All Stories

  1. Transesterification of activated esters

    Article • European Journal of Organic Chemistry, March 2020, Wiley

    Dr Fabrizio Machetti

  2. Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

    Article • Journal of Materials Chemistry B, January 2019, Royal Society of Chemistry

    Dr Giuliano Giambastiani, Dr Fabrizio Machetti, Paolo Paoli

  3. The role of molecular structure in determining the acidity of nitroacetoamides in water.

    Article • Molecules, December 2018, MDPI AG

    Dr Fabrizio Machetti

  4. From nitro compounds to isoxazoles

    Article • European Journal of Organic Chemistry, August 2016, Wiley

    Dr Fabrizio Machetti

  5. ChemInform Abstract: Reactivity of [60]Fullerene with Primary Nitro Compounds: Addition or Catalyzed Condensation to Isoxazolo[60]fullerenes.

    Article • ChemInform, March 2015, Wiley

    Dr Fabrizio Machetti

  6. Reactivity of [60]Fullerene with Primary Nitro Compounds: Addition or Catalysed Condensation to Isoxazolo[60]fullerenes

    Article • European Journal of Organic Chemistry, October 2014, Wiley

    Dr Fabrizio Machetti

  7. Condensation of Primary Nitro Compounds to Isoxazole Derivatives: Stoichiometric To Catalytic

    Article • January 2014, Wiley

    Dr Fabrizio Machetti

  8. ChemInform Abstract: Conjugate Addition versus Cycloaddition/Condensation of Nitro Compounds in Water: Selectivity, Acid-Base Catalysis, and Induction Period.

    Article • ChemInform, June 2013, Wiley

    Dr Fabrizio Machetti

  9. Conjugate Addition versus Cycloaddition/Condensation of Nitro Compounds in Water: Selectivity, Acid-Base Catalysis, and Induction Period

    Article • Chemistry - A European Journal, November 2012, Wiley

    Dr Fabrizio Machetti

  10. ChemInform Abstract: Acid-Base-Catalyzed Condensation Reaction in Water: Isoxazolines and Isoxazoles from Nitroacetates and Dipolarophiles.

    Article • ChemInform, May 2012, Wiley

    Dr Fabrizio Machetti

  11. Acid-Base-Catalysed Condensation Reaction in Water: Isoxazolines and Isoxazoles from Nitroacetates and Dipolarophiles

    Article • Chemistry - A European Journal, January 2012, Wiley

    Dr Fabrizio Machetti

  12. ChemInform Abstract: Five-Membered Heterocycles: 1,3-Azoles

    Article • ChemInform, December 2011, Wiley

    Dr Fabrizio Machetti

  13. Five-Membered Heterocycles: 1,3-Azoles

    Article • July 2011, Wiley

    Dr Fabrizio Machetti

  14. ChemInform Abstract: Practical Synthesis of Both Enantiomers of Protected 4-Oxopipecolic Acid.

    Article • ChemInform, May 2010, Wiley

    Dr Fabrizio Machetti

  15. ChemInform Abstract: Design and Synthesis of a New Bicyclic Dipeptide Isostere.

    Article • ChemInform, May 2010, Wiley

    Dr Fabrizio Machetti

  16. ChemInform Abstract: Synthesis of Taurine Analogues. Part 2. Amino-Sulfonation of Alkenes in a Three-Component Reaction.

    Article • ChemInform, May 2010, Wiley

    Dr Fabrizio Machetti

  17. Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds

    Article • Journal of Medicinal Chemistry, February 2010, American Chemical Society (ACS)

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  18. Copper-Catalyzed Synthesis of Isoxazoles

    Article • Synfacts, January 2010, Thieme Publishing Group

    Dr Fabrizio Machetti

  19. Conversion of a nitrosocarbonyl hetero Diels–Alder cycloadduct to useful isoxazoline-carbocyclic aminols

    Article • Tetrahedron, December 2009, Elsevier

    Dr Fabrizio Machetti

  20. Base- and Copper-Catalysed Condensation of Primary Activated Nitro Compounds with Enolisable Compounds

    Article • European Journal of Organic Chemistry, December 2009, Wiley

    Dr Fabrizio Machetti

  21. Michael Additions versus Cycloaddition Condensations with Ethyl Nitroacetate and Electron-Deficient Olefins

    Article • Chemistry - A European Journal, August 2009, Wiley

    Dr Fabrizio Machetti

  22. ChemInform Abstract: Synthesis of 4,5-Dihydroisoxazoles by Condensation of Primary Nitro Compounds with Alkenes by Using a Copper/Base Catalytic System.

