All Stories

  1. A multiplexed bacterial two-hybrid for rapid characterization of protein–protein interactions and iterative protein design
  2. Crystal Structure of de Novo Designed Coiled-Coil Protein Origami Triangle
  3. Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor
  4. Segmentation strategy of de novo designed four-helical bundles expands protein oligomerization modalities for cell regulation
  5. RBD-Modified Polyaniline-Based Label-Free Immunosensor for Sensitive Impedimetric Detection of Anti-SARS-CoV-2 Antibodies
  6. Correlation between Phenotype and Genotype in CTNNB1 Syndrome: A Systematic Review of the Literature
  7. Coiled-coil heterodimer-based recruitment of an exonuclease to CRISPR/Cas for enhanced gene editing
  8. Metal ion–regulated assembly of designed modular protein cages
  9. Binding of the transcription activator-like effector augments transcriptional regulation by another transcription factor
  10. Designed allosteric protein logic
  11. The Relevance of Physico-Chemical Properties and Protein Corona for Evaluation of Nanoparticles Immunotoxicity—In Vitro Correlation Analysis on THP-1 Macrophages
  12. Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage
  13. Lipid droplets control mitogenic lipid mediator production in human cancer cells
  14. Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage
  15. A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures
  16. Author Correction: Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
  17. Designed folding pathway of modular coiled-coil-based proteins
  18. Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
  19. A guide to the design of synthetic gene networks in mammalian cells
  20. Coiled-coil heterodimers with increased stability for cellular regulation and sensing SARS-CoV-2 spike protein-mediated cell fusion
  21. A Multiplexed Bacterial Two-Hybrid for Rapid Characterization of Protein-Protein Interactions and Iterative Protein Design
  22. Increased gene translation stringency in mammalian cells by nonsense suppression at multiple permissive sites with a single noncanonical amino acid
  23. Metabolic enzyme clustering by coiled coils improves the biosynthesis of resveratrol and mevalonate
  24. Synthetic biology principles for the design of protein with novel structures and functions
  25. A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cells
  26. Design of split superantigen fusion proteins for cancer immunotherapy
  27. Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
  28. NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway
  29. Polarized displacement by transcription activator-like effectors for regulatory circuits
  30. SwitCCh: Metal‐Site Design for Controlling the Assembly of a Coiled‐Coil Homodimer
  31. Extracellular vesicle–mediated transfer of constitutively active MyD88L265P engages MyD88wt and activates signaling
  32. Publisher Correction: Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9
  33. Publisher Correction: Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9
  34. Coiled coil protein origami: from modular design principles towards biotechnological applications
  35. Peptide and protein nanotechnology into the 2020s: beyond biology
  36. Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9
  37. Advances in design of protein folds and assemblies
  38. The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5
  39. Modulation of Coiled-Coil Dimer Stability through Surface Residues while Preserving Pairing Specificity
  40. Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
  41. Design principles for rapid folding of knotted DNA nanostructures
  42. Toll-like receptor 4 senses oxidative stress mediated by the oxidation of phospholipids in extracellular vesicles
  43. Minimal Sequence Requirements for Oligodeoxyribonucleotides Activating Human TLR9
  44. MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4
  45. The molecular mechanism of species-specific recognition of lipopolysaccharides by the MD-2/TLR4 receptor complex
  46. Postulates for validating TLR4 agonists
  47. Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization
  48. Chemistry of Lipid A: At the Heart of Innate Immunity
  49. Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators
  50. A bistable genetic switch based on designable DNA-binding domains
  51. Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists
  52. Species-Specific Activation of TLR4 by Hypoacylated Endotoxins Governed by Residues 82 and 122 of MD-2
  53. TOPOFOLD , the designed modular biomolecular folds: polypeptide‐based molecular origami nanostructures following the footsteps of DNA
  54. Vanadate from Air Pollutant Inhibits Hrs-Dependent Endosome Fusion and Augments Responsiveness to Toll-Like Receptors
  55. N-acylated Peptides Derived from Human Lactoferricin Perturb Organization of Cardiolipin and Phosphatidylethanolamine in Cell Membranes and Induce Defects in Escherichia coli Cell Division
