All Stories

  1. OspA Antibodies Inhibit the In vitro Transmigration of Borreliellia burgdorferi

    Article • November 2025, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  2. A Salmonella enterica serovar Typhimurium genome-wide CRISPRi screen reveals a role for type 1 fimbriae in evasion of antibody-mediated agglutination

    Article • Infection and Immunity, May 2025, ASM Journals

    Dr Nicholas J Mantis

  3. Inter-laboratory harmonization of microsphere immunoassays for SARS-CoV-2 antibody detection in contrived dried blood spots and oral fluids

    Article • Microbiology Spectrum, May 2025, ASM Journals

    Dr Nicholas J Mantis

  4. Maternal transfer of mRNA LNP-derived, pathogen-specific, monoclonal IgG to suckling mice

    Article • March 2025, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  5. A Refined Human Linear B Cell Epitope Map of Outer Surface Protein C (OspC) From the Lyme Disease Spirochete, Borrelia burgdorferi

    Article • Pathogens and Immunity, February 2025, Case Western Reserve University

    Dr Nicholas J Mantis

  6. PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse immunogenicity studies

    Article • Human Vaccines & Immunotherapeutics, February 2025, Taylor & Francis

    Dr Nicholas J Mantis

  7. ASalmonella entericaserovar Typhimurium Genome-wide CRISPRi Screen Reveals a Role for Type 1 Fimbriae in Evasion of Antibody-Mediated Agglutination

    Article • December 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  8. Quantitating SARS-CoV-2 neutralizing antibodies from human dried blood spots

    Article • Microbiology Spectrum, December 2024, ASM Journals

    Dr Nicholas J Mantis

  9. A type-specific B cell epitope at the apex of Outer surface protein C (OspC) of the Lyme disease spirochete,Borreliella burgdorferi

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  10. Antibody Profiles Elicited by Potent and Subpotent Whole Cell Pertussis Vaccines in Mice

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  11. Inter-laboratory harmonization of microsphere immunoassays for SARS-CoV-2 antibody detection in dried blood spots and oral fluids

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  12. A Biparatopic Intrabody Renders Vero Cells Impervious to Ricin Intoxication

    Article • Biochemistry, September 2024, American Chemical Society (ACS)

    Dr Nicholas J Mantis

  13. Structure of a Human Monoclonal Antibody in Complex with Outer Surface Protein C of the Lyme Disease Spirochete, Borreliella burgdorferi

    Article • The Journal of Immunology, September 2024, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  14. A Biparatopic Intrabody Renders Vero Cells Impervious to Ricin Intoxication

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  15. Evaluating the Compatibility of New Recombinant Protein Antigens (Trivalent NRRV) with a Mock Pentavalent Combination Vaccine Containing Whole-Cell Pertussis: Analytical and Formulation Challenges

    Article • Vaccines, June 2024, MDPI AG

    Dr Nicholas J Mantis

  16. A refined human linear B cell epitope map of Outer surface protein C (OspC) from the Lyme disease spirochete,Borreliella burgdorferi

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  17. Inflammatory Profiles Induced by Intranasal Immunization with Ricin Toxin-immune Complexes

    Article • ImmunoHorizons, June 2024, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  18. Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete,Borreliella burgdorferi

    Article • April 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  19. Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA)

    Article • Infection and Immunity, April 2024, ASM Journals

    Dr Nicholas J Mantis

  20. Quantitating SARS-CoV-2 Neutralizing Antibodies from Human Dried Blood Spots

    Article • March 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  21. Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study

    Article • Nature Communications, February 2024, Springer Science + Business Media

    Dr Nicholas J Mantis

  22. Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  23. Clinical Assessment of SARS-CoV-2 Antibodies in Oral Fluids Following Infection and Vaccination

    Article • Clinical Chemistry, December 2023, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  24. The 2022 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference: Summary of breakout workshops

