All Stories

  1. Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities
  2. Optimization of Plasmodium vivax infection of colonized Amazonian Anopheles darlingi
  3. Using molecular networking and docking to explore arginase inhibitors among Drimys brasiliensis chemical constituents
  4. Editorial: Antimalarial chemotherapy in the XXIst century, volume II
  5. Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.
  6. Copper-Catalyzed Synthesis of Pyrrolo[1,2-c]quinazolines and Pyrrolo[2,1-a]isoquinolines and Antiplasmodial Evaluation
  7. Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease
  8. Inhibition of 3-Hydroxykynurenine Transaminase from Aedes aegypti and Anopheles gambiae: A Mosquito-Specific Target to Combat the Transmission of Arboviruses
  9. Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PLpro Protein
  10. Discovery of aminothiazole derivatives as a chemical scaffold for glutaminase inhibition
  11. Editorial: Antimalarial chemotherapy in the XXIst century
  12. Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues
  13. New Strategies for Novel Drugs: Antimicrobial Peptides Containing Ferrocene with Improved Antifungal and Antiplasmodial Biological Activity
  14. Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches
  15. Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika
  16. Structural basis of nirmatrelvir and ensitrelvir resistance profiles against SARS-CoV-2 Main Protease naturally occurring polymorphisms
  17. Antimicrobial activity of some celastroloids and their derivatives
  18. Synthesis, Structure–Activity Relationships, and Parasitological Profiling of Brussonol Derivatives as New Plasmodium falciparum Inhibitors
  19. Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
  20. Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins
  21. Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and improves glucose tolerance in diet-induced obese mice
  22. Synthesis and antiplasmodial assessment of nitazoxanide and analogs as new antimalarial candidates
  23. New Isoquinoline Alkaloids from Paraphaeosphaeria sporulosa F03, a Fungal Endophyte Isolated from Paepalanthus planifolius
  24. High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules
  25. Parasitological profiling shows 4(1H)-quinolone derivatives as new lead candidates for malaria
  26. The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity
  27. ‘Molecular constipation’ caused by a new antimalarial drug candidate.
  28. Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors
  29. Anthelmintic activity of a nanoformulation based on thiophenes identified in Tagetes patula L. (Asteraceae) against the small ruminant nematode Haemonchus contortus
  30. Antiprotozoal and Antibacterial Activity of Ravenelin, a Xanthone Isolated from the Endophytic Fungus Exserohilum rostratum
  31. Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
  32. Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors
  33. Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
  34. Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors
  35. 3-aryl-indolinones derivatives as antiplasmodial agents: synthesis, biological activity and computational analysis
  36. Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors
  37. A novel scaffold to fight Pseudomonas aeruginosa pyocyanin production: early steps to novel antivirulence drugs
  38. Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19
  39. QSAR studies on benzothiophene derivatives as Plasmodium falciparum N‐myristoyltransferase inhibitors: Molecular insights into affinity and selectivity
  40. Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity
  41. Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti
  42. Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies
  43. Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases
  44. New Molecular Targets and Strategies for Antimalarial Discovery
  45. Organocatalytic asymmetric vinylogous 1,4-addition of α,α-Dicyanoolefins to chalcones under a bio-based reaction media: Discovery of new Michael adducts with antiplasmodial activity
  46. In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol
  47. In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya procera (Lem.) Traub (Amaryllidaceae)
  48. Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents
  49. Dimeric chalcones from Myracrodruon urundeuva act as cathepsin V inhibitors
  50. Phthalimide Derivatives with Bioactivity against Plasmodium falciparum: Synthesis, Evaluation, and Computational Studies Involving bc1 Cytochrome Inhibition
  51. Molecular Cloning and Biochemical Characterization of Iron Superoxide Dismutase from Leishmania braziliensis
  52. Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity
  53. Ceratocystis cacaofunesta genome analysis reveals a large expansion of extracellular phosphatidylinositol-specific phospholipase-C genes (PI-PLC)
