All Stories

  1. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

    Article • Journal of Clinical Investigation, November 2023, American Society for Clinical Investigation

    Noriko Gotoh

  2. Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy

    Article • Biochemical and Biophysical Research Communications, September 2023, Elsevier

    Noriko Gotoh

  3. A model-based clustering algorithm with covariates adjustment and its application to lung cancer stratification

    Article • Journal of Bioinformatics and Computational Biology, August 2023, World Scientific Pub Co Pte Lt

    Noriko Gotoh

  4. Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line

    Article • Cell Death and Disease, April 2023, Springer Science + Business Media

    Noriko Gotoh, Professor Luca Scorrano

  5. Inflammatory cytokine‐enriched microenvironment plays key roles in the development of breast cancers

    Article • Cancer Science, February 2023, Wiley

    Noriko Gotoh

  6. Cryopreservation of tissues by slow-freezing using an emerging zwitterionic cryoprotectant

    Article • Scientific Reports, January 2023, Springer Science + Business Media

    Noriko Gotoh

  7. A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer

    Article • Biochemical and Biophysical Research Communications, December 2021, Elsevier

    Noriko Gotoh

  8. The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis

    Article • Proceedings of the National Academy of Sciences, October 2021, Proceedings of the National Academy of Sciences

    Noriko Gotoh

  9. Patient-Derived Xenograft Models of Breast Cancer and Their Application

    Article • Cells, June 2019, MDPI AG

    Noriko Gotoh

  10. Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis

    Article • PLoS Genetics, October 2017, PLOS

    Noriko Gotoh

  11. Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer

    Article • Cancer Science, May 2017, Wiley

    Noriko Gotoh

  12. The RB–IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity

    Article • Oncogene, May 2017, Springer Science + Business Media

    Noriko Gotoh

  13. Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids

    Article • Journal of Crohn s and Colitis, October 2016, Oxford University Press (OUP)

    Noriko Gotoh

  14. Intrinsic Resistance to 5-Fluorouracil in a Brain Metastatic Variant of Human Breast Cancer Cell Line, MDA-MB-231BR

    Article • PLOS One, October 2016, PLOS

    Noriko Gotoh

  15. Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells

    Article • Oncogene, August 2016, Springer Science + Business Media

    Noriko Gotoh

  16. Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis

    Article • Cancer Letters, August 2016, Elsevier

    Noriko Gotoh

  17. Oncogenic Fusion Gene CD74-NRG1 Confers Cancer Stem Cell–like Properties in Lung Cancer through a IGF2 Autocrine/Paracrine Circuit

    Article • Cancer Research, February 2016, American Association for Cancer Research (AACR)

    Noriko Gotoh

  18. Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming

    Article • PLOS One, July 2015, PLOS

    Noriko Gotoh

  19. Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells

    Article • Regenerative Therapy, June 2015, Elsevier

    Noriko Gotoh

  20. MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells

    Article • PLOS One, May 2015, PLOS

    Noriko Gotoh

  21. The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell

    Article • Experimental Hematology, November 2014, Elsevier

    Noriko Gotoh

  22. Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition

    Article • Proceedings of the National Academy of Sciences, October 2014, Proceedings of the National Academy of Sciences

    Noriko Gotoh

  23. Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma

    Article • Neuro-Oncology, January 2014, Oxford University Press (OUP)

    Noriko Gotoh

  24. FGFR1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation

    Article • PLoS Genetics, January 2014, PLOS

    Noriko Gotoh

  25. Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo

    Article • Oncogenesis, September 2013, Springer Science + Business Media

    Noriko Gotoh

  26. Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma

    Article • Development, July 2013, The Company of Biologists

    Noriko Gotoh

  27. The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein

    Article • Biochemical and Biophysical Research Communications, March 2013, Elsevier

    Noriko Gotoh

  28. Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation

    Article • Cancer Science, February 2013, Wiley

    Noriko Gotoh

  29. Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development

    Article • Journal of Cell Science, January 2013, The Company of Biologists

    Noriko Gotoh

  30. Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

    Article • Molecular Therapy, January 2013, Elsevier

    Noriko Gotoh

  31. Epidermal Growth Factor Receptor Tyrosine Kinase Defines Critical Prognostic Genes of Stage I Lung Adenocarcinoma

    Article • PLOS One, September 2012, PLOS

    Noriko Gotoh

  32. Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer

    Article • Expert Opinion on Therapeutic Targets, July 2012, Taylor & Francis

    Noriko Gotoh

  33. ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    Noriko Gotoh

  34. Abstract 2904: EGFR-targeted gold liposome for molecular imaging and therapy on NSCLC cells

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Noriko Gotoh

  35. Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing

    Article • BMC Genomics, January 2012, Springer Science + Business Media

    Noriko Gotoh

  36. Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

    Article • Cancer Research, January 2012, American Association for Cancer Research (AACR)

