All Stories

  1. Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling

    Article • mSystems, October 2023, ASM Journals

    Dr Robert Ernst

  2. Mouse Lung Inflation Protocol for Mass Spectrometry Imaging (DMS22) v1

    Article • August 2023, ZappyLab, Inc.

    Dr Robert Ernst

  3. Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists

    Article • Heliyon, July 2023, Elsevier

    Dr Robert Ernst

  4. Genomic and Functional Characterization of Longitudinal Pseudomonas aeruginosa Isolates from Young Patients with Cystic Fibrosis

    Article • Microbiology Spectrum, June 2023, ASM Journals

    Dr Robert Ernst

  5. Interpretable dimensionality reduction and classification of mass spectrometry imaging data in a visceral pain model via non-negative matrix factorization

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Dr Robert Ernst

  6. A protein subunit vaccine elicits a balanced immune response that protects against Pseudomonas pulmonary infection

    Article • npj Vaccines, March 2023, Springer Science + Business Media

    Dr Robert Ernst

  7. Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach

    Article • Nature Communications, December 2022, Springer Science + Business Media

    Dr Robert Ernst

  8. A Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Direct-from-Urine-Specimen Diagnostic for Gram-Negative Pathogens

    Article • Microbiology Spectrum, October 2022, ASM Journals

    Dr Robert Ernst

  9. Enhancing the Protection of Influenza Virus Vaccines with BECC TLR4 Adjuvant in Aged Mice

    Article • September 2022, Research Square

    Dr Robert Ernst

  10. Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation

    Article • Infection and Immunity, July 2022, ASM Journals

    Dr Robert Ernst

  11. Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11

    Article • Infection and Immunity, July 2022, ASM Journals

    Dr Robert Ernst

  12. MgrB-Dependent Colistin Resistance in Klebsiella pneumoniae Is Associated with an Increase in Host-to-Host Transmission

    Article • mBio, March 2022, ASM Journals

    Dr Robert Ernst

  13. Remodeling of Lipid A in Pseudomonas syringae pv. phaseolicola In Vitro

    Article • International Journal of Molecular Sciences, February 2022, MDPI AG

    Dr Robert Ernst

  14. A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin-Resistant Enterobacter Species

    Article • Microbiology Spectrum, February 2022, ASM Journals

    Dr Robert Ernst

  15. Position-specific secondary acylation determines detection of lipid A by murine TLR4 and caspase-11

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Dr Robert Ernst

  16. Rapid identification of mcr-1-positive Escherichia coli from patient urine using a novel lipid-based MALDI-TOF-MS assay

    Article • Access Microbiology, December 2021, Society for General Microbiology

    Dr Robert Ernst

  17. Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variants

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Dr Robert Ernst

  18. MgrB dependent colistin resistance in Klebsiella pneumoniae is associated with an increase in host-to-host transmission

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Dr Robert Ernst

  19. Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics

    Article • mSystems, August 2021, ASM Journals

    Dr Robert Ernst

  20. Loss of RND-type multidrug efflux pumps triggers iron starvation and lipid A modifications in Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, July 2021, ASM Journals

    Dr Robert Ernst

  21. Bacterial factors drive the differential targeting of Guanylate Binding Proteins to Francisella and Shigella

    Article • June 2021, Cold Spring Harbor Laboratory Press

    Dr Robert Ernst

  22. Lipid A Structural Divergence in Rickettsia Pathogens

    Article • mSphere, May 2021, ASM Journals

    Dr Robert Ernst

  23. Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii

    Article • Molecular Microbiology, September 2020, Wiley

    Dr Robert Ernst, Helen Zgurskaya

  24. Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis

    Article • Proceedings of the National Academy of Sciences, August 2020, Proceedings of the National Academy of Sciences

    Dr Robert Ernst

  25. Scnn1b-Transgenic BALB/c Mice as a Model of Pseudomonas aeruginosa Infections of the Cystic Fibrosis Lung

    Article • Infection and Immunity, July 2020, ASM Journals

    Dr Robert Ernst

  26. Synergistic Biophysical Techniques Reveal Structural Mechanisms of Engineered Cationic Antimicrobial Peptides in Lipid Model Membranes

