All Stories

  1. A variant NS1 protein from H5N2 avian influenza virus suppresses PKR activation and promotes replication and virulence in mammals

    Article • Emerging Microbes & Infections, October 2022, Taylor & Francis

    Dr Randy A Albrecht

  2. Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine

    Article • Microbiology Spectrum, June 2022, ASM Journals

    Dr Randy A Albrecht

  3. Detection of Velogenic Avian Paramyxoviruses in Rock Doves in New York City, New York

    Article • Microbiology Spectrum, April 2022, ASM Journals

    Dr Randy A Albrecht

  4. Limited extent and consequences of pancreatic SARS-CoV-2 infection

    Article • Cell Reports, March 2022, Elsevier

    Dr Randy A Albrecht

  5. Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

    Article • Cell Host & Microbe, March 2022, Elsevier

    Dr Randy A Albrecht

  6. Profiling Selective Packaging of Host RNA and Viral RNA Modification in SARS-CoV-2 Viral Preparations

    Article • Frontiers in Cell and Developmental Biology, February 2022, Frontiers

    Dr Randy A Albrecht

  7. Functional Effects of Cardiomyocyte Injury in COVID-19

    Article • Journal of Virology, January 2022, ASM Journals

    Dr Randy A Albrecht

  8. Advances and gaps in SARS-CoV-2 infection models

    Article • PLoS Pathogens, January 2022, PLOS

    Dr Randy A Albrecht, Johan Neyts

  9. Tox2 is required for the maintenance of GC T FH cells and the generation of memory T FH cells

    Article • Science Advances, October 2021, American Association for the Advancement of Science

    Dr Randy A Albrecht

  10. Interaction between NS1 and Cellular MAVS Contributes to NS1 Mitochondria Targeting

    Article • Viruses, September 2021, MDPI AG

    Dr Randy A Albrecht

  11. Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy

    Article • Nature Microbiology, September 2021, Springer Science + Business Media

    Dr Randy A Albrecht

  12. Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity

    Article • Cell Reports Medicine, August 2021, Elsevier

    Dr Randy A Albrecht

  13. Tissue-based SARS-CoV-2 detection in fatal COVID-19 infections: Sustained direct viral-induced damage is not necessary to drive disease progression

    Article • Human Pathology, August 2021, Elsevier

    Dr Randy A Albrecht

  14. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

    Article • Nature Biomedical Engineering, May 2021, Springer Science + Business Media

    Dr Randy A Albrecht

  15. TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation

    Article • Cell, May 2021, Elsevier

    Dr Randy A Albrecht

  16. Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model

    Article • Vaccines, January 2021, MDPI AG

    Dr Randy A Albrecht

  17. A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

    Article • Vaccines, December 2020, MDPI AG

    Dr Randy A Albrecht

  18. Mass Cytometry Defines Virus-Specific CD4+ T Cells in Influenza Vaccination

    Article • ImmunoHorizons, December 2020, The American Association of Immunologists

    Dr Randy A Albrecht

  19. Real-Time Investigation of a Large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology

    Article • Clinical Infectious Diseases, November 2020, Oxford University Press (OUP)

    Dr Randy A Albrecht

  20. Animal models for COVID-19

    Article • Nature, September 2020, Springer Science + Business Media

    Professor (Associate) Bart L. Haagmans, Dr Randy A Albrecht, Dr Jens H. Kuhn

  21. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

    Article • Nature, July 2020, Springer Science + Business Media

    Dr Randy A Albrecht

  22. An In Vitro Microneutralization Assay for SARS‐CoV‐2 Serology and Drug Screening

    Article • Current Protocols in Microbiology, June 2020, Wiley

    Dr Randy A Albrecht

  23. Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

    Article • Nature Communications, May 2020, Springer Science + Business Media

    Dr Randy A Albrecht

  24. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

    Article • Cell, May 2020, Elsevier

    Dr Randy A Albrecht

  25. Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

    Article • The Lancet Infectious Diseases, January 2020, Elsevier

    Dr Randy A Albrecht

  26. Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts

    Article • npj Vaccines, December 2019, Springer Science + Business Media

    Dr Randy A Albrecht

  27. Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells

    Article • Journal of Virology, November 2019, ASM Journals

    Dr Randy A Albrecht

  28. Vaccination With Viral Vectors Expressing Chimeric Hemagglutinin, NP and M1 Antigens Protects Ferrets Against Influenza Virus Challenge