    Article • Vaccine, November 2023, Elsevier

    Dr Kurt Hanevik, Dr Nicholas J Mantis

  25. An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions

    Article • Cell Reports Medicine, November 2023, Elsevier

    Dr Nicholas J Mantis

  26. Structural Basis of Antibody-Mediated Inhibition of Ricin Toxin Attachment to Host Cells

    Article • Biochemistry, October 2023, American Chemical Society (ACS)

    Dr Nicholas J Mantis

  27. Clinical Utility of SARS-CoV-2 Serological Testing and Defining a Correlate of Protection

    Article • Vaccines, October 2023, MDPI AG

    Dr Nicholas J Mantis

  28. Inflammatory Profiles Induced following Intranasal Vaccination with Ricin Toxin-Immune Complexes

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  29. Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

    Article • Human Vaccines & Immunotherapeutics, August 2023, Taylor & Francis

    Dr Nicholas J Mantis

  30. The SeroNet Clinical and Translational Serology Task Force (CTTF) SARS-CoV-2 mucosal immunity methodological considerations and best practices workshop

    Article • Human Vaccines & Immunotherapeutics, August 2023, Taylor & Francis

    Dr Nicholas J Mantis

  31. An ancillary carbohydrate recognition domain on ricin toxin's B subunit is the target of receptor-blocking, neutralizing monoclonal antibodies

    Article • July 2023, Wiley

    Dr Nicholas J Mantis

  32. Structure of a transmission blocking antibody in complex with Outer surface protein A from the Lyme disease spirochete, Borreliella burgdorferi

    Article • Proteins Structure Function and Bioinformatics, July 2023, Wiley

    Dr Nicholas J Mantis

  33. Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  34. Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018TM Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen

    Article • Vaccines, May 2023, MDPI AG

    Dr Nicholas J Mantis

  35. Flagellar-based motility accelerates IgA-mediated agglutination of Salmonella Typhimurium at high bacterial cell densities

    Article • Frontiers in Immunology, May 2023, Frontiers

    Dr Nicholas J Mantis

  36. Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi

    Article • mBio, April 2023, ASM Journals

    Dr Nicholas J Mantis

  37. mRNA delivery of dimeric human IgA protects mucosal tissues from bacterial infection

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  38. An mRNA-Based Platform for the Delivery of Pathogen-Specific IgA into Mucosal Secretions

    Article • January 2023, Elsevier

    Dr Nicholas J Mantis

  39. Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques

    Article • npj Vaccines, December 2022, Springer Science + Business Media

    Dr Nicholas J Mantis

  40. High-Throughput Epitope Mapping by Hydrogen Exchange-Mass Spectrometry

    Article • Journal of the American Society for Mass Spectrometry, November 2022, American Chemical Society (ACS)

    Dr Nicholas J Mantis

  41. Structural Elucidation of a Protective B cell Epitope on Outer Surface Protein C (OspC) of the Lyme disease spirochete,Borreliella burgdorferi

    Article • November 2022, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  42. Human B Cell Epitope Map of the Lyme Disease Vaccine Antigen, OspA

    Article • ACS Infectious Diseases, November 2022, American Chemical Society (ACS)

    Dr Nicholas J Mantis

  43. Agglutination of Borreliella burgdorferi by Transmission-Blocking OspA Monoclonal Antibodies and Monovalent Fab Fragments

    Article • Infection and Immunity, September 2022, ASM Journals

    Dr Nicholas J Mantis

  44. Gut microbiome and breast-feeding: Implications for early immune development

    Article • Journal of Allergy and Clinical Immunology, September 2022, Elsevier

    Dr Nicholas J Mantis

  45. Serological Analysis Identifies Consequential B Cell Epitopes on the Flexible Linker and C-Terminus of Decorin Binding Protein A (DbpA) from Borrelia burgdorferi