    Article • Chemistry - A European Journal, April 2020, Wiley

    Dr Robert Ernst

  27. Toll-like Receptor 4-Independent Effects of Lipopolysaccharide Identified Using Longitudinal Serum Proteomics

    Article • Journal of Proteome Research, February 2020, American Chemical Society (ACS)

    Dr Robert Ernst

  28. Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Dr Robert Ernst

  29. The UDP‐GalNAcA biosynthesis genes gna ‐ gne2 are required to maintain cell envelope integrity and in vivo fitness in multi‐drug resistant Acinetobacter baumannii

    Article • Molecular Microbiology, November 2019, Wiley

    Dr Harry L. T. Hmobley, Dr Robert Ernst

  30. Lipopolysaccharides from Different Burkholderia Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient Sera

    Article • Infection and Immunity, September 2019, ASM Journals

    Dr Robert Ernst

  31. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria

    Article • ACS Infectious Diseases, August 2019, American Chemical Society (ACS)

    Dr Robert Ernst

  32. Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane

    Article • Antimicrobial Agents and Chemotherapy, August 2019, ASM Journals

    Dr Robert Ernst

  33. Model-Based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids

    Article • Analytical Chemistry, August 2019, American Chemical Society (ACS)

    Dr Robert Ernst

  34. Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria

    Article • Bioorganic & Medicinal Chemistry, May 2019, Elsevier

    Dr Robert Ernst

  35. Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii

    Article • ACS Infectious Diseases, April 2019, American Chemical Society (ACS)

    Dr Robert Ernst

  36. Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants

    Article • Science, April 2019, American Association for the Advancement of Science

    Dr Robert Ernst

  37. Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis

    Article • PLoS ONE, February 2019, PLOS

    Dr Robert Ernst, Jeffrey Schertzer

  38. Temporal proteomic profiling reveals changes that support Burkholderia biofilms

    Article • Pathogens and Disease, February 2019, Oxford University Press (OUP)

    Dr Robert Ernst

  39. Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity andd-enantiomers

    Article • Soft Matter, January 2019, Royal Society of Chemistry

    Dr Robert Ernst

  40. Rapid Microbial Identification and Antibiotic Resistance Detection by Mass Spectrometric Analysis of Membrane Lipids

    Article • Analytical Chemistry, December 2018, American Chemical Society (ACS)

    Dr Robert Ernst

  41. A Prospective Study of Acinetobacter baumannii Complex Isolates and Colistin Susceptibility Monitoring by Mass Spectrometry of Microbial Membrane Glycolipids

    Article • Journal of Clinical Microbiology, December 2018, ASM Journals

    Dr Robert Ernst

  42. Genomic and Phenotypic Diversity among Ten Laboratory Isolates of Pseudomonas aeruginosa PAO1

    Article • Journal of Bacteriology, December 2018, ASM Journals

    Dr Robert Ernst

  43. Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids

    Article • Scientific Reports, October 2018, Springer Science + Business Media

    Dr Robert Ernst

  44. Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii

    Article • Journal of Antimicrobial Chemotherapy, August 2018, Oxford University Press (OUP)

    Dr Robert Ernst

  45. Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin

    Article • Journal of Molecular Biology, August 2018, Elsevier

    Dr Robert Ernst

  46. RickettsiaLipid A Biosynthesis Utilizes the Late Acyltransferase LpxJ for Secondary Fatty Acid Addition

    Article • Journal of Bacteriology, July 2018, ASM Journals

    Dr Robert Ernst

  47. In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays

    Article • Infection and Immunity, July 2018, ASM Journals

    Dr Robert Ernst

  48. A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model

    Article • Vaccine, June 2018, Elsevier

    Dr Robert Ernst

  49. Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate

    Article • Journal of the American Society for Mass Spectrometry, April 2018, American Chemical Society (ACS)

