All Stories

  1. Acidosis attenuates the hypoxic stabilization of HIF-1α by activating lysosomal degradation

    Article • Journal of Cell Biology, June 2025, Rockefeller University Press

    Dr Pawel Swietach

  2. Innovating cancer drug discovery with refined phenotypic screens

    Article • Trends in Pharmacological Sciences, August 2024, Elsevier

    Dr Pawel Swietach

  3. Lysosomal signalling pathways influence heart rhythm, and regulate atrial function

    Article • June 2024, Springer Science + Business Media

    Dr Pawel Swietach

  4. Lysosomal signalling pathways influence heart rhythm, and regulate atrial function

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Dr Pawel Swietach

  5. Protocol for separating cancer cell subpopulations by metabolic activity using flow cytometry

    Article • STAR Protocols, June 2024, Elsevier

    Dr Pawel Swietach

  6. Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance

    Article • Proceedings of the National Academy of Sciences, March 2024, Proceedings of the National Academy of Sciences

    Dr Pawel Swietach

  7. Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells

    Article • Cell Reports, January 2024, Elsevier

    Dr Pawel Swietach

  8. What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?

    Article • Pflügers Archiv - European Journal of Physiology, November 2023, Springer Science + Business Media

    Dr Pawel Swietach

  9. How protons pave the way to aggressive cancers

    Article • Nature Reviews Drug Discovery, October 2023, Springer Science + Business Media

    Dr Pawel Swietach

  10. Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

    Article • Cell Reports, June 2023, Elsevier

    Dr Pawel Swietach

  11. Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?

    Article • Oncotarget, January 2023, Impact Journals, LLC

    Dr Pawel Swietach

  12. Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells

    Article • Blood Advances, September 2022, American Society of Hematology

    Dr Pawel Swietach

  13. Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

    Article • eLife, September 2022, eLife

    Dr Pawel Swietach

  14. Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

    Article • British Journal of Cancer, July 2022, Springer Science + Business Media

    Dr Pawel Swietach

  15. Proton export upregulates aerobic glycolysis

    Article • BMC Biology, July 2022, Springer Science + Business Media

    Dr Pawel Swietach

  16. Channelling protons out of the heart

    Article • The Journal of Physiology, May 2022, Wiley

    Dr Pawel Swietach

  17. Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

    Article • Cell Reports, May 2022, Elsevier

    Dr Pawel Swietach

  18. Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

    Article • Basic Research in Cardiology, March 2022, Springer Science + Business Media

    Dr Pawel Swietach, Professor Andrew Trafford

  19. CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

    Article • Cell Reports, March 2022, Elsevier

    Dr Pawel Swietach

  20. Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid–base transporters and auto-regulate cardiomyocyte pH

    Article • Cardiovascular Research, December 2021, Oxford University Press (OUP)

    Dr Pawel Swietach

  21. What do cellular responses to acidity tell us about cancer?

    Article • Cancer and Metastasis Reviews, November 2021, Springer Science + Business Media

    Dr Pawel Swietach

  22. Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter

    Article • Haematologica, September 2021, Ferrata Storti Foundation (Haematologica)

    Dr Pawel Swietach

  23. Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays

    Article • Chemosensors, June 2021, MDPI AG

    Dr Pawel Swietach

  24. SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens

    Article • Cardiovascular Research, May 2021, Oxford University Press (OUP)

    Dr Pawel Swietach

  25. Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release

    Article • Circulation, February 2021, Wolters Kluwer Health

    Dr Pawel Swietach

  26. Cardiomyocyte Na+/H+ Exchanger-1 Activity Is Reduced in Hypoxia

    Article • Frontiers in Cardiovascular Medicine, January 2021, Frontiers

    Dr Pawel Swietach

  27. Iron-Deficiency Anemia Results in Transcriptional and Metabolic Remodeling in the Heart Toward a Glycolytic Phenotype

    Article • Frontiers in Cardiovascular Medicine, January 2021, Frontiers

    Dr Pawel Swietach

  28. Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities

    Article • Cancers, December 2020, MDPI AG

    Dr Pawel Swietach

  29. Cardiac Complications of Propionic and Other Inherited Organic Acidemias

    Article • Frontiers in Cardiovascular Medicine, December 2020, Frontiers

    Dr Pawel Swietach

  30. Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart

    Article • Cardiovascular Research, November 2020, Oxford University Press (OUP)

