All Stories

  1. Light‐Triggered Control of Glucocerebrosidase Inhibitors: Towards Photoswitchable Pharmacological Chaperones

    Article • Chemistry - A European Journal, March 2023, Wiley

    Paolo Paoli

  2. Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara

    Article • Pharmaceutics, February 2023, MDPI AG

    Paolo Paoli

  3. Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis

    Article • Molecules, June 2022, MDPI AG

    Paolo Paoli

  4. 3,4,5‐Trihydroxypiperidine Based Multivalent Glucocerebrosidase (GCase) Enhancers

    Article • ChemBioChem, April 2022, Wiley

    Paolo Paoli

  5. Identifying Human PTP1B Enzyme Inhibitors from Marine Natural Products: Perspectives for Developing of Novel Insulin-Mimetic Drugs

    Article • Pharmaceuticals, March 2022, MDPI AG

    Paolo Paoli

  6. Insights into Cytotoxic Behavior of Lepadins and Structure Elucidation of the New Alkaloid Lepadin L from the Mediterranean Ascidian Clavelina lepadiformis

    Article • Marine Drugs, January 2022, MDPI AG

    Paolo Paoli

  7. Photoswitchable inhibitors of human β-glucocerebrosidase

    Article • Organic & Biomolecular Chemistry, January 2022, Royal Society of Chemistry

    Paolo Paoli

  8. Dual Targeting of PTP1B and Aldose Reductase with Marine Drug Phosphoeleganin: A Promising Strategy for Treatment of Type 2 Diabetes

    Article • Marine Drugs, September 2021, MDPI AG

    Paolo Paoli

  9. Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs

    Article • Molecules, August 2021, MDPI AG

    Paolo Paoli

  10. Bioactive Properties of Breads Made with Sourdough of Hull-Less Barley or Conventional and Pigmented Wheat Flours

    Article • Applied Sciences, April 2021, MDPI AG

    Paolo Paoli

  11. Enzymatic Inhibitors from Natural Sources: A Huge Collection of New Potential Drugs

    Article • Biomolecules, January 2021, MDPI AG

    Paolo Paoli

  12. In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B

    Article • Molecules, January 2021, MDPI AG

    Paolo Paoli

  13. Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment

    Article • Cancers, September 2020, MDPI AG

    Paolo Paoli

  14. Antioxidant and anti-inflammatory properties of sourdoughs containing selected Lactobacilli strains are retained in breads

    Article • Food Chemistry, August 2020, Elsevier

    Paolo Paoli

  15. Does Fermentation Really Increase the Phenolic Content in Cereals? A Study on Millet

    Article • Foods, March 2020, MDPI AG

    Paolo Paoli

  16. miR‐210‐3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5‐fluorouracil

    Article • Molecular Carcinogenesis, August 2019, Wiley

    Paolo Paoli

  17. Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes

    Article • Bioorganic Chemistry, June 2019, Elsevier

    Paolo Paoli

  18. Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells

    Article • Biomedicine & Pharmacotherapy, May 2019, Elsevier

    Paolo Paoli

  19. Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction

    Article • Circulation Research, April 2019, Wolters Kluwer Health

    Paolo Paoli

  20. Study on a Fermented Whole Wheat: Phenolic Content, Activity on PTP1B Enzyme and In Vitro Prebiotic Properties

    Article • Molecules, March 2019, MDPI AG

    Paolo Paoli

  21. LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy

    Article • Cancer Cell International, March 2019, Springer Science + Business Media

    Paolo Paoli

  22. Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease

    Article • ACS Medicinal Chemistry Letters, February 2019, American Chemical Society (ACS)

    Paolo Paoli

  23. Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc -driven model of colon cancer

    Article • Molecular Carcinogenesis, January 2019, Wiley

    Paolo Paoli

  24. Liquid Crystal-Induced Myoblast Alignment

    Article • Advanced Healthcare Materials, January 2019, Wiley

    Paolo Paoli

  25. In depth study of phenolic profile and PTP-1B inhibitory power of cold-pressed grape seed oils of different varieties

    Article • Food Chemistry, January 2019, Elsevier

    Lorenzo Cecchi, Paolo Paoli

  26. Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

    Article • Journal of Materials Chemistry B, January 2019, Royal Society of Chemistry

    Dr Giuliano Giambastiani, Dr Fabrizio Machetti, Paolo Paoli

  27. Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus

    Article • Critical Reviews in Food Science and Nutrition, December 2018, Taylor & Francis

    Dr Chao Zhao, Prof Sydney C Tang, Christian Carpene, Dr Jianbo Xiao, Paolo Paoli, María Portillo

