All Stories

  1. A Ketone Ester Drink Lowers Human Ghrelin and Appetite

    Article • Obesity, November 2017, Wiley

    Prof. Kieran Clarke, Brianna Stubbs

  2. Ketone bodies mimic the life span extending properties of caloric restriction

    Article • IUBMB Life, April 2017, Wiley

    Prof. Kieran Clarke

  3. Weighted averaging in spectroscopic studies improves statistical power

    Article • Magnetic Resonance in Medicine, January 2017, Wiley

    Prof. Kieran Clarke

  4. Novel ketone diet enhances physical and cognitive performance

    Article • The FASEB Journal, August 2016, Federation of American Societies For Experimental Biology (FASEB)

    Prof. Kieran Clarke, Professor Jeremy Robertson, Dr Andrew J Murray, Dr Robert deacon, Richard Veech

  5. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

    Article • Cell Metabolism, August 2016, Elsevier

    Prof. Kieran Clarke

  6. Ectopic and Visceral Fat Deposition in Lean and Obese Patients With Type 2 Diabetes

    Article • Journal of the American College of Cardiology, July 2016, Elsevier

    Prof. Kieran Clarke

  7. The Effects Of Oral Ketones On Human Muscle Recovery Following Exercise

    Article • Medicine & Science in Sports & Exercise, May 2016, Wolters Kluwer Health

    Prof. Kieran Clarke

  8. On the pivotal role of PPAR  in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

    Article • The FASEB Journal, April 2016, Federation of American Societies For Experimental Biology (FASEB)

    Dr Andrew J Murray, Prof. Kieran Clarke, Prof Peter A Robbins, Christopher Schofield

  9. Cardiac and hepatic phenotype of diabetes in the presence and the absence of obesity - mechanistic role of ectopic/visceral adiposity

    Article • Journal of Cardiovascular Magnetic Resonance, January 2016, Springer Science + Business Media

    Prof. Kieran Clarke

  10. Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation

    Article • The Journal of Physiology, December 2015, Wiley

    Prof. Kieran Clarke

  11. Cardiac MRS Studies in Rodents and Other Animals

    Article • December 2015, Wiley

    Prof. Kieran Clarke

  12. An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans

    Article • Lipids, October 2015, Springer Science + Business Media

    Prof. Kieran Clarke

  13. Relationship between Left Ventricular Structural and Metabolic Remodelling in Type 2 Diabetes Mellitus

    Article • Diabetes, October 2015, American Diabetes Association

    Prof. Kieran Clarke

  14. No Evidence of Myocardial Oxygen Deprivation in Non-Ischemic Heart Failure

    Article • Circulation Heart Failure, September 2015, Wolters Kluwer Health

    Prof. Kieran Clarke, Dr Theodoros Karamitsos

  15. 122 Relationship Between Coronary Microvascular Dysfunction, Myocardial Oxygenation and Abnormal Myocardial Energetics at Rest and Stress in Patients with Type 2 Diabetes Mellitus

    Article • Heart, June 2015, BMJ

    Prof. Kieran Clarke

  16. Effect of exercise on myocardial energy metabolism and relationship between coronary microvascular dysfunction and abnormal myocardial energetics in diabetic cardiomyopathy

    Article • Journal of Cardiovascular Magnetic Resonance, January 2015, Springer Science + Business Media

    Prof. Kieran Clarke

  17. Murine Cardiosphere-Derived Cells Are Impaired by Age but Not by Cardiac Dystrophic Dysfunction

    Article • Stem Cells and Development, May 2014, Mary Ann Liebert Inc

    Prof. Kieran Clarke

  18. Effect of isoproterenol on myocardial perfusion, function, energy metabolism and nitric oxide pathway in the rat heart - a longitudinal MR study

    Article • NMR in Biomedicine, February 2014, Wiley

    Prof. Kieran Clarke

  19. Acute nutritional ketosis: implications for exercise performance and metabolism

    Article • Extreme Physiology & Medicine, January 2014, Springer Science + Business Media

