All Stories

  1. The association between body mass index and treatment outcomes in major depressive disorder: a CAN-BIND-1 study

    Article • Journal of Psychiatric Research, July 2026, Elsevier

    Dr Raymond W Lam

  2. Evaluating the efficacy and cost-effectiveness of a digital, app-based intervention for depression (VMood) in community-based settings in Vietnam: A stepped-wedge cluster randomized controlled trial

    Article • March 2026, openRxiv

    Dr Raymond W Lam

  3. Evaluating the Efficacy and Cost-Effectiveness of a Digital, App-Based Intervention for Depression (VMood) in Community-Based Settings in Vietnam: A Stepped-Wedge Cluster Randomised Controlled Trial

    Article • January 2026, Elsevier

    Dr Raymond W Lam

  4. Which aspects of anhedonia predict response to pharmacotherapy in major depressive disorder?

    Article • Psychological Medicine, December 2025, Cambridge University Press

    Dr Raymond W Lam

  5. The Canadian Network for Mood and Anxiety Treatments Task Force Recommendations for the Use of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplants in Adults With Major Depressive Disorder: Recommandations du Groupe de travail du Réseau...

    Article • The Canadian Journal of Psychiatry, November 2025, SAGE Publications

    Dr Raymond W Lam

  6. Symptom network connectivity indices as predictors of relapse in major depressive disorder

    Article • Psychiatry Research, August 2025, Elsevier

    Dr Raymond W Lam

  7. Light therapy for bipolar disorders: Clinical recommendations from the international society for bipolar disorders (ISBD) Chronobiology and Chronotherapy Task Force

    Article • Dialogues in Clinical Neuroscience, July 2025, Taylor & Francis

    Dr Raymond W Lam, Dr Pierre Alexis Geoffroy

  8. Feasibility and proof-of-concept of an app-based physical activity intervention for individuals with depression (MoodMover): A single-arm, pre-post study (Preprint)

    Article • JMIR Formative Research, June 2025, JMIR Publications Inc.

    Dr Raymond W Lam

  9. Abuse liability for esketamine in a cohort of patients undergoing an acute treatment course to manage treatment-resistant depression: a secondary analysis of an observational study in real-world clinical practicee

    Article • Therapeutic Advances in Drug Safety, June 2025, SAGE Publications

    Dr Raymond W Lam

  10. Predicting Relapse of Depressive Episodes During Maintenance Treatment: The Canadian Biomarker Integration Network in Depression (CAN-BIND) Wellness Monitoring in Major Depressive Disorder Study: Prédire la rechute d’épisodes dépressifs pendant le trai...

    Article • The Canadian Journal of Psychiatry, April 2025, SAGE Publications

    Dr Raymond W Lam

  11. Feasibility and preliminary effects of an app-based physical activity intervention for individuals with depression (MoodMover): A protocol for a single-arm, pre-post intervention study

    Article • PLOS One, April 2025, PLOS

    Dr Raymond W Lam

  12. Digital health interventions for depression and anxiety in low- and middle-income countries: A rapid scoping review (Preprint)

    Article • March 2025, JMIR Publications Inc.

    Dr Raymond W Lam

  13. Digital Health Interventions for Depression and Anxiety in Low- and Middle-Income Countries: A Rapid Scoping Review (Preprint)

    Article • JMIR Mental Health, March 2025, JMIR Publications Inc.

    Dr Raymond W Lam

  14. The state of implementation science in major depressive disorder: A narrative review

    Article • Psychiatry Research, February 2025, Elsevier

    Dr Raymond W Lam

  15. Lam Employment Absence and Productivity Scale (LEAPS): Analysis of the minimal clinically important difference (MCID) in patients with major depressive disorder using data from the CAN-BIND-1 study

    Article • December 2024, Center for Open Science

    Dr Raymond W Lam

  16. Challenges and mitigation strategies in the development, usability testing, and implementation of a digital mental health intervention for depression (VMood) in Vietnam: A feasibility study (Preprint)

    Article • November 2024, JMIR Publications Inc.

    Dr Raymond W Lam

  17. Challenges and mitigation strategies in the development and feasibility assessment of a digital mental health intervention for depression (VMood) in Vietnam: Lessons learned (Preprint)

    Article • JMIR Formative Research, November 2024, JMIR Publications Inc.

    Dr Raymond W Lam

  18. IN Esketamine and IV Ketamine: Results of a multi-site observational study assessing the effectiveness and tolerability of two novel therapies for treatment-resistant depression

    Article • Psychiatry Research, October 2024, Elsevier

    Dr Raymond W Lam

  19. Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy

    Article • eNeuro, June 2024, Society for Neuroscience

    Dr Raymond W Lam

  20. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes ...

    Article • The Canadian Journal of Psychiatry, May 2024, SAGE Publications

    Dr Raymond W Lam

  21. Relation of hippocampal volume and SGK1 gene expression to treatment remission in major depression is moderated by childhood maltreatment: A CAN-BIND-1 report

    Article • European Neuropsychopharmacology, January 2024, Elsevier

    Dr Raymond W Lam

  22. Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Dr Raymond W Lam

  23. Values and preferences related to workplace mental health programs and interventions: An international survey

    Article • PLOS One, September 2023, PLOS

    Dr Raymond W Lam

  24. Values and Preferences Related to Workplace Mental Health Programs and Interventions: An International Survey

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Dr Raymond W Lam

  25. Co-design of virtual reality cognitive remediation program (bWell-D) with patient end-users and clinicians: A qualitative study (Preprint)

    Article • October 2022, JMIR Publications Inc.

    Dr Raymond W Lam

  26. Co-design of a virtual reality cognitive remediation program for depression (bWell-D) with patient end-users and clinicians: A qualitative study (Preprint)

    Article • JMIR Serious Games, October 2022, JMIR Publications Inc.

    Dr Raymond W Lam

  27. Blue-Light Therapy for Seasonal and Non-Seasonal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Article • The Canadian Journal of Psychiatry, May 2022, SAGE Publications

    Dr Raymond W Lam

  28. Rhythmicity of sleep and clinical outcomes in major depressive disorder: A CAN-BIND-1 Report

    Article • Journal of Affective Disorders Reports, May 2022, Elsevier

    Dr Raymond W Lam

  29. The Effectiveness of Internet-guided Self-help Interventions to Promote Physical Activity Among Individuals with Depression: Systematic Review (Preprint)

    Article • March 2022, JMIR Publications Inc.

    Dr Raymond W Lam

  30. The effectiveness of internet-guided self-help interventions to promote physical activity among individuals with depression: A systematic review (Preprint)

    Article • JMIR Mental Health, March 2022, JMIR Publications Inc.

    Dr Raymond W Lam

  31. Advancing Implementation Science Measurement for Global Mental Health Research

    Article • The Canadian Journal of Psychiatry, February 2022, SAGE Publications

    Dr Raymond W Lam

  32. Subcutaneous and Intramuscular Parental Ketamine for Treatment of Depression: Clinical Treatment Protocol

    Article • January 2022, Center for Open Science

    Dr Raymond W Lam

  33. “One Degree of Separation”: A Mixed-Methods Evaluation of Canadian Mental Health Care User and Provider Experiences With Remote Care During COVID-19

    Article • The Canadian Journal of Psychiatry, January 2022, SAGE Publications

    Dr Raymond W Lam

  34. Response Inhibition and Predicting Response to Pharmacological and Cognitive Behavioral Therapy Treatments for Major Depressive Disorder: A CAN-BIND Study

    Article • Biological Psychiatry Cognitive Neuroscience and Neuroimaging, January 2022, Elsevier

    Dr Raymond W Lam

  35. Biophysical compartment models for single-shell diffusion MRI in the human brain: a model fitting comparison

    Article • Physics in Medicine and Biology, December 2021, Institute of Physics Publishing

    Dr Raymond W Lam

  36. Patient Attitudes About Light Therapy and Negative Ion Therapy for Nonseasonal Depression: An Online Survey Study

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Dr Raymond W Lam

  37. Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report

    Article • Translational Psychiatry, September 2021, Springer Science + Business Media

