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  1. Metavac-RSV mucosal bivalent vaccine candidate protects cotton rats against pneumoviruses and is produced using serum-free cell culture in bioreactor

    Article • npj Vaccines, August 2025, Springer Science + Business Media

    Dr Jorge C Blanco

  2. Enterovirus D68 infection in cotton rats results in systemic inflammation with detectable viremia associated with extracellular vesicle and neurologic disease

    Article • Scientific Reports, February 2025, Springer Science + Business Media

    Dr Jorge C Blanco

  3. An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases

    Article • mBio, February 2025, ASM Journals

    Dr Jorge C Blanco

  4. Preclinical development of the TLR4 antagonist FP12 as a drug lead targeting the HMGB1/MD-2/TLR4 axis in lethal influenza infection

    Article • Innate Immunity, January 2025, SAGE Publications

    Dr Jorge C Blanco

  5. Optimising Bioprinting Nozzles through Computational Modelling and Design of Experiments

    Article • Biomimetics, July 2024, MDPI AG

    Dr Jorge C Blanco

  6. Systematic computer-aided disulfide design as a general strategy to stabilize prefusion class I fusion proteins

    Article • Frontiers in Immunology, July 2024, Frontiers

    Dr Jorge C Blanco

  7. Alzheimer’s disease and multiple sclerosis: a possible connection through the viral demyelinating neurodegenerative trigger (vDENT)

    Article • Frontiers in Aging Neuroscience, June 2023, Frontiers

    Dr Jorge C Blanco

  8. Novel neuroendocrine role of γ-aminobutyric acid and gastrin-releasing peptide in the host response to influenza infection

    Article • Mucosal Immunology, June 2023, Elsevier

    Dr Jorge C Blanco

  9. Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly

    Article • Viruses, May 2023, MDPI AG

    Dr Jorge C Blanco

  10. Human Metapneumovirus (hMPV) Infection and MPV467 Treatment in Immunocompromised Cotton Rats Sigmodon hispidus

    Article • Viruses, February 2023, MDPI AG

    Dr Jorge C Blanco

  11. SARS-CoV-2 infection augments species- and age-specific predispositions in cotton rats

    Article • Scientific Reports, January 2023, Springer Science + Business Media

    Dr Jorge C Blanco

  12. Correlative outcomes of maternal immunization against RSV in cotton rats

    Article • Human Vaccines & Immunotherapeutics, December 2022, Taylor & Francis

    Dr Jorge C Blanco

  13. Evidence for Interplay Between the Renin–Angiotensin System and Toll-Like Receptor 4 Signaling Pathways in the Induction of Virus-Induced Acute Lung Injury

    Article • Journal of Interferon & Cytokine Research, December 2022, Mary Ann Liebert Inc

    Dr Jorge C Blanco

  14. Species-specific transcriptomic changes upon respiratory syncytial virus infection in cotton rats

    Article • Scientific Reports, October 2022, Springer Science + Business Media

    Dr Jorge C Blanco

  15. Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation

    Article • Frontiers in Immunology, August 2022, Frontiers

    Dr Jorge C Blanco

  16. Human Adenovirus Type 4 Comprises Two Major Phylogroups with Distinct Replicative Fitness and Virulence Phenotypes

    Article • Journal of Virology, March 2022, ASM Journals

    Dr Jorge C Blanco

  17. Evolution of protection after maternal immunization for respiratory syncytial virus in cotton rats

    Article • PLoS Pathogens, December 2021, PLOS

    Dr Jorge C Blanco

  18. Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury

    Article • Frontiers in Immunology, July 2021, Frontiers

    Dr Jorge C Blanco

  19. Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats

    Article • Animal Microbiome, April 2021, Springer Science + Business Media

    Dr Jorge C Blanco

  20. HUMAN ADENOVIRUS TYPE 4 COMPRISES TWO MAJOR PHYLOGROUPS WITH DISTINCT REPLICATIVE FITNESS AND VIRULENCE PHENOTYPES

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Dr Jorge C Blanco

  21. A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses

    Article • Journal of Experimental Medicine, November 2020, Rockefeller University Press

