All Stories

  1. Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies

    Article • PLoS Neglected Tropical Diseases, March 2020, PLOS

    Dr Nicholas J Mantis

  2. An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation

    Article • Human Vaccines & Immunotherapeutics, October 2019, Taylor & Francis

    Dr Nicholas J Mantis

  3. Intracellular Neutralization of Ricin Toxin by Single Domain Antibodies Targeting the Active Site Pocket

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  4. Inhibition of Invasive Salmonella by Orally Administered IgA and IgG Monoclonal Antibodies

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  5. Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin–Ab complexes

    Article • Journal of Leukocyte Biology, July 2019, Wiley

    Dr Nicholas J Mantis

  6. A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site

    Article • Antibodies, December 2018, MDPI AG

    Dr Nicholas J Mantis

  7. TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death

    Article • mSphere, September 2018, ASM Journals

    Dr Nicholas J Mantis

  8. Biomedical Applications of Lumazine Synthase

    Article • Journal of Pharmaceutical Sciences, September 2018, Elsevier

    Dr Nicholas J Mantis

  9. Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine

    Article • Vaccine, September 2018, Elsevier

    Dr Nicholas J Mantis

  10. Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity

    Article • Protein Engineering Design and Selection, July 2018, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  11. TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  12. Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication

    Article • Human Vaccines & Immunotherapeutics, April 2018, Taylor & Francis

    Dr Nicholas J Mantis

  13. Vibrio cholerae O1 secretes an extracellular matrix in response to antibody-mediated agglutination

    Article • PLoS ONE, January 2018, PLOS

    Dr Nicholas J Mantis

  14. A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits

    Article • Toxins, November 2017, MDPI AG

    Dr Nicholas J Mantis

  15. High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine

    Article • Clinical and Vaccine Immunology, October 2017, ASM Journals

    Dr Nicholas J Mantis

  16. High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin

    Article • Clinical and Vaccine Immunology, October 2017, ASM Journals

    Dr Nicholas J Mantis

  17. Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display

    Article • Protein Science, September 2017, Wiley

    Dr Nicholas J Mantis

  18. Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies

    Article • Proteins Structure Function and Bioinformatics, August 2017, Wiley

    Dr Nicholas J Mantis

  19. Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin’s binding subunit

    Article • PLoS ONE, July 2017, PLOS

    Dr Nicholas J Mantis

  20. Structural analysis of single domain antibodies bound to a second neutralizing hot spot on ricin toxin's enzymatic subunit

    Article • Journal of Biological Chemistry, November 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Nicholas J Mantis

  21. super-resolution

    Article • Microscopy and Microanalysis, November 2016, Cambridge University Press

    Prof Richard Cole, Dr Nicholas J Mantis

  22. A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes

    Article • Vaccine, November 2016, Elsevier

    Dr Nicholas J Mantis

  23. A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

    Article • Toxins, September 2016, MDPI AG

    Dr Nicholas J Mantis

  24. Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge

    Article • Clinical and Vaccine Immunology, July 2016, ASM Journals

    Dr Nicholas J Mantis, Larry Zeitlin

  25. Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit

    Article • Proteins Structure Function and Bioinformatics, June 2016, Wiley

    Dr Nicholas J Mantis

  26. A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking

    Article • PLoS ONE, June 2016, PLOS

    Dr Nicholas J Mantis

  27. Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice

    Article • Journal of Pharmaceutical Sciences, May 2016, Elsevier

    Dr Nicholas J Mantis

  28. Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils

    Article • Journal of Leukocyte Biology, April 2016, Society for Leukocyte Biology

    Dr Nicholas J Mantis

  29. Progress and challenges associated with the development of ricin toxin subunit vaccines

    Article • Expert Review of Vaccines, April 2016, Informa Healthcare

    Dr Nicholas J Mantis

  30. Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin’s Enzymatic Subunit Interfere with Intracellular Toxin Transport