    Dr Pawel Swietach

  31. T-cells produce acidic niches in lymph nodes to suppress their own effector functions

    Article • Nature Communications, August 2020, Springer Science + Business Media

    Dr Pawel Swietach

  32. Single‐cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID‐19 patients

    Article • British Journal of Haematology, August 2020, Wiley

    Dr Pawel Swietach

  33. Detection of Intravascular Hemolysis in Newborn Infants Using Urinary Carbonic Anhydrase I Immunoreactivity

    Article • The Journal of Applied Laboratory Medicine, June 2020, Oxford University Press (OUP)

    Dr Pawel Swietach

  34. Single-cell O 2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells

    Article • Proceedings of the National Academy of Sciences, April 2020, Proceedings of the National Academy of Sciences

    Dr Pawel Swietach

  35. Causes and Consequences of Variable Tumor Cell Metabolism on Heritable Modifications and Tumor Evolution

    Article • Frontiers in Oncology, March 2020, Frontiers

    Dr Pawel Swietach

  36. Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1

    Article • Cardiovascular Research, November 2019, Oxford University Press (OUP)

    Dr Pawel Swietach

  37. A high-throughput ratiometric method for imaging hypertrophic growth in cultured primary cardiac myocytes

    Article • Journal of Molecular and Cellular Cardiology, May 2019, Elsevier

    Dr Pawel Swietach

  38. Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

    Article • Communications Biology, April 2019, Springer Science + Business Media

    Dr Pawel Swietach

  39. Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity

    Article • JCI Insight, April 2019, American Society for Clinical Investigation

    Dr Pawel Swietach

  40. What is pH regulation, and why do cancer cells need it?

    Article • Cancer and Metastasis Reviews, February 2019, Springer Science + Business Media

    Dr Pawel Swietach

  41. A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions

    Article • Cancers, January 2019, MDPI AG

    Dr Pawel Swietach

  42. Recovery from hypoxia-induced internalization of cardiac Na+ /H + exchanger 1 requires an adequate intracellular store of antioxidants

    Article • Journal of Cellular Physiology, September 2018, Wiley

    Dr Pawel Swietach

  43. Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

    Article • British Journal of Cancer, August 2018, Springer Science + Business Media

    Dr Pawel Swietach

  44. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane

    Article • Proceedings of the National Academy of Sciences, June 2018, Proceedings of the National Academy of Sciences

    Dr Pawel Swietach

  45. Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2

    Article • British Journal of Pharmacology, April 2018, Wiley

    Dr Pawel Swietach

  46. Distinct moieties underlie biphasic H+gating of connexin43 channels, producing a pH optimum for intercellular communication

    Article • The FASEB Journal, November 2017, Federation of American Societies For Experimental Biology (FASEB)

    Dr Pawel Swietach

  47. Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths

    Article • The FASEB Journal, September 2017, Federation of American Societies For Experimental Biology (FASEB)

    Dr Pawel Swietach

  48. Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells

    Article • Oncogene, April 2017, Springer Science + Business Media

    Dr Pawel Swietach

  49. Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes

    Article • Cardiovascular Research, February 2017, Oxford University Press (OUP)

    Dr Pawel Swietach

  50. Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm

    Article • Scientific Reports, October 2016, Springer Science + Business Media

    Dr Pawel Swietach

  51. Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid

    Article • Proceedings of the National Academy of Sciences, August 2016, Proceedings of the National Academy of Sciences

    Dr Pawel Swietach

  52. Nuclear proton dynamics and interactions with calcium signaling

    Article • Journal of Molecular and Cellular Cardiology, July 2016, Elsevier

    Dr Pawel Swietach

  53. Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth

    Article • Cancer Research, June 2016, American Association for Cancer Research (AACR)

    Dr Pawel Swietach

  54. Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

    Article • Cardiovascular Research, April 2016, European Society of Cardiology

    Dr Pawel Swietach

  55. CrossTalk opposing view: Physiological CO2exchange does not normally depend on membrane channels

    Article • The Journal of Physiology, November 2015, Wiley

    Dr Pawel Swietach

  56. Rebuttal from Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer

    Article • The Journal of Physiology, November 2015, Wiley

    Dr Pawel Swietach

  57. Na+ ions as spatial intracellular messengers for co-ordinating Ca2+ signals during pH heterogeneity in cardiomyocytes

    Article • Cardiovascular Research, December 2014, European Society of Cardiology

    Dr Pawel Swietach

  58. Intracellular Carbonic Anhydrase Activity Sensitizes Cancer Cell pH Signaling to Dynamic Changes in CO 2 Partial Pressure

    Article • Journal of Biological Chemistry, July 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Pawel Swietach