    Prof. Kieran Clarke

  20. Concentric left ventricular remodeling and aortic stiffness: A comparison of obesity and hypertension

    Article • International Journal of Cardiology, September 2013, Elsevier

    Prof. Kieran Clarke, Professor Steffen E Petersen

  21. Hyperpolarized butyrate: A metabolic probe of short chain fatty acid metabolism in the heart

    Article • Magnetic Resonance in Medicine, June 2013, Wiley

    Prof. Kieran Clarke

  22. Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13 C]pyruvate

    Article • NMR in Biomedicine, June 2013, Wiley

    Prof. Kieran Clarke

  23. Stem Cell-Based Therapy for Ischemic Heart Disease

    Article • Cell Transplantation, April 2013, Cognizant Communication Corporation

    Prof. Kieran Clarke

  24. Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance

    Article • Brain and Behavior, February 2013, Wiley

    Prof. Kieran Clarke

  25. An Extra-Mitochondrial Domain Rich in Carbonic Anhydrase Activity Improves Myocardial Energetics

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Pawel Swietach, Prof. Kieran Clarke

  26. Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

    Article • Regulatory Toxicology and Pharmacology, August 2012, Elsevier

    Prof. Kieran Clarke

  27. Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate

    Article • Regulatory Toxicology and Pharmacology, July 2012, Elsevier

    Prof. Kieran Clarke

  28. Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors

    Article • Molecular Biology Reports, November 2011, Springer Science + Business Media

    Prof. Kieran Clarke

  29. Metabolism, hypoxia and the diabetic heart

    Article • Journal of Molecular and Cellular Cardiology, April 2011, Elsevier

    Prof. Kieran Clarke

  30. Erratum to: A comparison of visual and quantitative assessment of left ventricular ejection fraction by cardiac magnetic resonance

    Article • The International Journal of Cardiovascular Imaging, April 2011, Springer Science + Business Media

    Prof. Kieran Clarke

  31. Isolation and Expansion of Cardiosphere-Derived Stem Cells

    Article • Current Protocols in Stem Cell Biology, February 2011, Wiley

    Prof. Kieran Clarke

  32. A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart

    Article • Basic Research in Cardiology, February 2011, Springer Science + Business Media

    Prof. Kieran Clarke

  33. Functional and Morphological Maturation of Implanted Neonatal Cardiomyocytes as a Comparator for Cell Therapy

    Article • Stem Cells and Development, July 2010, Mary Ann Liebert Inc

    Enca Martin-Rendon, Prof. Kieran Clarke

  34. Is MR Spectroscopy of the Heart Ready for Humans?

    Article • Heart Lung and Circulation, March 2010, Elsevier

    Prof. Kieran Clarke

  35. Novel MRI method to detect altered left ventricular ejection and filling patterns in rodent models of disease

    Article • Magnetic Resonance in Medicine, September 2008, Wiley

    Prof. Kieran Clarke

  36. Cine-MRI versus two-dimensional echocardiography to measurein vivoleft ventricular function in rat heart

    Article • NMR in Biomedicine, August 2008, Wiley

    Prof. Kieran Clarke

  37. A comparison of cardiac 31 P MRS at 1.5 and 3 T

    Article • NMR in Biomedicine, June 2008, Wiley

    Prof. Kieran Clarke

  38. High-fat diet alters physical and mental performance via changes in mitochondrial UCPS

    Article • Journal of Molecular and Cellular Cardiology, April 2008, Elsevier

    Prof. Kieran Clarke

  39. Investigation of a mouse model of familial DCM with ACTC E361G mutation

    Article • Journal of Molecular and Cellular Cardiology, April 2008, Elsevier

    Prof. Kieran Clarke

  40. Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart

    Article • Journal of Molecular and Cellular Cardiology, April 2008, Elsevier

    Prof. Kieran Clarke

  41. Mitochondria and heart failure

    Article • Current Opinion in Clinical Nutrition & Metabolic Care, November 2007, Wolters Kluwer Health

    Prof. Kieran Clarke

  42. �MRI?HREM pipeline for high-throughput, high-resolution phenotyping of murine embryos