    Article • mSphere, August 2022, ASM Journals

    Dr Nicholas J Mantis

  46. Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids

    Article • Infection and Immunity, June 2022, ASM Journals

    Dr Nicholas J Mantis

  47. Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

    Article • Human Vaccines & Immunotherapeutics, June 2022, Taylor & Francis

    Dr Nicholas J Mantis

  48. Durable Immunity to Ricin Toxin Elicited by Intranasally Administered Monoclonal Antibody–Based Immune Complexes

    Article • ImmunoHorizons, June 2022, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  49. Editorial: Mucosal Vaccination: Strategies to Induce and Evaluate Mucosal Immunity

    Article • Frontiers in Immunology, April 2022, Frontiers

    Dr Nicholas J Mantis

  50. Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies

    Article • Open Forum Infectious Diseases, April 2022, Oxford University Press (OUP)

    Robert Hagan, Dr Nicholas J Mantis

  51. Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins

    Article • Journal of Biological Chemistry, April 2022, Elsevier

    Dr Nicholas J Mantis

  52. The Flexible Linker of Decorin Binding Protein A from Borrelia burgdorferi is a Target of Antibodies in Lyme disease

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  53. Neutralization of Typhoid Toxin by Alpaca-Derived, Single-Domain Antibodies Targeting the PltB and CdtB Subunits

    Article • Infection and Immunity, February 2022, ASM Journals

    Dr Nicholas J Mantis

  54. Necroptosis of Lung Epithelial Cells Triggered by Ricin Toxin and Bystander Inflammation

    Article • Cellular Physiology and Biochemistry, January 2022, Cell Physiol Biochem Press GmbH and Co KG

    Dr Nicholas J Mantis

  55. Single-Domain Antibodies for Intracellular Toxin Neutralization

    Article • January 2022, Springer Science + Business Media

    Dr Nicholas J Mantis

  56. Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine

    Article • mSphere, December 2021, ASM Journals

    Dr Nicholas J Mantis

  57. Estimating Vaccine Potency Using Antibody-Based Competition Assays

    Article • December 2021, Springer Science + Business Media

    Dr Nicholas J Mantis

  58. Salmonella Uptake into Gut-Associated Lymphoid Tissues: Implications for Targeted Mucosal Vaccine Design and Delivery

    Article • December 2021, Springer Science + Business Media

    Dr Nicholas J Mantis

  59. Differential ER stress as a driver of cell fate following ricin toxin exposure

    Article • FASEB BioAdvances, October 2021, Wiley

    Dr Nicholas J Mantis

  60. Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine

    Article • September 2021, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  61. The prospect of orally administered monoclonal secretory IgA (SIgA) antibodies to prevent enteric bacterial infections

    Article • Human Vaccines & Immunotherapeutics, September 2021, Taylor & Francis

    Dr Nicholas J Mantis

  62. The structural basis of Salmonella A2B5 toxin neutralization by antibodies targeting the glycan-receptor binding subunits

    Article • Cell Reports, September 2021, Elsevier

    Dr Nicholas J Mantis

  63. Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity

    Article • Cell Reports Medicine, July 2021, Elsevier

    Dr Nicholas J Mantis

  64. Structural Analysis of Toxin-Neutralizing, Single-Domain Antibodies that Bridge Ricin’s A-B Subunit Interface

    Article • Journal of Molecular Biology, July 2021, Elsevier

    Dr Nicholas J Mantis

  65. Blocking Borrelia burgdorferi transmission from infected ticks to nonhuman primates with a human monoclonal antibody

    Article • Journal of Clinical Investigation, June 2021, American Society for Clinical Investigation

    Dr Nicholas J Mantis

  66. Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits

    Article • iScience, May 2021, Elsevier

    Dr Nicholas J Mantis

  67. Recombinant Human Secretory IgA Induces Salmonella Typhimurium Agglutination and Limits Bacterial Invasion into Gut-Associated Lymphoid Tissues

    Article • ACS Infectious Diseases, March 2021, American Chemical Society (ACS)

    Dr Nicholas J Mantis

  68. Slaying SARS-CoV-2 One (Single-domain) Antibody at a Time

    Article • Trends in Microbiology, March 2021, Elsevier

    Dr Nicholas J Mantis

  69. Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis

    Article • Nature Microbiology, January 2021, Springer Science + Business Media

    Dr Nicholas J Mantis

  70. Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  71. Sensitization of Airway Epithelial Cells to Toxin-Induced Death by TNF Superfamily Cytokines