    Dr Raymond W Lam

  38. EMBED Phase 2 Study Protocol v.1.4: A Cluster Randomized Controlled Trial of Enhanced versus Standard Measurement-Based Care Implementation for Depression

    Article • August 2021, Center for Open Science

    Dr Raymond W Lam

  39. Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response

    Article • Translational Psychiatry, August 2021, Springer Science + Business Media

    Dr Raymond W Lam

  40. Using Machine Learning to Predict Remission in Patients With Major Depressive Disorder Treated With Desvenlafaxine

    Article • The Canadian Journal of Psychiatry, August 2021, SAGE Publications

    Dr Raymond W Lam

  41. Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report

    Article • Communications Biology, July 2021, Springer Science + Business Media

    Dr Raymond W Lam

  42. Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1

    Article • PLOS One, June 2021, PLOS

    Dr Raymond W Lam

  43. Weight gain as a risk factor for progressive neurochemical abnormalities in first episode mania patients: a longitudinal magnetic resonance spectroscopy study

    Article • Psychological Medicine, March 2021, Cambridge University Press

    Dr Raymond W Lam

  44. Probing the clinical and brain structural boundaries of bipolar and major depressive disorder

    Article • Translational Psychiatry, January 2021, Springer Science + Business Media

    Dr Raymond W Lam

  45. Exploring the Effects of Temperament on Gray Matter Volume of Frontal Cortex in Patients with Mood Disorders

    Article • January 2021, Taylor & Francis

    Dr Raymond W Lam

  46. Implementing Measurement-Based Care for Depression: Practical Solutions for Psychiatrists and Primary Care Physicians

    Article • January 2021, Taylor & Francis

    Dr Raymond W Lam

  47. Cognition and Its Association with Psychosocial and Occupational Functioning during Treatment with Escitalopram in Patients with Major Depressive Disorder: A CAN-BIND-1 Report: La Cognition Et Son Association Avec Le Fonctionnement Psychosocial Et Prof...

    Article • The Canadian Journal of Psychiatry, December 2020, SAGE Publications

    Dr Raymond W Lam

  48. Mental Health Service Challenges during the Early Stage of the COVID-19 Pandemic: Experience and Best Practices from China

    Article • The Canadian Journal of Psychiatry, November 2020, SAGE Publications

    Dr Raymond W Lam

  49. The APEC Digital Hub-WONCA Collaborative Framework on Integration of Mental Health into Primary Care in the Asia Pacific

    Article • Journal of Multidisciplinary Healthcare, November 2020, Taylor & Francis

    Dr Raymond W Lam

  50. Association of Serum Vitamin D Levels with Depression in Adults: A Nationwide Population-based Study in Korea

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Dr Raymond W Lam

  51. The Quality of Life in Bipolar Disorder (QoL.BD) Questionnaire a decade on – A systematic review of the measurement of condition-specific aspects of quality of life in bipolar-disorder

    Article • Journal of Affective Disorders, September 2020, Elsevier

    Dr Raymond W Lam

  52. Our Digital Moment: Innovations and Opportunities in Digital Mental Health Care

    Article • The Canadian Journal of Psychiatry, June 2020, SAGE Publications

    Dr Raymond W Lam

  53. Quality of Life Impacts of Bright Light Treatment, Fluoxetine, and the Combination in Patients with Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial

    Article • The Canadian Journal of Psychiatry, June 2020, SAGE Publications

    Dr Raymond W Lam

  54. A Randomized Sham-controlled Trial of 1-Hz and 10-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) of the Right Dorsolateral Prefrontal Cortex in Civilian Post-traumatic Stress Disorder

    Article • The Canadian Journal of Psychiatry, May 2020, SAGE Publications

    Dr Raymond W Lam

  55. Cannabidiol as a Treatment for Mood Disorders: A Systematic Review

    Article • The Canadian Journal of Psychiatry, December 2019, SAGE Publications

    Dr Raymond W Lam, Kamyar Keramatian

  56. Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Article • The Canadian Journal of Psychiatry, December 2019, SAGE Publications

    Dr Raymond W Lam

  57. Men’s Work-Related Stress and Mental Health: Illustrating the Workings of Masculine Role Norms

    Article • American Journal of Men s Health, March 2019, SAGE Publications

    Dr Raymond W Lam

  58. Risperidone Adjunctive Therapy Duration in the Maintenance Treatment of Bipolar I Disorder: A Post hoc Analysis

    Article • Journal of Affective Disorders, January 2019, Elsevier

    Dr Raymond W Lam

  59. Discrepancy between objective and subjective cognition in major depressive disorder

    Article • European Neuropsychopharmacology, January 2019, Elsevier

    Dr Raymond W Lam

  60. Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective MRI study

    Article • Bipolar Disorders, December 2018, Wiley

    Dr Raymond W Lam

  61. Revising Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for the bipolar disorders: Phase I of the AREDOC project

    Article • Australian & New Zealand Journal of Psychiatry, October 2018, SAGE Publications

    Dr Raymond W Lam

  62. Psychometric validation of the Perceived Deficits Questionnaire-Depression (PDQ-D) instrument in US and UK respondents with major depressive disorder

    Article • October 2018, Dove Medical Press

    Dr Raymond W Lam, Mr Aaron Yarlas

  63. Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: a CAN-BIND-1 report

    Article • Psychological Medicine, September 2018, Cambridge University Press

    Dr Raymond W Lam

  64. Evidence for the Efficacy of Bright Light Therapy for Bipolar Depression

    Article • American Journal of Psychiatry, September 2018, American Psychiatric Association

    Dr Raymond W Lam

  65. Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers

    Article • International Journal of Methods in Psychiatric Research, August 2018, Wiley

    Dr Raymond W Lam

  66. Use of Placebo in Clinical Trials of Psychotropic Medication

    Article • The Canadian Journal of Psychiatry, April 2018, SAGE Publications

    Dr Raymond W Lam

  67. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial

    Article • The Lancet, April 2018, Elsevier

    Dr Raymond W Lam

  68. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

    Article • Bipolar Disorders, March 2018, Wiley

    Dr. Verinder Sharma, Dr Raymond W Lam

  69. The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study

    Article • Journal of Affective Disorders, February 2018, Elsevier

    Dr Raymond W Lam

  70. Implications of Cannabis Legalization on Youth and Young Adults

    Article • The Canadian Journal of Psychiatry, January 2018, SAGE Publications

    Dr Raymond W Lam

  71. Efficacy and tolerability of lisdexamfetamine as an antidepressant augmentation strategy: A meta-analysis of randomized controlled trials

    Article • Journal of Affective Disorders, January 2018, Elsevier

    Dr Raymond W Lam

  72. Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management

    Article • The Journal of Clinical Psychiatry, December 2017, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  73. Impact of Cognitive Impairment on Functioning in Patients With Depression

    Article • The Journal of Clinical Psychiatry, December 2017, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  74. A multicomponent intervention for the management of chronic pain in older adults: study protocol for a randomized controlled trial

    Article • Trials, November 2017, Springer Science + Business Media

    Dr Raymond W Lam

  75. Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial

    Article • The Lancet Psychiatry, November 2017, Elsevier

    Dr Raymond W Lam

  76. Subcortical structural volumes in recently remitted first episode mania

    Article • Journal of Affective Disorders, November 2017, Elsevier

    Dr Raymond W Lam

  77. The impact of fatigue and energy on work functioning and impairment in patients with major depressive disorder treated with desvenlafaxine

    Article • International Clinical Psychopharmacology, November 2017, Wolters Kluwer Health

    Dr Raymond W Lam

  78. Cognitive impairment as measured by the THINC-integrated tool (THINC-it): Association with psychosocial function in major depressive disorder

    Article • Journal of Affective Disorders, November 2017, Elsevier

    Dr Raymond W Lam

  79. Monitoring for antidepressant-associated adverse events in the treatment of patients with major depressive disorder: An international consensus statement

    Article • The World Journal of Biological Psychiatry, October 2017, Taylor & Francis

    Dr Raymond W Lam

  80. A sparse representation-based method for parcellation of the resting brain and its application to treatment-resistant major depressive disorder