    Noriko Gotoh

  37. Potential Signaling Pathways Activated in Cancer Stem Cells in Breast Cancer

    Article • March 2011, IntechOpen

    Noriko Gotoh

  38. Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study

    Article • Journal of Clinical Bioinformatics, January 2011, ClinTransMed, AB

    Noriko Gotoh

  39. Inflammatory signaling pathways in self-renewing breast cancer stem cells

    Article • Current Opinion in Pharmacology, December 2010, Elsevier

    Noriko Gotoh

  40. Phosphoproteomics-Based Modeling Defines the Regulatory Mechanism Underlying Aberrant EGFR Signaling

    Article • PLOS One, November 2010, PLOS

    Noriko Gotoh

  41. FRS2α Regulates Erk Levels to Control a Self-Renewal Target Hes1 and Proliferation of FGF-Responsive Neural Stem/Progenitor Cells

    Article • Stem Cells, July 2010, Oxford University Press (OUP)

    Noriko Gotoh

  42. Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells

    Article • British Journal of Cancer, December 2009, Springer Science + Business Media

    Noriko Gotoh

  43. An FGF4-FRS2α-Cdx2 Axis in Trophoblast Stem Cells Induces Bmp4 to Regulate Proper Growth of Early Mouse Embryos  

    Article • Stem Cells, November 2009, Oxford University Press (OUP)

    Noriko Gotoh

  44. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

    Article • Nature, July 2009, Springer Science + Business Media

    Noriko Gotoh

  45. The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment

    Article • Expert Opinion on Therapeutic Targets, May 2009, Informa Healthcare

    Noriko Gotoh

  46. Theme: Oncology - Molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates

    Article • Biomarkers in Medicine, April 2009, Future Medicine

    Noriko Gotoh

  47. Feedback inhibitors of the epidermal growth factor receptor signaling pathways

    Article • The International Journal of Biochemistry & Cell Biology, March 2009, Elsevier

    Noriko Gotoh

  48. FRS2αis required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus

    Article • Developmental Dynamics, March 2009, Wiley

    Noriko Gotoh

  49. Prominent expression of FRS2β protein in neural cells and its association with intracellular vesicles

    Article • FEBS Letters, January 2009, Wiley

    Noriko Gotoh

  50. Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

    Article • Cancer Science, July 2008, Wiley

    Noriko Gotoh

  51. FRS2α mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve

    Article • Developmental Biology, February 2008, Elsevier

    Noriko Gotoh

  52. EGFR phosphorylation-dependent formation of cell–cell contacts by Ras/Erks cascade inhibition

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, June 2007, Elsevier

    Noriko Gotoh

  53. Essential role of Shp2-binding sites on FRS2α for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells

    Article • Proceedings of the National Academy of Sciences, October 2005, Proceedings of the National Academy of Sciences

    Noriko Gotoh

  54. The Docking Protein FRS2α Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development

    Article • Molecular and Cellular Biology, May 2005, ASM Journals

    Noriko Gotoh

  55. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation

    Article • Biochemical and Biophysical Research Communications, November 2004, Elsevier

    Noriko Gotoh

  56. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts

    Article • FEBS Letters, March 2004, Wiley

    Noriko Gotoh

  57. Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway

    Article • Oncogene, June 2002, Springer Science + Business Media

    Noriko Gotoh

  58. Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules

    Article • Oncogene, January 2002, Springer Science + Business Media

    Noriko Gotoh

  59. Tyrosine Residues 239 and 240 of Shc Are Phosphatidylinositol 4,5-Bisphosphate-Dependent Phosphorylation Sites by c-Src

    Article • Biochemical and Biophysical Research Communications, November 1997, Elsevier

    Noriko Gotoh

  60. Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.

    Article • Proceedings of the National Academy of Sciences, January 1994, Proceedings of the National Academy of Sciences

    Noriko Gotoh

  61. A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor

    Article • Biochemical and Biophysical Research Communications, July 1992, Elsevier

    Noriko Gotoh