    Article • November 2020, Springer Science + Business Media

    Dr Nicholas J Mantis

  72. Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies

    Article • PLOS One, November 2020, PLOS

    Dr Nicholas J Mantis

  73. Potency determination of ricin toxin using a monoclonal antibody-based competition assay

    Article • Journal of Immunological Methods, November 2020, Elsevier

    Dr Nicholas J Mantis

  74. Serological Analysis Reveals an Imbalanced IgG Subclass Composition Associated with COVID-19 Disease Severity

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  75. Endpoint and epitope-specific antibody responses as correlates of vaccine-mediated protection of mice against ricin toxin

    Article • Vaccine, October 2020, Elsevier

    Dr Nicholas J Mantis

  76. Sites of Vulnerability on Ricin B Chain Revealed through Epitope Mapping of Toxin-Neutralizing Monoclonal Antibodies

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  77. Transcriptional profiling of Vibrio cholerae O1 following exposure to human anti- lipopolysaccharide monoclonal antibodies

    Article • Pathogens and Disease, June 2020, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  78. Endpoint and Epitope-specific Antibody Responses as Correlates of Vaccine-mediated Protection of Mice against Ricin Toxin

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  79. Passive Immunity to <em>Vibrio cholerae</em> O1 Afforded by a Human Monoclonal IgA1 Antibody Expressed in Milk

    Article • Pathogens and Immunity, May 2020, Case Western Reserve University

    Dr Nicholas J Mantis

  80. The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease

    Article • Infection and Immunity, April 2020, ASM Journals

    Dr Nicholas J Mantis

  81. A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication

    Article • Toxins, March 2020, MDPI AG

    Dr Nicholas J Mantis

  82. Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies

    Article • PLoS Neglected Tropical Diseases, March 2020, PLOS

    Dr Nicholas J Mantis

  83. Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin

    Article • npj Vaccines, February 2020, Springer Science + Business Media

    Dr Nicholas J Mantis

  84. Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site

    Article • Journal of Molecular Biology, February 2020, Elsevier

    Dr Nicholas J Mantis

  85. Mechanisms of Typhoid Toxin Neutralization by Antibodies Targeting Receptor-Binding and Nuclease Subunits

    Article • SSRN Electronic Journal, January 2020, Elsevier

    Dr Nicholas J Mantis

  86. The Structural Basis of Salmonella A <sub>2</sub>B <sub>5</sub> Neutralization by Antibodies Targeting the Glycan-Receptor Binding Subunits

    Article • SSRN Electronic Journal, January 2020, Elsevier

    Dr Nicholas J Mantis

  87. An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation

    Article • Human Vaccines & Immunotherapeutics, October 2019, Taylor & Francis

    Dr Nicholas J Mantis

  88. Intracellular Neutralization of Ricin Toxin by Single Domain Antibodies Targeting the Active Site Pocket

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  89. Inhibition of Invasive Salmonella by Orally Administered IgA and IgG Monoclonal Antibodies

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  90. TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin

    Article • Toxins, August 2019, MDPI AG

    Dr Nicholas J Mantis

  91. Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin–Ab complexes

    Article • Journal of Leukocyte Biology, July 2019, Wiley

    Dr Nicholas J Mantis

  92. Rescue of rhesus macaques from the lethality of aerosolized ricin toxin

    Article • JCI Insight, January 2019, American Society for Clinical Investigation

    Dr Nicholas J Mantis

  93. A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site

    Article • Antibodies, December 2018, MDPI AG

    Dr Nicholas J Mantis

  94. TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death

    Article • mSphere, September 2018, ASM Journals

    Dr Nicholas J Mantis

  95. A Humanized Monoclonal Antibody against the Enzymatic Subunit of Ricin Toxin Rescues Rhesus macaques from the Lethality of Aerosolized Ricin

