Professor Michael Hsiao

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c-Myc transactivates CFL1 to induce senescence-like phenotype and potentiate the bystander effects for the migration and proliferation in lung cancer cells

Article • Cell Death Discovery, March 2026, Springer Science + Business Media

Professor Michael Hsiao
Squalene synthase induces ERα expression via cholesterol supplementation to confer statin resistance in lung cancer cells

Article • Cancer Cell International, February 2026, Springer Science + Business Media

Professor Michael Hsiao
Nano-Enabled Broadband Near-Infrared Light Boosts Secondary Metabolite Production for Nanoliposomal Delivery toward Glioblastoma Applications

Article • ACS Applied Nano Materials, February 2026, American Chemical Society (ACS)

Professor Michael Hsiao
Loss of estrogen receptor alpha promotes distant metastasis through epithelial-mesenchymal transition in luminal-type breast cancer

Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, January 2026, Elsevier

Professor Michael Hsiao
Correction: Bamodu et al. 4-Acetyl-Antroquinonol B Suppresses SOD2-Enhanced Cancer Stem Cell-like Phenotypes and Chemoresistance of Colorectal Cancer Cells by Inducing hsa-miR-324 re-Expression. Cancers 2018, 10, 269

Article • Cancers, October 2025, MDPI AG

Professor Michael Hsiao
Targeting ESR1 restores SQSTM1-dependent autophagy and sensitizes ER-positive breast cancer to oxidative and radiation stress

Article • Cell Death Discovery, October 2025, Springer Science + Business Media

Professor Michael Hsiao
KSRP-mediated Wnt/β-catenin activation promotes follicular thyroid cancer progression and stemness

Article • British Journal of Cancer, August 2025, Springer Science + Business Media

Professor Michael Hsiao
Non-invasive photobiomodulation using near-infrared photon irradiation to alleviate amyloid-beta aggregation in Alzheimer’s disease

Article • Microchemical Journal, August 2025, Elsevier

Professor Michael Hsiao
Blocking XIAP:CASP7-p19 selectively induces apoptosis of CASP3/DR malignancies by a novel reversible small molecule

Article • Cell Death and Disease, June 2025, Springer Science + Business Media

Professor Michael Hsiao
The miR-876-5p/SOCS4/STAT3 pathway induced the expression of PD-L1 and suppressed antitumor immune responses

Article • Cancer Cell International, March 2025, Springer Science + Business Media

Professor Michael Hsiao
Cyclic increase in the histamine receptor H1-ADAM9-Snail/Slug axis as a potential therapeutic target for EMT-mediated progression of oral squamous cell carcinoma

Article • Cell Death and Disease, March 2025, Springer Science + Business Media

Professor Michael Hsiao
Oral Cancer-Derived miR-762 Suppresses T-Cell Infiltration and Activation by Horizontal Inhibition of CXCR3 Expression

Article • International Journal of Molecular Sciences, January 2025, MDPI AG

Professor Michael Hsiao
Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma

Article • Journal for ImmunoTherapy of Cancer, January 2025, BMJ

Professor Michael Hsiao
Biomimetic red blood cell membrane-coated FePt metal–organic framework nanoparticles: a multifunctional theranostic system for enhanced MRI and targeted therapy

Article • Nanoscale, January 2025, Royal Society of Chemistry

Professor Michael Hsiao
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

Article • British Journal of Pharmacology, December 2024, Wiley

Professor Michael Hsiao
Dehydroepiandrosterone suppresses human colorectal cancer progression through ER stress-mediated autophagy and apoptosis in a p53-independent manner

Article • Frontiers in Pharmacology, October 2024, Frontiers

Professor Michael Hsiao
B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis

Article • Cell Death and Disease, September 2024, Springer Science + Business Media

Professor Michael Hsiao
WNT1-inducible signaling pathway protein 1 activation through C-X-C motif chemokine ligand 5/C-X-C chemokine receptor type 2/leukemia inhibitory factor/leukemia inhibitory factor receptor signaling promotes immunosuppression and neuroendocrine differen...

Article • iScience, August 2024, Elsevier

Professor Michael Hsiao
Magnetically Guided Theranostics: Novel Nanotubular Magnetic Resonance Imaging Contrast System Using Halloysite Nanotubes Embedded with Iron–Platinum Nanoparticles for Hepatocellular Carcinoma Treatment

Article • Small Structures, August 2024, Wiley

Professor Michael Hsiao
CD47-mediated immune evasion in early-stage lung cancer progression

Article • Biochemical and Biophysical Research Communications, August 2024, Elsevier

Professor Michael Hsiao
MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT

Article • Science Signaling, June 2024, American Association for the Advancement of Science

Professor Michael Hsiao
NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy

Article • ACS Applied Materials & Interfaces, May 2024, American Chemical Society (ACS)

Professor Michael Hsiao
PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression

Article • Cell Communication and Signaling, May 2024, Springer Science + Business Media

Professor Michael Hsiao
Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1

Article • Environmental Pollution, April 2024, Elsevier

Professor Michael Hsiao
RAB31 drives extracellular vesicle fusion and cancer‐associated fibroblast formation leading to oxaliplatin resistance in colorectal cancer

