Contact

All Stories

  1. Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

    Article • Nature Reviews Microbiology, June 2017, Nature

    Professor Alan H Fairlamb

  2. Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

    Article • Nature Reviews Microbiology, February 2017, Nature

    Professor Alan H Fairlamb

  3. How two-ringed nitro-drugs are activated to kill leishmania parasites

    Article • PLoS Pathogens, November 2016, PLOS

    Professor Alan H Fairlamb

  4. The Role of Folate Transport in Antifolate Drug Action inTrypanosoma brucei

    Article • Journal of Biological Chemistry, October 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  5. The N-myristoylome of Trypanosoma cruzi

    Article • Scientific Reports, August 2016, Nature

    Professor Alan H Fairlamb

  6. Corrigendum: Drug resistance in eukaryotic microorganisms

    Article • Nature Microbiology, August 2016, Nature

    Professor Alan H Fairlamb

  7. Drug resistance in eukaryotic microorganisms

    Article • Nature Microbiology, June 2016, Nature

    Professor Alan H Fairlamb

  8. The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

    Article • eLife, May 2016, eLife

    Professor Alan H Fairlamb

  9. Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase

    Article • PLoS Neglected Tropical Diseases, May 2016, PLOS

    Professor Alan H Fairlamb

  10. Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases

    Article • Nature Reviews Drug Discovery, March 2016, Nature

    Professor Alan H Fairlamb

  11. Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

    Article • PLoS Neglected Tropical Diseases, December 2015, PLOS

    Professor Alan H Fairlamb

  12. Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

    Article • Journal of Antimicrobial Chemotherapy, December 2015, Oxford University Press (OUP)

    Professor Alan H Fairlamb

  13. Nitroheterocyclic drug resistance mechanisms inTrypanosoma brucei

    Article • Journal of Antimicrobial Chemotherapy, November 2015, Oxford University Press (OUP)

    Professor Alan H Fairlamb

  14. Arsenic Exposure and Outcomes of Antimonial Treatment in Visceral Leishmaniasis Patients in Bihar, India: A Retrospective Cohort Study

    Article • PLoS Neglected Tropical Diseases, March 2015, PLOS

    Professor Vijay Kumar Prajapati, Professor Alan H Fairlamb

  15. Arsenic, antimony, and Leishmania: has arsenic contamination of drinking water in India led to treatment- resistant kala-azar?

    Article • The Lancet, February 2015, Elsevier

    Professor Alan H Fairlamb

  16. How parasitic trypanosomes make the essential amino acid threonine in the tsetse fly

    Article • Molecular Microbiology, November 2014, Wiley

    Professor Alan H Fairlamb

  17. Biochemical and genetic characterization ofTrypanosoma cruzi N-myristoyltransferase

    Article • Biochemical Journal, April 2014, Portland Press Ltd.

    Professor Alan H Fairlamb

  18. Norspermidine Is Not a Self-Produced Trigger for Biofilm Disassembly

    Article • Cell, February 2014, Elsevier

    Professor Alan H Fairlamb

  19. Parasites escape inhibition of an essential pathway with a little help from their host

    Article • Molecular Microbiology, September 2013, Wiley

    Professor Alan H Fairlamb

  20. [Opening Lecture] - Natural products and drug discovery for tropical diseases - successes, failures and lessons learned

    Article • Planta Medica, August 2013, Thieme Publishing Group

    Professor Alan H Fairlamb

  21. PA-824 as a potential treatment for visceral leishmaniasis

    Article • Antimicrobial Agents and Chemotherapy, July 2013, ASM Journals

    Professor Alan H Fairlamb

  22. Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  23. Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

    Article • Antimicrobial Agents and Chemotherapy, December 2012, ASM Journals

    Professor Alan H Fairlamb

  24. A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes

    Article • PLoS Neglected Tropical Diseases, November 2012, PLOS

    Professor Alan H Fairlamb

  25. Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

    Article • Molecular Microbiology, August 2012, Wiley

    Professor Alan H Fairlamb

  26. Crystal structure of pyridoxal kinase from Trypanosoma brucei

    Article • June 2012, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  27. Genomics decodes drug action

    Article • Nature, February 2012, Springer Science + Business Media

    Professor Alan H Fairlamb

  28. Quinol derivatives as potential trypanocidal agents

    Article • Bioorganic & Medicinal Chemistry, February 2012, Elsevier

    Professor Alan H Fairlamb

  29. Fexinidazole - a potential treatment for Visceral Leishmaniasis

    Article • Science Translational Medicine, February 2012, American Association for the Advancement of Science

    Professor Alan H Fairlamb

  30. CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

    Article • December 2011, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  31. CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

    Article • December 2011, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  32. Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

    Article • ChemMedChem, December 2011, Wiley

    Professor Alan H Fairlamb

  33. Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

    Article • Journal of Medicinal Chemistry, December 2011, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  34. Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

    Article • PLoS Neglected Tropical Diseases, September 2011, PLOS

    Professor Alan H Fairlamb, Professor Vijay Kumar Prajapati

  35. Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

    Article • Journal of Medicinal Chemistry, September 2011, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  36. Optimisation of the Anti‐Trypanosoma brucei Activity of the Opioid Agonist U50488

    Article • ChemMedChem, August 2011, Wiley

    Professor Alan H Fairlamb

  37. Antimicrobial drug discovery

    Article • Future Microbiology, June 2011, Future Medicine

    Professor Alan H Fairlamb

  38. Methylglyoxal metabolism in trypanosomes and leishmania

    Article • Seminars in Cell and Developmental Biology, May 2011, Elsevier

    Professor Alan H Fairlamb

  39. Target Validation: Linking Target and Chemical Properties to Desired Product Profile

    Article • Current Topics in Medicinal Chemistry, May 2011, Bentham Science Publishers

    Professor Alan H Fairlamb

  40. Cover Picture: Synthesis and Evaluation of Indatraline‐Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′‐Trityl Nucleosides as...