    Dr Jorge C Blanco

  22. Effect of aging on immunogenicity and efficacy of inactivated influenza vaccines in cotton rats Sigmodon hispidus

    Article • Human Vaccines & Immunotherapeutics, July 2020, Taylor & Francis

    Dr Jorge C Blanco

  23. Early or Late Bacterial Lung Infection Increases Mortality After Traumatic Brain Injury in Male Mice and Chronically Impairs Monocyte Innate Immune Function

    Article • Critical Care Medicine, May 2020, Wolters Kluwer Health

    Dr Jorge C Blanco

  24. Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring

    Article • Vaccines, March 2020, MDPI AG

    Dr Jorge C Blanco

  25. Select targeting of intracellular Toll-interleukin-1 receptor resistance domains for protection against influenza-induced disease

    Article • Innate Immunity, January 2020, SAGE Publications

    Dr Jorge C Blanco

  26. Classical Drug Digitoxin Inhibits Influenza Cytokine Storm, With Implications for Covid-19 Therapy

    Article • In Vivo, January 2020, International Institute of Anticancer Research

    Dr Jorge C Blanco

  27. Herpes Simplex Virus 1 Induces Brain Inflammation and Multifocal Demyelination in the Cotton Rat Sigmodon hispidus

    Article • Journal of Virology, October 2019, ASM Journals

    Dr Jorge C Blanco

  28. Alternative Virus-Like Particle-Associated Prefusion F Proteins as Maternal Vaccines for Respiratory Syncytial Virus

    Article • Journal of Virology, September 2019, ASM Journals

    Dr Jorge C Blanco

  29. Influenza “Trains” the Host for Enhanced Susceptibility to Secondary Bacterial Infection

    Article • mBio, May 2019, ASM Journals

    Dr Jorge C Blanco

  30. Novel role of gastrin releasing peptide-mediated signaling in the host response to influenza infection

    Article • Mucosal Immunology, October 2018, Springer Science + Business Media

    Dr Jorge C Blanco

  31. Cotton rat lung transcriptome reveals host immune response to Respiratory Syncytial Virus infection

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Dr Jorge C Blanco

  32. Improving ability of RSV microneutralization assay to detect G-specific and cross-reactive neutralizing antibodies through immortalized cell line selection

    Article • Vaccine, July 2018, Elsevier

    Dr Jorge C Blanco

  33. A multifaceted approach to RSV vaccination

    Article • Human Vaccines & Immunotherapeutics, May 2018, Taylor & Francis

    Dr Jorge C Blanco

  34. Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model

    Article • Nature Communications, May 2018, Springer Science + Business Media

    Dr Jorge C Blanco

  35. Serum High-Mobility-Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections

    Article • mBio, March 2018, ASM Journals

    Dr Jorge C Blanco

  36. Cotton rat model for testing vaccines and antivirals against respiratory syncytial virus

    Article • Antiviral Chemistry and Chemotherapy, January 2018, SAGE Publications

    Dr Jorge C Blanco

  37. Enhancing the Thermostability and Immunogenicity of a Respiratory Syncytial Virus (RSV) Live-Attenuated Vaccine by Incorporating Unique RSV Line19F Protein Residues

    Article • Journal of Virology, December 2017, ASM Journals

    Dr Jorge C Blanco

  38. Immunization with Live Human Rhinovirus (HRV) 16 Induces Protection in Cotton Rats against HRV14 Infection

    Article • Frontiers in Microbiology, August 2017, Frontiers

    Dr Jorge C Blanco

  39. Preclinical assessment of safety of maternal vaccination against respiratory syncytial virus (RSV) in cotton rats

    Article • Vaccine, July 2017, Elsevier

    Dr Jorge C Blanco

  40. TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Dr Jorge C Blanco

  41. A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

    Article • Nature Communications, December 2016, Springer Science + Business Media

    Dr Jorge C Blanco

  42. Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus)

    Article • PLOS One, November 2016, PLOS

    Dr Jorge C Blanco

  43. Evaluation of the potential effects of AS03-adjuvanted A(H1N1)pdm09 vaccine administration on the central nervous system of non-primed and A(H1N1)pdm09-primed cotton rats

    Article • Human Vaccines & Immunotherapeutics, September 2016, Taylor & Francis

    Dr Jorge C Blanco

  44. Epigenetic Mechanisms Governing Innate Inflammatory Responses

    Article • Journal of Interferon & Cytokine Research, July 2016, Mary Ann Liebert Inc

    Dr Jorge C Blanco

  45. A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats

    Article • Journal of Virology, June 2016, ASM Journals

    Dr Jorge C Blanco

  46. Enhanced allergic responsiveness after early childhood infection with respiratory viruses: Are long-lived alternatively activated macrophages the missing link?