Article • Journal of Extracellular Biology, February 2024, Wiley

Professor Michael Hsiao
Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma

Article • Cell Death and Disease, January 2024, Springer Science + Business Media

Professor Michael Hsiao
Loss of LECT2 promotes ovarian cancer progression by inducing cancer invasiveness and facilitating an immunosuppressive environment

Article • Oncogene, January 2024, Springer Science + Business Media

Professor Michael Hsiao
ESM1 facilitates the EGFR/HER3-triggered epithelial-to-mesenchymal transition and progression of gastric cancer via modulating interplay between Akt and angiopoietin-2 signaling

Article • International Journal of Biological Sciences, January 2024, Ivyspring International Publisher

Professor Michael Hsiao
Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats

Article • European Journal of Pharmacology, January 2024, Elsevier

Professor Michael Hsiao
Inorganic nanoparticles for photothermal treatment of cancer

Article • Journal of Materials Chemistry B, January 2024, Royal Society of Chemistry

Professor Michael Hsiao
Heterogeneity of Phase II Enzyme Ligands on Controlling the Progression of Human Gastric Cancer Organoids as Stem Cell Therapy Model

Article • International Journal of Molecular Sciences, November 2023, MDPI AG

Professor Michael Hsiao
Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer

Article • Nature Communications, October 2023, Springer Science + Business Media

Professor Michael Hsiao
Comprehensive Neurotoxicity of Lead Halide Perovskite Nanocrystals in Nematode Caenorhabditis elegans

Article • Small, September 2023, Wiley

Professor Michael Hsiao
Escitalopram reversibility of the impacts following chronic stress on central 5-HT profiles – Implications to depression and anxiety

Article • Behavioural Brain Research, September 2023, Elsevier

Professor Michael Hsiao
The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase

Article • Journal of Biomedical Science, August 2023, Springer Science + Business Media

Professor Michael Hsiao
Detecting intragenic trans-splicing events from non-co-linearly spliced junctions by hybrid sequencing

Article • Nucleic Acids Research, July 2023, Oxford University Press (OUP)

Professor Michael Hsiao
ICAM2 initiates trans-blood-CSF barrier migration and stemness properties in leptomeningeal metastasis of triple-negative breast cancer

Article • Oncogene, July 2023, Springer Science + Business Media

Professor Michael Hsiao
Cerium Niobate Hollow Sphere Engineered Graphitic Carbon Nitride for Synergistic Photothermal/Chemodynamic Cancer Therapy

Article • Crystals, June 2023, MDPI AG

Professor Michael Hsiao
Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer

Article • Redox Biology, June 2023, Elsevier

Professor Michael Hsiao
Glucose transporter 4: Insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression

Article • Cancer Letters, June 2023, Elsevier

Professor Michael Hsiao
CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer

Article • Cell Death and Disease, May 2023, Springer Science + Business Media

Professor Michael Hsiao
Near‐Infrared I/II Nanophosphors with Cr3+/Ni2+ Energy Transfer for Bioimaging

Article • Advanced Optical Materials, May 2023, Wiley

Professor Michael Hsiao
Independent Signaling of Hepatoma Derived Growth Factor and Tumor Necrosis Factor-Alpha in Human Gastric Cancer Organoids Infected by Helicobacter pylori

Article • International Journal of Molecular Sciences, March 2023, MDPI AG

Professor Michael Hsiao
Tunable single-atom nanozyme catalytic system for biological applications of therapy and diagnosis

Article • Materials Today Advances, March 2023, Elsevier

Professor Michael Hsiao
The cytoplasmic expression of FSTL3 correlates with colorectal cancer progression, metastasis status and prognosis

Article • Journal of Cellular and Molecular Medicine, February 2023, Wiley

Professor Michael Hsiao
Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells

Article • Molecular Oncology, February 2023, Wiley

Professor Michael Hsiao
The activation of EP300 by F11R leads to EMT and acts as a prognostic factor in triple‐negative breast cancers

Article • The Journal of Pathology Clinical Research, February 2023, Wiley

Professor Michael Hsiao
Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant Progression of Clear Cell Renal Cell Carcinoma via Triggering the Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition

Article • Cells, January 2023, MDPI AG

Professor Michael Hsiao
Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination

Article • Molecules, January 2023, MDPI AG

Professor Michael Hsiao
A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer

Article • Neoplasia, January 2023, Elsevier

Professor Michael Hsiao
Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy

Article • Nanoscale, January 2023, Royal Society of Chemistry

Professor Michael Hsiao
Near‐Infrared Windows I and II Phosphors for Theranostic Applications: Spectroscopy, Bioimaging, and Light‐Emitting Diode Photobiomodulation

Article • Advanced Optical Materials, December 2022, Wiley

Professor Michael Hsiao
Iron-Based Ceramic Composite Nanomaterials for Magnetic Fluid Hyperthermia and Drug Delivery

Article • Pharmaceutics, November 2022, MDPI AG

Professor Michael Hsiao
Naa10p promotes cell invasiveness of esophageal cancer by coordinating the c-Myc and PAI1 regulatory axis