    Article • Journal of Anatomy, July 2007, Wiley

    Prof. Kieran Clarke

  43. Investigation of Muscle Bioenergetics in the Marfan Syndrome Indicates Reduced Metabolic Efficiency

    Article • Journal of Cardiovascular Magnetic Resonance, July 2007, Taylor & Francis

    Prof. Kieran Clarke

  44. MRI tracking of systemically administered bone marrow stem cells

    Article • Journal of Molecular and Cellular Cardiology, June 2007, Elsevier

    Prof. Kieran Clarke

  45. Cation Movements Across Cell Walls of Intact Tissues using MRS

    Article • March 2007, Wiley

    Prof. Kieran Clarke

  46. Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure

    Article • European Journal of Heart Failure, March 2007, Wiley

    Prof. Kieran Clarke

  47. Cardiac Cine MR-Imaging at 3T: FLASH vs SSFP

    Article • Journal of Cardiovascular Magnetic Resonance, October 2006, Taylor & Francis

    Prof. Kieran Clarke, Professor Steffen E Petersen

  48. Abnormal Cardiac High-Energy Phosphate Metabolism in a Patient With Type 2 Diabetes Mellitus

    Article • Journal of the CardioMetabolic Syndrome, September 2006, Wiley

    Prof. Kieran Clarke

  49. Modification of myocardial substrate use as a therapy for heart failure

    Article • Nature Clinical Practice Neurology, September 2006, Nature

    Prof. Kieran Clarke

  50. MLP accumulation and remodelling in the infarcted rat heart

    Article • European Journal of Heart Failure, June 2006, Wiley

    Prof. Kieran Clarke

  51. PPARα is involved in triiodothyronine-induced cardiac hypertrophy and high-energy phosphate metabolism: A 31P MRS study of the PPARα-null mouse

    Article • Journal of Molecular and Cellular Cardiology, June 2006, Elsevier

    Prof. Kieran Clarke

  52. CINE-MR Imaging of the Normal and Infarcted Rat Heart Using an 11.7 T Vertical Bore MR System

    Article • Journal of Cardiovascular Magnetic Resonance, May 2006, Taylor & Francis

    Prof. Kieran Clarke

  53. Haemoglobin and flow-mediated vasodilation

    Article • Clinical Science, April 2006, Portland Press Ltd.

    Prof. Kieran Clarke

  54. Determination of cardiac volumes and mass with FLASH and SSFP cine sequences at 1.5 vs. 3 Tesla: A validation study

    Article • Journal of Magnetic Resonance Imaging, January 2006, Wiley

    Prof. Kieran Clarke, Professor Steffen E Petersen

  55. Long-term stability of cardiac function in normal and chronically failing mouse hearts in a vertical-bore MR system

    Article • Magnetic Resonance Materials in Physics Biology and Medicine, November 2004, Springer Science + Business Media

    Prof. Kieran Clarke

  56. Uncoupling proteins in human heart

    Article • The Lancet, November 2004, Elsevier

    Prof. Kieran Clarke

  57. Accumulation of 2-deoxy-d-glucose-6-phosphate as a measure of glucose uptake in the isolated perfused heart: a 31P NMR study

    Article • Metabolic Engineering, January 2004, Elsevier

    Prof. Kieran Clarke

  58. The mechanism underlying the positive inotropic effect of angiotensin II in the isolated perfused rabbit heart: a 31P NMR study

    Article • The International Journal of Biochemistry & Cell Biology, June 2003, Elsevier

    Prof. Kieran Clarke

  59. High-resolution imaging of normal anatomy, and neural and adrenal malformations in mouse embryos using magnetic resonance microscopy

    Article • Journal of Anatomy, February 2003, Wiley

    Prof. Kieran Clarke

  60. High-resolution, high-throughput magnetic resonance imaging of mouse embryonic anatomy using a fast gradient-echo sequence

    Article • Magnetic Resonance Materials in Physics Biology and Medicine, February 2003, Springer Science + Business Media