    Article • ChemMedChem, January 2011, Wiley

    Professor Alan H Fairlamb

  41. Dissecting the Metabolic Roles of Pteridine Reductase 1 inTrypanosoma bruceiandLeishmania major

    Article • Journal of Biological Chemistry, January 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  42. Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

    Article • Journal of Biological Chemistry, January 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  43. Triclosan is minimally effective in rodent malaria models

    Article • Nature Reports Stem Cells, January 2011, Springer Science + Business Media

    Professor Alan H Fairlamb, Professor David A Fidock

  44. Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

    Article • ChemMedChem, December 2010, Wiley

    Professor Alan H Fairlamb

  45. Synthesis and Evaluation of Indatraline‐Based Inhibitors for Trypanothione Reductase

    Article • ChemMedChem, December 2010, Wiley

    Professor Alan H Fairlamb

  46. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

    Article • Biochemical Pharmacology, November 2010, Elsevier

    Professor Alan H Fairlamb

  47. Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00073357)

    Article • October 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  48. Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00065414)

    Article • October 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  49. Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00073359)

    Article • October 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  50. Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00071494)

    Article • October 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  51. Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00085762)

    Article • October 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  52. Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

    Article • Molecular and Biochemical Parasitology, October 2010, Elsevier

    Professor Alan H Fairlamb, Dr Neeloo Singh

  53. Trypanosoma brucei trypanothione reductase with NADP and trypanothione bound

    Article • August 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  54. Trypanothione reductase from Trypanosoma brucei

    Article • August 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  55. Trypanosoma brucei trypanothione reductase with bound NADP.

    Article • August 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  56. Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

    Article • Molecular Microbiology, July 2010, Wiley

    Professor Alan H Fairlamb

  57. Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

    Article • Antimicrobial Agents and Chemotherapy, May 2010, ASM Journals

    Professor Alan H Fairlamb

  58. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

    Article • Nature, April 2010, Springer Science + Business Media

    Professor Alan H Fairlamb

  59. Crystal Structure of Leishmania major N-myristoyltransferase (NMT) with bound myristoyl-CoA and a pyrazole sulphonamide ligand (DDD85646)

    Article • March 2010, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  60. Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

    Article • Molecular and Biochemical Parasitology, January 2010, Elsevier

    Professor Alan H Fairlamb

  61. Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

    Article • Analytical Biochemistry, January 2010, Elsevier

    Professor Alan H Fairlamb

  62. Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

    Article • ChemMedChem, November 2009, Wiley

    Professor Alan H Fairlamb

  63. Properties of Trypanothione Reductase From T. brucei

    Article • November 2009, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  64. Dissecting the essentiality of the bifunctional trypanothione synthetase‐amidase in Trypanosoma brucei using chemical and genetic methods

    Article • Molecular Microbiology, October 2009, Wiley

    Professor Alan H Fairlamb

  65. Chemical Validation of Trypanothione Synthetase

    Article • Journal of Biological Chemistry, October 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  66. Activity of Novel Tryptophan Analogs against Trypanosoma cruzi and Leishmania donovani

    Article • East and Central African Journal of Pharmaceutical Sciences, September 2009, African Journals Online (AJOL)

    Professor Alan H Fairlamb

  67. Pteridine Reductase 1 (PTR1) from Trypanosoma Brucei in complex with NADP and DDD00066641

    Article • September 2009, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  68. Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

    Article • ChemMedChem, July 2009, Wiley

    Professor Alan H Fairlamb

  69. Synthesis and Evaluation of 1‐(1‐(Benzo[b]thiophen‐2‐yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

    Article • ChemMedChem, July 2009, Wiley

    Professor Alan H Fairlamb

  70. Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1‐(1‐(Benzo[b]thiophen‐2‐yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase...

    Article • ChemMedChem, July 2009, Wiley

    Professor Alan H Fairlamb

  71. One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

    Article • Journal of Medicinal Chemistry, June 2009, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  72. Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

    Article • Journal of Medicinal Chemistry, February 2009, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  73. A comparative study of methylglyoxal metabolism in trypanosomatids

    Article • FEBS Journal, December 2008, Wiley

    Professor Alan H Fairlamb

  74. Properties of Trypanothione Reductase from T. brucei

    Article • November 2008, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  75. ATP‐dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

    Article • FEBS Journal, October 2008, Wiley

    Professor Alan H Fairlamb

  76. Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

    Article • Biochemical Journal, September 2008, Portland Press Ltd.

