or Leu: structural snapshots of mistranslation in Candida albicans
  51. Molecular and computational analyses of genes involved in mannose 6-phosphate independent trafficking
  52. T. potens IscR
  53. E. coli IscR-DNA complex
  54. The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium
  55. Correction: Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
  56. Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
  57. A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3
  58. The Drosophila melanogaster methuselah Gene: A Novel Gene with Ancient Functions
  59. BIOCHEMICAL AND BIOPHYSICAL CHARACTERIZATION OF RECOMBINANT YEAST PROTEASOME MATURATION FACTOR UMP1
  60. The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65
  61. Trinucleotide Repeats: A Structural Perspective
  62. Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector
  63. Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
  64. Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
  65. Genome Sequence of Mycobacterium hassiacum DSM 44199, a Rare Source of Heat-Stable Mycobacterial Proteins
  66. Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments
  67. Cloning, purification and preliminary crystallographic studies of the 2AB protein from hepatitis A virus
  68. Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease
  69. Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen
  70. Candida albicans seryl-tRNA synthetase
  71. Crystal structure of the seryl-tRNA synthetase from Candida albicans
  72. Crystal Structure of the seryl-tRNA synthetase from Candida albicans
  73. Crystal Structure of seryl-tRNA synthetase from Candida albicans
  74. Lysosomal multienzymatic complex-related diseases: a genetic study among Portuguese patients
  75. Purification, crystallization and preliminary X-ray diffraction analysis of the seryl-tRNA synthetase fromCandida albicans
  76. Crystal structure of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus
  77. Crystal structure of R. xylanophilus MpgS in complex with GDP-Mannose
  78. Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity
  79. Ataxin-3 Plays a Role in Mouse Myogenic Differentiation through Regulation of Integrin Subunit Levels
  80. Leech-Derived Thrombin Inhibitors: From Structures to Mechanisms to Clinical Applications
  81. Mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus
  82. Tick-derived Kunitz-type inhibitors as antihemostatic factors
  83. Nucleocytoplasmic Shuttling Activity of Ataxin-3
  84. Crystal structure of M. tuberculosis glucosyl-3-phosphoglycerate synthase
  85. Crystal structure of M. tuberculosis glucosyl-3-phosphoglycerate synthase
  86. Mycobacterium tuberculosis Glucosyl-3-Phosphoglycerate Synthase: Structure of a Key Enzyme in Methylglucose Lipopolysaccharide Biosynthesis
  87. Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase fromRubrobacter xylanophilus
  88. Molecular and structural analyses of maple syrup urine disease and identification of a founder mutation in a Portuguese Gypsy community
  89. Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase
  90. Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick
  91. Crystal Structure of a Trapped Phosphate-Intermediate in Vanadium Apochloroperoxidase Catalyzing a Dephosphorylation Reaction
  92. Thrombin-bound boophilin displays a functional and accessible reactive-site loop
  93. Crystal Structure of a Trapped Phosphate Intermediate in Vanadium Apochloroperoxidase Catalyzing a Dephosphorylation Reaction‡
  94. NEDD8: A new ataxin-3 interactor
  95. Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor
  96. Polyglutamine Expansion Diseases – the Case of Machado-Joseph Disease
  97. Towards a Structural Understanding of the Fibrillization Pathway in Machado-Joseph's Disease: Trapping Early Oligomers of Non-expanded Ataxin-3
  98. Crystal structure of transthyretin in complex with iododiflunisal
  99. Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor
  100. The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe
  101. Structure of TTR R104H: a non-amyloidogenic variant with protective clinical effects
  102. NAD+-dependent (R)-2-Hydroxyglutarate Dehydrogenase from Acidaminococcus fermentans
  103. X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis
  104. Structural basis for stereo-specific catalysis in NAD+-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans
  105. The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis
  106. TRYPANOSOMA CRUZI MACROPHAGE INFECTIVITY POTENTIATOR (TCMIP)
  107. Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helix
  108. New Insights into Thermostability of Bacterial Ferredoxins: High Resolution Crystal Structure of the Seven-Iron Ferredoxin from Thermus thermophilus
  109. New insights into the thermostability of bacterial ferredoxins: high-resolution crystal structure of the seven-iron ferredoxin from Thermus thermophilus
  110. Human biliverdin IX beta reductase: NADP complex
  111. Human biliverdin IX beta reductase: NADP/biliverdin IX alpha ternary complex
  112. Human biliverdin IX beta reductase: NADP/mesobiliverdin IV alpha ternary complex
  113. Human biliverdin IX beta reductase: NADP/Lumichrome ternary complex
  114. Human biliverdin IX beta reductase: NADP/FMN ternary complex
  115. Identification of Functionally Important Amino Acid Residues within the C2-Domain of Human Factor V Using Alanine-Scanning Mutagenesis†
  116. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V
  117. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: DIMERIC CRYSTAL FORM
  118. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: COMPLEX WITH PHENYLMERCURY
  119. Crystal structures of the membrane-binding C2 domain of human coagulation factor V
  120. Heterologous Expression of the Vanadium-containing Chloroperoxidase from Curvularia inaequalis inSaccharomyces cerevisiae and Site-directed Mutagenesis of the Active Site Residues His496, Lys353, Arg360, and Arg490
  121. RECOMBINANT APO-CHLOROPEROXIDASE FROM CURVULARIA INAEQUALIS
  122. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT R360A
  123. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT H496A
  124. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: RECOMBINANT HOLO-CHLOROPEROXIDASE
  125. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT H404A
  126. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT D292A
  127. X-ray crystal structures of active site mutants of the vanadium-containing chloroperoxidase from the fungus Curvularia inaequalis
  128. HUMAN BETA-TRYPTASE: A RING-LIKE TETRAMER WITH ACTIVE SITES FACING A CENTRAL PORE
  129. Human β-tryptase is a ring-like tetramer with active sites facing a central pore
  130. STRUCTURE OF OXIDOREDUCTASE (NADP+(A),FERREDOXIN(A))
  131. Small structural changes account for the high thermostability of 1[4Fe–4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima
  132. Structure of the Val122Ile Variant Transthyretin – a Cardiomyopathic Mutant