    Article • Pathogens and Disease, May 2016, Oxford University Press (OUP)

    Dr Jorge C Blanco

  47. Novel strategies for targeting innate immune responses to influenza

    Article • Mucosal Immunology, January 2016, Springer Science + Business Media

    Dr Jorge C Blanco

  48. Cotton rat immune responses to virus-like particles containing the pre-fusion form of respiratory syncytial virus fusion protein

    Article • Journal of Translational Medicine, November 2015, Springer Science + Business Media

    Dr Jorge C Blanco

  49. Maternal transfer of RSV immunity in cotton rats vaccinated during pregnancy

    Article • Vaccine, October 2015, Elsevier

    Dr Jorge C Blanco

  50. Treatment with novel RSV Ig RI-002 controls viral replication and reduces pulmonary damage in immunocompromised Sigmodon hispidus

    Article • Bone Marrow Transplantation, September 2015, Springer Science + Business Media

    Dr Jorge C Blanco

  51. Efficacy of the Herpes Simplex Virus 2 (HSV-2) Glycoprotein D/AS04 Vaccine against Genital HSV-2 and HSV-1 Infection and Disease in the Cotton Rat Sigmodon hispidus Model

    Article • Journal of Virology, July 2015, ASM Journals

    Dr Jorge C Blanco

  52. Novel drugs targeting Toll-like receptors for antiviral therapy

    Article • Future Virology, September 2014, Future Medicine

    Dr Jorge C Blanco

  53. Agents that increase AAM differentiation blunt RSV-mediated lung pathology

    Article • Journal of Leukocyte Biology, July 2014, Wiley

    Dr Jorge C Blanco

  54. A recombinant anchorless respiratory syncytial virus (RSV) fusion (F) protein/monophosphoryl lipid A (MPL) vaccine protects against RSV-induced replication and lung pathology

    Article • Vaccine, March 2014, Elsevier

    Dr Jorge C Blanco

  55. Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus)

    Article • Journal of Antivirals & Antiretrovirals, January 2014, OMICS Publishing Group

    Dr Jorge C Blanco

  56. Prophylactic antibody treatment and intramuscular immunization reduce infectious human rhinovirus 16 load in the lower respiratory tract of challenged cotton rats

    Article • Trials in Vaccinology, January 2014, Elsevier

    Dr Jorge C Blanco

  57. Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology

    Article • Mucosal Immunology, September 2013, Springer Science + Business Media

    Dr Jorge C Blanco

  58. The TLR4 antagonist Eritoran protects mice from lethal influenza infection

    Article • Nature, May 2013, Springer Science + Business Media

    Dr Jorge C Blanco, Dr Robert Ernst

  59. The Cotton Rat Sigmodon Hispidus Model of Respiratory Syncytial Virus Infection

    Article • January 2013, Springer Science + Business Media

    Dr Jorge C Blanco

  60. Chronic Helminth Infection Does Not Exacerbate Mycobacterium tuberculosis Infection

    Article • PLoS Neglected Tropical Diseases, December 2012, PLOS

    Dr Jorge C Blanco

  61. Receptor Characterization and Susceptibility of Cotton Rats to Avian and 2009 Pandemic Influenza Virus Strains

    Article • Journal of Virology, November 2012, ASM Journals

    Dr Jorge C Blanco

  62. Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

    Article • mBio, August 2012, ASM Journals

    Dr Jorge C Blanco

  63. The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo

    Article • Journal of Leukocyte Biology, November 2010, Wiley

    Dr Jorge C Blanco

  64. New insights for development of a safe and protective RSV vaccine

    Article • Human Vaccines, June 2010, Taylor & Francis

    Dr Jorge C Blanco

  65. Activation of Interferon Response Through Toll-Like Receptor 3 Impacts Viral Pathogenesis and Pulmonary Toll-Like Receptor Expression During Respiratory Syncytial Virus and Influenza Infections in the Cotton RatSigmodon hispidusModel

    Article • Journal of Interferon & Cytokine Research, April 2010, Mary Ann Liebert Inc