    Professor Alan H Fairlamb

  77. Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes

    Article • Molecular Microbiology, June 2008, Wiley

    Professor Alan H Fairlamb

  78. Crystal structure of a type II tryparedoxin-dependant peroxidase from Trypanosoma brucei

    Article • June 2008, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  79. TRYPANOTHIONE SYNTHETASE

    Article • May 2008, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  80. Structure Of The Bifunctional Leishmania Major Trypanothione Synthetase-Amidase

    Article • May 2008, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  81. LeishmaniaTrypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities

    Article • Journal of Biological Chemistry, April 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  82. Kinetoplastids: related protozoan pathogens, different diseases

    Article • Journal of Clinical Investigation, April 2008, American Society for Clinical Investigation

    Professor Alan H Fairlamb, Dr Rick L Tarleton

  83. Roles of Trypanothione S-Transferase and Tryparedoxin Peroxidase in Resistance to Antimonials

    Article • Antimicrobial Agents and Chemotherapy, February 2008, ASM Journals

    Professor Alan H Fairlamb

  84. Enzymatic Inhibitory Activity and Trypanocidal Effects of Extracts and Compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

    Article • Zeitschrift für Naturforschung C, January 2008, De Gruyter

    Professor Alan H Fairlamb, Prof. Dr. RAFAEL VICTORIO CARVALHO GUIDO

  85. Target assessment for antiparasitic drug discovery

    Article • Trends in Parasitology, December 2007, Elsevier

    Professor Alan H Fairlamb

  86. A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major

    Article • FEBS Journal, October 2007, Wiley

    Professor Alan H Fairlamb

  87. Increased levels of thiols protect antimony unresponsiveLeishmania donovanifield isolates against reactive oxygen species generated by trivalent antimony

    Article • Parasitology, July 2007, Cambridge University Press

    Professor Alan H Fairlamb

  88. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

    Article • Bioorganic & Medicinal Chemistry Letters, March 2007, Elsevier

    Professor Alan H Fairlamb

  89. Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

    Article • Bioorganic & Medicinal Chemistry Letters, March 2007, Elsevier

    Professor Alan H Fairlamb

  90. Trypanothione-dependent glyoxalase I inTrypanosoma cruzi

    Article • Biochemical Journal, December 2006, Portland Press Ltd.

    Professor Alan H Fairlamb

  91. Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate

    Article • September 2006, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  92. Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major

    Article • Molecular and Biochemical Parasitology, September 2006, Elsevier

    Professor Alan H Fairlamb

  93. Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

    Article • Molecular Microbiology, August 2006, Wiley

    Professor Alan H Fairlamb

  94. Time-dependent inhibitors of trypanothione reductase: Analogues of the spermidine alkaloid lunarine and related natural products

    Article • Bioorganic & Medicinal Chemistry, April 2006, Elsevier

    Professor Alan H Fairlamb

  95. Refinement of techniques for the propagation of Leishmania donovani in hamsters

    Article • Acta Tropica, March 2006, Elsevier

    Professor Alan H Fairlamb

  96. Specificity of the Trypanothione-dependednt Leishmania major Glyoxalase I: Structure and biochemical comparison with the human enzyme

    Article • February 2006, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  97. Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase fromPlasmodium falciparum, a key enzyme in fatty acid biosynthesis

    Article • Biochemical Journal, January 2006, Portland Press Ltd.

    Professor Alan H Fairlamb

  98. Specificity of the trypanothione‐dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme

    Article • Molecular Microbiology, January 2006, Wiley

    Professor Alan H Fairlamb

  99. Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line

    Article • Biochemical Pharmacology, January 2006, Elsevier

    Professor Alan H Fairlamb

  100. Drug Resistance in Leishmaniasis

    Article • Clinical Microbiology Reviews, January 2006, ASM Journals

    Professor Alan H Fairlamb

  101. MYST Family Histone Acetyltransferases in the Protozoan Parasite Toxoplasma gondii

    Article • Eukaryotic Cell, December 2005, ASM Journals

    Professor Alan H Fairlamb, Dr William J Sullivan

  102. Oxoacyl-ACP reductase of Plasmodium falciparum

    Article • October 2005, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  103. Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome

    Article • Biochemical Journal, October 2005, Portland Press Ltd.

    Professor Alan H Fairlamb

  104. Crystallization and preliminary X-ray analysis ofLeishmania majorglyoxalase I

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, July 2005, International Union of Crystallography

    Professor Alan H Fairlamb

  105. Activity of Novel Tryptophan Analogs against Mammalian and Trypanosomal Monoamine Oxidases

    Article • East and Central African Journal of Pharmaceutical Sciences, May 2005, African Journals Online (AJOL)

    Professor Alan H Fairlamb

  106. Very Short and Efficient Syntheses of the Spermine Alkaloid Kukoamine A and Analogs Using Isolable Succinimidyl Cinnamates

    Article • Chemistry Letters, February 2005, The Chemical Society of Japan

    Professor Alan H Fairlamb

  107. Trypanothione biosynthesis in Leishmania major

    Article • Molecular and Biochemical Parasitology, January 2005, Elsevier

    Professor Alan H Fairlamb

  108. A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major

    Article • Proceedings of the National Academy of Sciences, August 2004, Proceedings of the National Academy of Sciences

    Professor Alan H Fairlamb

  109. Leishmania majorElongation Factor 1B Complex Has TrypanothioneS-Transferase and Peroxidase Activity

    Article • Journal of Biological Chemistry, August 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  110. Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human PathogenLeishmania donovani

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  111. CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH THE INHIBITOR QUINACRINE MUSTARD