    Article • ChemInform, January 2009, Wiley

    Dr Fabrizio Machetti

  23. Synthesis of 4,5-Dihydroisoxazoles by Condensation of Primary Nitro Compounds with Alkenes by Using a Copper/Base Catalytic System

    Article • Chemistry - A European Journal, September 2008, Wiley

    Dr Fabrizio Machetti

  24. ChemInform Abstract: 4,5-Dihydroisoxazoles by Copper(II)-Catalyzed Condensation of Primary Nitroalkanes with Dipolarophiles.

    Article • ChemInform, January 2008, Wiley

    Dr Fabrizio Machetti

  25. ChemInform Abstract: Isoxazoles and Isoxazolines by 1,3-Dipolar Cycloaddition: Base-Catalyzed Condensation of Primary Nitro Compounds with Dipolarophiles.

    Article • ChemInform, January 2008, Wiley

    Dr Fabrizio Machetti

  26. Isoxazoles

    Article • January 2008, Elsevier

    Dr Fabrizio Machetti

  27. 4,5-Dihydroisoxazoles by Copper(II)-Catalysed Condensation of Primary Nitroalkanes with Dipolarophiles

    Article • Synlett, September 2007, Thieme Publishing Group

    Dr Fabrizio Machetti

  28. Isoxazoles and Isoxazolines by 1,3-Dipolar Cycloaddition: Base-Catalysed Condensation of Primary Nitro Compounds with Dipolarophiles

    Article • European Journal of Organic Chemistry, September 2007, Wiley

    Dr Fabrizio Machetti

  29. Parallel Synthesis of an Amide Library Based on the 6,8-Dioxa-3-azabicyclo[3.2.1]octane Scaffold by Direct Aminolysis of Methyl Esters

    Article • Journal of Combinatorial Chemistry, May 2007, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  30. 1,4-Diazabicyclo[2.2.2]octane (DABCO) as an Efficient Reagent for the Synthesis of Isoxazole Derivatives from Primary Nitro Compounds and Dipolarophiles: The Role of the Base.

    Article • ChemInform, February 2007, Wiley

    Dr Fabrizio Machetti

  31. Synthesis of bicyclic molecular scaffolds (BTAa): An investigation towards new selective MMP-12 inhibitors

    Article • Bioorganic & Medicinal Chemistry, November 2006, Elsevier

    Dr Fabrizio Machetti

  32. 1,4-Diazabicyclo[2.2.2]octane (DABCO) as an Efficient Reagent for the Synthesis of Isoxazole Derivatives from Primary Nitro Compounds and Dipolarophiles: The Role of the Base

    Article • European Journal of Organic Chemistry, November 2006, Wiley

    Dr Fabrizio Machetti

  33. Synthesis of Benzo[c]quinolizin-3-ones: Discovery and Development of Novel Inhibitors of Human Steroid 5α-Reductase

    Article • ChemInform, August 2006, Wiley

    Dr Fabrizio Machetti

  34. The Synthesis of 4-Hydroxypipecolic Acids by Stereoselective Cycloaddition of Configurationally Stable Nitrones

    Article • European Journal of Organic Chemistry, July 2006, Wiley

    Dr Fabrizio Machetti

  35. 1,2,5-Oxadiazole (Furazan) Derivatives from Benzoylnitromethane and Dipolarophiles in the Presence of DABCO: Structure and Intermediates

    Article • European Journal of Organic Chemistry, July 2006, Wiley

    Dr Fabrizio Machetti

  36. Design, Synthesis, and Applications of 3-Aza-6,8-dioxabicyclo[3.2.1]octane-Based Scaffolds for Peptidomimetic Chemistry