    Article • Journal of Neuroscience Methods, October 2017, Elsevier

    Dr Raymond W Lam

  81. Quality of life in bipolar disorder: towards a dynamic understanding

    Article • Psychological Medicine, September 2017, Cambridge University Press

    Dr Raymond W Lam, Professor GREG MURRAY

  82. The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction

    Article • The Journal of Clinical Psychiatry, August 2017, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  83. Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the canadian biomarker integration network in depression

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Dr Raymond W Lam

  84. The Efficacy of Psychostimulants in Major Depressive Episodes

    Article • Journal of Clinical Psychopharmacology, August 2017, Wolters Kluwer Health

    Dr Raymond W Lam

  85. A Positron Emission Tomography Study of Norepinephrine Transporter Occupancy and Its Correlation with Symptom Response in Depressed Patients Treated with Quetiapine XR

    Article • The International Journal of Neuropsychopharmacology, July 2017, Oxford University Press (OUP)

    Dr Raymond W Lam

  86. Effect of desvenlafaxine 50 mg and 100 mg on energy and lassitude in patients with major depressive disorder: A pooled analysis

    Article • Journal of Psychopharmacology, July 2017, SAGE Publications

    Dr Raymond W Lam

  87. Adjunctive ketamine in electroconvulsive therapy: Updated systematic review and meta-analysis

    Article • The British Journal of Psychiatry, June 2017, Royal College of Psychiatrists

    Dr Raymond W Lam

  88. MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Dr Raymond W Lam

  89. Response to Letter Regarding CANMAT Recommendations for the Pharmacological Treatment of Late-life Depression

    Article • The Canadian Journal of Psychiatry, May 2017, SAGE Publications

    Dr Raymond W Lam

  90. A Longitudinal Study of the Relationships Between Mood Symptoms, Body Mass Index, and Serum Adipokines in Bipolar Disorder

    Article • The Journal of Clinical Psychiatry, April 2017, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  91. Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder

    Article • Translational Psychiatry, March 2017, Springer Science + Business Media

    Dr Raymond W Lam

  92. Lurasidone versus treatment as usual for cognitive impairment in euthymic patients with bipolar I disorder: a randomised, open-label, pilot study

    Article • The Lancet Psychiatry, March 2017, Elsevier

    Dr Raymond W Lam

  93. APEC digital hub for mental health

    Article • The Lancet Psychiatry, March 2017, Elsevier

    Dr Raymond W Lam

  94. Rating Short-Term Psychodynamic Therapy for the Canadian Network for Mood and Anxiety Treatments Depression Guidelines

    Article • The Canadian Journal of Psychiatry, January 2017, SAGE Publications

    Dr Raymond W Lam

  95. Trajectories of body mass index change in first episode of mania: 3-year data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

    Article • Journal of Affective Disorders, January 2017, Elsevier

    Dr Raymond W Lam

  96. Lower cognitive functioning as a predictor of weight gain in bipolar disorder: a 12-month study

    Article • Acta Psychiatrica Scandinavica, December 2016, Wiley

    Dr Raymond W Lam

  97. Structural brain changes in first episode mania with and without psychosis: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

    Article • The World Journal of Biological Psychiatry, December 2016, Taylor & Francis

    Dr Raymond W Lam

  98. Safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression: a systematic review and meta-analysis of randomised placebo-controlled trials

    Article • The Lancet Psychiatry, December 2016, Elsevier

    Dr Raymond W Lam

  99. The Effects of an E-Mental Health Program and Job Coaching on the Risk of Major Depression and Productivity in Canadian Male Workers: Protocol for a Randomized Controlled Trial

    Article • JMIR Research Protocols, November 2016, JMIR Publications Inc.

    Dr Raymond W Lam

  100. Efficacy of Vortioxetine on Cognitive Functioning in Working Patients With Major Depressive Disorder

    Article • The Journal of Clinical Psychiatry, October 2016, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  101. S-adenosyl methionine (SAMe) for depression in adults

    Article • Cochrane Database of Systematic Reviews, October 2016, Wiley

    Dr Raymond W Lam

  102. The effects of desvenlafaxine on neurocognitive and work functioning in employed outpatients with major depressive disorder

    Article • Journal of Affective Disorders, October 2016, Elsevier

    Dr Raymond W Lam

  103. Neuroprogression and episode recurrence in bipolar I disorder: A study of gray matter volume changes in first-episode mania and association with clinical outcome

    Article • Bipolar Disorders, September 2016, Wiley

    Dr Raymond W Lam

  104. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

    Article • The Canadian Journal of Psychiatry, August 2016, SAGE Publications

    Dr Raymond W Lam

  105. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

    Article • The Canadian Journal of Psychiatry, August 2016, SAGE Publications

    Dr Raymond W Lam

  106. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

    Article • The Canadian Journal of Psychiatry, August 2016, SAGE Publications

    Dr Raymond W Lam

  107. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

    Article • The Canadian Journal of Psychiatry, August 2016, SAGE Publications

    Dr Raymond W Lam

  108. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

    Article • The Canadian Journal of Psychiatry, August 2016, SAGE Publications

    Dr Raymond W Lam

  109. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

    Article • The Canadian Journal of Psychiatry, August 2016, SAGE Publications

    Dr Raymond W Lam

  110. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

    Article • The Canadian Journal of Psychiatry, August 2016, SAGE Publications

    Arun Ravindran, Dr Raymond W Lam

  111. Heparin-Based Polyelectrolyte Complex Enhances the Therapeutic Efficacy of Bone Morphogenetic Protein-2 for Posterolateral Fusion in a Large Animal Model

    Article • Spine, August 2016, Wolters Kluwer Health

    Dr Raymond W Lam

  112. Preferred Features of E-Mental Health Programs for Prevention of Major Depression in Male Workers: Results From a Canadian National Survey

    Article • Journal of Medical Internet Research, June 2016, JMIR Publications Inc.

    Dr Raymond W Lam

  113. Selection of cognitive tests for trials of therapeutic agents

    Article • The Lancet Psychiatry, June 2016, Elsevier

    Dr Raymond W Lam

  114. Ketamine: stimulating antidepressant treatment?

    Article • BJPsych Open, May 2016, Royal College of Psychiatrists

    Dr Raymond W Lam

  115. Midodrine for severe orthostatic hypotension

    Article • Drug and Therapeutics Bulletin, May 2016, BMJ

    Dr Raymond W Lam

  116. The Effects of Newer Antidepressants on Occupational Impairment in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Article • CNS Drugs, April 2016, Springer Science + Business Media

    Dr Raymond W Lam

  117. Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort

    Article • BMC Psychiatry, April 2016, Springer Science + Business Media

    Dr Raymond W Lam

  118. Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder

    Article • Psychoneuroendocrinology, March 2016, Elsevier

    Dr Raymond W Lam

  119. Efficacy of Bright Light Treatment, Fluoxetine, and the Combination in Patients With Nonseasonal Major Depressive Disorder

    Article • JAMA Psychiatry, January 2016, American Medical Association (AMA)

    Dr Raymond W Lam

  120. Sinus Tachycardia Induced by Methocarbamol and Repetitive Transcranial Magnetic Stimulation (rTMS)

    Article • Brain Stimulation, January 2016, Elsevier

    Dr Raymond W Lam

  121. Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder

    Article • The British Journal of Psychiatry, November 2015, Royal College of Psychiatrists

    Dr Raymond W Lam

  122. Optimal duration of risperidone or olanzapine adjunctive therapy to mood stabilizer following remission of a manic episode: A CANMAT randomized double-blind trial

    Article • Molecular Psychiatry, October 2015, Nature

    Dr Raymond W Lam

  123. Enhanced inflammatory and T-helper-1 type responses but suppressed lymphocyte proliferation in patients with seasonal affective disorder and treated by light therapy

    Article • Journal of Affective Disorders, October 2015, Elsevier

    Dr Raymond W Lam

  124. Corrigendum to “A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: Efficacy and tolerability” [J Psychiatr Res (2015) 62: 23–30]

