All Stories

  1. Light‐Triggered Control of Glucocerebrosidase Inhibitors: Towards Photoswitchable Pharmacological Chaperones
  2. Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara
  3. Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis
  4. 3,4,5‐Trihydroxypiperidine Based Multivalent Glucocerebrosidase (GCase) Enhancers
  5. Identifying Human PTP1B Enzyme Inhibitors from Marine Natural Products: Perspectives for Developing of Novel Insulin-Mimetic Drugs
  6. Insights into Cytotoxic Behavior of Lepadins and Structure Elucidation of the New Alkaloid Lepadin L from the Mediterranean Ascidian Clavelina lepadiformis
  7. Photoswitchable inhibitors of human β-glucocerebrosidase
  8. Dual Targeting of PTP1B and Aldose Reductase with Marine Drug Phosphoeleganin: A Promising Strategy for Treatment of Type 2 Diabetes
  9. Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs
  10. Bioactive Properties of Breads Made with Sourdough of Hull-Less Barley or Conventional and Pigmented Wheat Flours
  11. Enzymatic Inhibitors from Natural Sources: A Huge Collection of New Potential Drugs
  12. In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B
  13. Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment
  14. Antioxidant and anti-inflammatory properties of sourdoughs containing selected Lactobacilli strains are retained in breads
  15. Does Fermentation Really Increase the Phenolic Content in Cereals? A Study on Millet
  16. miR‐210‐3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5‐fluorouracil
  17. Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes
  18. Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells
  19. Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction
  20. Study on a Fermented Whole Wheat: Phenolic Content, Activity on PTP1B Enzyme and In Vitro Prebiotic Properties
  21. LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy
  22. Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease
  23. Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc -driven model of colon cancer
  24. Liquid Crystal-Induced Myoblast Alignment
  25. In depth study of phenolic profile and PTP-1B inhibitory power of cold-pressed grape seed oils of different varieties
  26. Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study
  27. Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus
  28. Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds
  29. An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications
  30. Effect of selected strains of lactobacilli on the antioxidant and anti-inflammatory properties of sourdough
  31. LMW-PTP modulates glucose metabolism in cancer cells
  32. Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study
  33. Metformin salts with oxidized multiwalled carbon nanotubes: In vitro biological activity and inhibition of CNT internalization
  34. Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy
  35. Ursolic acid derivatives as potential antidiabetic agents: In vitro , in vivo , and in silico studies
  36. Combined therapies with nanostructured carbon materials: there is room still available at the bottom
  37. Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair
  38. A single amino acid mutation affects elicitor and expansins-like activities of cerato-platanin, a non-catalytic fungal protein
  39. Multiwalled carbon nanotubes for drug delivery: Efficiency related to length and incubation time
  40. Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents
  41. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme
  42. In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives
  43. Morin: A Promising Natural Drug
  44. The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes
  45. Evidence for a multivalent effect in inhibition of sulfatases involved in lysosomal storage disorders (LSDs)
  46. Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth
  47. 5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits
  48. Azido-Substituted BODIPY Dyes for the Production of Fluorescent Carbon Nanotubes
  49. Human Acid β-Glucosidase Inhibition by Carbohydrate Derived Iminosugars: Towards New Pharmacological Chaperones for Gaucher Disease
  50. Effect of Natural Compounds on Insulin Signaling
  51. Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition
  52. Tumor Microenvironment and Metabolism in Prostate Cancer
  53. Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells
  54. Anoikis molecular pathways and its role in cancer progression
  55. The insulin-mimetic effect of Morin: A promising molecule in diabetes treatment
  56. Effect of IR laser on myoblasts: a proteomic study
  57. The effects of CA IX catalysis products within tumor microenvironment
  58. Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors
  59. New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells
  60. Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP–1B: In vitro, in silico, and in vivo approaches
  61. Protein N-Homocysteinylation Induces the Formation of Toxic Amyloid-Like Protofibrils
  62. PrPcactivation induces neurite outgrowth and differentiation in PC12 cells: role for caveolin-1 in the signal transduction pathway
  63. Structure-Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B and Low Molecular Weight Protein Tyrosine Phosphatase
  64. Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity
  65. Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors
  66. 5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors
  67. Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress
  68. 5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases
  69. Low Molecular Weight Protein Tyrosine Phosphatase and Caveolin-1:  Interaction and Isoenzyme-Dependent Regulation†
  70. Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1
  71. Insulin Inhibits Platelet-derived Growth Factor-induced Cell Proliferation
  72. The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1
  73. A Nucleophilic Catalysis Step is Involved in the Hydrolysis of Aryl Phosphate Monoesters by Human CT Acylphosphatase
  74. Hydrogen Peroxide Triggers the Formation of a Disulfide Dimer of Muscle Acylphosphatase and Modifies Some Functional Properties of the Enzyme
  75. Acylphosphatase possesses nucleoside triphosphatase and nucleoside diphosphatase activities
  76. Acylphosphatase Is a Strong Apoptosis Inducer in HeLa Cell Line
  77. The Contribution of Acidic Residues to the Conformational Stability of Common-Type Acylphosphatase
  78. Thermodynamics and Kinetics of Folding of Common-Type Acylphosphatase:  Comparison to the Highly Homologous Muscle Isoenzyme†
  79. Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform
  80. Mechanism of acylphosphatase inactivation by Woodward's reagent K
  81. Common-type acylphosphatase: steady-state kinetics and leaving-group dependence
  82. 2-Methoxybenzoyl phosphate: a new substrate for continuous fluorimetric and spectrophotometric acyl phosphatase assays
  83. Porcine liver low Mr phosphotyrosine protein phosphatase: The amino acid sequence