  56. Tetraacylated Lipid A and Paclitaxel-Selective Activation of TLR4/MD-2 Conferred through Hydrophobic Interactions
  57. Designable DNA-binding domains enable construction of logic circuits in mammalian cells
  58. Self-assembled bionanostructures: proteins following the lead of DNA nanostructures
  59. Modulation of CD14 and TLR4⋅MD-2 Activities by a Synthetic Lipid A Mimetic
  60. New designed protein assemblies
  61. Noninvasive High-Throughput Single-Cell Analysis of HIV Protease Activity Using Ratiometric Flow Cytometry
  62. Determination of the physiological 2:2 TLR5:flagellin activation stoichiometry revealed by the activity of a fusion receptor
  63. Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments
  64. Interactions of Archaeal Chromatin Proteins Alba1 and Alba2 with Nucleic Acids
  65. Suppression of TLR Signaling by Targeting TIR domain-Containing Proteins
  66. Chimeric flagellin as the self-adjuvanting antigen for the activation of immune response against Helicobacter pylori
  67. Functional self-assembling polypeptide bionanomaterials
  68. Delivery system for the enhanced efficiency of immunostimulatory nucleic acids
  69. The Lipopolysaccharide Core of Brucella abortus Acts as a Shield Against Innate Immunity Recognition
  70. MARCKS as a Negative Regulator of Lipopolysaccharide Signaling
  71. In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B
  72. Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process
  73. DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency
  74. Studies on Lactoferricin-derived Escherichia coli Membrane-active Peptides Reveal Differences in the Mechanism of N-Acylated Versus Nonacylated Peptides
  75. Response to Apostol and Surewicz: Structural Underpinnings of Prion Protein Conversion
  76. Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines
  77. Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion
  78. On the Origin and Features of an Evolved Boolean Model for Subcellular Signal Transduction Systems
  79. Toll-Like Receptor 4 Activation in Cancer Progression and Therapy
  80. De novodesign of orthogonal peptide pairs forming parallel coiled-coil heterodimers
  81. Structural Features Governing the Activity of Lactoferricin-Derived Peptides That Act in Synergy with Antibiotics againstPseudomonas aeruginosa In VitroandIn Vivo
  82. Surface with antimicrobial activity obtained through silane coating with covalently bound polymyxin B
  83. Recognition of Nucleic Acids by Toll-Like Receptors and Development of Immunomodulatory Drugs
  84. Tetracysteine-tagged prion protein allows discrimination between the native and converted forms
  85. Novel Roles of Lysines 122, 125, and 58 in Functional Differences between Human and Murine MD-2
  86. Production of Recombinant Antimicrobial Peptides in Bacteria
  87. Free Thiol Group of MD-2 as the Target for Inhibition of the Lipopolysaccharide-induced Cell Activation
  88. The Differential Interaction of Brucella and Ochrobactrum with Innate Immunity Reveals Traits Related to the Evolution of Stealthy Pathogens
  89. Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin
  90. Different functional role of domain boundaries of Toll-like receptor 4
  91. Expression, purification and structural studies of a short antimicrobial peptide
  92. Expression of soluble versatile peroxidase of Bjerkandera adusta in Escherichia coli
  93. The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes
  94. Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides
  95. Taxanes inhibit human TLR4 signaling by binding to MD-2
  96. Erratum
  97. Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics
  98. A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation
  99. Prevention of microvesiculation by adhesion of buds to the mother cell membrane — A possible anticoagulant effect of healthy donor plasma
  100. Curcumin binds to the α-helical intermediate and to the amyloid form of prion protein - a new mechanism for the inhibition of PrPSc accumulation
  101. Structural biology of the LPS recognition
  102. Synthetic lipopeptides: a novel class of anti-infectives
  103. MD-2 as the target of curcumin in the inhibition of response to LPS
  104. Engineered human cells: say no to sepsis
  105. The Acyl Group as the Central Element of the Structural Organization of Antimicrobial Lipopeptide
  106. Green Tea Catechins Inhibit Bacterial DNA Gyrase by Interaction with Its ATP Binding Site
  107. Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD‐2
  108. Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity
  109. In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors
  110. Similarities and Specificities of Fungal Keratinolytic Proteases: Comparison of Keratinases of Paecilomyces marquandii and Doratomyces microsporus to Some Known Proteases