    Article • Journal of Psychiatric Research, September 2015, Elsevier

    Dr Raymond W Lam

  125. Course and outcome following a first episode of mania: Four-year prospective data from the Systematic Treatment Optimization Program (STOP-EM)

    Article • Journal of Affective Disorders, April 2015, Elsevier

    Dr Raymond W Lam

  126. Recovery and Recurrence Following a First Episode of Mania

    Article • The Journal of Clinical Psychiatry, March 2015, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  127. A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: Efficacy and tolerability

    Article • Journal of Psychiatric Research, March 2015, Elsevier

    Dr Raymond W Lam

  128. Verbal memory impairment in new onset bipolar disorder: Relationship with frontal and medial temporal morphology

    Article • The World Journal of Biological Psychiatry, February 2015, Taylor & Francis

    Dr Raymond W Lam

  129. The relationship between burnout and depressive symptoms in patients with depressive disorders

    Article • Journal of Affective Disorders, February 2015, Elsevier

    Dr Raymond W Lam

  130. STAR*D and Measurement-Based Care for Depression: Don't Toss Out the Baby!

    Article • The Canadian Journal of Psychiatry, January 2015, SAGE Publications

    Dr Raymond W Lam

  131. The Relationship Between Neurocognitive and Psychosocial Functioning in Major Depressive Disorder

    Article • The Journal of Clinical Psychiatry, December 2014, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  132. Neurocognitive Functioning in Overweight and Obese Patients with Bipolar Disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

    Article • The Canadian Journal of Psychiatry, December 2014, SAGE Publications

    Dr Raymond W Lam

  133. Predictors of functional improvement in employed adults with major depressive disorder treated with desvenlafaxine

    Article • International Clinical Psychopharmacology, September 2014, Wolters Kluwer Health

    Dr Raymond W Lam

  134. Improvements in quality of life with desvenlafaxine 50mg/d vs placebo in employed adults with major depressive disorder

    Article • Journal of Affective Disorders, September 2014, Elsevier

    Dr Raymond W Lam

  135. A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes

    Article • Psychological Medicine, July 2014, Cambridge University Press

    Dr Raymond W Lam

  136. Body Mass Index–Related Regional Gray and White Matter Volume Reductions in First-Episode Mania Patients

    Article • Biological Psychiatry, July 2014, Elsevier

    Dr Raymond W Lam

  137. Cognitive Change in the Year After a First Manic Episode

    Article • The Journal of Clinical Psychiatry, June 2014, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  138. Early Switching Strategies in Antidepressant Non-Responders: Current Evidence and Future Research Directions

    Article • CNS Drugs, May 2014, Springer Science + Business Media

    Paul Kudlow, Dr Raymond W Lam

  139. Research-Track Programs for Residents in Psychiatry: A Review of Literature and a Report of 3 Canadian Experiences

    Article • The Canadian Journal of Psychiatry, May 2014, SAGE Publications

    Dr Raymond W Lam

  140. Core Discrete Event Simulation Model for the Evaluation of Health Care Technologies in Major Depressive Disorder

    Article • Value in Health, March 2014, Elsevier

    Dr Raymond W Lam

  141. Long-Term Neuropsychological Safety of Subgenual Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression

    Article • Journal of Neuropsychiatry, January 2014, American Psychiatric Association

    Dr Raymond W Lam

  142. Childhood maltreatment and corpus callosum volume in recently diagnosed patients with bipolar I disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

    Article • Journal of Psychiatric Research, January 2014, Elsevier

    Dr Raymond W Lam

  143. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders

    Article • BMC Psychiatry, January 2014, Springer Science + Business Media

    Dr Raymond W Lam

  144. Preclinical evaluation of strontium-containing bioactive bone cement

    Article • Materials Science and Engineering C, December 2013, Elsevier

    Dr Raymond W Lam

  145. 12-month longitudinal cognitive functioning in patients recently diagnosed with bipolar disorder

    Article • Bipolar Disorders, November 2013, Wiley

    Dr Raymond W Lam

  146. Sleep architecture variation: a mediator of metabolic disturbance in individuals with major depressive disorder

    Article • Sleep Medicine, October 2013, Elsevier

    Dr Raymond W Lam

  147. Effects of combined pharmacotherapy and psychotherapy for improving work functioning in major depressive disorder

    Article • The British Journal of Psychiatry, September 2013, Royal College of Psychiatrists

    Dr Raymond W Lam

  148. Efficacy of second generation antipsychotics in treating acute mixed episodes in bipolar disorder: A meta-analysis of placebo-controlled trials

    Article • Journal of Affective Disorders, September 2013, Elsevier

    Dr Raymond W Lam

  149. Do the symptoms of bipolar disorderreallyshow seasonal variation?

    Article • Bipolar Disorders, August 2013, Wiley

    Dr Raymond W Lam

  150. Relationship between frontostriatal morphology and executive function deficits in bipolar I disorder following a first manic episode: data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

    Article • Bipolar Disorders, August 2013, Wiley

    Dr Raymond W Lam

  151. The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM).

    Article • Journal of Affective Disorders, June 2013, Elsevier

    Dr Raymond W Lam

  152. Author response

    Article • Journal of Psychiatry and Neuroscience, June 2013, Canadian Medical Association (CMA)

    Dr Raymond W Lam

  153. Escitalopram and QTc prolongation

    Article • Journal of Psychiatry and Neuroscience, June 2013, Canadian Medical Association (CMA)

    Dr Raymond W Lam

  154. Fatigue and occupational functioning in major depressive disorder

    Article • Australian & New Zealand Journal of Psychiatry, May 2013, SAGE Publications

    Dr Raymond W Lam

  155. Conceptualising the neurobiology of fatigue

    Article • Australian & New Zealand Journal of Psychiatry, April 2013, SAGE Publications

    Dr Raymond W Lam

  156. A double-blind, placebo-controlled study of adjunctive calcitonin nasal spray in acute refractory mania

    Article • Bipolar Disorders, April 2013, Wiley

    Dr Raymond W Lam

  157. Response to commentaries on the Canadian Network for Mood and Anxiety Treatments/International Society for Bipolar Disorders 2013 updated Bipolar Disorder Guidelines

    Article • Bipolar Disorders, March 2013, Wiley

    Dr Raymond W Lam

  158. Antidepressants and QTc prolongation

    Article • Journal of Psychiatry and Neuroscience, March 2013, Canadian Medical Association (CMA)

    Dr Raymond W Lam

  159. The relationship between clinical outcomes and quality of life in first-episode mania: a longitudinal analysis

    Article • Bipolar Disorders, February 2013, Wiley

    Dr Raymond W Lam

  160. Systematic review of neurocognition and occupational functioning in major depressive disorder

    Article • Neuropsychiatry, February 2013, OMICS Publishing Group

    Dr Raymond W Lam

  161. The Prevalence and Impact of Depression in Self-Referred Clients Attending an Employee Assistance Program

    Article • Journal of Occupational and Environmental Medicine, November 2012, Wolters Kluwer Health

    Dr Raymond W Lam

  162. The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction

    Article • Current Pharmaceutical Design, October 2012, Bentham Science Publishers

    Dr Raymond W Lam

  163. Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis

    Article • Bipolar Disorders, July 2012, Wiley

    Dr Raymond W Lam

  164. Selective-serotonin reuptake inhibitors

    Article • June 2012, Future Medicine

    Dr Raymond W Lam

  165. Positron Emission Tomography Study of the Effects of Tryptophan Depletion on Brain Serotonin 2 Receptors in Subjects Recently Remitted From Major Depression

    Article • Archives of General Psychiatry, June 2012, American Medical Association (AMA)

    Dr Raymond W Lam

  166. Seasonal Affective Disorders

    Article • Issues in Mental Health Nursing, April 2012, Taylor & Francis

    Dr Raymond W Lam

  167. Comparison of neuropsychological effects of adjunctive risperidone or quetiapine in euthymic patients with bipolar I disorder

    Article • International Clinical Psychopharmacology, March 2012, Wolters Kluwer Health

    Dr Raymond W Lam

  168. Letter to the Editor

    Article • Journal of Neurosurgery, February 2012, Journal of Neurosurgery Publishing Group (JNSPG)

    Dr Raymond W Lam, Chris Honey

  169. A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression

    Article • Journal of Neurosurgery, February 2012, Journal of Neurosurgery Publishing Group (JNSPG)

    Dr Raymond W Lam, Chris Honey, Dr Andres Lozano

  170. Which Depressive Symptoms and Medication Side Effects Are Perceived by Patients as Interfering Most with Occupational Functioning?