    Dr Robert Ernst

  50. Optimized surface acoustic wave nebulization facilitates bacterial phenotyping

    Article • International Journal of Mass Spectrometry, April 2018, Elsevier

    Dr Robert Ernst

  51. Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation

    Article • PLoS Neglected Tropical Diseases, February 2018, PLOS

    Dr Robert Ernst

  52. Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate

    Article • Journal of the American Society for Mass Spectrometry, February 2018, American Chemical Society (ACS)

    Dr Robert Ernst

  53. CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens

    Article • mBio, November 2017, ASM Journals

    Dr Robert Ernst

  54. Host-based lipid inflammation drives pathogenesis in Francisella infection

    Article • Proceedings of the National Academy of Sciences, November 2017, Proceedings of the National Academy of Sciences

    Dr Robert Ernst

  55. Probing the sRNA regulatory landscape of P. aeruginosa : post-transcriptional control of determinants of pathogenicity and antibiotic susceptibility

    Article • Molecular Microbiology, November 2017, Wiley

    Dr Robert Ernst

  56. Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, November 2017, Elsevier

    Dr Robert Ernst

  57. Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness

    Article • PLoS ONE, October 2017, PLOS

    Dr Robert Ernst

  58. Mass spectrometry analysis of intact Francisella bacteria identifies lipid A structure remodeling in response to acidic pH stress

    Article • Biochimie, October 2017, Elsevier

    Dr Robert Ernst

  59. Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria

    Article • Bioorganic & Medicinal Chemistry, October 2017, Elsevier

    Dr Robert Ernst

  60. Structural basis of MsbA-mediated lipopolysaccharide transport

    Article • Nature, September 2017, Springer Science + Business Media

    Dr Robert Ernst

  61. Structural modification of LPS in colistin-resistant, KPC-producing Klebsiella pneumoniae

    Article • Journal of Antimicrobial Chemotherapy, August 2017, Oxford University Press (OUP)

    Dr Robert Ernst

  62. Bacterial lipids: powerful modifiers of the innate immune response

    Article • F1000Research, August 2017, Faculty of 1000, Ltd.

    Dr Robert Ernst

  63. Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids

    Article • Scientific Reports, July 2017, Springer Science + Business Media

    Dr Robert Ernst

  64. Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery

    Article • mBio, May 2017, ASM Journals

    Dr Robert Ernst

  65. Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens

    Article • Antimicrobial Agents and Chemotherapy, April 2017, ASM Journals

    Dr Robert Ernst

  66. Infection-derived lipids elicit an immune deficiency circuit in arthropods

    Article • Nature Communications, February 2017, Springer Science + Business Media

    Dr Robert Ernst

  67. Monophosphoryl Lipid A Enhances Efficacy of a Francisella tularensis LVS-Catanionic Nanoparticle Subunit Vaccine against F. tularensis Schu S4 Challenge by Augmenting both Humoral and Cellular Immunity

    Article • Clinical and Vaccine Immunology, January 2017, ASM Journals

    Dr Robert Ernst

  68. In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress

    Article • Antimicrobial Agents and Chemotherapy, December 2016, ASM Journals

    Dr Robert Ernst

  69. Global Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms

    Article • mSystems, December 2016, ASM Journals

    Dr Robert Ernst

  70. Autopiquer - a Robust and Reliable Peak Detection Algorithm for Mass Spectrometry

    Article • Journal of the American Society for Mass Spectrometry, December 2016, Springer Science + Business Media

    Dr Magnus Palmblad, Dr Robert Ernst

  71. 1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens

    Article • ACS Infectious Diseases, November 2016, American Chemical Society (ACS)

    Dr Robert Ernst

  72. Rapid lipid a structure determination via surface acoustic wave nebulization and hierarchical tandem mass spectrometry algorithm

    Article • Rapid Communications in Mass Spectrometry, October 2016, Wiley

    Prof David R Goodlett, Dr Robert Ernst

  73. Norharmane matrix enhances detection of endotoxin by MALDI-MS for simultaneous profiling of pathogen, host and vector systems

    Article • Pathogens and Disease, September 2016, Oxford University Press (OUP)

