All Stories

  1. Propionic acidemia as a framework for understanding the impact of disturbed propionyl-CoA on histone modifications
  2. 2-Triazolylphenols as potent and versatile clicksalicylamide protonophores
  3. Relief with a catch: hemodilution in chronic mountain sickness sparks an erythropoietin surge
  4. Storage under hypoxia improves the ability of red cells to release oxygen in ex vivo–perfused human kidneys
  5. Urinary carbonic anhydrase 1 excretion is a marker of hemolysis-triggering conditions suitable for point-of-care testing
  6. Calcium Regulation of Mitochondrial Metabolism
  7. Rapid oxygen release from stored red blood cells can be preserved for longer with refined additive solutions
  8. Lipid cubosome nanoparticles for drug delivery
  9. Hypoxia Increases Sarcolemmal Na + /HCO 3 − Cotransport Activity via an ERK1/2‐Dependent Pathway in Cardiac HL‐1 Cell Line
  10. A Langendorff-heart discovery pipeline demonstrates cardiomyocyte targeting by extracellular vesicles functionalized with beta-blockers using click-chemistry
  11. Acidosis attenuates the hypoxic stabilization of HIF-1α by activating lysosomal degradation
  12. FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes
  13. Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood
  14. The release of GLP‐1 from gut L cells is inhibited by low extracellular pH
  15. Innovating cancer drug discovery with refined phenotypic screens
  16. Contact-based transfer of thymidylate promotes collective tumor growth
  17. CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH
  18. Lysosomal signalling pathways influence heart rhythm, and regulate atrial function
  19. Lysosomal signalling pathways influence heart rhythm, and regulate atrial function
  20. Protocol for separating cancer cell subpopulations by metabolic activity using flow cytometry
  21. Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance
  22. Carnosine facilitates lysosomal release of inhibitors of T cell surveillance
  23. Impaired O2 unloading from stored blood results in diffusion-limited O2 release at tissues: evidence from human kidneys
  24. Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells
  25. What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?
  26. Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
  27. How protons pave the way to aggressive cancers
  28. Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2
  29. Diffusion-limited O 2 release in human kidneys perfused with stored blood
  30. Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?
  31. Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells
  32. Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes
  33. Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production
  34. Proton export upregulates aerobic glycolysis
  35. Channelling protons out of the heart
  36. Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
  37. Optimal Thinning of MCMC Output
  38. Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart
  39. Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes
  40. CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH
  41. Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid–base transporters and auto-regulate cardiomyocyte pH
  42. What do cellular responses to acidity tell us about cancer?
  43. Proton export drives the Warburg Effect
  44. Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter
  45. Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays
  46. SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens
  47. Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release
  48. Cardiomyocyte Na+/H+ Exchanger-1 Activity Is Reduced in Hypoxia
  49. Iron-Deficiency Anemia Results in Transcriptional and Metabolic Remodeling in the Heart Toward a Glycolytic Phenotype