    Article • May 2004, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  112. Two Interacting Binding Sites for Quinacrine Derivatives in the Active Site of Trypanothione Reductase

    Article • Journal of Biological Chemistry, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  113. TrypanothioneS-Transferase Activity in a Trypanosomatid Ribosomal Elongation Factor 1B

    Article • Journal of Biological Chemistry, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  114. Chemotherapy of human African trypanosomiasis: current and future prospects

    Article • Trends in Parasitology, November 2003, Elsevier

    Professor Alan H Fairlamb

  115. Benzofuranyl 3,5-bis-Polyamine derivatives as time-Dependent inhibitors of trypanothione reductase

    Article • Bioorganic & Medicinal Chemistry, August 2003, Elsevier

    Professor Alan H Fairlamb

  116. 8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase

    Article • Memórias do Instituto Oswaldo Cruz, June 2003, FapUNIFESP (SciELO)

    Professor Alan H Fairlamb

  117. Bis(glutathionyl)spermine and Other Novel Trypanothione Analogues inTrypanosoma cruzi

    Article • Journal of Biological Chemistry, May 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  118. Tryparedoxins fromCrithidia fasciculataandTrypanosoma brucei

    Article • Journal of Biological Chemistry, April 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  119. Properties of Phosphoenolpyruvate Mutase, the First Enzyme in the Aminoethylphosphonate Biosynthetic Pathway inTrypanosoma cruzi

    Article • Journal of Biological Chemistry, April 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  120. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

    Article • Nature Immunology, March 2003, Springer Science + Business Media

    Professor Alan H Fairlamb

  121. Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents

    Article • Tetrahedron, March 2003, Elsevier

    Professor Alan H Fairlamb

  122. Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase

    Article • Biochemical Journal, February 2003, Portland Press Ltd.

    Professor Alan H Fairlamb

  123. Antiprotozoal Agents

    Article • January 2003, Wiley

    Professor Alan H Fairlamb

  124. Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: Substitution of the glycine part

    Article • Bioorganic & Medicinal Chemistry Letters, October 2002, Elsevier

    Professor Alan H Fairlamb

  125. Genome sequence of the human malaria parasite Plasmodium falciparum

    Article • Nature, October 2002, Springer Science + Business Media

    Professor Alan H Fairlamb, Prof. Jonathan A. Eisen, Chris Mungall

  126. ChemInform Abstract: Regiocontrolled Synthesis of the Macrocyclic Polyamine Alkaloid (.+‐.)‐Lunarine, a Time‐Dependent Inhibitor of Trypanothione Reductase.

    Article • ChemInform, September 2002, Wiley

    Professor Alan H Fairlamb

  127. Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group

    Article • Bioorganic & Medicinal Chemistry Letters, September 2002, Elsevier

    Professor Alan H Fairlamb

  128. A Single Enzyme Catalyses Formation of Trypanothione from Glutathione and Spermidine inTrypanosoma cruzi

    Article • Journal of Biological Chemistry, July 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  129. Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata

    Article • Biochemical Journal, June 2002, Portland Press Ltd.

    Professor Alan H Fairlamb

  130. Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead

    Article • Amino Acids, June 2002, Springer Science + Business Media

    Professor Alan H Fairlamb

  131. Regiocontrolled synthesis of the macrocyclic polyamine alkaloid (±)-lunarine, a time-dependent inhibitor of trypanothione reductase

    Article • Journal of the Chemical Society Perkin Transactions 1, April 2002, Royal Society of Chemistry

    Professor Alan H Fairlamb

  132. A new expression vector for Crithidia fasciculata and Leishmania

    Article • Molecular and Biochemical Parasitology, April 2002, Elsevier

    Professor Alan H Fairlamb

  133. Computer assisted design of potentially active anti-trypanosomal compounds

    Article • Journal of Molecular Structure THEOCHEM, April 2002, Elsevier

    Professor Alan H Fairlamb, Professor Orlando Tapia, Ignez Caracelli

  134. ChemInform Abstract: Antiprotozoal and Cytotoxicity Evaluation of Sulfonamide and Urea Analogues of Quinacrine.

    Article • ChemInform, January 2002, Wiley

    Professor Alan H Fairlamb

  135. Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

    Article • Bioorganic & Medicinal Chemistry Letters, October 2001, Elsevier

    Professor Alan H Fairlamb

  136. Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, September 2001, Elsevier

    Professor Alan H Fairlamb

  137. Brave new world of post-genomics!

    Article • Trends in Parasitology, June 2001, Elsevier

    Professor Alan H Fairlamb

  138. Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks

    Article • Amino Acids, March 2001, Springer Science + Business Media

    Professor Alan H Fairlamb

  139. Cloning of a pyruvate phosphate dikinase from Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, February 2001, Elsevier

    Professor Alan H Fairlamb, Dr Rosa A. Maldonado

  140. Trypanosoma Cruzitrypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals

    Article • Free Radical Research, January 2001, Taylor & Francis

    Professor Alan H Fairlamb

  141. Cloning, expression and functional characterisation of a peroxiredoxin from the potato cyst nematode Globodera rostochiensis

    Article • Molecular and Biochemical Parasitology, November 2000, Elsevier

    Professor Alan H Fairlamb

  142. ChemInform Abstract: Synthesis and Evaluation of 9,9‐Dimethylxanthene Tricyclics Against Trypanothione Reductase, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani.