    Dr Robert Ernst

  74. Structural derivation of lipid A fromCronobacter sakazakiiusing tandem mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, September 2016, Wiley

    Dr Robert Ernst

  75. A Pseudomonas aeruginosa hepta-acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils

    Article • Journal of Leukocyte Biology, August 2016, Wiley

    Dr Robert Ernst

  76. Type IV pili promote early biofilm formation byClostridium difficile

    Article • Pathogens and Disease, June 2016, Oxford University Press (OUP)

    Dr Robert Ernst

  77. Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

    Article • Tetrahedron, June 2016, Elsevier

    Dr Robert Ernst

  78. Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Dr Robert Ernst

  79. Modification of the 1-Phosphate Group during Biosynthesis of Capnocytophaga canimorsus Lipid A

    Article • Infection and Immunity, December 2015, ASM Journals

    Dr Robert Ernst

  80. Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains

    Article • BMC Genomics, October 2015, Springer Science + Business Media

    Dr George Liechti, Dr Robert Ernst

  81. A PmrB-Regulated Deacetylase Required for Lipid A Modification and Polymyxin Resistance in Acinetobacter baumannii

    Article • Antimicrobial Agents and Chemotherapy, October 2015, ASM Journals

    Dr Robert Ernst

  82. Site-specific activity of the acyltransferases HtrB1 and HtrB2 inPseudomonas aeruginosalipid A biosynthesis

    Article • Pathogens and Disease, July 2015, Oxford University Press (OUP)

    Dr Robert Ernst

  83. Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance

    Article • Clinical Infectious Diseases, January 2015, Oxford University Press (OUP)

    Dr Robert Ernst

  84. TheprrF-Encoded Small Regulatory RNAs Are Required for Iron Homeostasis and Virulence of Pseudomonas aeruginosa

    Article • Infection and Immunity, December 2014, ASM Journals

    Amanda Oglesby-Sherrouse, Dr Robert Ernst

  85. Bordetella parapertussis PagP Mediates the Addition of Two Palmitates to the Lipopolysaccharide Lipid A

    Article • Journal of Bacteriology, November 2014, ASM Journals

    Dr Robert Ernst, Dr Andrew Preston

  86. Characterization of BPSS1521 (bprD), a Regulator of Burkholderia pseudomallei Virulence Gene Expression in the Mouse Model

    Article • PLoS ONE, August 2014, PLOS

    Dr Robert Ernst

  87. Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

    Article • Cell Host & Microbe, August 2014, Elsevier

    Dr Robert Ernst

  88. Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS

    Article • Proceedings of the National Academy of Sciences, April 2014, Proceedings of the National Academy of Sciences

    Dr Robert Ernst

  89. Identification and Quantitation of Biomarkers for Radiation-induced Injury via Mass Spectrometry

    Article • Health Physics, January 2014, Wolters Kluwer Health

    Dr Robert Ernst

  90. Mass Spectrometry Imaging Enriches Biomarker Discovery Approaches with Candidate Mapping

    Article • Health Physics, January 2014, Wolters Kluwer Health

    Dr Robert Ernst

  91. Novel Catanionic Surfactant Vesicle Vaccines Protect against Francisella tularensis LVS and Confer Significant Partial Protection against F. tularensis Schu S4 Strain

    Article • Clinical and Vaccine Immunology, December 2013, ASM Journals

    Dr Robert Ernst

  92. A divergentPseudomonas aeruginosapalmitoyltransferase essential for cystic fibrosis-specific lipid A

    Article • Molecular Microbiology, November 2013, Wiley

    Dr David A Rasko, Dr Robert Ernst

  93. Survey of Innate Immune Responses to Burkholderia pseudomallei in Human Blood Identifies a Central Role for Lipopolysaccharide

    Article • PLoS ONE, November 2013, PLOS

    Dr Robert Ernst

  94. Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance

    Article • ACS Chemical Biology, October 2013, American Chemical Society (ACS)

    Dr Robert Ernst

  95. Enzymatic Modification of Lipid A by ArnT Protects Bordetella bronchiseptica against Cationic Peptides and Is Required for Transmission