  111. Combination of Antimicrobial and Endotoxin-Neutralizing Activities of Novel Oleoylamines
  112. MD-2 and Der p 2 – a tale of two cousins or distant relatives?
  113. Structural Origin of Endotoxin Neutralization and Antimicrobial Activity of a Lactoferrin-based Peptide
  114. Mixed-valence Cu(II)/Cu(I) complex of quinolone ciprofloxacin isolated by a hydrothermal reaction in the presence of l-histidine: comparison of biological activities of various copper–ciprofloxacin compounds
  115. Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide
  116. Preparation of chimeric genes without subcloning
  117. Endotoxin Neutralizing Peptides
  118. Structural Model of MD-2 and Functional Role of Its Basic Amino Acid Clusters Involved in Cellular Lipopolysaccharide Recognition
  119. Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide
  120. Comparison of backbone dynamics of monomeric and domain-swapped stefin A
  121. Monoclonal Antibody against a Peptide of Human Prion Protein Discriminates between Creutzfeldt-Jacob's Disease-affected and Normal Brain Tissue
  122. Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide
  123. Characterization of quercetin binding site on DNA gyrase
  124. Enhancement of antibacterial and lipopolysaccharide binding activities of a human lactoferrin peptide fragment by the addition of acyl chain
  125. Identification of LPS-Binding Peptide Fragment of MD-2, a Toll-Receptor Accessory Protein
  126. Semiautomatic sequence-specific assignment of proteins based on the tertiary structure-The programst2nmr
  127. Three-dimensional domain swapping in the folded and molten-globule states of cystatins, an amyloid-forming structural superfamily
  128. Major differences in stability and dimerization properties of two chimeric mutants of human stefins
  129. Bacterial expression and refolding of different fragments of human CD14
  130. Expression and Refolding of Functional Fragments of the Human Lipopolysaccharide Receptor CD14 in Escherichia coli and Pichia pastoris
  131. Accessing the global minimum conformation of stefin A dimer by annealing under partially denaturing conditions
  132. Differences in the effects of TFE on the folding pathways of human stefins A and B
  133. Mutational Analysis of Two Stefin A Epitopes
  134. On the mechanism of human stefin B folding: I. Comparison to homologous stefin A. Influence of pH and trifluoroethanol on the fast and slow folding phases
  135. On the mechanism of human stefin B folding: II. Folding from GuHCl unfolded, TFE denatured, acid denatured, and acid intermediate states
  136. pH-induced Conformational Transitions of the Propeptide of Human Cathepsin L
  137. A 3D 1H, 15N, and 13C NOESY Correlating Experiment
  138. The Three-dimensional Solution Structure of Human Stefin A
  139. Compactness of the molten globule in comparison to unfolded states as observed by size-exclusion chromatography
  140. Structural Characterisation of Human Stefin A in Solution and Implications for Binding to Cysteine Proteinases
  141. Improved Expression and Evaluation of Polyethyleneimine Precipitation in Isolation of Recombinant Cysteine Proteinase Inhibitor Stefin B
  142. The primary structure of inhibitor of cysteine proteinases from potato
  143. Monoclonal antibodies to human stefin B and determination of their epitopes
  144. Calorimetric measurements of thermal denaturation of stefins A and B. Comparison to predicted thermodynamics of stefin-B unfolding
  145. Conformation and Fluctuations of free Stefin B: A Molecular Dynamics Study
  146. Folding studies of the cysteine proteinase inhibitor — human stefin A
  147. Primary structure of a new cysteine proteinase inhibitor from pig leucocytes
  148. Cloning a synthetic gene for human stefin B and its expression inE. coli