    Article • ChemInform, September 2000, Wiley

    Professor Alan H Fairlamb

  143. The Structure of Reduced Tryparedoxin Peroxidase Reveals a Decamer and Insight into Reactivity of 2Cys-peroxiredoxins

    Article • Journal of Molecular Biology, July 2000, Elsevier

    Professor Alan H Fairlamb

  144. Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei , Trypanosoma cruzi and Leishmania donovani

    Article • Bioorganic & Medicinal Chemistry Letters, June 2000, Elsevier

    Professor Alan H Fairlamb

  145. The three-dimensional structure of a Plasmodium falciparum cyclophilin in complex with the potent anti-malarial cyclosporin A

    Article • Journal of Molecular Biology, April 2000, Elsevier

    Professor Alan H Fairlamb

  146. Uptake of the nitroimidazole drug megazol by African trypanosomes

    Article • Biochemical Pharmacology, March 2000, Elsevier

    Professor Alan H Fairlamb

  147. CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-BASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS

    Article • November 1999, Protein Data Bank, Rutgers University

    Professor Alan H Fairlamb

  148. Renewed Strategies for Drug Development against Parasitic Diseases

    Article • Parasitology Today, October 1999, Elsevier

    Professor Alan H Fairlamb

  149. The High Resolution Crystal Structure of RecombinantCrithidia fasciculataTryparedoxin-I

    Article • Journal of Biological Chemistry, September 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  150. Entamoeba histolytica lacks trypanothione metabolism

    Article • Molecular and Biochemical Parasitology, September 1999, Elsevier

    Professor Alan H Fairlamb

  151. Synthesis and enzymology of modifiedN-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide disulphides as alternative substrates for trypanothione reductase fromTrypanosoma crud: Part 3

    Article • Amino Acids, June 1999, Springer Science + Business Media

    Professor Alan H Fairlamb

  152. Crystallization of RecombinantCrithidia fasciculataTryparedoxin

    Article • Journal of Structural Biology, June 1999, Elsevier

    Professor Alan H Fairlamb

  153. Characterization of protein Ser/Thr phosphatases of the malaria parasite, Plasmodium falciparum: inhibition of the parasitic calcineurin by cyclophilin-cyclosporin complex

    Article • Molecular and Biochemical Parasitology, April 1999, Elsevier

    Professor Alan H Fairlamb

  154. The Biochemical Basis of Arsenical–Diamidine Crossresistance in African Trypanosomes

    Article • Parasitology Today, April 1999, Elsevier

    Professor Alan H Fairlamb

  155. ChemInform Abstract: Macrocyclic Polyamine Lactam Synthesis by Diphenyl Ether Closure of 23‐, 24‐ and 28‐Membered Rings.

    Article • ChemInform, February 1999, Wiley

    Professor Alan H Fairlamb

  156. Ornithine Decarboxylase Gene Deletion Mutants ofLeishmania donovani

    Article • Journal of Biological Chemistry, February 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  157. Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

    Article • Structure, January 1999, Elsevier

    Professor Alan H Fairlamb

  158. Diamine auxotrophy in a eukaryotic parasite

    Article • Biochemical Society Transactions, November 1998, Portland Press Ltd.

    Professor Alan H Fairlamb

  159. Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial Drugs

    Article • Journal of Medicinal Chemistry, October 1998, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  160. Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata1Note: Nucleotide sequence data reported in this paper are available in the EMBL, GenBank and DDJB databases under the GenBank accession num...

    Article • Molecular and Biochemical Parasitology, October 1998, Elsevier

    Professor Alan H Fairlamb

  161. Identification and characterisation of a functional peroxidoxin from Leishmania major1Note: Nucleotide sequence data reported in this paper are available in the EMBL, GenBank™ and DDJB databases under the accession number AF069386.1

    Article • Molecular and Biochemical Parasitology, October 1998, Elsevier

    Professor Alan H Fairlamb

  162. SURFACE RECEPTORS AND TRANSPORTERS OF TRYPANOSOMA BRUCEI

    Article • Annual Review of Microbiology, October 1998, Annual Reviews

    Professor Alan H Fairlamb

  163. Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum

    Article • Biochemical Journal, September 1998, Portland Press Ltd.

    Professor Alan H Fairlamb

  164. Cloning and Characterization of the Two Enzymes Responsible for Trypanothione Biosynthesis inCrithidia fasciculata

    Article • Journal of Biological Chemistry, July 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  165. Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

    Article • Molecular Microbiology, July 1998, Wiley

    Professor Alan H Fairlamb

  166. An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes

    Article • Bioorganic & Medicinal Chemistry Letters, April 1998, Elsevier

    Professor Alan H Fairlamb

  167. Macrocyclic polyamine lactam synthesis by diphenyl ether closure of 23-, 24- and 28-membered rings

    Article • Chemical Communications, January 1998, Royal Society of Chemistry

    Professor Alan H Fairlamb

  168. Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial Drugs

    Article • Journal of Medicinal Chemistry, January 1998, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  169. Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiophen-4,9-quinones

    Article • Bioorganic & Medicinal Chemistry, December 1997, Elsevier

    Professor Alan H Fairlamb

  170. Molecular characterization and expression of Onchocerca volvulus glutathione reductase

    Article • Biochemical Journal, August 1997, Portland Press Ltd.