    Prof. Kieran Clarke

  61. Metabolite and water apparent diffusion coefficients in the isolated rat heart: Effects of ischemia

    Article • Magnetic Resonance in Medicine, August 2000, Wiley

    Prof. Kieran Clarke

  62. Control of cardiac energetics: from models to human disease

    Article • Magnetic Resonance Materials in Physics Biology and Medicine, February 2000, Springer Science + Business Media

    Prof. Kieran Clarke

  63. Metabolite and water apparent diffusion coefficients in the isolated rat heart: Effects of ischemia

    Article • Magnetic Resonance in Medicine, January 2000, Wiley

    Prof. Kieran Clarke

  64. Decreased Myocardial nNOS, Increased iNOS and Abnormal ECGs in Mouse Models of Duchenne Muscular Dystrophy

    Article • Journal of Molecular and Cellular Cardiology, October 1999, Elsevier

    Prof. Kieran Clarke

  65. Fatty acids, ischaemic damage and the diabetic heart

    Article • Magnetic Resonance Materials in Physics Biology and Medicine, September 1998, Springer Science + Business Media

    Prof. Kieran Clarke

  66. Cation MR spectroscopy (7Li,23Na,39K and87Rb)

    Article • Magnetic Resonance Materials in Physics Biology and Medicine, September 1998, Springer Science + Business Media

    Prof. Kieran Clarke

  67. Glycogen levels modulate myocardial glucose uptake

    Article • Biochemical Society Transactions, February 1997, Portland Press Ltd.

    Prof. Kieran Clarke

  68. Modeling of Internal pH, Ion Concentration, and Bioenergetic Changes during Myocardial Ischemia

    Article • January 1997, Springer Science + Business Media

    Prof. Kieran Clarke

  69. Is Lactate-induced Myocardial Ischaemic Injury Mediated by Decreased pH or Increased Intracellular Lactate?

    Article • Journal of Molecular and Cellular Cardiology, July 1995, Elsevier

    Prof. Kieran Clarke

  70. Trans-sarcolemmal Pi fluxes in perfused rat heart: a quantitative analysis

    Article • Biochemical Society Transactions, May 1995, Portland Press Ltd.

    Prof. Kieran Clarke

  71. Insulin insensitivity in the ischaemic heart

    Article • Biochemical Society Transactions, May 1995, Portland Press Ltd.

    Prof. Kieran Clarke

  72. Substrate Dependence of the Mitochondrial Energy Status In the Isolated Working Rat Heart

    Article • Biochemical Society Transactions, May 1995, Portland Press Ltd.

    Prof. Kieran Clarke

  73. Transsarcolemmal Movement of Inorganic Phosphate in Glucose-perfused Rat Heart: A 31P Nuclear Magnetic Resonance Spectroscopic Study

    Article • Journal of Molecular and Cellular Cardiology, February 1994, Elsevier

    Prof. Kieran Clarke

  74. Changes in probe sensitivity during nmr spectroscopic studies of the perfused rat heart: a warning

    Article • Magnetic Resonance in Medicine, October 1992, Wiley

    Prof. Kieran Clarke

  75. Analysis of23Na NMR spectra from isolated perfused hearts

    Article • Magnetic Resonance in Medicine, March 1991, Wiley

    Prof. Kieran Clarke

  76. Hypoxic failure of the hypertrophied myocardium: 31P NMR spectroscopic studies David E. Atkinson, Kieran Clarke and Joanne S. Ingwall. NMR Laboratory for Physiological Chemistry, Brigham and Women's Hospital, Boston MA 02115

    Article • Journal of Molecular and Cellular Cardiology, April 1989, Elsevier

    Prof. Kieran Clarke

  77. The 31P-Nuclear Magnetic Resonance Spectrum of Heart: Will It Be of Diagnostic Use in Clinical Cardiology?

    Article • Cardiology, January 1987, Karger Publishers

    Prof. Kieran Clarke

  78. Evaluation of the stoichiometry and strength of chloroquine-porphyrin interactions by difference spectroscopy

    Article • Biochemical Pharmacology, January 1985, Elsevier

    Prof. Kieran Clarke

  79. Protein synthesis in the early stages of cardiac hypertrophy

    Article • International Journal of Biochemistry, January 1983, Elsevier

    Prof. Kieran Clarke