    Article • Frontiers in Immunology, August 2019, Frontiers

    Dr Randy A Albrecht

  29. Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1

    Article • Journal of Virology, August 2019, ASM Journals

    Dr Randy A Albrecht

  30. Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism

    Article • Journal of Virology, May 2019, ASM Journals

    Dr Randy A Albrecht

  31. STAT2 is a determinant of yellow fever virus host tropism

    Article • The Journal of Immunology, May 2019, The American Association of Immunologists

    Dr Randy A Albrecht

  32. Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

    Article • Frontiers in Immunology, April 2019, Frontiers

    Dr Randy A Albrecht

  33. Diminished B-Cell Response After Repeat Influenza Vaccination

    Article • The Journal of Infectious Diseases, November 2018, Oxford University Press (OUP)

    Dr Randy A Albrecht

  34. Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance

    Article • Journal of Clinical Investigation, October 2018, American Society for Clinical Investigation

    Dr Randy A Albrecht

  35. A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study

    Article • Vaccines, July 2018, MDPI AG

    Dr Randy A Albrecht

  36. Microbiome disturbance and resilience dynamics of the upper respiratory tract in response to influenza A virus infection in humans and ferrets

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Randy A Albrecht

  37. Analyses of Cellular Immune Responses in Ferrets Following Influenza Virus Infection

    Article • January 2018, Springer Science + Business Media

    Dr Randy A Albrecht

  38. Assessment of Influenza Virus Hemagglutinin Stalk-Specific Antibody Responses

    Article • January 2018, Springer Science + Business Media

    Dr Randy A Albrecht

  39. Timing of Influenza Vaccine Response in Patients That Receive Autologous Hematopoietic Cell Transplantation

    Article • Biology of Blood and Marrow Transplantation, March 2017, Elsevier

    Dr Randy A Albrecht

  40. Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins

    Article • Nature Immunology, February 2017, Springer Science + Business Media

    Dr Randy A Albrecht

  41. A point mutation in the polymerase protein PB2 allows a reassortant H9N2 influenza isolate of wild-bird origin to replicate in human cells

    Article • Infection Genetics and Evolution, July 2016, Elsevier

    Dr Randy A Albrecht

  42. ICOS+PD-1+CXCR3+ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

    Article • Scientific Reports, May 2016, Springer Science + Business Media

    Dr Randy A Albrecht

  43. Suppression of dendritic cell necroptosis by pandemic influenza virus

    Article • The Journal of Immunology, May 2016, The American Association of Immunologists

    Dr Randy A Albrecht

  44. H7N9 influenza virus neutralizing antibodies that possess few somatic mutations

    Article • Journal of Clinical Investigation, March 2016, American Society for Clinical Investigation

    Dr James E Crowe, Dr Randy A Albrecht

  45. Active opioid use does not attenuate the humoral responses to inactivated influenza vaccine

    Article • Vaccine, March 2016, Elsevier

    Dr Randy A Albrecht

  46. Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets

    Article • Journal of Virology, December 2015, ASM Journals

    Dr Florian Krammer, Dr Randy A Albrecht

  47. Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

    Article • Cell Host & Microbe, December 2015, Elsevier

    Dr Randy A Albrecht

  48. Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases

    Article • Immunity, September 2015, Elsevier

    Dr Randy A Albrecht

  49. Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses

    Article • Journal of Virology, July 2015, ASM Journals

    Dr Randy A Albrecht

  50. Regulation of necroptosis as a viral immune antagonistic mechanism (INM3P.361)

    Article • The Journal of Immunology, May 2015, The American Association of Immunologists

    Dr Randy A Albrecht

  51. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

    Article • Science, March 2015, American Association for the Advancement of Science