  50. Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities
  51. Cardiac Complications of Propionic and Other Inherited Organic Acidemias
  52. Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart
  53. T-cells produce acidic niches in lymph nodes to suppress their own effector functions
  54. Single‐cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID‐19 patients
  55. Detection of Intravascular Hemolysis in Newborn Infants Using Urinary Carbonic Anhydrase I Immunoreactivity
  56. Single-cell O 2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells
  57. Causes and Consequences of Variable Tumor Cell Metabolism on Heritable Modifications and Tumor Evolution
  58. Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1
  59. Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches
  60. A high-throughput ratiometric method for imaging hypertrophic growth in cultured primary cardiac myocytes
  61. Evidence-based guidelines for controlling pH in mammalian live-cell culture systems
  62. Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity
  63. What is pH regulation, and why do cancer cells need it?
  64. A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions
  65. Recovery from hypoxia-induced internalization of cardiac Na+ /H + exchanger 1 requires an adequate intracellular store of antioxidants
  66. Correction for Burdyga et al., Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane
  67. Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
  68. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane
  69. Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2
  70. Distinct moieties underlie biphasic H+gating of connexin43 channels, producing a pH optimum for intercellular communication
  71. Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths
  72. Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells
  73. Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes
  74. Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm
  75. Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid
  76. Nuclear proton dynamics and interactions with calcium signaling
  77. Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth
  78. Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes
  79. CrossTalk opposing view: Physiological CO2exchange does not normally depend on membrane channels
  80. Rebuttal from Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer
  81. Na+ ions as spatial intracellular messengers for co-ordinating Ca2+ signals during pH heterogeneity in cardiomyocytes
  82. Intracellular Carbonic Anhydrase Activity Sensitizes Cancer Cell pH Signaling to Dynamic Changes in CO 2 Partial Pressure
  83. Rapid CO 2 permeation across biological membranes: implications for CO 2 venting from tissue
  84. Pumping Ca2+ up H+ gradients: a Ca2+–H+ exchanger without a membrane
  85. The chemistry, physiology and pathology of pH in cancer
  86. Facilitation by intracellular carbonic anhydrase of Na + –HCO 3 − co‐transport but not Na +
  87. Antitumor Efficacy of a Monoclonal Antibody That Inhibits the Activity of Cancer-Associated Carbonic Anhydrase XII
  88. H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH
  89. Coupled Ca 2+ /H + transport by cytoplasmic buffers regulates local Ca 2+ and H ...
  90. Sarcolemmal localisation of Na+/H+exchange and Na+-HCO3−co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes
  91. Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics
  92. Low and High pH Gating of Connexin43 Channels
  93. Intracellular Na+ Spatially Controls Ca2+ Signaling during Acidosis in the Ventricular Myocyte
  94. An Extra-Mitochondrial Domain Rich in Carbonic Anhydrase Activity Improves Myocardial Energetics
  95. Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia
  96. Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin
  97. Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy
  98. Acid-extrusion from Tissue: The Interplay Between Membrane Transporters and pH Buffers
  99. Spatial Localisation and Function of pH-Regulatory Transporters in the Rat Ventricular Myocyte
  100. Role of Cytoplasmic Buffers in Spatial H+-Ca2+ Interactions in Ventricular Myocytes
  101. Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX
  102. Dual Role of CO2/HCOFormula Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths
  103. Hydrogen ion dynamics in human red blood cells
  104. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
  105. A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform
  106. The importance of carbonic anhydrase II in red blood cells during exposure of chicken embryos to CO2
  107. The Tumor Microenvironment: New Insights into Regulation of Tumor pH by Carbonic Anhydrases
  108. Modeling calcium waves in cardiac myocytes: importance of calcium diffusion
  109. Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study
  110. Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes
  111. The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths
  112. Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells
  113. Intracellular pH regulation in heart
  114. Confocal Imaging Of Extracellular pH With Fluorescein Derivatives
  115. Modulation Of Cardiac Na+/H+ Exchange Activity By Muscarinic Agonists, Nitric Oxide and Cyclic GMP
  116. Comparison of pH-dependence of Carbonic Anhydrase Activity in vitro and in Living Cells
  117. Pushing and Pulling the Cardiac Sodium/Hydrogen Exchanger
  118. Ca2+-Mobility in the Sarcoplasmic Reticulum of Ventricular Myocytes Is Low
  119. Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2diffusion
  120. Extracellular Acidification Elicits Spatially and Temporally Distinct Ca 2+ Signals
  121. Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths
  122. Measuring and Modeling Chloride-Hydroxyl Exchange in the Guinea-Pig Ventricular Myocyte
  123. S0859, an N -cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart
  124. H + Ion Activation and Inactivation of the Ventricular Gap Junction
  125. Regulation of tumor pH and the role of carbonic anhydrase 9
  126. pH-Dependence of Extrinsic and Intrinsic H+-Ion Mobility in the Rat Ventricular Myocyte, Investigated Using Flash Photolysis of a Caged-H+ Compound
  127. pH-Regulated Na+ Influx into the Mammalian Ventricular Myocyte: The Relative Role of Na+-H+ Exchange and Na+-HCO3- Co-Transport
  128. Spatial aspects of intracellular pH regulation in heart muscle
  129. Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes
  130. Spatial Regulation of Intracellular pH in the Ventricular Myocyte
  131. Experimental Generation and Computational Modeling of Intracellular pH Gradients in Cardiac Myocytes
  132. Functional diversity of electrogenic Na+-HCO3−cotransport in ventricular myocytes from rat, rabbit and guinea pig
  133. Novel method for measuring junctional proton permeation in isolated ventricular myocyte cell pairs
  134. Temperature dependence of Na+−H+exchange, Na+−HCO3−co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes
  135. Proton Permeation Through the Myocardial Gap Junction
  136. Modelling intracellular H+ ion diffusion
  137. Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig
  138. Amino Acid Transport
  139. Functional and molecular determination of carbonic anhydrase levels in bovine and cultured human chondrocytes