  54. Isolation, Derivative Synthesis, and Structure–Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis
  56. A composite docking approach for the identification and characterization of ectosteric inhibitors of cathepsin K
  57. A evolução da Química Medicinal no Brasil: avanços nos 40 anos da Sociedade Brasileira de Química
  58. Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
  59. Chemical Composition, Antiprotozoal and Cytotoxic Activities of Indole Alkaloids and Benzofuran Neolignan of Aristolochia cordigera
  60. Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene
  61. Insecticidal activity of an essential oil of Tagetes patula L. (Asteraceae) on common bed bug Cimex lectularius L. and molecular docking of major compounds at the catalytic site of ClAChE1
  62. Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2α) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum
  63. Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation
  64. HTP-OligoDesigner: An Online Primer Design Tool for High-Throughput Gene Cloning and Site-Directed Mutagenesis
  65. A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K
  66. The (5Z)-5-Pentacosenoic and 5-Pentacosynoic Acids Inhibit the HIV-1 Reverse Transcriptase
  67. REPLY to Nanomedicine: NMB, 2015; 11:1035
  68. Encapsulation of metalloporphyrins improves their capacity to block the viability of the human malaria parasite Plasmodium falciparum
  69. Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor
  70. 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes
  71. Pattern Recognition Techniques Applied to the Study of Leishmanial Glyceraldehyde-3-Phosphate Dehydrogenase Inhibition
  72. A pharmacophore-based virtual screening approach for the discovery of Trypanosoma cruzi GAPDH inhibitors
  73. Discovery of New Inhibitors of Mycobacterium tuberculosis InhA Enzyme Using Virtual Screening and a 3D-Pharmacophore-Based Approach
  74. Synthetic chalcones and sulfonamides as new classes of Yersinia enterocolitica YopH tyrosine phosphatase inhibitors
  75. Identification of Electronic and Structural Descriptors of Adenosine Analogues Related to Inhibition of Leishmanial Glyceraldehyde-3-Phosphate Dehydrogenase
  76. Doenças tropicais negligenciadas: uma nova era de desafios e oportunidades
  77. Molecular Features for Antitrypanosomal Activity of Thiosemicarbazones Revealed by OPS-PLS QSAR Studies
  78. Theoretical models for the antitrypanosomal activity of thiosemicarbazone derivatives
  79. Structure- and ligand-based drug design approaches for neglected tropical diseases
  80. Synthesis, Biological Evaluation, And Molecular Modeling of Chalcone Derivatives As Potent Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatases (PtpA and PtpB)
  81. Modern Drug Discovery Technologies: Opportunities and Challenges in Lead Discovery
  82. Quantitative Structure-Activity Studies on a Series of Migrastatin Analogs as Inhibitors of Cancer Cell Metastasis
  83. In silicoscreening strategies for novel inhibitors of parasitic diseases
  84. Acridone alkaloids as potent inhibitors of cathepsin V
  85. Sulfonyl-hydrazones of cyclic imides derivatives as potent inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB)
  86. Discovery of New Inhibitors of Schistosoma mansoni PNP by Pharmacophore-Based Virtual Screening
  87. Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: Kinetics, molecular modeling, toxicity and effect on growth
  88. Planejamento de fármacos, biotecnologia e química medicinal: aplicações em doenças infecciosas
  89. Quantitative structure–activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: Molecular modeling, CoMFA and CoMSIA studies
  90. Structure-Based Drug Discovery for Tropical Diseases
  91. Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate
  92. Classical and Hologram QSAR Studies on a Series of Inhibitors of Trypanosomatid Glyceraldehyde‐3‐Phosphate Dehydrogenase
  93. Structural Basis for Selective Inhibition of Trypanosomatid Glyceraldehyde-3-Phosphate Dehydrogenase: Molecular Docking and 3D QSAR Studies
  94. The development of an immobilized enzyme reactor containing glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi: the effect of species' specific differences on the immobilization
  95. Virtual Screening and Its Integration with Modern Drug Design Technologies
  96. Enzymatic Inhibitory Activity and Trypanocidal Effects of Extracts and Compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.
  97. Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi
  98. 2D Quantitative structure–activity relationship studies on a series of cholesteryl ester transfer protein inhibitors
  99. Classical and Hologram QSAR Studies on a Series of Tacrine Derivatives as Butyrylcholinesterase Inhibitors
  100. Advances in Prodrug Design
  101. Synthesis and in vitro evaluation of potential antichagasic hydroxymethylnitrofurazone (NFOH-121): a new nitrofurazone prodrug