    Article • September 2018, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  96. Biomedical Applications of Lumazine Synthase

    Article • Journal of Pharmaceutical Sciences, September 2018, Elsevier

    Dr Nicholas J Mantis

  97. Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine

    Article • Vaccine, September 2018, Elsevier

    Dr Nicholas J Mantis

  98. Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

    Article • ImmunoHorizons, September 2018, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  99. Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity

    Article • Protein Engineering Design and Selection, July 2018, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  100. Fine Specificity Epitope Analysis by HX-MS Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

    Article • June 2018, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  101. TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Nicholas J Mantis

  102. Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication

    Article • Human Vaccines & Immunotherapeutics, April 2018, Taylor & Francis

    Dr Nicholas J Mantis

  103. Vibrio cholerae O1 secretes an extracellular matrix in response to antibody-mediated agglutination

    Article • PLOS One, January 2018, PLOS

    Dr Nicholas J Mantis

  104. A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits

    Article • Toxins, November 2017, MDPI AG

    Dr Nicholas J Mantis

  105. High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine

    Article • Clinical and Vaccine Immunology, October 2017, ASM Journals

    Dr Nicholas J Mantis

  106. High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin

    Article • Clinical and Vaccine Immunology, October 2017, ASM Journals

    Dr Nicholas J Mantis

  107. Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display

    Article • Protein Science, September 2017, Wiley

    Dr Nicholas J Mantis

  108. Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies

    Article • Proteins Structure Function and Bioinformatics, August 2017, Wiley

    Dr Nicholas J Mantis

  109. Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin’s binding subunit

    Article • PLOS One, July 2017, PLOS

    Dr Nicholas J Mantis

  110. Structural analysis of single domain antibodies bound to a second neutralizing hot spot on ricin toxin's enzymatic subunit

    Article • Journal of Biological Chemistry, November 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Nicholas J Mantis

  111. super-resolution

    Article • Microscopy and Microanalysis, November 2016, Cambridge University Press

    Prof Richard Cole, Dr Nicholas J Mantis

  112. A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes

    Article • Vaccine, November 2016, Elsevier

    Dr Nicholas J Mantis

  113. A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

    Article • Toxins, September 2016, MDPI AG

    Dr Nicholas J Mantis

  114. Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge

    Article • Clinical and Vaccine Immunology, July 2016, ASM Journals

    Dr Nicholas J Mantis, Larry Zeitlin

  115. Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit

    Article • Proteins Structure Function and Bioinformatics, June 2016, Wiley

    Dr Nicholas J Mantis

  116. A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking

    Article • PLOS One, June 2016, PLOS

    Dr Nicholas J Mantis

  117. Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice

    Article • Journal of Pharmaceutical Sciences, May 2016, Elsevier

    Dr Nicholas J Mantis

  118. Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils

    Article • Journal of Leukocyte Biology, April 2016, Society for Leukocyte Biology

    Dr Nicholas J Mantis

  119. Progress and challenges associated with the development of ricin toxin subunit vaccines

    Article • Expert Review of Vaccines, April 2016, Informa Healthcare

    Dr Nicholas J Mantis

  120. Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin’s Enzymatic Subunit Interfere with Intracellular Toxin Transport

    Article • Scientific Reports, March 2016, Nature

    Dr Nicholas J Mantis

  121. Recent advances in the development of vaccines against ricin

    Article • Human Vaccines & Immunotherapeutics, January 2016, Taylor & Francis

    Dr Nicholas J Mantis

  122. Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance

    Article • PLOS One, December 2015, PLOS

    Dr Nicholas J Mantis

  123. Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer’s patches

    Article • Immunology Letters, November 2015, Elsevier

    Dr Nicholas J Mantis

  124. Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens

    Article • Clinical and Vaccine Immunology, October 2015, ASM Journals

    Dr Nicholas J Mantis

  125. Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies

    Article • Journal of Biological Chemistry, September 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Nicholas J Mantis, Dr. Charles B Shoemaker