  59. Rapid CO 2 permeation across biological membranes: implications for CO 2 venting from tissue

    Article • The FASEB Journal, March 2014, Wiley

    Dr Pawel Swietach

  60. Pumping Ca2+ up H+ gradients: a Ca2+–H+ exchanger without a membrane

    Article • The Journal of Physiology, March 2014, Wiley

    Dr Pawel Swietach

  61. The chemistry, physiology and pathology of pH in cancer

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, February 2014, Royal Society Publishing

    Dr Pawel Swietach

  62. Facilitation by intracellular carbonic anhydrase of Na+–HCO3− co‐transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte

    Article • The Journal of Physiology, January 2014, Wiley

    Dr Pawel Swietach

  63. Antitumor Efficacy of a Monoclonal Antibody That Inhibits the Activity of Cancer-Associated Carbonic Anhydrase XII

    Article • Cancer Research, September 2013, American Association for Cancer Research (AACR)

    Dr Pawel Swietach

  64. H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH

    Article • Journal of Molecular and Cellular Cardiology, August 2013, Elsevier

    Dr Pawel Swietach

  65. Coupled Ca 2+ /H + transport by cytoplasmic buffers regulates local Ca 2+ and H + ion signaling

    Article • Proceedings of the National Academy of Sciences, May 2013, Proceedings of the National Academy of Sciences

    Dr Pawel Swietach

  66. Sarcolemmal localisation of Na+/H+exchange and Na+-HCO3−co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes

    Article • The Journal of Physiology, April 2013, Wiley

    Dr Pawel Swietach

  67. Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics

    Article • Proceedings of the National Academy of Sciences, February 2013, Proceedings of the National Academy of Sciences

    Dr Pawel Swietach

  68. Low and High pH Gating of Connexin43 Channels

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Pawel Swietach

  69. Intracellular Na+ Spatially Controls Ca2+ Signaling during Acidosis in the Ventricular Myocyte

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Pawel Swietach

  70. An Extra-Mitochondrial Domain Rich in Carbonic Anhydrase Activity Improves Myocardial Energetics

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Pawel Swietach, Prof. Kieran Clarke

  71. Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia

    Article • Journal of Cellular Physiology, December 2012, Wiley

    Dr Pawel Swietach

  72. Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin

    Article • PLOS One, April 2012, PLOS

    Dr Pawel Swietach

  73. Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

    Article • Clinical Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Pawel Swietach

  74. Acid-extrusion from Tissue: The Interplay Between Membrane Transporters and pH Buffers

    Article • Current Pharmaceutical Design, April 2012, Bentham Science Publishers

    Dr Pawel Swietach

  75. Spatial Localisation and Function of pH-Regulatory Transporters in the Rat Ventricular Myocyte

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Pawel Swietach

  76. Role of Cytoplasmic Buffers in Spatial H+-Ca2+ Interactions in Ventricular Myocytes

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Pawel Swietach

  77. Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX

    Article • European Journal of Pharmacology, April 2011, Elsevier

    Dr Pawel Swietach

  78. Dual Role of CO2/HCOFormula Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Pawel Swietach

  79. Hydrogen ion dynamics in human red blood cells

    Article • The Journal of Physiology, December 2010, Wiley

    Dr Pawel Swietach

  80. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

    Article • Oncogene, October 2010, Springer Science + Business Media

    Dr Pawel Swietach

  81. A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform

    Article • AJP Heart and Circulatory Physiology, July 2010, American Physiological Society

    Dr Pawel Swietach

  82. The importance of carbonic anhydrase II in red blood cells during exposure of chicken embryos to CO2

    Article • Respiratory Physiology & Neurobiology, July 2010, Elsevier

    Dr Pawel Swietach

  83. The Tumor Microenvironment: New Insights into Regulation of Tumor pH by Carbonic Anhydrases

    Article • January 2010, Springer Science + Business Media

    Dr Pawel Swietach

  84. Modeling calcium waves in cardiac myocytes: importance of calcium diffusion

    Article • Frontiers in Bioscience, January 2010, Frontiers in Bioscience

    Dr Pawel Swietach

  85. Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study

    Article • Cardiovascular Research, December 2009, European Society of Cardiology

    Dr Pawel Swietach

  86. Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes

    Article • Cardiovascular Research, October 2009, European Society of Cardiology

    Dr Pawel Swietach

  87. The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths

    Article • Journal of Biological Chemistry, May 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Pawel Swietach