    Article • ChemInform, May 2006, Wiley

    Dr Fabrizio Machetti

  37. Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: A kinetic analysis

    Article • Biochemical Pharmacology, May 2006, Elsevier

    Dr Fabrizio Machetti

  38. Isoxazoline Derivatives from Activated Primary Nitro Compounds and Tertiary Diamines.

    Article • ChemInform, February 2006, Wiley

    Dr Fabrizio Machetti

  39. Design, Synthesis, and Applications of 3-Aza-6,8-Dioxabicyclo[3.2.1]Octane-Based Scaffolds for Peptidomimetic Chemistry

    Article • Synlett, January 2006, Thieme Publishing Group

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  40. Isoxazoline derivatives from activated primary nitrocompounds and tertiary diamines

    Article • Tetrahedron Letters, November 2005, Elsevier

    Dr Fabrizio Machetti

  41. A New Bicyclic Dipeptide Isostere with Pyrrolizidinone Skeleton

    Article • The Journal of Organic Chemistry, February 2005, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  42. Synthesis of Free andNα-Fmoc-/Nγ-Boc-Protected (2S,4S)- and (2S,4R)-4-Aminopipecolic Acids

    Article • European Journal of Organic Chemistry, July 2004, Wiley

    Dr Fabrizio Machetti

  43. Enantiospecific synthesis of 3-aza-6,8-dioxa-bicyclo[3.2.1]octane carboxylic acids from erythrose

    Article • Tetrahedron, July 2003, Elsevier

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  44. A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation

    Article • British Journal of Pharmacology, June 2003, Wiley

    Dr Fabrizio Machetti

  45. Neat reaction of carboxylic acid methyl esters and amines for efficient parallel synthesis of scaffold amide libraries

    Article • Comptes Rendus Chimie, May 2003, Elsevier

    Dr Fabrizio Machetti

  46. Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain

    Article • British Journal of Pharmacology, March 2003, Wiley

    Dr Fabrizio Machetti

  47. Synthesis of a new enantiopure bicyclic γ/δ-amino acid (BTKa) derived from tartaric acid and α-amino acetophenone

    Article • Tetrahedron, December 2002, Elsevier

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  48. Synthesis of analogues of taurine: 2-aminoalkanesulfonic acids

    Article • European Journal of Organic Chemistry, April 2002, Wiley

    Dr Fabrizio Machetti

  49. Bicyclic Compounds Derived from Tartaric Acid and α-Amino Acids (BTAas): Synthesis of New Molecular Scaffolds Derived from the Combination of (R,R)-Tartaric Acid andL-Serine

    Article • European Journal of Organic Chemistry, March 2002, Wiley

    Dr Fabrizio Machetti

  50. Novel inhibitors of 5α-reductase

    Article • Expert Opinion on Therapeutic Patents, February 2002, Informa Healthcare

    Dr Fabrizio Machetti

  51. Synthesis of Taurine Analogues from Alkenes

    Article • January 2002, Springer Science + Business Media

    Dr Fabrizio Machetti

  52. Effects of Taurine and some Structurally Related Analogues on the Central Mechanism of Thermoregulation

    Article • January 2002, Springer Science + Business Media

    Dr Fabrizio Machetti

  53. Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1

    Article • Bioorganic & Medicinal Chemistry, June 2001, Elsevier

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  54. Practical synthesis of both enantiomers of protected 4-oxopipecolic acid

    Article • Tetrahedron, June 2001, Elsevier

    Dr Fabrizio Machetti

  55. ChemInform Abstract: Modification of the Aza-Robinson Annulation for the Synthesis of 4-Methyl-benzo[c]quinolizin-3-ones, Potent Inhibitors of Steroid 5α-Reductase 1.

    Article • ChemInform, April 2001, Wiley

    Dr Fabrizio Machetti

  56. ChemInform Abstract: Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1.

    Article • ChemInform, March 2001, Wiley

    Dr Fabrizio Machetti

  57. ChemInform Abstract: Synthesis of Taurine Analogues. Part 1. 2-Aminosulfonic Acids from Alkene-Sulfur Monochloride Adducts.