  126. Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide

    Article • Journal of Immunological Methods, July 2015, Elsevier

    Dr Nicholas J Mantis

  127. Phenotypic Analysis of a Population of IgA+ Cells in the Follicle-Associated Epithelium of Mouse Peyer's Patches

    Article • PLOS One, April 2015, PLOS

    Dr Nicholas J Mantis

  128. Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection

    Article • Proceedings of the National Academy of Sciences, March 2015, Proceedings of the National Academy of Sciences

    Dr Nicholas J Mantis

  129. Rapid Effects of a Protective O-Polysaccharide-Specific Monoclonal IgA on Vibrio cholerae Agglutination, Motility, and Surface Morphology

    Article • Infection and Immunity, February 2015, ASM Journals

    Dr Nicholas J Mantis

  130. Glassy-State Stabilization of a Dominant Negative Inhibitor Anthrax Vaccine Containing Aluminum Hydroxide and Glycopyranoside Lipid A Adjuvants

    Article • Journal of Pharmaceutical Sciences, February 2015, Elsevier

    Dr Nicholas J Mantis, theodore Randolph

  131. Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

    Article • Vaccine, January 2015, Elsevier

    Dr Nicholas J Mantis

  132. Biological Activities of IgA

    Article • January 2015, Elsevier

    Professor Michael W Russell, Dr Nicholas J Mantis

  133. A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

    Article • Toxicon, December 2014, Elsevier

    Dr Nicholas J Mantis

  134. Oral Interleukin-10 Alleviates Polyposis via Neutralization of Pathogenic T-Regulatory Cells

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Dr Nicholas J Mantis

  135. Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies

    Article • Journal of Molecular Biology, August 2014, Elsevier

    Dr Nicholas J Mantis

  136. Mice Deficient in Intestinal Epithelium Cytochrome P450 Reductase are Prone to Acute Toxin-induced Mucosal Damage

    Article • Scientific Reports, July 2014, Springer Science + Business Media

    Dr Nicholas J Mantis

  137. Differential Neutralizing Activities of a Single Domain Camelid Antibody (VHH) Specific for Ricin Toxin’s Binding Subunit (RTB)

    Article • PLOS One, June 2014, PLOS

    Dr Nicholas J Mantis, Dr. Charles B Shoemaker

  138. Antibody-Mediated Inhibition of Ricin Toxin Retrograde Transport

    Article • mBio, April 2014, ASM Journals

    Dr Nicholas J Mantis

  139. A Population of Langerin-Positive Dendritic Cells in Murine Peyer's Patches Involved in Sampling β-Glucan Microparticles

    Article • PLOS One, March 2014, PLOS

    Dr Nicholas J Mantis

  140. Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA)

    Article • Immunology Letters, March 2014, Elsevier

    Dr Nicholas J Mantis

  141. Chimeric Plantibody Passively Protects Mice against Aerosolized Ricin Challenge

    Article • Clinical and Vaccine Immunology, February 2014, ASM Journals

    Dr Nicholas J Mantis

  142. Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin

    Article • Journal of Biological Chemistry, November 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Nicholas J Mantis, Dr. Charles B Shoemaker

  143. Three-Dimensional Reconstruction of Murine Peyer's Patches from Immunostained Cryosections

    Article • Microscopy and Microanalysis, November 2013, Oxford University Press (OUP)

    Dr Nicholas J Mantis

  144. Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine

    Article • Human Vaccines & Immunotherapeutics, November 2013, Taylor & Francis

    Dr Nicholas J Mantis

  145. Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization

    Article • European Journal of Pharmaceutics and Biopharmaceutics, October 2013, Elsevier

    Dr Nicholas J Mantis

  146. Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro

    Article • Journal of Immunological Methods, September 2013, Elsevier

    Dr Nicholas J Mantis

  147. Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments

    Article • Toxicon, September 2013, Elsevier

    Dr Nicholas J Mantis

  148. LT-IIb(T13I), a Non-Toxic Type II Heat-Labile Enterotoxin, Augments the Capacity of a Ricin Toxin Subunit Vaccine to Evoke Neutralizing Antibodies and Protective Immunity