    Article • Scientific Reports, March 2016, Nature

    Dr Nicholas J Mantis

  31. Recent advances in the development of vaccines against ricin

    Article • Human Vaccines & Immunotherapeutics, January 2016, Taylor & Francis

    Dr Nicholas J Mantis

  32. Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance

    Article • PLoS ONE, December 2015, PLOS

    Dr Nicholas J Mantis

  33. Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer’s patches

    Article • Immunology Letters, November 2015, Elsevier

    Dr Nicholas J Mantis

  34. Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens

    Article • Clinical and Vaccine Immunology, October 2015, ASM Journals

    Dr Nicholas J Mantis

  35. Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies

    Article • Journal of Biological Chemistry, September 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Nicholas J Mantis, Dr. Charles B Shoemaker

  36. Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide

    Article • Journal of Immunological Methods, July 2015, Elsevier

    Dr Nicholas J Mantis

  37. Phenotypic Analysis of a Population of IgA+ Cells in the Follicle-Associated Epithelium of Mouse Peyer's Patches

    Article • PLoS ONE, April 2015, PLOS

    Dr Nicholas J Mantis

  38. Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection

    Article • Proceedings of the National Academy of Sciences, March 2015, Proceedings of the National Academy of Sciences

    Dr Nicholas J Mantis

  39. Rapid Effects of a Protective O-Polysaccharide-Specific Monoclonal IgA on Vibrio cholerae Agglutination, Motility, and Surface Morphology

    Article • Infection and Immunity, February 2015, ASM Journals

    Dr Nicholas J Mantis

  40. Glassy-State Stabilization of a Dominant Negative Inhibitor Anthrax Vaccine Containing Aluminum Hydroxide and Glycopyranoside Lipid A Adjuvants

    Article • Journal of Pharmaceutical Sciences, February 2015, Elsevier

    Dr Nicholas J Mantis, theodore Randolph

  41. Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

    Article • Vaccine, January 2015, Elsevier

    Dr Nicholas J Mantis

  42. Biological Activities of IgA

    Article • January 2015, Elsevier

    Professor Michael W Russell, Dr Nicholas J Mantis

  43. A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

    Article • Toxicon, December 2014, Elsevier

    Dr Nicholas J Mantis

  44. Oral Interleukin-10 Alleviates Polyposis via Neutralization of Pathogenic T-Regulatory Cells

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Dr Nicholas J Mantis

  45. Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies

    Article • Journal of Molecular Biology, August 2014, Elsevier

    Dr Nicholas J Mantis

  46. Mice Deficient in Intestinal Epithelium Cytochrome P450 Reductase are Prone to Acute Toxin-induced Mucosal Damage

    Article • Scientific Reports, July 2014, Springer Science + Business Media

    Dr Nicholas J Mantis

  47. Differential Neutralizing Activities of a Single Domain Camelid Antibody (VHH) Specific for Ricin Toxin’s Binding Subunit (RTB)

    Article • PLoS ONE, June 2014, PLOS

    Dr Nicholas J Mantis, Dr. Charles B Shoemaker

  48. Antibody-Mediated Inhibition of Ricin Toxin Retrograde Transport

    Article • mBio, April 2014, ASM Journals

    Dr Nicholas J Mantis

  49. A Population of Langerin-Positive Dendritic Cells in Murine Peyer's Patches Involved in Sampling β-Glucan Microparticles

    Article • PLoS ONE, March 2014, PLOS

    Dr Nicholas J Mantis

  50. Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA)

    Article • Immunology Letters, March 2014, Elsevier

    Dr Nicholas J Mantis

  51. Chimeric Plantibody Passively Protects Mice against Aerosolized Ricin Challenge

    Article • Clinical and Vaccine Immunology, February 2014, ASM Journals

    Dr Nicholas J Mantis

  52. Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin

    Article • Journal of Biological Chemistry, November 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Nicholas J Mantis, Dr. Charles B Shoemaker

  53. Three-Dimensional Reconstruction of Murine Peyer's Patches from Immunostained Cryosections

    Article • Microscopy and Microanalysis, November 2013, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  54. Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine

    Article • Human Vaccines & Immunotherapeutics, November 2013, Taylor & Francis

    Dr Nicholas J Mantis

  55. Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization

    Article • European Journal of Pharmaceutics and Biopharmaceutics, October 2013, Elsevier

