All Stories

  1. Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling
  2. Mouse Lung Inflation Protocol for Mass Spectrometry Imaging (DMS22) v1
  3. Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists
  4. Genomic and Functional Characterization of Longitudinal Pseudomonas aeruginosa Isolates from Young Patients with Cystic Fibrosis
  5. Interpretable dimensionality reduction and classification of mass spectrometry imaging data in a visceral pain model via non-negative matrix factorization
  6. A protein subunit vaccine elicits a balanced immune response that protects against Pseudomonas pulmonary infection
  7. Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach
  8. A Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Direct-from-Urine-Specimen Diagnostic for Gram-Negative Pathogens
  9. Enhancing the Protection of Influenza Virus Vaccines with BECC TLR4 Adjuvant in Aged Mice
  10. Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation
  11. Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11
  12. MgrB-Dependent Colistin Resistance in Klebsiella pneumoniae Is Associated with an Increase in Host-to-Host Transmission
  13. Remodeling of Lipid A in Pseudomonas syringae pv. phaseolicola In Vitro
  14. A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin-Resistant Enterobacter Species
  15. Position-specific secondary acylation determines detection of lipid A by murine TLR4 and caspase-11
  16. Rapid identification of mcr-1-positive Escherichia coli from patient urine using a novel lipid-based MALDI-TOF-MS assay
  17. Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variants
  18. MgrB dependent colistin resistance in Klebsiella pneumoniae is associated with an increase in host-to-host transmission
  19. Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics
  20. Loss of RND-type multidrug efflux pumps triggers iron starvation and lipid A modifications in Pseudomonas aeruginosa
  21. Bacterial factors drive the differential targeting of Guanylate Binding Proteins to Francisella and Shigella
  22. Lipid A Structural Divergence in Rickettsia Pathogens
  23. Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii
  24. Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis
  25. Scnn1b-Transgenic BALB/c Mice as a Model of Pseudomonas aeruginosa Infections of the Cystic Fibrosis Lung
  26. Synergistic Biophysical Techniques Reveal Structural Mechanisms of Engineered Cationic Antimicrobial Peptides in Lipid Model Membranes
  27. Toll-like Receptor 4-Independent Effects of Lipopolysaccharide Identified Using Longitudinal Serum Proteomics
  28. Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging
  29. The UDP‐GalNAcA biosynthesis genes gna ‐ gne2 are required to maintain cell envelope integrity and in vivo fitness in multi‐drug resistant Acinetobacter baumannii
  30. Lipopolysaccharides from Different Burkholderia Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient Sera
  31. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria
  32. Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane
  33. Model-Based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids
  34. Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria
  35. Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii
  36. Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants
  37. Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis
  38. Temporal proteomic profiling reveals changes that support Burkholderia biofilms
  39. Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity andd-enantiomers
  40. Rapid Microbial Identification and Antibiotic Resistance Detection by Mass Spectrometric Analysis of Membrane Lipids
  41. A Prospective Study of Acinetobacter baumannii Complex Isolates and Colistin Susceptibility Monitoring by Mass Spectrometry of Microbial Membrane Glycolipids
  42. Genomic and Phenotypic Diversity among Ten Laboratory Isolates of Pseudomonas aeruginosa PAO1
  43. Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids
  44. Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii
  45. Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin
  46. RickettsiaLipid A Biosynthesis Utilizes the Late Acyltransferase LpxJ for Secondary Fatty Acid Addition
  47. In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays
  48. A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model
  49. Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate
  50. Optimized surface acoustic wave nebulization facilitates bacterial phenotyping
  51. Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation
  52. Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate
  53. CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens
  54. Host-based lipid inflammation drives pathogenesis in Francisella infection
  55. Probing the sRNA regulatory landscape of P. aeruginosa : post-transcriptional control of determinants of pathogenicity and antibiotic susceptibility
  56. Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship
  57. Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness
  58. Mass spectrometry analysis of intact Francisella bacteria identifies lipid A structure remodeling in response to acidic pH stress
  59. Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria
  60. Structural basis of MsbA-mediated lipopolysaccharide transport
  61. Structural modification of LPS in colistin-resistant, KPC-producing Klebsiella pneumoniae
  62. Bacterial lipids: powerful modifiers of the innate immune response
  63. Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids
  64. Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery
  65. Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens
  66. Infection-derived lipids elicit an immune deficiency circuit in arthropods
  67. Monophosphoryl Lipid A Enhances Efficacy of a Francisella tularensis LVS-Catanionic Nanoparticle Subunit Vaccine against F. tularensis Schu S4 Challenge by Augmenting both Humoral and Cellular Immunity
  68. In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress
  69. Global Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms
  70. Autopiquer - a Robust and Reliable Peak Detection Algorithm for Mass Spectrometry
  71. 1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens
  72. Rapid lipid a structure determination via surface acoustic wave nebulization and hierarchical tandem mass spectrometry algorithm
  73. Norharmane matrix enhances detection of endotoxin by MALDI-MS for simultaneous profiling of pathogen, host and vector systems
  74. Structural derivation of lipid A fromCronobacter sakazakiiusing tandem mass spectrometry
  75. A Pseudomonas aeruginosa hepta-acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils
  76. Type IV pili promote early biofilm formation byClostridium difficile
  77. Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity
  78. Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants
  79. Modification of the 1-Phosphate Group during Biosynthesis of Capnocytophaga canimorsus Lipid A
  80. Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains
  81. A PmrB-Regulated Deacetylase Required for Lipid A Modification and Polymyxin Resistance in Acinetobacter baumannii
  82. Site-specific activity of the acyltransferases HtrB1 and HtrB2 inPseudomonas aeruginosalipid A biosynthesis
  83. Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance
  84. TheprrF-Encoded Small Regulatory RNAs Are Required for Iron Homeostasis and Virulence of Pseudomonas aeruginosa
  85. Bordetella parapertussis PagP Mediates the Addition of Two Palmitates to the Lipopolysaccharide Lipid A
  86. Characterization of BPSS1521 (bprD), a Regulator of Burkholderia pseudomallei Virulence Gene Expression in the Mouse Model
  87. Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens
  88. Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS
  89. Identification and Quantitation of Biomarkers for Radiation-induced Injury via Mass Spectrometry
  90. Mass Spectrometry Imaging Enriches Biomarker Discovery Approaches with Candidate Mapping
  91. Novel Catanionic Surfactant Vesicle Vaccines Protect against Francisella tularensis LVS and Confer Significant Partial Protection against F. tularensis Schu S4 Strain
  92. A divergentPseudomonas aeruginosapalmitoyltransferase essential for cystic fibrosis-specific lipid A
  93. Survey of Innate Immune Responses to Burkholderia pseudomallei in Human Blood Identifies a Central Role for Lipopolysaccharide
  94. Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance
  95. Enzymatic Modification of Lipid A by ArnT Protects Bordetella bronchiseptica against Cationic Peptides and Is Required for Transmission
  96. Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
  97. Influence of Lipid A Acylation Pattern on Membrane Permeability and Innate Immune Stimulation
  98. Unique Structural Modifications Are Present in the Lipopolysaccharide from Colistin-Resistant Strains of Acinetobacter baumannii
  99. Increased Long Chain acyl-Coa Synthetase Activity and Fatty Acid Import Is Linked to Membrane Synthesis for Development of Picornavirus Replication Organelles
  100. The TLR4 antagonist Eritoran protects mice from lethal influenza infection
  101. Induction of the Yersinia pestis PhoP-PhoQ Regulatory System in the Flea and Its Role in Producing a Transmissible Infection
  102. Activities of Vancomycin-Containing Regimens against Colistin-Resistant Acinetobacter baumannii Clinical Strains
  103. Turning up Francisella pathogenesis
  104. Characterization of the AggR Regulon in Enteroaggregative Escherichia coli
  105. Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica
  106. Correction for Li et al., LPS remodeling is an evolved survival strategy for bacteria
  107. Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis
  108. LPS remodeling is an evolved survival strategy for bacteria
  109. Role of Francisella Lipid A Phosphate Modification in Virulence and Long-Term Protective Immune Responses
  110. A Transposon Site Hybridization Screen Identifies galU and wecBC as Important for Survival of Yersinia pestis in Murine Macrophages
  111. Salmonellaexpressing detoxified lipopolysaccharide is immunogenic and protective both as an attenuated vaccine and for delivery of foreign antigens
  112. A rapid one-step method for the characterization of membrane lipid remodeling in Francisella using matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry
  113. Evaluation of the Ability of LL-37 to Neutralise LPS In Vitro and Ex Vivo
  114. A rapid one-step method for the characterization of membrane lipid remodeling inFrancisellausing matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry
  115. Salmonella enterica Serovar Enteritidis Core O Polysaccharide Conjugated to H:g,m Flagellin as a Candidate Vaccine for Protection against Invasive Infection withS.Enteritidis
  116. Role of pagL and lpxO in Bordetella bronchiseptica Lipid A Biosynthesis
  117. Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1
  118. Automated Lipid A Structure Assignment from Hierarchical Tandem Mass Spectrometry Data
  119. In VitroSusceptibility of Burkholderia vietnamiensis to Aminoglycosides
  120. Mutations of Francisella novicida that Alter the Mechanism of Its Phagocytosis by Murine Macrophages
  121. Comprehensive structure characterization of lipid a extracted from Yersinia pestis for determination of its phosphorylation configuration
