All Stories

  1. The AUUUC repeat RNA aggregates sequester RNA-binding proteins like NOVA2 and lead to iron dyshomeostasis in spinocerebellar ataxia type 37
  2. Effect of levodopa/carbidopa on the progression of Machado-Joseph disease /spinocerebellar ataxia type 3 (MJD/SCA3)
  3. Evolutionary model of repeat insertions in Ataxin‐3 traces the origin of the polyglutamine stretch to an ancestral ubiquitin binding module
  4. Drug repurposing of dopaminergic drugs to inhibit ataxin-3 aggregation
  5. Transthyretin has conformation-selective proteolytic activity against α-synuclein
  6. Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets
  7. The structural plasticity of polyglutamine repeats
  8. Advances in Nucleotide Repeat Expansion Diseases: Transcription Gets in Phase
  9. Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms
  10. Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides
  11. Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms
  12. Quantification of surface tension effects and nucleation-and-growth rates during self-assembly of biological condensates
  13. Pathogen-specific structural features of two key players in Candida albicans morphogenetic switch
  14. Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides
  15. A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly
  16. The Repeating, Modular Architecture of the HtrA Proteases
  17. The Repeating, Modular Architecture of the HtrA Proteases
  18. interferENZY: A Web-Based Tool for Enzymatic Assay Validation and Standardized Kinetic Analysis
  19. Critical assessment of protein intrinsic disorder prediction
  20. Major Improvements in Robustness and Efficiency during the Screening of Novel Enzyme Effectors by the 3-Point Kinetics Assay
  21. MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments
  22. A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures
  23. Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions
  24. Pushing myelination: developmental regulation of myosin expression drives oligodendrocyte morphological differentiation
  25. Accurate prediction of protein beta-aggregation with generalized statistical potentials
  26. CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments
  27. DisProt: intrinsic protein disorder annotation in 2020
  28. Genetic code ambiguity modulates the activity of a C. albicans MAP kinase linked to cell wall remodeling
  29. Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity
  30. The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation
  31. Chemical Kinetic Strategies for High-Throughput Screening of Protein Aggregation Modulators
  32. Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1- O -methyltransferase specific for 3- O -methylated mannosides
  33. Molecular fingerprints for a novel glucosamine kinase family in Actinobacteria
  34. Anti-TTR Nanobodies Allow the Identification of TTR Neuritogenic Epitope Associated with TTR-Megalin Neurotrophic Activities
  35. Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws
  36. Polyglutamine expansion diseases: More than simple repeats
  37. Polyglutamine-Independent Features in Ataxin-3 Aggregation and Pathogenesis of Machado-Joseph Disease
  38. Distribution of Amyloid-Like and Oligomeric Species from Protein Aggregation Kinetics
  39. Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2
  40. Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in thePKLRgene
  41. DisProt 7.0: a major update of the database of disordered proteins
  42. Disclosing the essentiality of ribose-5-phosphate isomerase B in Trypanosomatids
  43. Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models
  44. Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity
  45. Severe neonatal jaundice due to ade novoglucose-6-phosphate dehydrogenase deficient mutation
  46. Biophysical characterization of laforin-carbohydrate interaction
  47. What a difference a cluster makes: The multifaceted roles of IscR in gene regulation and DNA recognition
  48. SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97
  49. Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides
  50. Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion
  51. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (ATP complex)
  52. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway
  53. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (AppCp complex)
  54. CRYSTAL STRUCTURE OF THE 2B PROTEIN SOLUBLE DOMAIN FROM HEPATITIS A VIRUS
  55. Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway
  56. Structural Basis for Host Membrane Remodeling Induced by Protein 2B of Hepatitis A Virus
  57. Ribose 5-Phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity
  58. Ser or Leu: structural snapshots of mistranslation in Candida albicans
  59. Molecular and computational analyses of genes involved in mannose 6-phosphate independent trafficking
  60. T. potens IscR
  61. E. coli IscR-DNA complex
  62. The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium
  63. Correction: Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
  64. Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
  65. A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3
  66. The Drosophila melanogaster methuselah Gene: A Novel Gene with Ancient Functions
  67. BIOCHEMICAL AND BIOPHYSICAL CHARACTERIZATION OF RECOMBINANT YEAST PROTEASOME MATURATION FACTOR UMP1
  68. The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65
  69. Trinucleotide Repeats: A Structural Perspective
  70. Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector
  71. Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
  72. Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
  73. Genome Sequence of Mycobacterium hassiacum DSM 44199, a Rare Source of Heat-Stable Mycobacterial Proteins
  74. Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments
  75. Cloning, purification and preliminary crystallographic studies of the 2AB protein from hepatitis A virus
  76. Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease
  77. Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen
  78. Candida albicans seryl-tRNA synthetase
  79. Crystal structure of the seryl-tRNA synthetase from Candida albicans
  80. Crystal Structure of the seryl-tRNA synthetase from Candida albicans
  81. Crystal Structure of seryl-tRNA synthetase from Candida albicans
  82. Lysosomal multienzymatic complex-related diseases: a genetic study among Portuguese patients
  83. Purification, crystallization and preliminary X-ray diffraction analysis of the seryl-tRNA synthetase fromCandida albicans
  84. Crystal structure of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus
  85. Crystal structure of R. xylanophilus MpgS in complex with GDP-Mannose
  86. Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity
  87. Ataxin-3 Plays a Role in Mouse Myogenic Differentiation through Regulation of Integrin Subunit Levels
  88. Leech-Derived Thrombin Inhibitors: From Structures to Mechanisms to Clinical Applications
  89. Mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus
  90. Tick-derived Kunitz-type inhibitors as antihemostatic factors
  91. Nucleocytoplasmic Shuttling Activity of Ataxin-3
  92. Crystal structure of M. tuberculosis glucosyl-3-phosphoglycerate synthase
  93. Crystal structure of M. tuberculosis glucosyl-3-phosphoglycerate synthase
  94. Mycobacterium tuberculosis Glucosyl-3-Phosphoglycerate Synthase: Structure of a Key Enzyme in Methylglucose Lipopolysaccharide Biosynthesis
  95. Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase fromRubrobacter xylanophilus
  96. Molecular and structural analyses of maple syrup urine disease and identification of a founder mutation in a Portuguese Gypsy community
  97. Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase
  98. Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick
  99. Crystal Structure of a Trapped Phosphate-Intermediate in Vanadium Apochloroperoxidase Catalyzing a Dephosphorylation Reaction
  100. Thrombin-bound boophilin displays a functional and accessible reactive-site loop
  101. Crystal Structure of a Trapped Phosphate Intermediate in Vanadium Apochloroperoxidase Catalyzing a Dephosphorylation Reaction‡
  102. NEDD8: A new ataxin-3 interactor
  103. Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor
  104. Polyglutamine Expansion Diseases – the Case of Machado-Joseph Disease
  105. Towards a Structural Understanding of the Fibrillization Pathway in Machado-Joseph's Disease: Trapping Early Oligomers of Non-expanded Ataxin-3
  106. Crystal structure of transthyretin in complex with iododiflunisal
  107. Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor
  108. The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe
  109. Structure of TTR R104H: a non-amyloidogenic variant with protective clinical effects
  110. NAD+-dependent (R)-2-Hydroxyglutarate Dehydrogenase from Acidaminococcus fermentans
  111. X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis
  112. Structural basis for stereo-specific catalysis in NAD+-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans
  113. The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis
  114. TRYPANOSOMA CRUZI MACROPHAGE INFECTIVITY POTENTIATOR (TCMIP)
  115. Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helix
  116. New Insights into Thermostability of Bacterial Ferredoxins: High Resolution Crystal Structure of the Seven-Iron Ferredoxin from Thermus thermophilus
  117. New insights into the thermostability of bacterial ferredoxins: high-resolution crystal structure of the seven-iron ferredoxin from Thermus thermophilus
  118. Human biliverdin IX beta reductase: NADP complex
  119. Human biliverdin IX beta reductase: NADP/biliverdin IX alpha ternary complex
  120. Human biliverdin IX beta reductase: NADP/mesobiliverdin IV alpha ternary complex
  121. Human biliverdin IX beta reductase: NADP/Lumichrome ternary complex
  122. Human biliverdin IX beta reductase: NADP/FMN ternary complex
  123. Identification of Functionally Important Amino Acid Residues within the C2-Domain of Human Factor V Using Alanine-Scanning Mutagenesis†
  124. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V
  125. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: DIMERIC CRYSTAL FORM
  126. CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: COMPLEX WITH PHENYLMERCURY
  127. Crystal structures of the membrane-binding C2 domain of human coagulation factor V
  128. Heterologous Expression of the Vanadium-containing Chloroperoxidase from Curvularia inaequalis inSaccharomyces cerevisiae and Site-directed Mutagenesis of the Active Site Residues His496, Lys353, Arg360, and Arg490
  129. RECOMBINANT APO-CHLOROPEROXIDASE FROM CURVULARIA INAEQUALIS
  130. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT R360A
  131. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT H496A
  132. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: RECOMBINANT HOLO-CHLOROPEROXIDASE
  133. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT H404A
  134. CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS: MUTANT D292A
  135. X-ray crystal structures of active site mutants of the vanadium-containing chloroperoxidase from the fungus Curvularia inaequalis
  136. HUMAN BETA-TRYPTASE: A RING-LIKE TETRAMER WITH ACTIVE SITES FACING A CENTRAL PORE
  137. Human β-tryptase is a ring-like tetramer with active sites facing a central pore
  138. STRUCTURE OF OXIDOREDUCTASE (NADP+(A),FERREDOXIN(A))
  139. Small structural changes account for the high thermostability of 1[4Fe–4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima
  140. Structure of the Val122Ile Variant Transthyretin – a Cardiomyopathic Mutant