    Dr Nicholas J Mantis

  56. Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro

    Article • Journal of Immunological Methods, September 2013, Elsevier

    Dr Nicholas J Mantis

  57. Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments

    Article • Toxicon, September 2013, Elsevier

    Dr Nicholas J Mantis

  58. LT-IIb(T13I), a Non-Toxic Type II Heat-Labile Enterotoxin, Augments the Capacity of a Ricin Toxin Subunit Vaccine to Evoke Neutralizing Antibodies and Protective Immunity

    Article • PLoS ONE, August 2013, PLOS

    Dr Nicholas J Mantis, Professor Casey Greene

  59. Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

    Article • Human Vaccines & Immunotherapeutics, April 2013, Taylor & Francis

    Dr Nicholas J Mantis

  60. Comparative Efficacy of Two Leading Candidate Ricin Toxin A Subunit Vaccines in Mice

    Article • Clinical and Vaccine Immunology, March 2013, ASM Journals

    Dr Nicholas J Mantis

  61. High‐Throughput, Cell‐Based Screens to Identify Small‐Molecule Inhibitors of Ricin Toxin and Related Category B Ribosome Inactivating Proteins (RIPs)

    Article • Current Protocols in Toxicology, February 2013, Wiley

    Dr Nicholas J Mantis

  62. Exposure of Salmonella enterica Serovar Typhimurium to a Protective Monoclonal IgA Triggers Exopolysaccharide Production via a Diguanylate Cyclase-Dependent Pathway

    Article • Infection and Immunity, December 2012, ASM Journals

    Dr Nicholas J Mantis

  63. Identification of Small Molecules That Suppress Ricin-Induced Stress-Activated Signaling Pathways

    Article • PLoS ONE, November 2012, PLOS

    Dr Nicholas J Mantis

  64. Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit

    Article • Toxicon, October 2012, Elsevier

    Dr Nicholas J Mantis

  65. FRUIT, a Scar-Free System for Targeted Chromosomal Mutagenesis, Epitope Tagging, and Promoter Replacement in Escherichia coli and Salmonella enterica

    Article • PLoS ONE, September 2012, PLOS

    Dr Nicholas J Mantis

  66. Sub-Domains of Ricin’s B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies

    Article • PLoS ONE, September 2012, PLOS

    Dr Nicholas J Mantis

  67. Association of a Protective Monoclonal IgA with the O Antigen of Salmonella enterica Serovar Typhimurium Impacts Type 3 Secretion and Outer Membrane Integrity

    Article • Infection and Immunity, April 2012, ASM Journals

    Dr Nicholas J Mantis

  68. Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit

    Article • Vaccine, February 2012, Elsevier

    Dr Nicholas J Mantis

  69. Rediscovering IgA

    Article • Mucosal Immunology, October 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  70. Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut

    Article • Mucosal Immunology, October 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  71. Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB)

    Article • Vaccine, October 2011, Elsevier

    Dr Nicholas J Mantis

  72. Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin

    Article • Toxins, September 2011, MDPI AG

    Dr Nicholas J Mantis

  73. Transient Suppression of Shigella flexneri Type 3 Secretion by a Protective O-Antigen-Specific Monoclonal IgA

    Article • mBio, May 2011, ASM Journals

    Dr Nicholas J Mantis

  74. Vaccine-induced intestinal immunity to ricin toxin in the absence of secretory IgA

    Article • Vaccine, January 2011, Elsevier

    Dr Nicholas J Mantis

  75. Small-Molecule Inhibitors of Ricin and Shiga Toxins

    Article • January 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  76. Mucosal Vaccines for Biodefense

    Article • January 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  77. Immunity to Ricin: Fundamental Insights into Toxin–Antibody Interactions

    Article • January 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  78. Folding domains within the ricin toxin A subunit as targets of protective antibodies