  28. Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds

    Article • Biomedicine & Pharmacotherapy, December 2018, Elsevier

    Paolo Paoli

  29. An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

    Article • Bioorganic & Medicinal Chemistry Letters, December 2018, Elsevier

    Paolo Paoli

  30. Effect of selected strains of lactobacilli on the antioxidant and anti-inflammatory properties of sourdough

    Article • International Journal of Food Microbiology, December 2018, Elsevier

    Paolo Paoli

  31. LMW-PTP modulates glucose metabolism in cancer cells

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, December 2018, Elsevier

    Paolo Paoli

  32. Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study

    Article • Biomedicine & Pharmacotherapy, November 2018, Elsevier

    Paolo Paoli

  33. Metformin salts with oxidized multiwalled carbon nanotubes: In vitro biological activity and inhibition of CNT internalization

    Article • Journal of Drug Delivery Science and Technology, October 2018, Elsevier

    Paolo Paoli

  34. Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy

    Article • Cancer Medicine, March 2018, Wiley

    Paolo Paoli

  35. Ursolic acid derivatives as potential antidiabetic agents: In vitro , in vivo , and in silico studies

    Article • Drug Development Research, January 2018, Wiley

    Dr Yolanda Rios Gómez, Paolo Paoli

  36. Combined therapies with nanostructured carbon materials: there is room still available at the bottom

    Article • Journal of Materials Chemistry B, January 2018, Royal Society of Chemistry

    Paolo Paoli, Dr Giuliano Giambastiani

  37. Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair

    Article • Small, October 2017, Wiley

    Paolo Paoli

  38. A single amino acid mutation affects elicitor and expansins-like activities of cerato-platanin, a non-catalytic fungal protein

    Article • PLoS ONE, May 2017, PLOS

    Paolo Paoli

  39. Multiwalled carbon nanotubes for drug delivery: Efficiency related to length and incubation time

    Article • International Journal of Pharmaceutics, April 2017, Elsevier

    Paolo Paoli

  40. Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents

    Article • European Journal of Medicinal Chemistry, February 2017, Elsevier

    Paolo Paoli

  41. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, October 2016, Elsevier

    Paolo Paoli

  42. In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, April 2016, Elsevier

    Dr Yolanda Rios Gómez, Paolo Paoli

  43. Morin: A Promising Natural Drug

    Article • Current Medicinal Chemistry, March 2016, Bentham Science Publishers

    Paolo Paoli

  44. The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

    Article • Journal of Materials Chemistry B, January 2016, Royal Society of Chemistry

    Dr Giuliano Giambastiani, Paolo Paoli

  45. Evidence for a multivalent effect in inhibition of sulfatases involved in lysosomal storage disorders (LSDs)

    Article • RSC Advances, January 2016, Royal Society of Chemistry

    Paolo Paoli

  46. Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 2015, Elsevier

    Paolo Paoli

  47. 5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

    Article • Oncotarget, October 2015, Impact Journals, LLC

    Paolo Paoli

  48. Azido-Substituted BODIPY Dyes for the Production of Fluorescent Carbon Nanotubes

    Article • Chemistry - A European Journal, August 2015, Wiley

    Dr Giuliano Giambastiani, Paolo Paoli

  49. Human Acid β-Glucosidase Inhibition by Carbohydrate Derived Iminosugars: Towards New Pharmacological Chaperones for Gaucher Disease

    Article • ChemBioChem, August 2015, Wiley

    Paolo Paoli

  50. Effect of Natural Compounds on Insulin Signaling

    Article • Current Medicinal Chemistry, November 2014, Bentham Science Publishers

    Paolo Paoli

  51. Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition

    Article • European Journal of Medicinal Chemistry, November 2014, Elsevier

    Dr Yolanda Rios Gómez, Paolo Paoli

  52. Tumor Microenvironment and Metabolism in Prostate Cancer

    Article • Seminars in Oncology, April 2014, Elsevier

    Paolo Paoli

  53. Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells

    Article • European Journal of Medicinal Chemistry, January 2014, Elsevier

    Paolo Paoli

  54. Anoikis molecular pathways and its role in cancer progression

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 2013, Elsevier

    Paolo Paoli

  55. The insulin-mimetic effect of Morin: A promising molecule in diabetes treatment

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, April 2013, Elsevier

    Paolo Paoli

  56. Effect of IR laser on myoblasts: a proteomic study

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Paolo Paoli

  57. The effects of CA IX catalysis products within tumor microenvironment

    Article • Cell Communication and Signaling, January 2013, Springer Science + Business Media