    Article • Depression Research and Treatment, January 2012, Hindawi Publishing Corporation

    Dr Raymond W Lam

  171. Onset, time course and trajectories of improvement with antidepressants

    Article • European Neuropsychopharmacology, January 2012, Elsevier

    Dr Raymond W Lam

  172. Direct Health Care Costs of Treating Seasonal Affective Disorder: A Comparison of Light Therapy and Fluoxetine

    Article • Depression Research and Treatment, January 2012, Hindawi Publishing Corporation

    Dr Raymond W Lam

  173. Do symptoms of bipolar disorder exhibit seasonal variation? A multisite prospective investigation

    Article • Bipolar Disorders, November 2011, Wiley

    Dr Raymond W Lam

  174. The Association of Elevated Body Mass Index with Reduced Brain Volumes in First-Episode Mania

    Article • Biological Psychiatry, August 2011, Elsevier

    Dr Raymond W Lam

  175. Clinical effectiveness: The importance of psychosocial functioning outcomes

    Article • Journal of Affective Disorders, August 2011, Elsevier

    Dr Raymond W Lam

  176. Adjunctive Medication Strategies for Treatment- Resistant Depression

    Article • The Canadian Journal of Psychiatry, June 2011, SAGE Publications

    Dr Raymond W Lam

  177. Evaluation of a disease-management intervention designed to reduce depression disability

    Article • Journal of Evaluation in Clinical Practice, March 2011, Wiley

    Dr Raymond W Lam

  178. Comparative efficacy of escitalopram in the treatment of major depressive disorder

    Article • Neuropsychiatric Disease and Treatment, February 2011, Taylor & Francis

    Dr Raymond W Lam

  179. The association of weight gain with mood symptoms and functional outcomes following a first manic episode: prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

    Article • Bipolar Disorders, September 2010, Wiley

    Dr Raymond W Lam

  180. Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorder

    Article • Psychological Medicine, September 2010, Cambridge University Press

    Dr Raymond W Lam

  181. Efficacy and tolerability of extended release quetiapine fumarate monotherapy as maintenance treatment of major depressive disorder: a randomized, placebo-controlled trial

    Article • Depression and Anxiety, August 2010, Wiley

    Dr Raymond W Lam

  182. Divalproex sodium versus placebo in the treatment of acute bipolar depression: A systematic review and meta-analysis

    Article • Journal of Affective Disorders, August 2010, Elsevier

    Dr Raymond W Lam

  183. Review: The importance of early symptom relief in antidepressant treatment: focus on agomelatine

    Article • Journal of Psychopharmacology, July 2010, SAGE Publications

    Dr Raymond W Lam

  184. Weight gain, obesity, and metabolic indices following a first manic episode: Prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

    Article • Journal of Affective Disorders, July 2010, Elsevier

    Dr Raymond W Lam

  185. Escitalopram versus serotonin noradrenaline reuptake inhibitors as second step treatment for patients with major depressive disorder: a pooled analysis

    Article • International Clinical Psychopharmacology, July 2010, Wolters Kluwer Health

    Dr Raymond W Lam

  186. Relief of Chronic or Resistant Depression (Re-ChORD): A pragmatic, randomized, open-treatment trial of an integrative program intervention for chronic depression

    Article • Journal of Affective Disorders, June 2010, Elsevier

    Dr Raymond W Lam

  187. Effect of electroconvulsive therapy on brain 5-HT2 receptors in major depression

    Article • The British Journal of Psychiatry, May 2010, Royal College of Psychiatrists

    Dr Raymond W Lam, A Jon Stoessl

  188. A Season-of-Birth/DRD4 Interaction Predicts Maximal Body Mass Index in Women with Bulimia Nervosa

    Article • Neuropsychopharmacology, March 2010, Nature

    Dr Raymond W Lam

  189. Neurocognitive Functioning in Patients With Bipolar I Disorder Recently Recovered From a First Manic Episode

    Article • The Journal of Clinical Psychiatry, March 2010, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  190. Brain serotonin-2 receptors in acute mania

    Article • The British Journal of Psychiatry, December 2009, Royal College of Psychiatrists

    Dr Raymond W Lam

  191. A new clinical rating scale for work absence and productivity: validation in patients with major depressive disorder

    Article • BMC Psychiatry, December 2009, Springer Science + Business Media

    Dr Raymond W Lam

  192. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults.

    Article • Journal of Affective Disorders, October 2009, Elsevier

    Dr Raymond W Lam

  193. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults.

    Article • Journal of Affective Disorders, October 2009, Elsevier

    Dr Raymond W Lam

  194. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults.

    Article • Journal of Affective Disorders, October 2009, Elsevier

    Dr Raymond W Lam

  195. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. II. Psychotherapy alone or in combination with antidepressant medication

    Article • Journal of Affective Disorders, October 2009, Elsevier

    Dr Raymond W Lam

  196. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical Guidelines for the Management of Major Depressive Disorder in Adults. I. Classification, Burden and Principles of Management

    Article • Journal of Affective Disorders, October 2009, Elsevier

    Dr Raymond W Lam

  197. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults

    Article • Journal of Affective Disorders, October 2009, Elsevier

    Dr Raymond W Lam

  198. Evidence of a Biological Effect of Light Therapy on the Retina of Patients with Seasonal Affective Disorder

    Article • Biological Psychiatry, August 2009, Elsevier

    Dr Raymond W Lam

  199. Review: high frequency repetitive transcranial magnetic stimulation improves symptoms of treatment resistant major depression

    Article • Evidence-Based Mental Health, July 2009, BMJ

    Dr Raymond W Lam

  200. Course and Outcome after the First Manic Episode in Patients with Bipolar Disorder: Prospective 12-Month Data from the Systematic Treatment Optimization Program for Early Mania Project

    Article • The Canadian Journal of Psychiatry, February 2009, SAGE Publications

    Dr Raymond W Lam

  201. Functional outcomes in first-episode patients with bipolar disorder: a prospective study from the Systematic Treatment Optimization Program for Early Mania project

    Article • Comprehensive Psychiatry, January 2009, Elsevier

    Dr Raymond W Lam

  202. Antidepressant-Associated Mood Elevations in Bipolar II Disorder Compared With Bipolar I Disorder and Major Depressive Disorder

    Article • The Journal of Clinical Psychiatry, October 2008, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  203. Accelerated age-related decrease in brain-derived neurotrophic factor levels in bipolar disorder

    Article • The International Journal of Neuropsychopharmacology, October 2008, Oxford University Press (OUP)

    Dr Raymond W Lam

  204. Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder

    Article • The International Journal of Neuropsychopharmacology, September 2008, Oxford University Press (OUP)

    Dr Raymond W Lam

  205. Addressing circadian rhythm disturbances in depressed patients

    Article • Journal of Psychopharmacology, September 2008, SAGE Publications

    Dr Raymond W Lam

  206. Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression: A Systematic Review and Metaanalysis

    Article • The Canadian Journal of Psychiatry, September 2008, SAGE Publications

    Dr Raymond W Lam

  207. Escitalopram and duloxetine in the treatment of major depressive disorder: a pooled analysis of two trials

    Article • International Clinical Psychopharmacology, July 2008, Wolters Kluwer Health

    Dr Raymond W Lam

  208. Burden of Bipolar Depression

    Article • CNS Drugs, January 2008, Springer Science + Business Media

    Dr Raymond W Lam

  209. Efficacy, effectiveness and efficiency of escitalopram in the treatment of major depressive and anxiety disorders

    Article • Expert Review of Pharmacoeconomics & Outcomes Research, December 2007, Taylor & Francis