Article • Cell Death and Disease, November 2022, Springer Science + Business Media

Professor Michael Hsiao
Carboxyl-terminal modulator protein facilitates tumor metastasis in triple-negative breast cancer

Article • Cancer Gene Therapy, November 2022, Springer Science + Business Media

Professor Michael Hsiao
The CHST11 gene is linked to lung cancer and pulmonary fibrosis

Article • The Journal of Gene Medicine, November 2022, Wiley

Professor Michael Hsiao
The aberrant cancer metabolic gene carbohydrate sulfotransferase 11 promotes non-small cell lung cancer cell metastasis via dysregulation of ceruloplasmin and intracellular iron balance

Article • Translational Oncology, November 2022, Elsevier

Professor Michael Hsiao
FAK Executes Anti-Senescence via Regulating EZH2 Signaling in Non-Small Cell Lung Cancer Cells

Article • Biomedicines, August 2022, MDPI AG

Professor Michael Hsiao
Dehydroepiandrosterone (DHEA) Sensitizes Irinotecan to Suppress Head and Neck Cancer Stem-Like Cells by Downregulation of WNT Signaling

Article • Frontiers in Oncology, July 2022, Frontiers

Professor Michael Hsiao
Targeting cancer stemness mediated by BMI1 and MCL1 for non‐small cell lung cancer treatment

Article • Journal of Cellular and Molecular Medicine, July 2022, Wiley

Professor Michael Hsiao
Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes

Article • Circulation Research, June 2022, Wolters Kluwer Health

Professor Michael Hsiao
Ultrasound and Nanomedicine for Cancer-Targeted Drug Delivery: Screening, Cellular Mechanisms and Therapeutic Opportunities

Article • Pharmaceutics, June 2022, MDPI AG

Professor Michael Hsiao
Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer

Article • Cancers, June 2022, MDPI AG

Professor Michael Hsiao
Effects of RU486 in Treatment of Traumatic Stress-Induced Glucocorticoid Dysregulation and Fear-Related Abnormalities: Early versus Late Intervention

Article • International Journal of Molecular Sciences, May 2022, MDPI AG

Professor Michael Hsiao
Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis

Article • Cell Death and Disease, April 2022, Springer Science + Business Media

Professor Michael Hsiao
Regorafenib inhibits epithelial-mesenchymal transition and suppresses cholangiocarcinoma metastasis via YAP1-AREG axis

Article • Cell Death and Disease, April 2022, Springer Science + Business Media

Professor Michael Hsiao
Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency

Article • Cell Death and Disease, March 2022, Springer Science + Business Media

Professor Michael Hsiao
FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis

Article • Cell Death Discovery, March 2022, Springer Science + Business Media

Professor Michael Hsiao
Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics

Article • Pharmaceutics, February 2022, MDPI AG

Professor Michael Hsiao
Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα /gp130 hexameric signaling complex formation

Article • mAbs, February 2022, Taylor & Francis

Professor Michael Hsiao
FAK in Cancer: From Mechanisms to Therapeutic Strategies

Article • International Journal of Molecular Sciences, February 2022, MDPI AG

Professor Michael Hsiao
Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer

Article • Frontiers in Oncology, January 2022, Frontiers

Professor Michael Hsiao
Fascin-1: Updated biological functions and therapeutic implications in cancer biology

Article • BBA Advances, January 2022, Elsevier

Professor Michael Hsiao
The optical research progress of nanophosphors composed of transition elements in the fourth period of near-infrared windows I and II for deep-tissue theranostics

Article • Nanoscale, January 2022, Royal Society of Chemistry

Professor Michael Hsiao
Integrated therapy platform of exosomal system: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment

Article • Nanoscale Horizons, January 2022, Royal Society of Chemistry

Professor Michael Hsiao
Novel monodisperse FePt nanocomposites for T2-weighted magnetic resonance imaging: biomedical theranostics applications

Article • Nanoscale Advances, January 2022, Royal Society of Chemistry

Professor Michael Hsiao
Oral Cancer Theranostic Application of FeAu Bimetallic Nanoparticles Conjugated with MMP-1 Antibody

Article • Nanomaterials, December 2021, MDPI AG

Professor Michael Hsiao
Phosphor Handbook

Article • December 2021, Taylor & Francis

Professor Michael Hsiao
PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer

Article • British Journal of Cancer, November 2021, Springer Science + Business Media

Professor Michael Hsiao
TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer

Article • Oncogenesis, November 2021, Springer Science + Business Media

Professor Michael Hsiao
OncomiR miR-182-5p Enhances Radiosensitivity by Inhibiting the Radiation-Induced Antioxidant Effect through SESN2 in Head and Neck Cancer

Article • Antioxidants, November 2021, MDPI AG

Professor Michael Hsiao
Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

Article • Pharmaceutics, November 2021, MDPI AG

Professor Michael Hsiao
Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates

Article • Biomedicines, October 2021, MDPI AG

Professor Michael Hsiao
Type V collagen alpha 1 chain promotes the malignancy of glioblastoma through PPRC1-ESM1 axis activation and extracellular matrix remodeling