    Dr Randy A Albrecht

  52. The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA

    Article • Journal of Virology, December 2014, ASM Journals

    Dr Randy A Albrecht, Dr Victor H Leyva-Grado

  53. A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory

    Article • Journal of Neuroimmunology, December 2014, Elsevier

    Dr Randy A Albrecht

  54. Influenza A Virus Transmission Bottlenecks Are Defined by Infection Route and Recipient Host

    Article • Cell Host & Microbe, November 2014, Elsevier

    Dr Randy A Albrecht

  55. Distinct Patterns of B-Cell Activation and Priming by Natural Influenza Virus Infection Versus Inactivated Influenza Vaccination

    Article • The Journal of Infectious Diseases, October 2014, Oxford University Press (OUP)

    Dr Randy A Albrecht

  56. Immunologic Characterization of a Rhesus Macaque H1N1 Challenge Model for Candidate Influenza Virus Vaccine Assessment

    Article • Clinical and Vaccine Immunology, October 2014, ASM Journals

    Dr Randy A Albrecht

  57. Effect of Cholecalciferol Supplementation on Inflammation and Cellular Alloimmunity in Hemodialysis Patients: Data from a Randomized Controlled Pilot Trial

    Article • PLOS One, October 2014, PLOS

    Dr Randy A Albrecht

  58. The origin of the PB1 segment of swine influenza A virus subtype H1N2 determines viral pathogenicity in mice

    Article • Virus Research, August 2014, Elsevier

    Dr Randy A Albrecht

  59. Differential Requirement for the IKKβ/NF-κB Signaling Module in Regulating TLR- versus RLR-Induced Type 1 IFN Expression in Dendritic Cells

    Article • The Journal of Immunology, July 2014, The American Association of Immunologists

    Dr Randy A Albrecht

  60. Human Responses to Influenza Vaccination Show Seroconversion Signatures and Convergent Antibody Rearrangements

    Article • Cell Host & Microbe, July 2014, Elsevier

    Dr Randy A Albrecht

  61. Mucosal Polyinosinic-Polycytidylic Acid Improves Protection Elicited by Replicating Influenza Vaccines via Enhanced Dendritic Cell Function and T Cell Immunity

    Article • The Journal of Immunology, June 2014, The American Association of Immunologists

    Dr Randy A Albrecht

  62. Model of influenza A virus infection: Dynamics of viral antagonism and innate immune response

    Article • Journal of Theoretical Biology, June 2014, Elsevier

    Dr Randy A Albrecht

  63. Turkey Versus Guinea Pig Red Blood Cells: Hemagglutination Differences Alter Hemagglutination Inhibition Responses Against Influenza A/H1N1

    Article • Viral Immunology, May 2014, Mary Ann Liebert Inc

    Dr Randy A Albrecht

  64. Cell death in pandemic and seasonal influenza viruses (VIR2P.1027)

    Article • The Journal of Immunology, May 2014, The American Association of Immunologists

    Dr Randy A Albrecht

  65. Suppression of Innate Immunity by Orthomyxoviruses

    Article • April 2014, ASM Journals

    Dr Randy A Albrecht

  66. Distinct Cross-reactive B-Cell Responses to Live Attenuated and Inactivated Influenza Vaccines

    Article • The Journal of Infectious Diseases, March 2014, Oxford University Press (OUP)

    Dr Randy A Albrecht

  67. Differences in Antibody Responses Between Trivalent Inactivated Influenza Vaccine and Live Attenuated Influenza Vaccine Correlate With the Kinetics and Magnitude of Interferon Signaling in Children

    Article • The Journal of Infectious Diseases, February 2014, Oxford University Press (OUP)