    Article • ChemInform, February 2001, Wiley

    Dr Fabrizio Machetti

  58. ChemInform Abstract: Oligomers of Enantiopure Bicyclic γ/δ-Amino Acids (BTAa). Part 1. Synthesis and Conformational Analysis of 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid Oligomers (PolyBTG).

    Article • ChemInform, February 2001, Wiley

    Dr Fabrizio Machetti

  59. Design and synthesis of a new bicyclic dipeptide isostere

    Article • Chemical Communications, January 2001, Royal Society of Chemistry

    Dr Fabrizio Machetti

  60. Oligomers of Enantiopure Bicyclic γ/δ-Amino Acids (BTAa). 1. Synthesis and Conformational Analysis of 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid Oligomers (PolyBTG)

    Article • Organic Letters, December 2000, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  61. Modification of the Aza-Robinson Annulation for the Synthesis of 4-Methyl-Benzo[ c ]quinolizin-3-ones, Potent Inhibitors of Steroid 5α-Reductase 1

    Article • The Journal of Organic Chemistry, November 2000, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  62. Benzo[ c ]quinolizin-3-ones:  A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

    Article • Journal of Medicinal Chemistry, October 2000, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  63. Synthesis and Reactivity of Bicycles Derived from Tartaric Acid and α-Amino Acids:  A Novel Class of Conformationally Constrained Dipeptide Isosteres Based upon Enantiopure 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid.

    Article • The Journal of Organic Chemistry, July 2000, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  64. Synthesis of taurine analogues. Part 1: 2-aminosulfonic acids from alkene-sulfur monochloride adducts

    Article • Journal of Chemical Research, March 2000, Science Reviews 2000 LTD

    Dr Fabrizio Machetti

  65. Synthesis and Reactivity of Bicycles Derived from Tartaric Acid and α-Amino Acids:  A Novel Class of Conformationally Constrained Dipeptide Isosteres Based upon Enantiopure 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid

    Article • The Journal of Organic Chemistry, September 1999, American Chemical Society (ACS)

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  66. 19-Nor-10-azasteroids. 5. 1 A Synthetic Strategy for the Preparation of (+)-17-(3-Pyridyl)-(5β)-10-azaestra-1,16- dien-3-one, a Novel Potential Inhibitor for Human Cytochrome P450 17 α (17α-Hydroxylase/C 17,20 -lyase)

    Article • The Journal of Organic Chemistry, June 1999, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  67. Stereoselectivity in the TiCl4-catalysed reaction of Danishefsky's diene with a N-(acyloxy)iminium ion: Synthesis of 5α versus 5β Δ1(2)-19-Nor-10-azasteroids. 4

    Article • Tetrahedron, September 1998, Elsevier

    Dr Fabrizio Machetti

  68. A Concise Route to 19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. 3. 1 Synthesis of (+)-19-Nor-10-azatestosterone and (+)-17β-(Acetyloxy)-(5β)-10-azaestr-1-en-3-one

    Article • The Journal of Organic Chemistry, June 1998, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  69. 19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. 2. 1 X-ray Structure, Molecular Modeling, Conformational Analysis of 19-Nor-10-azasteroids and Comparison with 4-Azasteroids and 6-Azasteroids

    Article • Journal of Medicinal Chemistry, October 1997, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  70. 19-Nor-10-azasteroids:  A Novel Class of Inhibitors for Human Steroid 5α-Reductases 1 and 2

    Article • Journal of Medicinal Chemistry, March 1997, American Chemical Society (ACS)

    Dr Fabrizio Machetti

  71. Synthesis and X-ray study of hexahydro- and tetrahydrophospholo-[2,3-d]isoxazoles, a new class of heterocycles of potential fungicidal activity

    Article • Journal of Heterocyclic Chemistry, July 1996, Wiley

    Dr Fabrizio Machetti

  72. A new synthesis of (2S)-4-oxopipecolic acid by thermal rearrangement of enantiopure spirocyclopropaneisoxazolidine

    Article • Tetrahedron Letters, June 1996, Elsevier

    Dr Fabrizio Machetti