    Article • PLOS One, August 2013, PLOS

    Dr Nicholas J Mantis, Professor Casey Greene

  149. Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

    Article • Human Vaccines & Immunotherapeutics, April 2013, Taylor & Francis

    Dr Nicholas J Mantis

  150. Comparative Efficacy of Two Leading Candidate Ricin Toxin A Subunit Vaccines in Mice

    Article • Clinical and Vaccine Immunology, March 2013, ASM Journals

    Dr Nicholas J Mantis

  151. High‐Throughput, Cell‐Based Screens to Identify Small‐Molecule Inhibitors of Ricin Toxin and Related Category B Ribosome Inactivating Proteins (RIPs)

    Article • Current Protocols in Toxicology, February 2013, Wiley

    Dr Nicholas J Mantis

  152. Exposure of Salmonella enterica Serovar Typhimurium to a Protective Monoclonal IgA Triggers Exopolysaccharide Production via a Diguanylate Cyclase-Dependent Pathway

    Article • Infection and Immunity, December 2012, ASM Journals

    Dr Nicholas J Mantis

  153. Identification of Small Molecules That Suppress Ricin-Induced Stress-Activated Signaling Pathways

    Article • PLOS One, November 2012, PLOS

    Dr Nicholas J Mantis

  154. Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit

    Article • Toxicon, October 2012, Elsevier

    Dr Nicholas J Mantis

  155. FRUIT, a Scar-Free System for Targeted Chromosomal Mutagenesis, Epitope Tagging, and Promoter Replacement in Escherichia coli and Salmonella enterica

    Article • PLOS One, September 2012, PLOS

    Dr Nicholas J Mantis

  156. Sub-Domains of Ricin’s B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies

    Article • PLOS One, September 2012, PLOS

    Dr Nicholas J Mantis

  157. Association of a Protective Monoclonal IgA with the O Antigen of Salmonella enterica Serovar Typhimurium Impacts Type 3 Secretion and Outer Membrane Integrity

    Article • Infection and Immunity, April 2012, ASM Journals

    Dr Nicholas J Mantis

  158. Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit

    Article • Vaccine, February 2012, Elsevier

    Dr Nicholas J Mantis

  159. Rediscovering IgA

    Article • Mucosal Immunology, October 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  160. Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut

    Article • Mucosal Immunology, October 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  161. Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB)

    Article • Vaccine, October 2011, Elsevier

    Dr Nicholas J Mantis

  162. Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin

    Article • Toxins, September 2011, MDPI AG

    Dr Nicholas J Mantis

  163. Transient Suppression of Shigella flexneri Type 3 Secretion by a Protective O-Antigen-Specific Monoclonal IgA

    Article • mBio, May 2011, ASM Journals

    Dr Nicholas J Mantis

  164. Vaccine-induced intestinal immunity to ricin toxin in the absence of secretory IgA

    Article • Vaccine, January 2011, Elsevier

    Dr Nicholas J Mantis

  165. Small-Molecule Inhibitors of Ricin and Shiga Toxins

    Article • January 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  166. Mucosal Vaccines for Biodefense

    Article • January 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  167. Immunity to Ricin: Fundamental Insights into Toxin–Antibody Interactions

    Article • January 2011, Springer Science + Business Media

    Dr Nicholas J Mantis

  168. Folding domains within the ricin toxin A subunit as targets of protective antibodies

    Article • Vaccine, October 2010, Elsevier

    Dr Nicholas J Mantis

  169. Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

    Article • Toxicon, September 2010, Elsevier

    Dr Nicholas J Mantis

  170. Identification of new classes of ricin toxin inhibitors by virtual screening

    Article • Toxicon, September 2010, Elsevier

    Dr Nicholas J Mantis

  171. Recognition of secretory IgA by DC-SIGN: Implications for immune surveillance in the intestine

    Article • Immunology Letters, June 2010, Elsevier

    Dr Nicholas J Mantis

  172. Secretory IgA: Arresting Microbial Pathogens at Epithelial Borders

    Article • Immunological Investigations, January 2010, Taylor & Francis

    Dr Nicholas J Mantis

  173. A Monoclonal Immunoglobulin G Antibody Directed against an Immunodominant Linear Epitope on the Ricin A Chain Confers Systemic and Mucosal Immunity to Ricin