    Dr Raymond W Lam

  210. Which antidepressants have demonstrated superior efficacy? A review of the evidence

    Article • International Clinical Psychopharmacology, November 2007, Wolters Kluwer Health

    Dr Raymond W Lam

  211. A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode mania

    Article • Bipolar Disorders, November 2007, Wiley

    Dr Raymond W Lam

  212. Seasonal Affective Disorder: A Clinical Update

    Article • Annals of Clinical Psychiatry, October 2007, CrossRef Test Account

    Dr Raymond W Lam

  213. High-quality remission: potential benefits of the melatonergic approach for patients with major depressive disorder

    Article • International Clinical Psychopharmacology, October 2007, Wolters Kluwer Health

    Dr Raymond W Lam

  214. A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)

    Article • BMC Psychiatry, August 2007, Springer Science + Business Media

    Dr Raymond W Lam

  215. The impact of bipolar disorder upon work functioning: a qualitative analysis

    Article • Bipolar Disorders, February 2007, Wiley

    Dr Raymond W Lam

  216. A pilot study of adherence with light treatment for seasonal affective disorder

    Article • Psychiatry Research, January 2007, Elsevier

    Dr Raymond W Lam

  217. Long-Term and Preventative Treatment for Seasonal Affective Disorder

    Article • CNS Drugs, January 2007, Springer Science + Business Media

    Dr Raymond W Lam

  218. Quality of life as an outcome indicator in patients with seasonal affective disorder: results from the Can-SAD study

    Article • Psychological Medicine, November 2006, Cambridge University Press

    Dr Raymond W Lam

  219. A Birth-Season/DRD4 Gene Interaction Predicts Weight Gain and Obesity in Women with Seasonal Affective Disorder: A Seasonal Thrifty Phenotype Hypothesis

    Article • Neuropsychopharmacology, November 2006, Nature

    Dr Raymond W Lam

  220. The Influence of Baseline Severity on Efficacy of Escitalopram and Citalopram in the Treatment of Major Depressive Disorder: An Extended Analysis

    Article • Pharmacopsychiatry, September 2006, Thieme Publishing Group

    Dr Raymond W Lam

  221. Personality and seasonal affective disorder: Results from the CAN-SAD study

    Article • Journal of Affective Disorders, July 2006, Elsevier

    Dr Raymond W Lam

  222. Oxcarbazepine in the Treatment of Bipolar Disorder: A Review

    Article • The Canadian Journal of Psychiatry, July 2006, SAGE Publications

    Dr Raymond W Lam

  223. A Birth-Season/DRD4 Gene Interaction Predicts Weight Gain and Obesity in Women with Seasonal Affective Disorder: A Seasonal Thrifty Phenotype Hypothesis

    Article • Neuropsychopharmacology, June 2006, Nature

    Dr Raymond W Lam

  224. The Can-SAD Study: A Randomized Controlled Trial of the Effectiveness of Light Therapy and Fluoxetine in Patients With Winter Seasonal Affective Disorder

    Article • American Journal of Psychiatry, May 2006, American Psychiatric Association

    Dr Raymond W Lam

  225. Sleep disturbances and depression: a challenge for antidepressants

    Article • International Clinical Psychopharmacology, February 2006, Wolters Kluwer Health

    Dr Raymond W Lam

  226. O sweet spot where art thou? Light treatment of Seasonal Affective Disorder and the circadian time of sleep

    Article • Journal of Affective Disorders, February 2006, Elsevier

    Dr Raymond W Lam

  227. Bipolar Disorder and Quality of Life: A Patient-Centered Perspective

    Article • Quality of Life Research, February 2006, Springer Science + Business Media

    Dr Raymond W Lam

  228. The Relevance of an Employee Assistance Program to the Treatment of Workplace Depression

    Article • Journal of Workplace Behavioral Health, January 2006, Taylor & Francis

    Dr Raymond W Lam

  229. EDITORIAL

    Article • International Journal of Psychiatry in Clinical Practice, January 2006, Taylor & Francis

    Dr Raymond W Lam

  230. Generalized anxiety disorder: how to treat, and for how long?

    Article • International Journal of Psychiatry in Clinical Practice, January 2006, Taylor & Francis

    Dr Raymond W Lam

  231. Challenges in the treatment of anxiety disorders: beyond guidelines

    Article • International Journal of Psychiatry in Clinical Practice, January 2006, Taylor & Francis

    Dr Raymond W Lam

  232. Oxcarbazepine add-on in the treatment of refractory bipolar disorder

    Article • Bipolar Disorders, December 2005, Wiley

    Dr Raymond W Lam

  233. A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania

    Article • Bipolar Disorders, December 2005, Wiley

    Dr Raymond W Lam

  234. Update on the Biology of Seasonal Affective Disorder

    Article • CNS Spectrums, August 2005, Cambridge University Press

    Dr Raymond W Lam

  235. Quality of Life in Patients with Seasonal Affective Disorder: Summer vs Winter Scores

    Article • The Canadian Journal of Psychiatry, April 2005, SAGE Publications

    Dr Raymond W Lam

  236. Chronotherapeutics (light and wake therapy) in affective disorders

    Article • Psychological Medicine, March 2005, Cambridge University Press

    Dr Raymond W Lam

  237. Using Metaanalysis to Evaluate Evidence: Practical Tips and Traps

    Article • The Canadian Journal of Psychiatry, March 2005, SAGE Publications

    Dr Raymond W Lam

  238. Perceived Quality of Life in Patients with Bipolar Disorder. Does Group Psychoeducation Have an Impact?

    Article • The Canadian Journal of Psychiatry, February 2005, SAGE Publications

    Dr Raymond W Lam

  239. Therapeutic Mechanism in Seasonal Affective Disorder: Do Fluoxetine and Light Operate Through Advancing Circadian Phase?

    Article • Chronobiology International, January 2005, Taylor & Francis

    Dr Raymond W Lam

  240. Article • Health and Quality of Life Outcomes, January 2005, Springer Science + Business Media

    Dr Raymond W Lam

  241. Treatment of seasonal affective disorder: Unipolar versus bipolar differences

    Article • Current Psychiatry Reports, December 2004, Springer Science + Business Media

    Dr Raymond W Lam

  242. The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: An evolutionary perspective

    Article • Biological Psychiatry, November 2004, Elsevier

    Dr Raymond W Lam

  243. Generic and health-related quality of life in patients with seasonal and nonseasonal depression

    Article • Psychiatry Research, October 2004, Elsevier

    Dr Raymond W Lam

  244. Is remission of depressive symptoms in primary care a realistic goal? A meta-analysis

    Article • BMC Family Practice, September 2004, Springer Science + Business Media

    Dr Raymond W Lam

  245. Priorities in treating depression only

    Article • International Journal of Psychiatry in Clinical Practice, September 2004, Taylor & Francis

    Dr Raymond W Lam

  246. A Comparison of Personality Function Among Patients with Seasonal Depression, Nonseasonal Depression, and Nonclinical Participants

    Article • Journal of Personality Disorders, August 2004, Guilford Publications

    Dr Raymond W Lam

  247. Electroretinography in patients with winter seasonal affective disorder

    Article • Psychiatry Research, June 2004, Elsevier

    Dr Raymond W Lam

  248. Hard Times and Good Friends: Negative Life Events and Social Support in Patients with Seasonal and Nonseasonal Depression

    Article • The Canadian Journal of Psychiatry, June 2004, SAGE Publications

    Dr Raymond W Lam

  249. Citalopram and Bupropion-SR

    Article • The Journal of Clinical Psychiatry, March 2004, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  250. Brightening Depression

    Article • Science, January 2004, American Association for the Advancement of Science

    Dr Raymond W Lam

  251. Editorial

    Article • International Journal of Psychiatry in Clinical Practice, January 2004, Taylor & Francis

    Dr Raymond W Lam

  252. Does neuroimmune dysfunction mediate seasonal mood changes in winter depression?

    Article • Medical Hypotheses, January 2004, Elsevier

    Dr Raymond W Lam

  253. Enhancing outcomes in the management of treatment resistant depression: a focus on atypical antipsychotics

    Article • Bipolar Disorders, December 2003, Wiley

    Dr Raymond W Lam

  254. Childhood Inattention and Dysphoria and Adult Obesity Associated with the Dopamine D4 receptor Gene in Overeating Women with Seasonal Affective Disorder

    Article • Neuropsychopharmacology, August 2003, Nature

    Dr Raymond W Lam

  255. Acute tryptophan depletion (ATD) induces depressive symptoms in subgroups of recovered depressed patients, including those with seasonal affective disorder (SAD) (Van der Does, 2001a, review).