    Article • Infection and Immunity, October 2013, ASM Journals

    Dr Robert Ernst

  96. Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

    Article • Science, September 2013, American Association for the Advancement of Science

    Dr Robert Ernst

  97. Influence of Lipid A Acylation Pattern on Membrane Permeability and Innate Immune Stimulation

    Article • Marine Drugs, August 2013, MDPI AG

    Xiaoyuan Wang, Dr Robert Ernst

  98. Unique Structural Modifications Are Present in the Lipopolysaccharide from Colistin-Resistant Strains of Acinetobacter baumannii

    Article • Antimicrobial Agents and Chemotherapy, July 2013, ASM Journals

    Dr Robert Ernst

  99. Increased Long Chain acyl-Coa Synthetase Activity and Fatty Acid Import Is Linked to Membrane Synthesis for Development of Picornavirus Replication Organelles

    Article • PLoS Pathogens, June 2013, PLOS

    Dr Robert Ernst

  100. The TLR4 antagonist Eritoran protects mice from lethal influenza infection

    Article • Nature, May 2013, Springer Science + Business Media

    Dr Jorge C Blanco, Dr Robert Ernst

  101. Induction of the Yersinia pestis PhoP-PhoQ Regulatory System in the Flea and Its Role in Producing a Transmissible Infection

    Article • Journal of Bacteriology, February 2013, ASM Journals

    Joe Hinnebusch, Dr Robert Ernst

  102. Activities of Vancomycin-Containing Regimens against Colistin-Resistant Acinetobacter baumannii Clinical Strains

    Article • Antimicrobial Agents and Chemotherapy, February 2013, ASM Journals

    Dr Robert Ernst

  103. Turning up Francisella pathogenesis

    Article • Virulence, November 2012, Taylor & Francis

    Dr Robert Ernst

  104. Characterization of the AggR Regulon in Enteroaggregative Escherichia coli

    Article • Infection and Immunity, October 2012, ASM Journals

    Dr Robert Ernst

  105. Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica

    Article • PLoS Pathogens, October 2012, PLOS

    Dr Robert Ernst

  106. Correction for Li et al., LPS remodeling is an evolved survival strategy for bacteria

    Article • Proceedings of the National Academy of Sciences, July 2012, Proceedings of the National Academy of Sciences

    Dr Robert Ernst

  107. Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis

    Article • Analytical Chemistry, July 2012, American Chemical Society (ACS)

    Dr Robert Ernst

  108. LPS remodeling is an evolved survival strategy for bacteria

    Article • Proceedings of the National Academy of Sciences, May 2012, Proceedings of the National Academy of Sciences

    Dr Robert Ernst

  109. Role of Francisella Lipid A Phosphate Modification in Virulence and Long-Term Protective Immune Responses

    Article • Infection and Immunity, January 2012, ASM Journals

    Dr Robert Ernst

  110. A Transposon Site Hybridization Screen Identifies galU and wecBC as Important for Survival of Yersinia pestis in Murine Macrophages

    Article • Journal of Bacteriology, December 2011, ASM Journals

    Dr Robert Ernst

  111. Salmonellaexpressing detoxified lipopolysaccharide is immunogenic and protective both as an attenuated vaccine and for delivery of foreign antigens

    Article • Expert Review of Vaccines, December 2011, Taylor & Francis

    Dr Robert Ernst

  112. A rapid one-step method for the characterization of membrane lipid remodeling in Francisella using matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, November 2011, Wiley

    Dr Robert Ernst

  113. Evaluation of the Ability of LL-37 to Neutralise LPS In Vitro and Ex Vivo

    Article • PLoS ONE, October 2011, PLOS

    Dr Robert Ernst

  114. A rapid one-step method for the characterization of membrane lipid remodeling inFrancisellausing matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, August 2011, Wiley

    Xiaoyuan Wang, Dr Robert Ernst

  115. Salmonella enterica Serovar Enteritidis Core O Polysaccharide Conjugated to H:g,m Flagellin as a Candidate Vaccine for Protection against Invasive Infection withS.Enteritidis