    Dr Jorge C Blanco

  66. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4- and IFN-β-dependent

    Article • Mucosal Immunology, March 2010, Springer Science + Business Media

    Dr Jorge C Blanco

  67. Methods for Monitoring Dynamics of Pulmonary RSV Replication by Viral Culture and by Real‐Time Reverse Transcription–PCR In Vivo: Detection of Abortive Viral Replication

    Article • Current Protocols in Cell Biology, March 2010, Wiley

    Dr Jorge C Blanco

  68. Inactivation of respiratory syncytial virus by zinc finger reactive compounds

    Article • Virology Journal, January 2010, Springer Science + Business Media

    Dr Jorge C Blanco

  69. The cotton rat model of respiratory viral infections

    Article • Biologicals, June 2009, Elsevier

    Dr Jorge C Blanco

  70. Characterization of late tuberculosis infection in Sigmodon hispidus

    Article • Tuberculosis, March 2009, Elsevier

    Dr Jorge C Blanco

  71. Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection

    Article • Virology Journal, January 2009, Springer Science + Business Media

    Dr Jorge C Blanco

  72. Induction of type I interferons and interferon-inducible Mx genes during respiratory syncytial virus infection and reinfection in cotton rats

    Article • Journal of General Virology, January 2008, Society for General Microbiology

    Dr Jorge C Blanco

  73. Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease

    Article • Microbial Pathogenesis, November 2007, Elsevier

    Dr Jorge C Blanco

  74. The Antiviral Potential of Interferon-Induced Cotton Rat Mx Proteins Against Orthomyxovirus (Influenza), Rhabdovirus, and Bunyavirus

    Article • Journal of Interferon & Cytokine Research, October 2007, Mary Ann Liebert Inc

    Dr Jorge C Blanco

  75. Association of TLR4 Polymorphisms with Symptomatic Respiratory Syncytial Virus Infection in High-Risk Infants and Young Children

    Article • The Journal of Immunology, August 2007, The American Association of Immunologists

    Dr Jorge C Blanco

  76. Respiratory Syncytial Virus Infects and Abortively Replicates in the Lungs in Spite of Preexisting Immunity

    Article • Journal of Virology, June 2007, ASM Journals

    Dr Jorge C Blanco

  77. Human metapneumovirus: Enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challenged

    Article • Vaccine, June 2007, Elsevier

    Dr Jorge C Blanco

  78. The American cotton rat: A novel model for pulmonary tuberculosis

    Article • Tuberculosis, March 2007, Elsevier

    Dr Jorge C Blanco

  79. Age‐Related Differences in Pulmonary Cytokine Response to Respiratory Syncytial Virus Infection: Modulation by Anti‐inflammatory and Antiviral Treatment

    Article • The Journal of Infectious Diseases, February 2007, Oxford University Press (OUP)

    Dr Jorge C Blanco

  80. Interferon-Inducible Mx Gene Expression in Cotton Rats: Cloning, Characterization, and Expression During Influenza Viral Infection

    Article • Journal of Interferon & Cytokine Research, December 2006, Mary Ann Liebert Inc

    Dr Jorge C Blanco

  81. Analysis of TLR4 Polymorphic Variants: New Insights into TLR4/MD-2/CD14 Stoichiometry, Structure, and Signaling

    Article • The Journal of Immunology, June 2006, The American Association of Immunologists

    Dr Jorge C Blanco

  82. The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease

    Article • Vaccine, June 2006, Elsevier

    Dr Jorge C Blanco

  83. Prospects of antiviral and anti-inflammatory therapy for respiratory syncytial virus infection

    Article • Expert Review of Anti-infective Therapy, December 2005, Taylor & Francis

    Dr Jorge C Blanco

  84. The cotton rat provides a useful small-animal model for the study of influenza virus pathogenesis

    Article • Journal of General Virology, October 2005, Society for General Microbiology

    Dr Jorge C Blanco

  85. Pathogenesis of Human Metapneumovirus Lung Infection in BALB/c Mice and Cotton Rats

    Article • Journal of Virology, July 2005, ASM Journals

    Dr Jorge C Blanco

  86. Respiratory Syncytial Virus (RSV) Infection Induces Cyclooxygenase 2: A Potential Target for RSV Therapy

    Article • The Journal of Immunology, March 2005, The American Association of Immunologists