    Article • Vaccine, October 2010, Elsevier

    Dr Nicholas J Mantis

  79. Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

    Article • Toxicon, September 2010, Elsevier

    Dr Nicholas J Mantis

  80. Identification of new classes of ricin toxin inhibitors by virtual screening

    Article • Toxicon, September 2010, Elsevier

    Dr Nicholas J Mantis

  81. Recognition of secretory IgA by DC-SIGN: Implications for immune surveillance in the intestine

    Article • Immunology Letters, June 2010, Elsevier

    Dr Nicholas J Mantis

  82. Secretory IgA: Arresting Microbial Pathogens at Epithelial Borders

    Article • Immunological Investigations, January 2010, Taylor & Francis

    Dr Nicholas J Mantis

  83. A Monoclonal Immunoglobulin G Antibody Directed against an Immunodominant Linear Epitope on the Ricin A Chain Confers Systemic and Mucosal Immunity to Ricin

    Article • Infection and Immunity, October 2009, ASM Journals

    Dr Nicholas J Mantis

  84. Neutralizing Monoclonal Antibodies Directed against Defined Linear Epitopes on Domain 4 of Anthrax Protective Antigen

    Article • Infection and Immunity, August 2009, ASM Journals

    Dr Nicholas J Mantis

  85. RicinA Type II Ribosome-Inactivating Protein

    Article • January 2009, Elsevier

    Dr Nicholas J Mantis

  86. Inhibition of Salmonella enterica Serovar Typhimurium Motility and Entry into Epithelial Cells by a Protective Antilipopolysaccharide Monoclonal Immunoglobulin A Antibody

    Article • Infection and Immunity, July 2008, ASM Journals

    Dr Nicholas J Mantis

  87. Evidence for Widespread Epithelial Damage and Coincident Production of Monocyte Chemotactic Protein 1 in a Murine Model of Intestinal Ricin Intoxication

    Article • Infection and Immunity, February 2007, ASM Journals

    Dr Nicholas J Mantis

  88. IgA and Antigen Sampling

    Article • January 2007, Springer Science + Business Media

    Dr Nicholas J Mantis

  89. Characterization of a Novel High-Affinity Monoclonal Immunoglobulin G Antibody against the Ricin B Subunit

    Article • Infection and Immunity, June 2006, ASM Journals

    Dr Nicholas J Mantis

  90. Immunoglobulin A Antibodies against Ricin A and B Subunits Protect Epithelial Cells from Ricin Intoxication

    Article • Infection and Immunity, June 2006, ASM Journals

    Dr Nicholas J Mantis

  91. Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway

    Article • Molecular Immunology, April 2006, Elsevier

    Dr Nicholas J Mantis

  92. Vaccines against the category B toxins: Staphylococcal enterotoxin B, epsilon toxin and ricin

    Article • Advanced Drug Delivery Reviews, June 2005, Elsevier

    Dr Nicholas J Mantis

  93. Analysis of Adhesion Molecules Involved in Leukocyte Homing into the Basolateral Pockets of Mouse Peyer's Patch M Cells

    Article • Journal of Drug Targeting, February 2004, Taylor & Francis

    Dr Nicholas J Mantis

  94. The Viral σ1 Protein and Glycoconjugates Containing α2-3-Linked Sialic Acid Are Involved in Type 1 Reovirus Adherence to M Cell Apical Surfaces

    Article • Journal of Virology, July 2003, ASM Journals

    Dr Nicholas J Mantis

  95. Collaboration of epithelial cells with organized mucosal lymphoid tissues

    Article • Nature Immunology, November 2001, Springer Science + Business Media

    Dr Nicholas J Mantis

  96. Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretory IgA antibodies

    Article • Vaccine, July 2001, Elsevier

    Dr Nicholas J Mantis

  97. Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles

    Article • Vaccine, August 1999, Elsevier

    Dr Nicholas J Mantis

  98. The composition and function of M cell apical membranes: Implications for microbial pathogenesis

    Article • Seminars in Immunology, June 1999, Elsevier

    Dr Nicholas J Mantis

  99. The

    Article • MGG Molecular & General Genetics, January 1996, Springer Science + Business Media

    Dr Nicholas J Mantis

  100. Host recognition by the VirA, VirG two-component regulatory proteins of Agrobacterium tumefaciens

    Article • Research in Microbiology, January 1994, Elsevier

    Dr Nicholas J Mantis

  101. The Intestinal Epithelium: The Interface Between Host and Pathogen

    Article • Springer Science + Business Media

    Dr Nicholas J Mantis