    Professor Alan H Fairlamb

  171. Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes

    Article • Molecular and Biochemical Parasitology, January 1997, Elsevier

    Professor Alan H Fairlamb

  172. Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata

    Article • Molecular and Biochemical Parasitology, January 1997, Elsevier

    Professor Alan H Fairlamb

  173. Rational design of selective ligands for trypanothione reductase fromtrypanosoma cruzStructural effects on the inhibition by dibenzazepines based on imipramine

    Article • Journal of Enzyme Inhibition, January 1997, Taylor & Francis

    Professor Alan H Fairlamb

  174. Editorial

    Article • Molecular and Biochemical Parasitology, January 1997, Elsevier

    Professor Alan H Fairlamb

  175. Regulation of a high-affinity diamine transport system inTrypanosoma cruziepimastigotes

    Article • Biochemical Journal, June 1996, Portland Press Ltd.

    Professor Alan H Fairlamb

  176. Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

    Article • Bioorganic & Medicinal Chemistry Letters, February 1996, Elsevier

    Professor Alan H Fairlamb

  177. ChemInform Abstract: Bimane Cyclic Esters, Possible Stereologues of Trypanothione as Antitrypanosomal Agents. Bimanes 29.

    Article • ChemInform, January 1996, Wiley

    Professor Alan H Fairlamb

  178. Fluphenazine photoaffinity labelling of binding sites for phenothiazine inhibitors of trypanothione reductase

    Article • Chemical Communications, January 1996, Royal Society of Chemistry

    Professor Alan H Fairlamb

  179. The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Å resolution

    Article • Protein Science, January 1996, Wiley

    Professor Alan H Fairlamb

  180. Chloroquine Resistance Is Not Associated with Drug Metabolism in Plasmodium falciparum

    Article • Journal of Parasitology, December 1995, JSTOR

    Professor Alan H Fairlamb

  181. Glutathionylspermidine metabolism inEscherichia coli

    Article • Biochemical Journal, December 1995, Portland Press Ltd.

    Professor Alan H Fairlamb

  182. Inhibitors of trypanothione reductase as potential antitrypanosomal drugs

    Article • Biochemical Society Transactions, November 1995, Portland Press Ltd.

    Professor Alan H Fairlamb

  183. Specificity of Ethanolamine Transport and Its Further Metabolism inTrypanosoma brucei

    Article • Journal of Biological Chemistry, July 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Alan H Fairlamb

  184. Trypanothione Reductase from Leishmania donovani. Purification, Characterisation and Inhibition by Trivalent Antimonials

    Article • European Journal of Biochemistry, June 1995, Wiley

    Professor Alan H Fairlamb

  185. Trypanothione Reductase from Leishmania donovani. Purification, Characterisation and Inhibition by Trivalent Antimonials

    Article • FEBS Journal, June 1995, Wiley

    Professor Alan H Fairlamb

  186. Differential susceptibility of filarial and human erythrocyte glutathione reductase to inhibition by the trivalent organic arsenical melarsen oxide

    Article • Molecular and Biochemical Parasitology, May 1995, Elsevier

    Professor Alan H Fairlamb

  187. Site-Directed Mutagenesis of the Redox-Active Cysteines of Trypanosoma cruzi Trypanothione Reductase

    Article • European Journal of Biochemistry, March 1995, Wiley

    Professor Alan H Fairlamb

  188. Site-Directed Mutagenesis of the Redox-Active Cysteines of Trypanosoma cruzi Trypanothione Reductase

    Article • FEBS Journal, March 1995, Wiley

    Professor Alan H Fairlamb

  189. Bimane cyclic esters, possible stereologues of trypanothione as antitrypanosomal agents. Bimanes 29

    Article • European Journal of Medicinal Chemistry, January 1995, Elsevier

    Professor Alan H Fairlamb

  190. Identification and Biosynthesis of N1,N9‐Bis(Glutathionyl)Aminopropylcadaverine (Homotrypanothione) in Trypanosoma Cruzi

    Article • European Journal of Biochemistry, December 1994, Wiley

    Professor Alan H Fairlamb

  191. Properties of melarsamine hydrochloride (Cymelarsan) in aqueous solution.

    Article • Antimicrobial Agents and Chemotherapy, June 1994, ASM Journals

    Professor Alan H Fairlamb

  192. High-performance liquid chromatographic method for the separation and quantitative estimation of anti-parasitic melaminophenyl arsenical compounds

    Article • Transactions of the Royal Society of Tropical Medicine and Hygiene, May 1994, Oxford University Press (OUP)

    Professor Alan H Fairlamb

  193. The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase

    Article • Molecular and Biochemical Parasitology, April 1994, Elsevier

    Professor Alan H Fairlamb

  194. Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals

    Article • European Journal of Biochemistry, April 1994, Wiley

    Professor Alan H Fairlamb

  195. Assessment of the polyamine metabolism of filarial worms as a target for chemotherapy

    Article • Parasite, March 1994, EDP Sciences

    Professor Alan H Fairlamb

  196. Rational design of peptide-based inhibitors of trypanothione reductase as potential antitrypanosomal drugs

    Article • Amino Acids, January 1994, Springer Science + Business Media

    Professor Alan H Fairlamb

  197. The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of γ-glutamyl-modified substrate analogues

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, November 1993, Elsevier

    Professor Alan H Fairlamb

  198. Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over‐express trypanothione reductase