  122. Francisella Tularensis Blue–Gray Phase Variation Involves Structural Modifications of Lipopolysaccharide O-Antigen, Core and Lipid A and Affects Intramacrophage Survival and Vaccine Efficacy
  123. The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infection
  124. Human Toll-like receptor 4 responses toP. gingivalisare regulated by lipid A 1- and 4′-phosphatase activities
  125. A Protein Important for Antimicrobial Peptide Resistance, YdeI/OmdA, Is in the Periplasm and Interacts with OmpD/NmpC
  126. The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses
  127. Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation
  128. A Straight Path to Circular Proteins
  129. A sensitive liquid chromatography/mass spectrometry-based assay for quantitation of amino-containing moieties in lipid A
  130. Determination of pyrophosphorylated forms of lipid A in Gram-negative bacteria using a multivaried mass spectrometric approach
  131. Acyl Chain Specificity of the Acyltransferases LpxA and LpxD and Substrate Availability Contribute to Lipid A Fatty Acid Heterogeneity in Porphyromonas gingivalis
  132. Pseudomonas aeruginosa activates caspase 1 through Ipaf
  133. A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity
  134. Activation of Toll-like receptors by Burkholderia pseudomallei
  135. Unique Lipid A Modifications inPseudomonas aeruginosaIsolated from the Airways of Patients with Cystic Fibrosis
  136. Structural heterogeneity and environmentally regulated remodeling of Francisella tularensis subspecies novicida lipid a characterized by tandem mass spectrometry
  137. Identification of an Orphan Response Regulator Required for the Virulence of Francisella spp. and Transcription of Pathogenicity Island Genes
  138. PmrA(Con) Confers pmrHFIJKL-Dependent EGTA and Polymyxin Resistance on msbB Salmonella by Decorating Lipid A with Phosphoethanolamine
  139. Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients
  140. The Structure and Function of Francisella Lipopolysaccharide
  141. Immunostimulatory Properties of the Emerging Pathogen Stenotrophomonas maltophilia
  142. Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains
  143. Differentiation and Distribution of Colistin- and Sodium Dodecyl Sulfate-Tolerant Cells in Pseudomonas aeruginosa Biofilms
  144. Lack of In Vitro and In Vivo Recognition of Francisella tularensis Subspecies Lipopolysaccharide by Toll-Like Receptors
  145. Characterization of Late Acyltransferase Genes of Yersinia pestis and Their Role in Temperature-Dependent Lipid A Variation
  146. The Pseudomonas aeruginosa Lipid A Deacylase: Selection for Expression and Loss within the Cystic Fibrosis Airway
  147. Exopolysaccharides fromBurkholderia cenocepaciaInhibit Neutrophil Chemotaxis and Scavenge Reactive Oxygen Species
  148. Mouse Paneth Cell Secretory Responses to Cell Surface Glycolipids of Virulent and Attenuated Pathogenic Bacteria
  149. Inhibition of Salmonella enterica Serovar Typhimurium Lipopolysaccharide Deacylation by Aminoarabinose Membrane Modification
  150. Purification and characterization of deacylated and/or palmitoylated lipid A species unique to Salmonella enterica serovar Typhimurium
  151. Use of Phage Display To Identify Potential Pseudomonas aeruginosa Gene Products Relevant to Early Cystic Fibrosis Airway Infections
  152. LPS, TLR4 and infectious disease diversity
  153. Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4
  154. Factors affecting the escape of Francisella tularensis from the phagolysosome
  155. Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin
  156. Variation in lipid A structure in the pathogenic yersiniae
  157. 3- O -Deacylation of Lipid A by PagL, a PhoP/PhoQ-regulated Deacylase of Salmonella typhimurium , Modulates Signaling through Toll-like Receptor 4
  158. PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa That Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A
  159. Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4
  160. Genome mosaicism is conserved but not unique inPseudomonas aeruginosaisolates from the airways of young children with cystic fibrosis
  161. Proteomic analysis of Pseudomonas aeruginosa grown under magnesium limitation
  162. Macrophages from High-Risk HLA-DQB1*0201/*0302 Type 1 Diabetes Mellitus Patients are Hypersensitive to Lipopolysaccharide Stimulation
  163. mig-14 Is a Salmonella Gene That Plays a Role in Bacterial Resistance to Antimicrobial Peptides
  164. Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity
  165. Carrier-mediated enhancement of cognate T cell help: the basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine
  166. Genetic and Functional Analysis of a PmrA-PmrB-Regulated Locus Necessary for Lipopolysaccharide Modification, Antimicrobial Peptide Resistance, and Oral Virulence of Salmonella entericaSerovar Typhimurium
  167. Salmonella enterica Serovar TyphimuriumwaaP Mutants Show Increased Susceptibility to Polymyxin and Loss of Virulence In Vivo
  168. Constitutive Mutations of the Salmonella entericaSerovar Typhimurium Transcriptional Virulence RegulatorphoP
  169. Peptides, Pseudomonas aeruginosa, polysaccharides and lipopolysaccharides – players in the predicament of cystic fibrosis patients: Response
  170. Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa
  171. How Intracellular Bacteria Survive: Surface Modifications That Promote Resistance to Host Innate Immune Responses
  172. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway
  173. A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA.
  174. Concanavalin A Promotes Adherence of Salmonella typhimurium to Small Intestinal Mucosa of Rats