    Dr Randy A Albrecht

  68. Divergent H7 Immunogens Offer Protection from H7N9 Virus Challenge

    Article • Journal of Virology, January 2014, ASM Journals

    Dr Florian Krammer, Dr Randy A Albrecht

  69. Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets

    Article • Journal of Virology, January 2014, ASM Journals

    Dr Florian Krammer, Dr Randy A Albrecht, Dr Victor H Leyva-Grado

  70. One-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge

    Article • Vaccine, January 2014, Elsevier

    Dr Florian Krammer, Dr Randy A Albrecht

  71. MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

    Article • Nature Biotechnology, August 2013, Springer Science + Business Media

    Dr Randy A Albrecht

  72. Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect against Group 2 Influenza A Viruses

    Article • Journal of Virology, July 2013, ASM Journals

    Dr Florian Krammer, Dr Randy A Albrecht

  73. Protection against Lethal Influenza with a Viral Mimic

    Article • Journal of Virology, May 2013, ASM Journals

    Professor Luis Martinez-Sobrido, Dr Randy A Albrecht, David Topham

  74. Glycosylations in the Globular Head of the Hemagglutinin Protein Modulate the Virulence and Antigenic Properties of the H1N1 Influenza Viruses

    Article • Science Translational Medicine, May 2013, American Association for the Advancement of Science

    Dr Randy A Albrecht

  75. Recombinant IgA Is Sufficient To Prevent Influenza Virus Transmission in Guinea Pigs

    Article • Journal of Virology, May 2013, ASM Journals

    Dr Florian Krammer, Dr Randy A Albrecht

  76. Substitutions T200A and E227A in the Hemagglutinin of Pandemic 2009 Influenza A Virus Increase Lethality but Decrease Transmission

    Article • Journal of Virology, March 2013, ASM Journals

    Dr Randy A Albrecht

  77. Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

    Article • Science Translational Medicine, March 2013, American Association for the Advancement of Science

    Dr Randy A Albrecht

  78. H3N2 Influenza Virus Infection Induces Broadly Reactive Hemagglutinin Stalk Antibodies in Humans and Mice

    Article • Journal of Virology, February 2013, ASM Journals

    Dr Florian Krammer, Dr Randy A Albrecht

  79. Accumulation of CD11b+Gr-1+ cells in the lung, blood and bone marrow of mice infected with highly pathogenic H5N1 and H1N1 influenza viruses

    Article • Archives of Virology, February 2013, Springer Science + Business Media

    Dr Randy A Albrecht

  80. Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

    Article • PLoS Pathogens, November 2012, PLOS

    Ricardo Rajsbaum, Dr Randy A Albrecht

  81. Mouse Dendritic Cell (DC) Influenza Virus Infectivity Is Much Lower than That for Human DCs and Is Hemagglutinin Subtype Dependent

    Article • Journal of Virology, November 2012, ASM Journals

    Dr Randy A Albrecht

  82. Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses

    Article • Journal of Virology, March 2012, ASM Journals

    Dr James E Crowe, Dr Randy A Albrecht

  83. Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes

    Article • Journal of Virology, March 2012, ASM Journals

    Dr Florian Krammer, Dr Randy A Albrecht

  84. Suppression of the antiviral response by an influenza histone mimic

    Article • Nature, March 2012, Springer Science + Business Media

    Dr Randy A Albrecht, Dr Rab K Prinjha

  85. Major Histocompatibility Complex Class II Expression and Hemagglutinin Subtype Influence the Infectivity of Type A Influenza Virus for Respiratory Dendritic Cells

    Article • Journal of Virology, September 2011, ASM Journals

    Dr Randy A Albrecht

  86. The M Segment of the 2009 New Pandemic H1N1 Influenza Virus Is Critical for Its High Transmission Efficiency in the Guinea Pig Model

    Article • Journal of Virology, August 2011, ASM Journals

    Dr Randy A Albrecht

  87. Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins

    Article • mBio, August 2011, ASM Journals

    Professor Luis Martinez-Sobrido, Dr Randy A Albrecht

  88. The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease

    Article • Journal of Translational Medicine, August 2011, Springer Science + Business Media