    Article • European Journal of Biochemistry, November 1993, Wiley

    Professor Alan H Fairlamb

  199. Polyamine and pentamidine metabolism in African trypanosomes

    Article • Acta Tropica, September 1993, Elsevier

    Professor Alan H Fairlamb

  200. Trypanosoma cruzi Trypanothione Reductase Crystallization, Unit Cell Dimensions and Structure Solution

    Article • Journal of Molecular Biology, August 1993, Elsevier

    Professor Alan H Fairlamb

  201. Cytochrome P450 in trypanosomatids

    Article • Biochemical Pharmacology, July 1993, Elsevier

    Professor Alan H Fairlamb

  202. Substrate interactions between trypanothione reductase and N1‐glutathionylspermidine disulphide at 0.28‐nm resolution

    Article • European Journal of Biochemistry, April 1993, Wiley

    Professor Alan H Fairlamb

  203. Arsenical-resistant trypanosomes lack an unusual adenosine transporter

    Article • Nature, January 1993, Springer Science + Business Media

    Professor Alan H Fairlamb

  204. Metabolism and Functions of Trypanothione in the Kinetoplastida

    Article • Annual Review of Microbiology, October 1992, Annual Reviews

    Professor Alan H Fairlamb

  205. Active site of trypanothione reductase

    Article • Journal of Molecular Biology, September 1992, Elsevier

    Professor Alan H Fairlamb, Professor John Richard Helliwell

  206. Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism

    Article • Molecular and Biochemical Parasitology, July 1992, Elsevier

    Professor Alan H Fairlamb

  207. The interaction of arsenical drugs with dihydrolipoamide and dihydrolipoamide dehydrogenase from arsenical resistant and sensitive strains of Trypanosoma brucei brucei

    Article • Molecular and Biochemical Parasitology, July 1992, Elsevier

    Professor Alan H Fairlamb

  208. Purification of glutathionylspermidine and trypanothione synthetases from crithidia fasciculata

    Article • Protein Science, July 1992, Wiley

    Professor Alan H Fairlamb

  209. Purification of glutathione reductase from muscle of the adult parasitic nematode Ascaris suum

    Article • Molecular and Biochemical Parasitology, April 1992, Elsevier

    Professor Alan H Fairlamb

  210. Interactions between immunity and chemotherapy in the treatment of the trypanosomiases and leishmaniases

    Article • Parasitology, January 1992, Cambridge University Press

    Professor Alan H Fairlamb

  211. Metabolism and Functions of Trypanothione in the Kinetoplastida

    Article • Annual Review of Microbiology, January 1992, Annual Reviews

    Professor Alan H Fairlamb

  212. Synthesis of N-benzyloxycarbonyl-l-cysteinylglycine 3-dimethylaminopropylamide disulfide: A cheap and convenient new assay for trypanothione reductase

    Article • Analytical Biochemistry, October 1991, Elsevier

    Professor Alan H Fairlamb

  213. Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, September 1991, Elsevier

    Professor Alan H Fairlamb, Professor Fred R. Opperdoes

  214. Inhibition of polyamine biosynthesis in Crithidia fasciculata by d,l-α-difluoromethylornithine and d,l-α-difluoromethylarginine

    Article • Molecular and Biochemical Parasitology, May 1991, Elsevier

    Professor Alan H Fairlamb

  215. The interaction of trypanocidal drugs with polyamine and trypanothione metabolism

    Article • Biochemical Society Transactions, December 1990, Portland Press Ltd.

    Professor Alan H Fairlamb

  216. Separation and quantitation of the polyamine biosynthesis inhibitor d,l-α-difluoromethylarginine and other guanidine-containing compounds by high-performance liquid chromatography

    Article • Analytical Biochemistry, November 1990, Elsevier

    Professor Alan H Fairlamb

  217. Initiating a crystallographic study of trypanothione reductase

    Article • Journal of Molecular Biology, November 1990, Elsevier

    Professor Alan H Fairlamb, Professor John Richard Helliwell

  218. Trypanothione metabolism and rational approaches to drug design

    Article • Biochemical Society Transactions, October 1990, Portland Press Ltd.

    Professor Alan H Fairlamb

  219. The trypanothione reductase gene ofLeishmania donovani

    Article • Biochemical Society Transactions, October 1990, Portland Press Ltd.

    Professor Alan H Fairlamb

  220. Future prospects for the chemotherapy of human trypanosomiasis

    Article • Transactions of the Royal Society of Tropical Medicine and Hygiene, September 1990, Oxford University Press (OUP)

    Professor Alan H Fairlamb

  221. Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata

    Article • Biochemistry, April 1990, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  222. Cloning by expression of a cDNA corresponding toLeishmania donovanitrypanothione reductase

    Article • Biochemical Society Transactions, June 1989, Portland Press Ltd.