Article • Cell Death Discovery, October 2021, Springer Science + Business Media

Professor Michael Hsiao
PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway

Article • International Journal of Molecular Sciences, October 2021, MDPI AG

Professor Michael Hsiao
Magnetically guided theranostics: montmorillonite-based iron/platinum nanoparticles for enhancing in situ MRI contrast and hepatocellular carcinoma treatment

Article • Journal of Nanobiotechnology, October 2021, Springer Science + Business Media

Professor Michael Hsiao
Stationed or Relocating: The Seesawing EMT/MET Determinants from Embryonic Development to Cancer Metastasis

Article • Biomedicines, September 2021, MDPI AG

Professor Michael Hsiao
A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling

Article • Cells, September 2021, MDPI AG

Professor Michael Hsiao
Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives

Article • Biomedicines, September 2021, MDPI AG

Professor Michael Hsiao
Does Positive Feeling Lead to More impulsiveness? – Implication of Previous Rewarded Experience on Location-Dependent Motoric Impulsivity

Article • The Chinese Journal of Physiology, September 2021, Medknow

Professor Michael Hsiao
A Transcriptomic Analysis of Head and Neck Squamous Cell Carcinomas for Prognostic Indications

Article • Journal of Personalized Medicine, August 2021, MDPI AG

Professor Michael Hsiao
Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers

Article • Biomedicines, July 2021, MDPI AG

Professor Michael Hsiao
Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries

Article • Scientific Reports, July 2021, Springer Science + Business Media

Professor Michael Hsiao
Bruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma

Article • Oncogenesis, July 2021, Springer Science + Business Media

Professor Michael Hsiao
Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the JAK2/STAT1/3/ALDH1A3 Pathway

Article • Biomedicines, July 2021, MDPI AG

Professor Michael Hsiao
Metabolic protein phosphoglycerate kinase 1 confers lung cancer migration by directly binding HIV Tat specific factor 1

Article • Cell Death Discovery, June 2021, Springer Science + Business Media

Professor Michael Hsiao
An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood–Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles

Article • ACS Applied Materials & Interfaces, June 2021, American Chemical Society (ACS)

Professor Michael Hsiao
Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122

Article • Cancers, May 2021, MDPI AG

Professor Michael Hsiao
Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma

Article • Journal of Biomedical Science, April 2021, Springer Science + Business Media

Professor Michael Hsiao
Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

Article • Biomedicines, March 2021, MDPI AG

Professor Michael Hsiao
Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments

Article • International Journal of Molecular Sciences, March 2021, MDPI AG

Professor Michael Hsiao
Aberrant Expression of microRNA Clusters in Head and Neck Cancer Development and Progression: Current and Future Translational Impacts

Article • Pharmaceuticals, February 2021, MDPI AG

Professor Michael Hsiao
Near‐Infrared Nanophosphor Embedded in Mesoporous Silica Nanoparticle with High Light‐Harvesting Efficiency for Dual Photosystem Enhancement

Article • Angewandte Chemie, February 2021, Wiley

Professor Michael Hsiao
Near‐Infrared Nanophosphor Embedded in Mesoporous Silica Nanoparticle with High Light‐Harvesting Efficiency for Dual Photosystem Enhancement

Article • Angewandte Chemie, February 2021, Wiley

Professor Michael Hsiao
An annotation-free whole-slide training approach to pathological classification of lung cancer types using deep learning

Article • Nature Communications, February 2021, Springer Science + Business Media

Professor Michael Hsiao
MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer

Article • Oncogene, February 2021, Springer Science + Business Media

Professor Michael Hsiao
Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites

Article • ACS Applied Materials & Interfaces, January 2021, American Chemical Society (ACS)

Professor Michael Hsiao
Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance

Article • Communications Biology, January 2021, Springer Science + Business Media

Professor Michael Hsiao
Direct interaction of β‐catenin with nuclear ESM1 supports stemness of metastatic prostate cancer

Article • The EMBO Journal, December 2020, Springer Science + Business Media

Professor Michael Hsiao
Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3β-β-Catenin and XIAP-Survivin Pathways

Article • Cancers, December 2020, MDPI AG

Professor Michael Hsiao
Lung Cancer Cell-Derived Secretome Mediates Paraneoplastic Inflammation and Fibrosis in Kidney in Mice

Article • Cancers, November 2020, MDPI AG

Professor Michael Hsiao
A selective drug delivery system based on phospholipid-type nanobubbles for lung cancer therapy

Article • Nanomedicine, October 2020, Future Medicine

Professor Michael Hsiao
Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-κB signaling pathway

Article • Cell Communication and Signaling, October 2020, Springer Science + Business Media

Professor Michael Hsiao
The Diverse Roles of TAO Kinases in Health and Diseases

Article • International Journal of Molecular Sciences, October 2020, MDPI AG

Professor Michael Hsiao
Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma

Article • Biomolecules, September 2020, MDPI AG

Professor Michael Hsiao
Downregulation of STK4 promotes colon cancer invasion/migration through blocking β‐catenin degradation