    Article • Psychological Medicine, July 2003, Cambridge University Press

    Dr Raymond W Lam

  256. The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality

    Article • Psychological Medicine, June 2003, Cambridge University Press

    Professor Timo Partonen, Dr Raymond W Lam

  257. Review: antidepressants and psychotherapy may be equally effective for promoting remission in major depressive disorder

    Article • Evidence-Based Mental Health, May 2003, BMJ

    Dr Raymond W Lam

  258. The interpersonal expression of perfection: Perfectionistic self-presentation and psychological distress.

    Article • Journal of Personality and Social Psychology, January 2003, American Psychological Association (APA)

    Dr Raymond W Lam

  259. Recent developments in the psychobiology and pharmacotherapy of depression: optimising existing treatments and novel approaches for the future

    Article • Expert Opinion on Investigational Drugs, January 2003, Informa Healthcare

    Dr Raymond W Lam

  260. PET Study of the Effects of Valproate on Dopamine D 2 Receptors in Neuroleptic- and Mood-Stabilizer-Naive Patients With Nonpsychotic Mania

    Article • American Journal of Psychiatry, October 2002, American Psychiatric Association

    Dr Raymond W Lam, A Jon Stoessl

  261. Evidence Supports Validity of Seasonal Affective Disorder

    Article • The Canadian Journal of Psychiatry, October 2002, SAGE Publications

    Dr Raymond W Lam

  262. Seasonal Affective Disorder: The Latitude Hypothesis Revisited

    Article • The Canadian Journal of Psychiatry, October 2002, SAGE Publications

    Dr Raymond W Lam

  263. Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder

    Article • Journal of Affective Disorders, September 2002, Elsevier

    Dr Raymond W Lam

  264. A comparison of open treatment of seasonal major and minor depression with light therapy

    Article • Journal of Affective Disorders, September 2002, Elsevier

    Dr Raymond W Lam

  265. Breaking the Myths: New Treatment Approaches for Chronic Depression

    Article • The Canadian Journal of Psychiatry, September 2002, SAGE Publications

    Dr Raymond W Lam

  266. Combining Antidepressants for Treatment-Resistant Depression

    Article • The Journal of Clinical Psychiatry, August 2002, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  267. PET Study of [ 18 F]6-Fluoro- l -Dopa Uptake in Neuroleptic- and Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium

    Article • American Journal of Psychiatry, May 2002, American Psychiatric Association

    Dr Raymond W Lam, A Jon Stoessl

  268. Effects of Alpha-Methyl-Para-Tyrosine-Induced Catecholamine Depletion in Patients with Seasonal Affective Disorder in Summer Remission

    Article • Neuropsychopharmacology, November 2001, Nature

    Dr Raymond W Lam

  269. Effects of rapid tryptophan depletion on brain 5-HT2 receptors: a PET study

    Article • The British Journal of Psychiatry, May 2001, Royal College of Psychiatrists

    Dr Raymond W Lam

  270. An Open Trial of Light Therapy for Women With Seasonal Affective Disorder and Comorbid Bulimia Nervosa

    Article • The Journal of Clinical Psychiatry, March 2001, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  271. Seasonal depression

    Article • Journal of Affective Disorders, March 2001, Elsevier

    Dr Raymond W Lam

  272. Immune–inflammatory markers in patients with seasonal affective disorder: effects of light therapy

    Article • Journal of Affective Disorders, March 2001, Elsevier

    Dr Raymond W Lam

  273. Patients' preferences and counselling for depression in primary care

    Article • The Lancet, February 2001, Elsevier

    Dr Raymond W Lam

  274. A PET study of brain 5-HT 2 receptors and their correlation with platelet 5-HT 2 receptors in healthy humans

    Article • Psychopharmacology, September 2000, Springer Science + Business Media

    Dr Raymond W Lam

  275. Brain Serotonin2 Receptors in Major Depression

    Article • Archives of General Psychiatry, September 2000, American Medical Association (AMA)

    Dr Raymond W Lam

  276. Does the Addition of Pindolol Accelerate the Response to Electroconvulsive Therapy in Patients with Major Depression? A Double-Blind, Placebo-Controlled Pilot Study

    Article • Journal of Clinical Psychopharmacology, June 2000, Wolters Kluwer Health

    Professor Manit Srisurapanont, Dr Raymond W Lam

  277. Review: lithium augmentation increases treatment response in refractory depression

    Article • Evidence-Based Mental Health, May 2000, BMJ

    Dr Raymond W Lam

  278. Erratum to “Growth hormone to baclofen in patients with seasonal affective disorder: effects of light therapy”

    Article • Psychoneuroendocrinology, April 2000, Elsevier

    Dr Raymond W Lam

  279. Effects of Light Therapy on Suicidal Ideation in Patients With Winter Depression

    Article • The Journal of Clinical Psychiatry, January 2000, Physicians Postgraduate Press, Inc

    Dr Raymond W Lam

  280. Effects of rapid tryptophan depletion in patients with seasonal affective disorder in natural summer remission

    Article • Psychological Medicine, January 2000, Cambridge University Press

    Dr Raymond W Lam

  281. Growth hormone response to baclofen in patients with mania: a pilot study

    Article • Psychopharmacology, December 1999, Springer Science + Business Media

    Dr Raymond W Lam

  282. Hypothermic, ACTH, and cortisol responses to ipsapirone in patients with mania and healthy controls

    Article • Journal of Affective Disorders, August 1999, Elsevier

    Dr Raymond W Lam

  283. Decrease in Brain Serotonin 2 Receptor Binding in Patients With Major Depression Following Desipramine Treatment

    Article • Archives of General Psychiatry, August 1999, American Medical Association (AMA)

    Dr Raymond W Lam

  284. Adverse Effects of Pindolol Augmentation in Patients With Bipolar Depression

    Article • Journal of Clinical Psychopharmacology, August 1999, Wolters Kluwer Health

    Dr Raymond W Lam

  285. A controlled study of light therapy in women with late luteal phase dysphoric disorder

    Article • Psychiatry Research, June 1999, Elsevier

    Dr Raymond W Lam

  286. Clinical Predictors of Short-Term Outcome in Electroconvulsive Therapy

    Article • The Canadian Journal of Psychiatry, March 1999, SAGE Publications

    Dr Raymond W Lam

  287. Growth hormone response to baclofen in patients with seasonal affective disorder: effects of light therapy

    Article • Psychoneuroendocrinology, February 1999, Elsevier

    Dr Raymond W Lam

  288. A Canadian Multicenter Study of Three Fixed Doses of Controlled-Release Ipsapirone in Outpatients With Moderate to Severe Major Depression

    Article • Journal of Clinical Psychopharmacology, August 1998, Wolters Kluwer Health

    Dr Raymond W Lam

  289. A Community-Based Clinic Survey of Antidepressant Use in Persons with Schizophrenia

    Article • The Canadian Journal of Psychiatry, June 1998, SAGE Publications

    Dr Raymond W Lam

  290. Effects of lamotrigine on the 5-HT1A receptor function in healthy human males

    Article • Journal of Affective Disorders, May 1998, Elsevier

    Dr Raymond W Lam

  291. Divalproex Sodium Attenuates Growth Hormone Response to Baclofen in Healthy Human Males

    Article • Neuropsychopharmacology, May 1998, Nature

    Dr Raymond W Lam

  292. Seasonal mood change and personality: an investigation of genetic co-morbidity

    Article • Psychiatry Research, March 1998, Elsevier

    Dr Raymond W Lam

  293. Cortisol, Hypothermic, and Behavioral Responses to Ipsapirone in Patients with Bipolar Depression and Normal Controls