    Paolo Paoli

  58. Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors

    Article • European Journal of Medicinal Chemistry, July 2012, Elsevier

    Paolo Paoli

  59. New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells

    Article • European Journal of Medicinal Chemistry, April 2012, Elsevier

    Paolo Paoli

  60. Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP–1B: In vitro, in silico, and in vivo approaches

    Article • European Journal of Medicinal Chemistry, June 2011, Elsevier

    Dr Yolanda Rios Gómez, Paolo Paoli

  61. Protein N-Homocysteinylation Induces the Formation of Toxic Amyloid-Like Protofibrils

    Article • Journal of Molecular Biology, July 2010, Elsevier

    Paolo Paoli

  62. PrPcactivation induces neurite outgrowth and differentiation in PC12 cells: role for caveolin-1 in the signal transduction pathway

    Article • Journal of Neurochemistry, July 2009, Wiley

    Paolo Paoli

  63. Structure-Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B and Low Molecular Weight Protein Tyrosine Phosphatase

    Article • ChemMedChem, June 2009, Wiley

    Paolo Paoli

  64. Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity

    Article • Bioorganic & Medicinal Chemistry, May 2009, Elsevier

    Paolo Paoli

  65. Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors

    Article • Bioorganic & Medicinal Chemistry, April 2009, Elsevier

    Paolo Paoli

  66. 5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors

    Article • Bioorganic & Medicinal Chemistry, March 2009, Elsevier

    Paolo Paoli

  67. Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress

    Article • Free Radical Biology and Medicine, April 2008, Elsevier

    Paolo Paoli

  68. 5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases

    Article • Bioorganic & Medicinal Chemistry, August 2007, Elsevier

    Paolo Paoli

  69. Low Molecular Weight Protein Tyrosine Phosphatase and Caveolin-1:  Interaction and Isoenzyme-Dependent Regulation†

    Article • Biochemistry, May 2007, American Chemical Society (ACS)

    Paolo Paoli

  70. Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, May 2007, Elsevier

    Paolo Paoli

  71. Insulin Inhibits Platelet-derived Growth Factor-induced Cell Proliferation

    Article • Molecular Biology of the Cell, October 2004, American Society for Cell Biology (ASCB)

    Paolo Paoli

  72. The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1

    Article • Biochemical and Biophysical Research Communications, August 2004, Elsevier

    Paolo Paoli

  73. A Nucleophilic Catalysis Step is Involved in the Hydrolysis of Aryl Phosphate Monoesters by Human CT Acylphosphatase

    Article • Journal of Biological Chemistry, October 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Paolo Paoli

  74. Hydrogen Peroxide Triggers the Formation of a Disulfide Dimer of Muscle Acylphosphatase and Modifies Some Functional Properties of the Enzyme

    Article • Journal of Biological Chemistry, September 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Paolo Paoli

  75. Acylphosphatase possesses nucleoside triphosphatase and nucleoside diphosphatase activities

    Article • Biochemical Journal, July 2000, Portland Press Ltd.

    Paolo Paoli

  76. Acylphosphatase Is a Strong Apoptosis Inducer in HeLa Cell Line

    Article • Molecular Cell Biology Research Communications, May 2000, Elsevier

    Paolo Paoli

  77. The Contribution of Acidic Residues to the Conformational Stability of Common-Type Acylphosphatase

    Article • Archives of Biochemistry and Biophysics, March 1999, Elsevier

    Paolo Paoli

  78. Thermodynamics and Kinetics of Folding of Common-Type Acylphosphatase:  Comparison to the Highly Homologous Muscle Isoenzyme†

    Article • Biochemistry, February 1999, American Chemical Society (ACS)

    Paolo Paoli

  79. Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform

    Article • FEBS Letters, October 1998, Wiley

    Paolo Paoli

  80. Mechanism of acylphosphatase inactivation by Woodward's reagent K

    Article • Biochemical Journal, December 1997, Portland Press Ltd.

    Paolo Paoli

  81. Common-type acylphosphatase: steady-state kinetics and leaving-group dependence

    Article • Biochemical Journal, October 1997, Portland Press Ltd.

    Paolo Paoli

  82. 2-Methoxybenzoyl phosphate: a new substrate for continuous fluorimetric and spectrophotometric acyl phosphatase assays

    Article • Cellular and Molecular Life Sciences, January 1995, Springer Science + Business Media

    Paolo Paoli

  83. Porcine liver low Mr phosphotyrosine protein phosphatase: The amino acid sequence

    Article • Journal of Protein Chemistry, January 1994, Springer Science + Business Media

    Paolo Paoli