    Article • Infection and Immunity, October 2009, ASM Journals

    Dr Nicholas J Mantis

  174. Neutralizing Monoclonal Antibodies Directed against Defined Linear Epitopes on Domain 4 of Anthrax Protective Antigen

    Article • Infection and Immunity, August 2009, ASM Journals

    Dr Nicholas J Mantis

  175. RicinA Type II Ribosome-Inactivating Protein

    Article • January 2009, Elsevier

    Dr Nicholas J Mantis

  176. Inhibition of Salmonella enterica Serovar Typhimurium Motility and Entry into Epithelial Cells by a Protective Antilipopolysaccharide Monoclonal Immunoglobulin A Antibody

    Article • Infection and Immunity, July 2008, ASM Journals

    Dr Nicholas J Mantis

  177. Evidence for Widespread Epithelial Damage and Coincident Production of Monocyte Chemotactic Protein 1 in a Murine Model of Intestinal Ricin Intoxication

    Article • Infection and Immunity, February 2007, ASM Journals

    Dr Nicholas J Mantis

  178. IgA and Antigen Sampling

    Article • January 2007, Springer Science + Business Media

    Dr Nicholas J Mantis

  179. Characterization of a Novel High-Affinity Monoclonal Immunoglobulin G Antibody against the Ricin B Subunit

    Article • Infection and Immunity, June 2006, ASM Journals

    Dr Nicholas J Mantis

  180. Immunoglobulin A Antibodies against Ricin A and B Subunits Protect Epithelial Cells from Ricin Intoxication

    Article • Infection and Immunity, June 2006, ASM Journals

    Dr Nicholas J Mantis

  181. Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway

    Article • Molecular Immunology, April 2006, Elsevier

    Dr Nicholas J Mantis

  182. Vaccines against the category B toxins: Staphylococcal enterotoxin B, epsilon toxin and ricin

    Article • Advanced Drug Delivery Reviews, June 2005, Elsevier

    Dr Nicholas J Mantis

  183. Analysis of Adhesion Molecules Involved in Leukocyte Homing into the Basolateral Pockets of Mouse Peyer's Patch M Cells

    Article • Journal of Drug Targeting, February 2004, Taylor & Francis

    Dr Nicholas J Mantis

  184. The Viral σ1 Protein and Glycoconjugates Containing α2-3-Linked Sialic Acid Are Involved in Type 1 Reovirus Adherence to M Cell Apical Surfaces

    Article • Journal of Virology, July 2003, ASM Journals

    Dr Nicholas J Mantis

  185. Collaboration of epithelial cells with organized mucosal lymphoid tissues

    Article • Nature Immunology, November 2001, Springer Science + Business Media

    Dr Nicholas J Mantis

  186. Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretory IgA antibodies

    Article • Vaccine, July 2001, Elsevier

    Dr Nicholas J Mantis

  187. Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles

    Article • Vaccine, August 1999, Elsevier

    Dr Nicholas J Mantis

  188. The composition and function of M cell apical membranes: Implications for microbial pathogenesis

    Article • Seminars in Immunology, June 1999, Elsevier

    Dr Nicholas J Mantis

  189. The

    Article • MGG Molecular & General Genetics, January 1996, Springer Science + Business Media

    Dr Nicholas J Mantis

  190. Host recognition by the VirA, VirG two-component regulatory proteins of Agrobacterium tumefaciens

    Article • Research in Microbiology, January 1994, Elsevier

    Dr Nicholas J Mantis

  191. The Intestinal Epithelium: The Interface Between Host and Pathogen

    Article • Springer Science + Business Media

    Dr Nicholas J Mantis