    Dr Jorge C Blanco

  87. The Cotton Rat: An Underutilized Animal Model for Human Infectious Diseases Can Now Be Exploited Using Specific Reagents to Cytokines, Chemokines, and Interferons

    Article • Journal of Interferon & Cytokine Research, January 2004, Mary Ann Liebert Inc

    Dr Jorge C Blanco

  88. Distinct Mutations inIRAK-4Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections

    Article • Journal of Experimental Medicine, August 2003, Rockefeller University Press

    Dr Jorge C Blanco

  89. A Cotton Rat Model of Human Parainfluenza 3 Laryngotracheitis: Virus Growth, Pathology, and Therapy

    Article • The Journal of Infectious Diseases, December 2002, Oxford University Press (OUP)

    Dr Jorge C Blanco

  90. The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitro

    Article • Journal of Endotoxin Research, October 2002, SAGE Publications

    Dr Jorge C Blanco

  91. Cytokine and Chemokine Gene Expression after Primary and Secondary Respiratory Syncytial Virus Infection in Cotton Rats

    Article • The Journal of Infectious Diseases, June 2002, Oxford University Press (OUP)

    Dr Jorge C Blanco

  92. Emerging genetic diversity of HIV-1 in South America

    Article • AIDS, August 2000, Wolters Kluwer Health

    Dr Jorge C Blanco

  93. Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression

    Article • Journal of Experimental Medicine, June 2000, Rockefeller University Press

    Dr Jorge C Blanco

  94. Limited Role of Ceramide in Lipopolysaccharide-mediated Mitogen-activated Protein Kinase Activation, Transcription Factor Induction, and Cytokine Release

    Article • Journal of Biological Chemistry, April 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jorge C Blanco

  95. The histone acetylase PCAF is a nuclear receptor coactivator

    Article • Genes & Development, June 1998, Cold Spring Harbor Laboratory Press

    Dr Jorge C Blanco

  96. Retinoid Receptor-Induced Alteration of the Chromatin Assembled on a Ligand-Responsive Promoter inXenopusOocytes

    Article • Molecular Endocrinology, March 1998, Endocrine Society

    Dr Jorge C Blanco

  97. Interaction between the Retinoid X Receptor and Transcription Factor IIB Is Ligand-dependentin Vivo

    Article • Journal of Biological Chemistry, January 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jorge C Blanco

  98. Mutations in the 1,25-Dihydroxyvitamin D3Receptor Identifying C-terminal Amino Acids Required for Transcriptional Activation That Are Functionally Dissociated from Hormone Binding, Heterodimeric DNA Binding, and Interaction with Basal Transcription Fac...

    Article • Journal of Biological Chemistry, June 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Peter W Jurutka, Dr Jorge C Blanco

  99. Myeloid differentiation is impaired in transgenic mice with targeted expression of a dominant negative form of retinoid X receptor β

    Article • British Journal of Haematology, January 1997, Wiley

    Dr Jorge C Blanco

  100. Interferon regulatory factors and TFIIB cooperatively regulate interferon-responsive promoter activity in vivo and in vitro.

    Article • Molecular and Cellular Biology, November 1996, ASM Journals

    Dr Jorge C Blanco

  101. Inhibition of ligand induced promoter occupancyin vivoby a dominant negative RXR

    Article • Genes to Cells, February 1996, Wiley

    Dr Peter W Jurutka, Dr Jorge C Blanco

  102. Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.

    Article • Proceedings of the National Academy of Sciences, February 1995, Proceedings of the National Academy of Sciences

    Dr Peter W Jurutka, Dr Jorge C Blanco

  103. Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers.

    Article • Molecular and Cellular Biology, October 1993, ASM Journals

    Dr Jorge C Blanco

  104. Repetitive DNA sequences of Toxoplasma gondii for development of diagnostic probes

    Article • Memórias do Instituto Oswaldo Cruz, December 1991, FapUNIFESP (SciELO)

    Dr Jorge C Blanco

  105. Toxoplasma gondii: a rapid method for the isolation of pure tachyzoites: preliminary characterization of its genome

    Article • Memórias do Instituto Oswaldo Cruz, December 1990, FapUNIFESP (SciELO)

    Dr Jorge C Blanco