Article • Molecular Oncology, August 2020, Wiley

Professor Michael Hsiao
Ovatodiolide, isolated from Anisomeles indica, suppresses bladder carcinogenesis through suppression of mTOR/β-catenin/CDK6 and exosomal miR-21 derived from M2 tumor-associated macrophages

Article • Toxicology and Applied Pharmacology, August 2020, Elsevier

Professor Michael Hsiao
An Annotation-free Whole-slide Training Approach to Pathological Classification of Lung Cancer Types by Deep Neural Network

Article • August 2020, Research Square

Professor Michael Hsiao
Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway

Article • Oncogenesis, August 2020, Springer Science + Business Media

Professor Michael Hsiao
Aberrantly expressed Bruton’s tyrosine kinase preferentially drives metastatic and stem cell-like phenotypes in neuroblastoma cells

Article • Cellular Oncology, July 2020, Springer Science + Business Media

Professor Michael Hsiao
Selection of a malignant subpopulation from a colorectal cancer cell line

Article • Oncology Letters, July 2020, Spandidos Publications

Professor Michael Hsiao
EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis

Article • Redox Biology, July 2020, Elsevier

Professor Michael Hsiao
Stabilization of ADAM9 by N-α-acetyltransferase 10 protein contributes to promoting progression of androgen-independent prostate cancer

Article • Cell Death and Disease, July 2020, Springer Science + Business Media

Professor Michael Hsiao
Circulating proteoglycan endocan mediates EGFR-driven progression of non-small cell lung cancer

Article • Cancer Research, June 2020, American Association for Cancer Research (AACR)

Professor Michael Hsiao
CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats

Article • Journal of Neuroinflammation, June 2020, Springer Science + Business Media

Professor Michael Hsiao
Melatonintriggered post‐transcriptional and post‐translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma

Article • Journal of Pineal Research, May 2020, Wiley

Professor Michael Hsiao
IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway

Article • Cancer Letters, May 2020, Elsevier

Professor Michael Hsiao
Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures

Article • International Journal of Molecular Sciences, April 2020, MDPI AG

Professor Michael Hsiao
Next‐Generation Cancer‐Specific Hybrid Theranostic Nanomaterials: MAGE‐A3 NIR Persistent Luminescence Nanoparticles Conjugated to Afatinib for In Situ Suppression of Lung Adenocarcinoma Growth and Metastasis

Article • Advanced Science, March 2020, Wiley

Professor Michael Hsiao
Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness

Article • Cell Death and Disease, March 2020, Springer Science + Business Media

Professor Michael Hsiao
PRKDC: new biomarker and drug target for checkpoint blockade immunotherapy

Article • Journal for ImmunoTherapy of Cancer, March 2020, BMJ

Professor Michael Hsiao
Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis

Article • Oncogene, January 2020, Springer Science + Business Media

Professor Michael Hsiao
Magnetically Guided Theranostics: Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy

Article • Chemistry of Materials, January 2020, American Chemical Society (ACS)

Professor Michael Hsiao
Theranostic nanobubble encapsulating a plasmon-enhanced upconversion hybrid nanosystem for cancer therapy

Article • Theranostics, January 2020, Ivyspring International Publisher

Professor Michael Hsiao
Pin1 coordinates HDAC6 upregulation with cell migration in lung cancer cells

Article • International Journal of Medical Sciences, January 2020, Ivyspring International Publisher

Professor Michael Hsiao
Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts

Article • Cancers, December 2019, MDPI AG

Professor Michael Hsiao
CD47-SIRPα Signaling Induces Epithelial-Mesenchymal Transition and Cancer Stemness and Links to a Poor Prognosis in Patients with Oral Squamous Cell Carcinoma

Article • Cells, December 2019, MDPI AG

Professor Michael Hsiao
FOXD1 and Gal-3 Form a Positive Regulatory Loop to Regulate Lung Cancer Aggressiveness

Article • Cancers, November 2019, MDPI AG

Professor Michael Hsiao
Follistatin-like protein 1 inhibits lung cancer metastasis by preventing proteolytic activation of osteopontin

Article • Cancer Research, October 2019, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis

Article • Scientific Reports, October 2019, Springer Science + Business Media

Professor Michael Hsiao
A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis

Article • Cancers, September 2019, MDPI AG

Professor Michael Hsiao
A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma

Article • Scientific Reports, August 2019, Springer Science + Business Media

Professor Michael Hsiao
Enrichment of Aldolase C Correlates with Low Non-Mutated IDH1 Expression and Predicts a Favorable Prognosis in Glioblastomas

Article • Cancers, August 2019, MDPI AG

Professor Michael Hsiao
Therapeutic Targeting of Aldolase A Interactions Inhibits Lung Cancer Metastasis and Prolongs Survival

Article • Cancer Research, July 2019, American Association for Cancer Research (AACR)

Professor Michael Hsiao
ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients

Article • Journal of Clinical Medicine, July 2019, MDPI AG

Professor Michael Hsiao
Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response

Article • Cell Death and Disease, July 2019, Springer Science + Business Media

Professor Michael Hsiao
Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD

Article • Aging, July 2019, Impact Journals, LLC

Professor Michael Hsiao
The Depletion of the “Don’t-Eat-Me” Signal CD47 Increases Radiosensitivity through Phenotypical Attenuation of Cancer Stem Cell and EMT Properties in Oral Squamous Cell Carcinoma Cells