    Professor Alan H Fairlamb

  223. Trypanothione is the primary target for arsenical drugs against African trypanosomes.

    Article • Proceedings of the National Academy of Sciences, April 1989, Proceedings of the National Academy of Sciences

    Professor Alan H Fairlamb

  224. Metabolism and Functions of Trypanothione with Special Reference to Leishmaniasis

    Article • January 1989, Springer Science + Business Media

    Professor Alan H Fairlamb

  225. Inhibition of Leishmania Species by α-Difluoromethylornithine

    Article • January 1989, Springer Science + Business Media

    Professor Alan H Fairlamb

  226. Novel biochemical pathways in parasitic protozoa

    Article • Parasitology, January 1989, Cambridge University Press

    Professor Alan H Fairlamb

  227. Levels of Polyamines, Glutathione and Glutathione-Spermidine Conjugates during Growth of the Insect Trypanosomatid Crithidia fasciculata

    Article • Microbiology, March 1988, Society for General Microbiology

    Professor Alan H Fairlamb

  228. The Role of Glutathionylspermidine and Trypanothione in Regulation of Intracellular Spermidine Levels During Growth of Crithidia Fasciculata

    Article • January 1988, Springer Science + Business Media

    Professor Alan H Fairlamb

  229. Biochemical changes associated with α-difluoromethylornithine uptake and resistance in Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, October 1987, Elsevier

    Professor Alan H Fairlamb

  230. Trypanothione metabolism: a chemotherapeutic target in trypanosomatids

    Article • Parasitology Today, October 1987, Elsevier

    Professor Alan H Fairlamb

  231. Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

    Article • Biochemistry, June 1987, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  232. In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, June 1987, Elsevier

    Professor Alan H Fairlamb

  233. Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, May 1987, Elsevier

    Professor Alan H Fairlamb

  234. Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme

    Article • European Journal of Biochemistry, April 1987, Wiley

    Professor Alan H Fairlamb

  235. Metabolism of Trypanothione and Glutathionylspermidine in Trypanosomatids

    Article • January 1987, Springer Science + Business Media

    Professor Alan H Fairlamb

  236. The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata

    Article • Molecular and Biochemical Parasitology, December 1986, Elsevier

    Professor Alan H Fairlamb

  237. Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases

    Article • Biochemistry, June 1986, American Chemical Society (ACS)

    Professor Alan H Fairlamb

  238. Carbohydrate Metabolism in African Trypanosomes, with Special Reference to the Glycosome

    Article • January 1986, Springer Science + Business Media

    Professor Alan H Fairlamb, Professor Fred R. Opperdoes

  239. Synthesis of the trypanosomatid metabolites trypanothione, and N 1-mono- and N 8-mono-glutathionylspermidine

    Article • Journal of the Chemical Society Chemical Communications, January 1986, Royal Society of Chemistry

    Professor Alan H Fairlamb

  240. Transport of ethanolamine and its incorporation into the variant surface glycoprotein of bloodstream forms of Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, June 1985, Elsevier

    Professor Alan H Fairlamb

  241. Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

    Article • Science, March 1985, American Association for the Advancement of Science

    Professor Alan H Fairlamb

  242. Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids

    Article • Molecular and Biochemical Parasitology, February 1985, Elsevier

    Professor Alan H Fairlamb

  243. A simple magnetic method for the purification of malarial pigment

    Article • Molecular and Biochemical Parasitology, July 1984, Elsevier

    Professor Alan H Fairlamb

  244. Lipoprotein lipase suppression in 3T3‐L1 cells by a haematoprotozoan‐induced mediator from peritoneal exudate cells

    Article • Parasite Immunology, May 1984, Wiley

    Professor Alan H Fairlamb

  245. Biochemistry of trypanosomiasis and rational approaches to chemotherapy

    Article • Trends in Biochemical Sciences, July 1982, Elsevier

    Professor Alan H Fairlamb

  246. Trypanosoma brucei: Maintenance of concentrated suspensions of bloodstream trypomastigotes in vitro using continuous dialysis for measurement of endocytosis

    Article • Experimental Parasitology, June 1980, Elsevier

    Professor Alan H Fairlamb

  247. Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo

    Article • Molecular and Biochemical Parasitology, January 1980, Elsevier

    Professor Alan H Fairlamb

  248. An improved method for the estimation of suramin in plasma and trypanosome samples

    Article • Molecular and Biochemical Parasitology, January 1980, Elsevier

    Professor Alan H Fairlamb

  249. Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei

    Article • The Journal of Cell Biology, February 1978, Rockefeller University Press

    Professor Alan H Fairlamb

  250. Trypanosoma brucei: Suramin and other trypanocidal compounds' effects on sn-glycerol-3-phosphate oxidase

    Article • Experimental Parasitology, December 1977, Elsevier

    Professor Alan H Fairlamb

  251. New approach to screening drugs for activity against African trypanosomes

    Article • Nature, January 1977, Springer Science + Business Media

    Professor Alan H Fairlamb, Professor Fred R. Opperdoes

  252. The isolation and characterisation of particulate sn-glycerol-3-phosphate oxidase from Trypanosoma brucei

    Article • International Journal of Biochemistry, January 1977, Elsevier

    Professor Alan H Fairlamb

  253. Inhibitor studies on particulate sn-glycerol-3-phosphate oxidase from Trypanosoma brucei

    Article • International Journal of Biochemistry, January 1977, Elsevier

    Professor Alan H Fairlamb

  254. Measurement of Polyamine Transport: Cells in Suspension

    Article • Springer Science + Business Media

    Professor Alan H Fairlamb

  255. The Determination of Polyamines and Amino Acids by a Fluorescamine-HPLC Method

    Article • Springer Science + Business Media

    Professor Alan H Fairlamb