    Professor Luis Martinez-Sobrido, Dr Randy A Albrecht

  89. Programming the magnitude and persistence of antibody responses with innate immunity

    Article • Nature, February 2011, Springer Science + Business Media

    Dr Randy A Albrecht

  90. Macaque Proteome Response to Highly Pathogenic Avian Influenza and 1918 Reassortant Influenza Virus Infections

    Article • Journal of Virology, September 2010, ASM Journals

    Dr Randy A Albrecht

  91. Oseltamivir-Resistant Variants of the 2009 Pandemic H1N1 Influenza A Virus Are Not Attenuated in the Guinea Pig and Ferret Transmission Models

    Article • Journal of Virology, August 2010, ASM Journals

    Dr Randy A Albrecht

  92. NF- B RelA Subunit Is Crucial for Early IFN-  Expression and Resistance to RNA Virus Replication

    Article • The Journal of Immunology, July 2010, The American Association of Immunologists

    Dr Randy A Albrecht

  93. Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus

    Article • Archives of Virology, April 2010, Springer Science + Business Media

    Dr Randy A Albrecht

  94. Complete-Proteome Mapping of Human Influenza A Adaptive Mutations: Implications for Human Transmissibility of Zoonotic Strains

    Article • PLOS One, February 2010, PLOS

    Dr Randy A Albrecht

  95. Innate immune evasion strategies of influenza viruses

    Article • Future Microbiology, January 2010, Future Medicine

    Dr Randy A Albrecht

  96. 1918 and 2009 H1N1 influenza viruses are not pathogenic in birds

    Article • Journal of General Virology, November 2009, Society for General Microbiology

    Dr Randy A Albrecht

  97. Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

    Article • Cell Host & Microbe, October 2009, Elsevier

    Dr Randy A Albrecht

  98. The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways

    Article • Journal of Virology, August 2009, ASM Journals

    Dr Randy A Albrecht

  99. Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

    Article • Cell Host & Microbe, May 2009, Elsevier

    Dr Randy A Albrecht

  100. Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

    Article • Proceedings of the National Academy of Sciences, March 2009, Proceedings of the National Academy of Sciences

    Dr Randy A Albrecht

  101. Experimental Infection of Pigs with the Human 1918 Pandemic Influenza Virus

    Article • Journal of Virology, February 2009, ASM Journals

    Dr Randy A Albrecht

  102. Live Attenuated Influenza Viruses Containing NS1 Truncations as Vaccine Candidates against H5N1 Highly Pathogenic Avian Influenza

    Article • Journal of Virology, December 2008, ASM Journals

    Dr Randy A Albrecht

  103. The Unique IR2 Protein of Equine Herpesvirus 1 Negatively Regulates Viral Gene Expression

    Article • Journal of Virology, May 2006, ASM Journals

    Dr Randy A Albrecht

  104. The EICP27 protein of equine herpesvirus 1 is recruited to viral promoters by its interaction with the immediate-early protein

    Article • Virology, March 2005, Elsevier

    Dr Randy A Albrecht

  105. A Negative Regulatory Element (Base Pairs −204 to −177) of the EICP0 Promoter of Equine Herpesvirus 1 Abolishes the EICP0 Protein's trans-Activation of Its Own Promoter

    Article • Journal of Virology, November 2004, ASM Journals

    Dr Randy A Albrecht

  106. The equine herpesvirus 1 EICP27 protein enhances gene expression via an interaction with TATA box-binding protein

    Article • Virology, July 2004, Elsevier

    Dr Randy A Albrecht

  107. Direct interaction of TFIIB and the IE protein of equine herpesvirus 1 is required for maximal trans-activation function

    Article • Virology, November 2003, Elsevier

    Dr Randy A Albrecht

  108. Interaction of the Equine Herpesvirus 1 EICP0 Protein with the Immediate-Early (IE) Protein, TFIIB, and TBP May Mediate the Antagonism between the IE and EICP0 Proteins

    Article • Journal of Virology, February 2003, ASM Journals

    Dr Randy A Albrecht

  109. Mapping the Sequences That Mediate Interaction of the Equine Herpesvirus 1 Immediate-Early Protein and Human TFIIB

    Article • Journal of Virology, November 2001, ASM Journals

    Dr Randy A Albrecht