    Article • Infection and Immunity, August 2011, ASM Journals

    Dr Robert Ernst

  116. Role of pagL and lpxO in Bordetella bronchiseptica Lipid A Biosynthesis

    Article • Journal of Bacteriology, July 2011, ASM Journals

    Dr Robert Ernst

  117. Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1

    Article • Molecular Microbiology, June 2011, Wiley

    Dr Robert Ernst

  118. Automated Lipid A Structure Assignment from Hierarchical Tandem Mass Spectrometry Data

    Article • Journal of the American Society for Mass Spectrometry, March 2011, American Chemical Society (ACS)

    Dr Robert Ernst

  119. In VitroSusceptibility of Burkholderia vietnamiensis to Aminoglycosides

    Article • Antimicrobial Agents and Chemotherapy, February 2011, ASM Journals

    Dr Robert Ernst

  120. Mutations of Francisella novicida that Alter the Mechanism of Its Phagocytosis by Murine Macrophages

    Article • PLoS ONE, July 2010, PLOS

    Dr Robert Ernst

  121. Comprehensive structure characterization of lipid a extracted from Yersinia pestis for determination of its phosphorylation configuration

    Article • Journal of the American Society for Mass Spectrometry, May 2010, American Chemical Society (ACS)

    Dr Robert Ernst

  122. Francisella Tularensis Blue–Gray Phase Variation Involves Structural Modifications of Lipopolysaccharide O-Antigen, Core and Lipid A and Affects Intramacrophage Survival and Vaccine Efficacy

    Article • Frontiers in Microbiology, January 2010, Frontiers

    Dr Robert Ernst

  123. The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infection

    Article • January 2010, Springer Science + Business Media

    Dr Robert Ernst

  124. Human Toll-like receptor 4 responses toP. gingivalisare regulated by lipid A 1- and 4′-phosphatase activities

    Article • Cellular Microbiology, November 2009, Wiley

    Dr Thao T To, Dr Robert Ernst

  125. A Protein Important for Antimicrobial Peptide Resistance, YdeI/OmdA, Is in the Periplasm and Interacts with OmpD/NmpC

    Article • Journal of Bacteriology, September 2009, ASM Journals

    Dr Robert Ernst

  126. The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses

    Article • Microbial Pathogenesis, August 2009, Elsevier

    Dr Robert Ernst

  127. Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation

    Article • Biochemical Society Transactions, July 2009, Portland Press Ltd.

    Dr Robert Ernst

  128. A Straight Path to Circular Proteins

    Article • Journal of Biological Chemistry, April 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert Ernst

  129. A sensitive liquid chromatography/mass spectrometry-based assay for quantitation of amino-containing moieties in lipid A

    Article • Rapid Communications in Mass Spectrometry, January 2009, Wiley

    Dr Robert Ernst

  130. Determination of pyrophosphorylated forms of lipid A in Gram-negative bacteria using a multivaried mass spectrometric approach

    Article • Proceedings of the National Academy of Sciences, September 2008, Proceedings of the National Academy of Sciences

    Dr Robert Ernst

  131. Acyl Chain Specificity of the Acyltransferases LpxA and LpxD and Substrate Availability Contribute to Lipid A Fatty Acid Heterogeneity in Porphyromonas gingivalis

    Article • Journal of Bacteriology, May 2008, ASM Journals

    Dr Robert Ernst

  132. Pseudomonas aeruginosa activates caspase 1 through Ipaf

    Article • Proceedings of the National Academy of Sciences, February 2008, Proceedings of the National Academy of Sciences

    Dr Robert Ernst

  133. A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity

    Article • PLoS Pathogens, February 2008, PLOS

    Dr Robert Ernst

  134. Activation of Toll-like receptors by Burkholderia pseudomallei

    Article • BMC Immunology, January 2008, Springer Science + Business Media

    Dr Robert Ernst

  135. Unique Lipid A Modifications inPseudomonas aeruginosaIsolated from the Airways of Patients with Cystic Fibrosis

    Article • The Journal of Infectious Diseases, October 2007, Oxford University Press (OUP)