Article • July 2019, MDPI AG

Professor Michael Hsiao
Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing

Article • Nanomedicine, July 2019, Future Medicine

Professor Michael Hsiao
Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2

Article • The FASEB Journal, June 2019, Federation of American Societies For Experimental Biology (FASEB)

Professor Michael Hsiao, YEN CHUN CHIU, Shang-Chih Yang, jean lu, Chun-Yu Lin
AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway

Article • Journal of Experimental & Clinical Cancer Research, June 2019, Springer Science + Business Media

Professor Michael Hsiao
Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis

Article • Journal of Experimental & Clinical Cancer Research, June 2019, Springer Science + Business Media

Professor Michael Hsiao
Comparison of cofilin‑1 and Twist‑1 protein expression in human non‑small cell lung cancer tissues

Article • Oncology Reports, June 2019, Spandidos Publications

Professor Michael Hsiao
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion

Article • Cancers, March 2019, MDPI AG

Professor Michael Hsiao
Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer

Article • Proceedings of the National Academy of Sciences, February 2019, Proceedings of the National Academy of Sciences

Professor Michael Hsiao, Professor Chuan Fa Chang
Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence

Article • Frontiers in Oncology, January 2019, Frontiers

Professor Michael Hsiao
Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

Article • Journal of Hematology & Oncology, January 2019, Springer Science + Business Media

Professor Michael Hsiao
Ovatodiolide Inhibits the Oncogenicity and Cancer Stem Cell-like Phenotype of Glioblastoma Cells, as well as Potentiate the Anticancer Effect of Temozolomide

Article • Phytomedicine, January 2019, Elsevier

Professor Michael Hsiao
Graphitic carbon nitride-based nanocomposites and their biological applications: a review

Article • Nanoscale, January 2019, Royal Society of Chemistry

Professor Michael Hsiao
The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells

Article • Molecular Imaging, January 2019, SAGE Publications

Professor Michael Hsiao
High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Article • Therapeutic Advances in Medical Oncology, January 2019, SAGE Publications

Professor Michael Hsiao
The Disruption of the β-Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo

Article • Cancers, December 2018, MDPI AG

Professor Michael Hsiao
Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells

Article • Frontiers in Pharmacology, November 2018, Frontiers

Professor Michael Hsiao
Over‐expression of TNNI3K is associated with early‐stage carcinogenesis of cholangiocarcinoma

Article • Molecular Carcinogenesis, November 2018, Wiley

Professor Michael Hsiao
Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models

Article • mAbs, October 2018, Taylor & Francis

Professor Michael Hsiao, HungJu Hsu
N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas

Article • Cancer Letters, October 2018, Elsevier

Professor Michael Hsiao
Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/β-Catenin Pathway

Article • Cancers, September 2018, MDPI AG

Professor Michael Hsiao
Correction to: CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation

Article • Cell Death and Differentiation, September 2018, Springer Science + Business Media

Professor Michael Hsiao
Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

Article • Journal of Experimental & Clinical Cancer Research, August 2018, Springer Science + Business Media

Professor Michael Hsiao
4-Acetyl-Antroquinonol B Suppresses SOD2-Enhanced Cancer Stem Cell-Like Phenotypes and Chemoresistance of Colorectal Cancer Cells by inducing hsa-miR-324 re-Expression

Article • Cancers, August 2018, MDPI AG

Professor Michael Hsiao
Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor

Article • Clinical Epigenetics, August 2018, Springer Science + Business Media

Professor Michael Hsiao
Roles of Aldolase Family Genes in Human Cancers and Diseases

Article • Trends in Endocrinology and Metabolism, August 2018, Elsevier

Professor Michael Hsiao
4-Acetyl-antroquinonol B Suppresses SOD2-Enhanced Cancer Stem Cell-Like Phenotypes and Chemoresistance of Colorectal Cancer Cells by Inducing hsa-miR-324 Re-Expression

Article • July 2018, MDPI AG

Professor Michael Hsiao
Over-expression of lysyl oxidase is associated with poor prognosis and response to therapy of patients with lower grade gliomas

Article • Biochemical and Biophysical Research Communications, June 2018, Elsevier

Professor Michael Hsiao
A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer

Article • Oncogene, May 2018, Springer Science + Business Media

Professor Michael Hsiao
Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

Article • Cancer Letters, May 2018, Elsevier

Professor Michael Hsiao
Leptin signaling axis specifically associates with clinical prognosis and is multifunctional in regulating cancer progression

Article • Oncotarget, March 2018, Impact Journals, LLC

Professor Michael Hsiao
Near-Infrared-Activated Fluorescence Resonance Energy Transfer-Based Nanocomposite to Sense MMP2-Overexpressing Oral Cancer Cells

Article • ACS Omega, February 2018, American Chemical Society (ACS)

Professor Michael Hsiao
Near-Infrared-Activated Fluorescence Resonance Energy Transfer-Based Nanocomposite to Sense MMP2-Overexpressing Oral Cancer Cells