  88. Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells

    Article • Cell Calcium, April 2009, Elsevier

    Dr Pawel Swietach

  89. Intracellular pH regulation in heart

    Article • Journal of Molecular and Cellular Cardiology, March 2009, Elsevier

    Dr Pawel Swietach

  90. Confocal Imaging Of Extracellular pH With Fluorescein Derivatives

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Pawel Swietach

  91. Modulation Of Cardiac Na+/H+ Exchange Activity By Muscarinic Agonists, Nitric Oxide and Cyclic GMP

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Pawel Swietach

  92. Comparison of pH-dependence of Carbonic Anhydrase Activity in vitro and in Living Cells

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Pawel Swietach

  93. Pushing and Pulling the Cardiac Sodium/Hydrogen Exchanger

    Article • Circulation Research, October 2008, Wolters Kluwer Health

    Dr Pawel Swietach

  94. Ca2+-Mobility in the Sarcoplasmic Reticulum of Ventricular Myocytes Is Low

    Article • Biophysical Journal, August 2008, Elsevier

    Dr Pawel Swietach

  95. Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2diffusion

    Article • BJU International, June 2008, Wiley

    Dr Pawel Swietach

  96. Extracellular Acidification Elicits Spatially and Temporally Distinct Ca 2+ Signals

    Article • Current Biology, May 2008, Elsevier

    Dr Pawel Swietach

  97. Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths

    Article • Journal of Biological Chemistry, April 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Pawel Swietach

  98. Measuring and Modeling Chloride-Hydroxyl Exchange in the Guinea-Pig Ventricular Myocyte

    Article • Biophysical Journal, March 2008, Elsevier

    Dr Pawel Swietach

  99. S0859, an N -cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart

    Article • British Journal of Pharmacology, March 2008, Wiley

    Dr Pawel Swietach

  100. H + Ion Activation and Inactivation of the Ventricular Gap Junction

    Article • Circulation Research, April 2007, Wolters Kluwer Health

    Dr Pawel Swietach

  101. Regulation of tumor pH and the role of carbonic anhydrase 9

    Article • Cancer and Metastasis Reviews, April 2007, Springer Science + Business Media

    Dr Pawel Swietach

  102. pH-Dependence of Extrinsic and Intrinsic H+-Ion Mobility in the Rat Ventricular Myocyte, Investigated Using Flash Photolysis of a Caged-H+ Compound

    Article • Biophysical Journal, January 2007, Elsevier

    Dr Pawel Swietach

  103. pH-Regulated Na+ Influx into the Mammalian Ventricular Myocyte: The Relative Role of Na+-H+ Exchange and Na+-HCO3- Co-Transport

    Article • Journal of Cardiovascular Electrophysiology, May 2006, Wiley

    Dr Pawel Swietach

  104. Spatial aspects of intracellular pH regulation in heart muscle

    Article • Progress in Biophysics and Molecular Biology, January 2006, Elsevier

    Dr Pawel Swietach

  105. Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes

    Article • The Journal of Physiology, July 2005, Wiley

    Dr Pawel Swietach

  106. Spatial Regulation of Intracellular pH in the Ventricular Myocyte

    Article • Annals of the New York Academy of Sciences, June 2005, Wiley

    Dr Pawel Swietach

  107. Experimental Generation and Computational Modeling of Intracellular pH Gradients in Cardiac Myocytes

    Article • Biophysical Journal, April 2005, Elsevier

    Dr Pawel Swietach

  108. Functional diversity of electrogenic Na+-HCO3−cotransport in ventricular myocytes from rat, rabbit and guinea pig

    Article • The Journal of Physiology, January 2005, Wiley

    Dr Pawel Swietach

  109. Novel method for measuring junctional proton permeation in isolated ventricular myocyte cell pairs

    Article • AJP Heart and Circulatory Physiology, July 2004, American Physiological Society

    Dr Pawel Swietach

  110. Temperature dependence of Na+−H+exchange, Na+−HCO3−co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes

    Article • The Journal of Physiology, November 2003, Wiley

    Dr Pawel Swietach

  111. Proton Permeation Through the Myocardial Gap Junction

    Article • Circulation Research, October 2003, Wolters Kluwer Health

    Dr Pawel Swietach

  112. Modelling intracellular H+ ion diffusion

    Article • Progress in Biophysics and Molecular Biology, October 2003, Elsevier

    Dr Pawel Swietach

  113. Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig

    Article • AJP Heart and Circulatory Physiology, September 2003, American Physiological Society

    Dr Pawel Swietach

  114. Amino Acid Transport

    Article • January 2003, Springer Science + Business Media

    Dr Pawel Swietach

  115. Functional and molecular determination of carbonic anhydrase levels in bovine and cultured human chondrocytes

    Article • Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, November 2002, Elsevier

    Dr Pawel Swietach