    Dr Robert Ernst

  136. Structural heterogeneity and environmentally regulated remodeling of Francisella tularensis subspecies novicida lipid a characterized by tandem mass spectrometry

    Article • Journal of the American Society for Mass Spectrometry, June 2007, American Chemical Society (ACS)

    Dr Robert Ernst

  137. Identification of an Orphan Response Regulator Required for the Virulence of Francisella spp. and Transcription of Pathogenicity Island Genes

    Article • Infection and Immunity, April 2007, ASM Journals

    Dr Robert Ernst

  138. PmrA(Con) Confers pmrHFIJKL-Dependent EGTA and Polymyxin Resistance on msbB Salmonella by Decorating Lipid A with Phosphoethanolamine

    Article • Journal of Bacteriology, April 2007, ASM Journals

    Dr Robert Ernst

  139. Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients

    Article • Molecular Microbiology, April 2007, Wiley

    Prof Eric Déziel, Dr Lucas Hoffman, Dr Robert Ernst

  140. The Structure and Function of Francisella Lipopolysaccharide

    Article • Annals of the New York Academy of Sciences, March 2007, Wiley

    Dr Robert Ernst

  141. Immunostimulatory Properties of the Emerging Pathogen Stenotrophomonas maltophilia

    Article • Infection and Immunity, January 2007, ASM Journals

    Dr Robert Ernst

  142. Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains

    Article • Genome Biology, January 2007, Springer Science + Business Media

    Dr Robert Ernst

  143. Differentiation and Distribution of Colistin- and Sodium Dodecyl Sulfate-Tolerant Cells in Pseudomonas aeruginosa Biofilms

    Article • Journal of Bacteriology, October 2006, ASM Journals

    Dr Robert Ernst

  144. Lack of In Vitro and In Vivo Recognition of Francisella tularensis Subspecies Lipopolysaccharide by Toll-Like Receptors

    Article • Infection and Immunity, September 2006, ASM Journals

    Dr Anders Sjöstedt, Dr Robert Ernst

  145. Characterization of Late Acyltransferase Genes of Yersinia pestis and Their Role in Temperature-Dependent Lipid A Variation

    Article • Journal of Bacteriology, February 2006, ASM Journals

    Dr Robert Ernst

  146. The Pseudomonas aeruginosa Lipid A Deacylase: Selection for Expression and Loss within the Cystic Fibrosis Airway

    Article • Journal of Bacteriology, January 2006, ASM Journals

    Dr Robert Ernst

  147. Exopolysaccharides fromBurkholderia cenocepaciaInhibit Neutrophil Chemotaxis and Scavenge Reactive Oxygen Species

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert Ernst

  148. Mouse Paneth Cell Secretory Responses to Cell Surface Glycolipids of Virulent and Attenuated Pathogenic Bacteria

    Article • Infection and Immunity, April 2005, ASM Journals

    Dr Robert Ernst

  149. Inhibition of Salmonella enterica Serovar Typhimurium Lipopolysaccharide Deacylation by Aminoarabinose Membrane Modification

    Article • Journal of Bacteriology, April 2005, ASM Journals

    Dr Robert Ernst

  150. Purification and characterization of deacylated and/or palmitoylated lipid A species unique to Salmonella enterica serovar Typhimurium

    Article • Journal of Endotoxin Research, February 2005, SAGE Publications

    Dr Robert Ernst

  151. Use of Phage Display To Identify Potential Pseudomonas aeruginosa Gene Products Relevant to Early Cystic Fibrosis Airway Infections

    Article • Infection and Immunity, January 2005, ASM Journals

    Dr Robert Ernst

  152. LPS, TLR4 and infectious disease diversity

    Article • Nature Reviews Microbiology, January 2005, Nature

    Dr Robert Ernst

  153. Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4

    Article • Journal of Endotoxin Research, December 2004, SAGE Publications

    Dr Robert Ernst

  154. Factors affecting the escape of Francisella tularensis from the phagolysosome

    Article • Journal of Medical Microbiology, October 2004, Society for General Microbiology