Article • ACS Omega, February 2018, American Chemical Society (ACS)

Professor Michael Hsiao
Single 808 nm Laser Treatment Comprising Photothermal and Photodynamic Therapies by Using Gold Nanorods Hybrid Upconversion Particles

Article • The Journal of Physical Chemistry C, January 2018, American Chemical Society (ACS)

Professor Michael Hsiao
Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein

Article • Oncogene, January 2018, Springer Science + Business Media

Professor Michael Hsiao
Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities

Article • Cellular Physiology and Biochemistry, January 2018, Karger Publishers

Professor Michael Hsiao
Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/β-Catenin Signaling

Article • The American Journal of Chinese Medicine, January 2018, World Scientific Pub Co Pte Lt

Professor Michael Hsiao
Nanobubble-embedded inorganic 808 nm excited upconversion nanocomposites for tumor multiple imaging and treatment

Article • Chemical Science, January 2018, Royal Society of Chemistry

Professor Michael Hsiao
Pin1 Is Involved in HDAC6-mediated Cancer Cell Motility

Article • International Journal of Medical Sciences, January 2018, Ivyspring International Publisher

Professor Michael Hsiao
Identification of MALT1 as both a prognostic factor and a potential therapeutic target of regorafenib in cholangiocarcinoma patients

Article • Oncotarget, December 2017, Impact Journals, LLC

Professor Michael Hsiao
miR-105/93-3p promotes chemoresistance and circulating miR-105/93-3p acts as a diagnostic biomarker for triple negative breast cancer

Article • December 2017, Springer Science + Business Media

Professor Michael Hsiao
CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells

Article • Free Radical Biology and Medicine, December 2017, Elsevier

Professor Michael Hsiao
BICD1 expression, as a potential biomarker for prognosis and predicting response to therapy in patients with glioblastomas

Article • Oncotarget, November 2017, Impact Journals, LLC

Professor Michael Hsiao
Hepatocellular carcinoma-targeted nanoparticles for cancer therapy

Article • International Journal of Oncology, November 2017, Spandidos Publications

Professor Michael Hsiao
Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance

Article • Free Radical Biology and Medicine, November 2017, Elsevier

Professor Michael Hsiao
Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma

Article • JCI Insight, October 2017, American Society for Clinical Investigation

Professor Michael Hsiao
KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer

Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, October 2017, Elsevier

Professor Michael Hsiao
Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways

Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, October 2017, Elsevier

Professor Michael Hsiao
Adenylate kinase-4 modulates oxidative stress and stabilizes HIF-1α to drive lung cancer metastasis

Article • October 2017, Cold Spring Harbor Laboratory Press

Professor Michael Hsiao
Feedback regulation of ALDOA activates the HIF-1α/MMP9 axis to promote lung cancer progression

Article • Cancer Letters, September 2017, Elsevier

Professor Michael Hsiao
Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma

Article • Scientific Reports, August 2017, Springer Science + Business Media

Professor Michael Hsiao
Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma

Article • Scientific Reports, August 2017, Springer Science + Business Media

Professor Michael Hsiao
CLEC5A is essential for host defense against bacterial infection.

Article • Nature Communications, August 2017, Nature

Dr Shie-Liang Hsieh, Professor Michael Hsiao
Protease-activated nanomaterials for targeted cancer theranostics

Article • Nanomedicine, August 2017, Future Medicine

Professor Michael Hsiao
Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

Article • Molecular Cancer, August 2017, Springer Science + Business Media

Professor Michael Hsiao
Ghrelin and cancer progression

Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, August 2017, Elsevier

Professor Michael Hsiao
Elimination of undifferentiated human embryonic stem cells by cardiac glycosides

Article • Scientific Reports, July 2017, Springer Science + Business Media

Professor Michael Hsiao
Antrodia cinnamomea sensitizes radio-/chemo-therapy of cancer stem-like cells by modulating microRNA expression

Article • Journal of Ethnopharmacology, July 2017, Elsevier

Professor Michael Hsiao
Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice

Article • July 2017, Institute of Electrical & Electronics Engineers (IEEE)

Professor Michael Hsiao
3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

Article • Scientific Reports, June 2017, Springer Science + Business Media

Professor Michael Hsiao
Differential synchrotron X-ray imaging markers based on the renal microvasculature for tubulointerstitial lesions and glomerulopathy

Article • Scientific Reports, June 2017, Springer Science + Business Media

Professor Michael Hsiao
4-Acetylantroquinonol B suppresses autophagic flux and improves cisplatin sensitivity in highly aggressive epithelial cancer through the PI3K/Akt/mTOR/p70S6K signaling pathway

Article • Toxicology and Applied Pharmacology, June 2017, Elsevier

Professor Michael Hsiao
Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic Nanocomposites Mediated by 808 nm Near-Infrared Light

Article • Small, May 2017, Wiley

Professor Michael Hsiao
CTMP, a predictive biomarker for trastuzumab resistance in HER2-enriched breast cancer patient

Article • Oncotarget, May 2017, Impact Journals, LLC

Professor Michael Hsiao
Corrigendum to “Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells” [383 (2016) 282–294]