    Article • Neuropsychobiology, January 1998, Karger Publishers

    Dr Raymond W Lam

  294. Effects of Divalproex Sodium on 5-HT1A Receptor Function in Healthy Human Males: Hypothermic, Hormonal, and Behavioral Responses to Ipsapirone

    Article • Neuropsychopharmacology, December 1997, Nature

    Dr Raymond W Lam

  295. Mania, Depression, and Mood Dependent Memory

    Article • Cognition & Emotion, November 1997, Taylor & Francis

    Dr Raymond W Lam

  296. Sumatriptan-Induced Growth Hormone Release in Patients with Major Depression, Mania, and Normal Controls

    Article • Neuropsychopharmacology, October 1997, Nature

    Dr Raymond W Lam

  297. Seasonality of symptoms in women with late luteal phase dysphoric disorder

    Article • American Journal of Psychiatry, October 1997, American Psychiatric Association

    Dr Raymond W Lam

  298. Growth hormone response to sumatriptan (5-HT1D agonist) challenge in seasonal affective disorder: Effects of light therapy

    Article • Biological Psychiatry, July 1997, Elsevier

    Dr Raymond W Lam

  299. Atypical depressive symptoms in seasonal and non-seasonal mood disorders

    Article • Journal of Affective Disorders, June 1997, Elsevier

    Dr Raymond W Lam

  300. The relationship between seasonal mood change and personality: more apparent than real?

    Article • Acta Psychiatrica Scandinavica, June 1997, Wiley

    Dr Raymond W Lam

  301. Gender differences in the heritability of seasonal mood change

    Article • Psychiatry Research, May 1997, Elsevier

    Dr Raymond W Lam

  302. L-Tryptophan Augmentation of Light Therapy in Patients with Seasonal Affective Disorder

    Article • The Canadian Journal of Psychiatry, April 1997, SAGE Publications

    Dr Raymond W Lam

  303. Effects of chronic lithium treatment on retinal electrophysiologic function

    Article • Biological Psychiatry, March 1997, Elsevier

    Dr Raymond W Lam

  304. Light Therapy for Depressive Disorders: Indications and Efficacy

    Article • January 1997, Karger Publishers

    Dr Raymond W Lam

  305. Atypical depressive symptoms and clusters in unipolar and bipolar depression

    Article • Acta Psychiatrica Scandinavica, December 1996, Wiley

    Dr Raymond W Lam

  306. The validity of atypical depression in DSM-IV

    Article • Comprehensive Psychiatry, November 1996, Elsevier

    Dr Raymond W Lam

  307. Effect of Stimulus Intensity on Prolactin and Cortisol Release Induced by Unilateral Electroconvulsive Therapy

    Article • Neuropsychopharmacology, September 1996, Nature

    Dr Raymond W Lam, Professor Manit Srisurapanont

  308. Major depression, minor depression, and double depression: Are they distinct clinical entities?

    Article • American Journal of Medical Genetics, July 1996, Wiley

    Dr Raymond W Lam

  309. Role of serotonin3 receptors in prolactin release induced by electroconvulsive therapy: A study with ondansetron

    Article • Psychiatry Research, February 1996, Elsevier

    Professor Manit Srisurapanont, Dr Raymond W Lam

  310. Seasonality of symptoms in anorexia and bulimia nervosa

    Article • International Journal of Eating Disorders, January 1996, Wiley

    Dr Raymond W Lam

  311. Effects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy

    Article • Archives of General Psychiatry, January 1996, American Medical Association (AMA)

    Dr Raymond W Lam

  312. Treatment of Seasonal Affective Disorder: A Review

    Article • The Canadian Journal of Psychiatry, October 1995, SAGE Publications

    Dr Raymond W Lam

  313. Prolactin response to buspirone challenge in the presence of dopaminergic blockade

    Article • Biological Psychiatry, August 1995, Elsevier

    Dr Raymond W Lam

  314. Mood disorder service genetic database: Morbidity risks for mood disorders in 3,942 first-degree relatives of 671 index cases with single depression, recurrent depression, bipolar I, or bipolar II

    Article • American Journal of Medical Genetics, June 1994, Wiley

    Dr Raymond W Lam

  315. Research Funding of Psychiatric Disorders in Canada: A Snapshot, 1990–1991

    Article • The Canadian Journal of Psychiatry, April 1994, SAGE Publications

    Dr Raymond W Lam

  316. Morning light therapy for winter depression: predictors of response

    Article • Acta Psychiatrica Scandinavica, February 1994, Wiley

    Dr Raymond W Lam

  317. Eating attitudes in seasonal affective disorder and bulimia nervosa

    Article • Journal of Affective Disorders, December 1993, Elsevier

    Dr Raymond W Lam

  318. Obtaining a Family Psychiatric History: Is it Worth the Effort?

    Article • The Canadian Journal of Psychiatry, November 1993, SAGE Publications

    Dr Raymond W Lam

  319. Comparison of fluoxetine and desipramine in depressed outpatients

    Article • Current Therapeutic Research, May 1993, Elsevier

    Dr Raymond W Lam

  320. Chronic Schizophrenia and Idiopathic Parkinson's Disease

    Article • The Canadian Journal of Psychiatry, March 1993, SAGE Publications

    Dr Raymond W Lam

  321. Light visor treament for seasonal affective disorder: A multicenter study

    Article • Psychiatry Research, January 1993, Elsevier

    Dr Raymond W Lam

  322. Electroretinography in seasonal affective disorder

    Article • Psychiatry Research, July 1992, Elsevier

    Dr Raymond W Lam

  323. Hypersomnia and morning light therapy for winter depression

    Article • Biological Psychiatry, May 1992, Elsevier

    Dr Raymond W Lam

  324. The effects of ultraviolet-A wavelengths in light therapy for seasonal depression

    Article • Journal of Affective Disorders, April 1992, Elsevier

    Dr Raymond W Lam

  325. Seasonal mood symptoms in bulimia nervosa and seasonal affective disorder

    Article • Comprehensive Psychiatry, November 1991, Elsevier

    Dr Raymond W Lam

  326. Seasonal Affective Disorder Presenting as Chronic Fatigue Syndrome

    Article • The Canadian Journal of Psychiatry, November 1991, SAGE Publications

    Dr Raymond W Lam

  327. ECT-induced prolactin release: Effect of sex, electrode placement and serotonin uptake inhibition

    Article • Human Psychopharmacology Clinical and Experimental, June 1991, Wiley

    Dr Raymond W Lam

  328. Melatonin suppression in bipolar and unipolar mood disorders

    Article • Psychiatry Research, August 1990, Elsevier

    Dr Raymond W Lam

  329. A Psychiatric Fellowship in the United States

    Article • The Canadian Journal of Psychiatry, April 1990, SAGE Publications

    Dr Raymond W Lam

  330. Treatment of depression in patients with dementia

    Article • American Journal of Psychiatry, January 1990, American Psychiatric Association

    Dr Raymond W Lam

  331. Light therapy for seasonal bulimia

    Article • American Journal of Psychiatry, December 1989, American Psychiatric Association

    Dr Raymond W Lam

  332. Phototherapy for Depressive Disorders: A Review

    Article • The Canadian Journal of Psychiatry, March 1989, SAGE Publications

    Dr Raymond W Lam

  333. The Clinical Use of EEG in a General Psychiatric Setting

    Article • Psychiatric Services, May 1988, American Psychiatric Association

    Dr Raymond W Lam

  334. The Lateralization of Atypical Facial Pain

    Article • The Canadian Journal of Psychiatry, March 1988, SAGE Publications

    Dr Raymond W Lam

  335. Antidepressant Drug Studies in the Elderly

    Article • Psychiatric Clinics of North America, March 1988, Elsevier

    Dr Raymond W Lam

  336. Quality of life impairment in bipolar disorder

    Article • Springer Science + Business Media

    Dr Raymond W Lam