    Dr Robert Ernst

  155. Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin

    Article • AJP Lung Cellular and Molecular Physiology, July 2004, American Physiological Society

    Dr Robert Ernst

  156. Variation in lipid A structure in the pathogenic yersiniae

    Article • Molecular Microbiology, April 2004, Wiley

    Dr Robert Ernst

  157. 3- O -Deacylation of Lipid A by PagL, a PhoP/PhoQ-regulated Deacylase of Salmonella typhimurium , Modulates Signaling through Toll-like Receptor 4

    Article • Journal of Biological Chemistry, March 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Samuel Irving Miller, Dr Robert Ernst

  158. PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa That Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A

    Article • Journal of Bacteriology, January 2004, ASM Journals

    Dr Robert Ernst

  159. Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4

    Article • Journal of Endotoxin Research, December 2003, SAGE Publications

    Dr Robert Ernst

  160. Genome mosaicism is conserved but not unique inPseudomonas aeruginosaisolates from the airways of young children with cystic fibrosis

    Article • Environmental Microbiology, November 2003, Wiley

    Dr Robert Ernst

  161. Proteomic analysis of Pseudomonas aeruginosa grown under magnesium limitation

    Article • Journal of the American Society for Mass Spectrometry, July 2003, American Chemical Society (ACS)

    Dr Robert Ernst

  162. Macrophages from High-Risk HLA-DQB1*0201/*0302 Type 1 Diabetes Mellitus Patients are Hypersensitive to Lipopolysaccharide Stimulation

    Article • Scandinavian Journal of Immunology, November 2002, Wiley

    Dr Robert Ernst

  163. mig-14 Is a Salmonella Gene That Plays a Role in Bacterial Resistance to Antimicrobial Peptides

    Article • Journal of Bacteriology, June 2002, ASM Journals

    Dr Robert Ernst

  164. Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity

    Article • Microbes and Infection, November 2001, Elsevier

    Dr Robert Ernst

  165. Carrier-mediated enhancement of cognate T cell help: the basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine

    Article • European Journal of Immunology, August 2001, Wiley

    Dr Robert Ernst

  166. Genetic and Functional Analysis of a PmrA-PmrB-Regulated Locus Necessary for Lipopolysaccharide Modification, Antimicrobial Peptide Resistance, and Oral Virulence of Salmonella entericaSerovar Typhimurium

    Article • Infection and Immunity, November 2000, ASM Journals

    Dr Robert Ernst

  167. Salmonella enterica Serovar TyphimuriumwaaP Mutants Show Increased Susceptibility to Polymyxin and Loss of Virulence In Vivo

    Article • Infection and Immunity, August 2000, ASM Journals

    Dr Robert Ernst

  168. Constitutive Mutations of the Salmonella entericaSerovar Typhimurium Transcriptional Virulence RegulatorphoP

    Article • Infection and Immunity, June 2000, ASM Journals

    Dr Robert Ernst

  169. Peptides, Pseudomonas aeruginosa, polysaccharides and lipopolysaccharides – players in the predicament of cystic fibrosis patients: Response

    Article • Trends in Microbiology, June 2000, Elsevier

    Dr Robert Ernst

  170. Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa

    Article • Science, November 1999, American Association for the Advancement of Science

    Dr Robert Ernst

  171. How Intracellular Bacteria Survive: Surface Modifications That Promote Resistance to Host Innate Immune Responses

    Article • The Journal of Infectious Diseases, March 1999, Oxford University Press (OUP)

    Dr Robert Ernst

  172. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway

    Article • The EMBO Journal, December 1997, Wiley

    Dr Robert Ernst

  173. A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA.

    Article • Molecular and Cellular Biology, January 1997, ASM Journals

    Dr Robert Ernst

  174. Concanavalin A Promotes Adherence of Salmonella typhimurium to Small Intestinal Mucosa of Rats

    Article • Experimental Biology and Medicine, October 1989, SAGE Publications

    Dr Robert Ernst