Article • Cancer Letters, May 2017, Elsevier

Professor Michael Hsiao
Erratum: Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association

Article • Oncogene, March 2017, Springer Science + Business Media

Professor Michael Hsiao
A Fas ligand (FasL)-fused humanized antibody against tumor-associated glycoprotein 72 selectively exhibits the cytotoxic effect against oral cancer cells with a low FasL/Fas ratio

Article • Molecular Cancer Therapeutics, March 2017, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Histone methyltransferase G9a drives chemotherapy resistance by regulating the glutamate-cysteine ligase catalytic subunit in head and neck squamous cell carcinoma

Article • Molecular Cancer Therapeutics, March 2017, American Association for Cancer Research (AACR)

Professor Michael Hsiao
MART-10 represses cholangiocarcinoma cell growth and high vitamin D receptor expression indicates better prognosis for cholangiocarcinoma

Article • Scientific Reports, March 2017, Nature

Professor Michael Hsiao
Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts

Article • Cancer Letters, March 2017, Elsevier

Professor Michael Hsiao
Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Article • Journal of Hematology & Oncology, February 2017, Springer Science + Business Media

Professor Michael Hsiao
Erratum: Corrigendum: Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

Article • Scientific Reports, February 2017, Springer Science + Business Media

Professor Michael Hsiao
The STAT3-miRNA-92-Wnt Signaling Pathway Regulates Spheroid Formation and Malignant Progression in Ovarian Cancer

Article • Cancer Research, February 2017, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Erratum to: E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer

Article • Annals of Surgical Oncology, February 2017, Springer Science + Business Media

Professor Michael Hsiao
Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis

Article • Oncotarget, January 2017, Impact Journals, LLC

Professor Michael Hsiao
Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation

Article • Scientific Reports, January 2017, Nature

Professor Michael Hsiao
Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis

Article • Journal of Hematology & Oncology, January 2017, Springer Science + Business Media

Professor Michael Hsiao
Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy

Article • Oncotarget, January 2017, Impact Journals, LLC

Professor Michael Hsiao
Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

Article • Journal of Clinical Investigation, January 2017, American Society for Clinical Investigation

Professor Michael Hsiao
Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension

Article • Scientific Reports, December 2016, Nature

Professor Michael Hsiao
Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

Article • Cancer Letters, December 2016, Elsevier

Professor Michael Hsiao
Plasmon-Enhanced Photodynamic Cancer Therapy by Upconversion Nanoparticles Conjugated with Au Nanorods

Article • ACS Applied Materials & Interfaces, November 2016, American Chemical Society (ACS)

Professor Michael Hsiao
Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex

Article • PLOS One, November 2016, PLOS

Dr GAN-GUANG LIOU, Professor Michael Hsiao
Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma

Article • Cancer Research, October 2016, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Near-Infrared Light-Mediated Photodynamic Therapy Nanoplatform by the Electrostatic Assembly of Upconversion Nanoparticles with Graphitic Carbon Nitride Quantum Dots

Article • Inorganic Chemistry, October 2016, American Chemical Society (ACS)

Professor Michael Hsiao
Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats

Article • Critical Care Medicine, September 2016, Wolters Kluwer Health

Professor Michael Hsiao
Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity

Article • Oncotarget, August 2016, Impact Journals, LLC

Professor Michael Hsiao
Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption

Article • BioFactors, August 2016, Wiley

Professor Michael Hsiao
The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I

Article • Scientific Reports, August 2016, Nature

Professor Michael Hsiao
Inhibition of VEGF165/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis

Article • Scientific Reports, August 2016, Nature

Professor Michael Hsiao
MiR-193a-5p/ERBB2 act as concurrent chemoradiation therapy response indicator of esophageal squamous cell carcinoma

Article • Oncotarget, June 2016, Impact Journals, LLC

Professor Michael Hsiao
Selective killing of cancer cells by nanoparticle-assisted ultrasound

Article • Journal of Nanobiotechnology, June 2016, Springer Science + Business Media

Professor Michael Hsiao
MMP2-sensing up-conversion nanoparticle for fluorescence biosensing in head and neck cancer cells

Article • Biosensors and Bioelectronics, June 2016, Elsevier

Professor Michael Hsiao
Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes

Article • Oncotarget, May 2016, Impact Journals, LLC

Professor Michael Hsiao
Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity

Article • Proceedings of the National Academy of Sciences, May 2016, Proceedings of the National Academy of Sciences

Professor Michael Hsiao
Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension

Article • Scientific Reports, May 2016, Nature

Professor Michael Hsiao
Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis

Article • Carcinogenesis, April 2016, Oxford University Press (OUP)

Professor Michael Hsiao
Huntingtin-Interacting Protein-1 Is an Early-Stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated Epithelial–Mesenchymal Transition

Article • American Review of Respiratory Disease, April 2016, American Thoracic Society

Professor Michael Hsiao
IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma

Article • Molecular Oncology, March 2016, Wiley

Professor Michael Hsiao
The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation

Article • eLife, March 2016, eLife

Professor Michael Hsiao
Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448

Article • BMC Cancer, February 2016, Springer Science + Business Media

Professor Michael Hsiao
Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

Article • Journal of Pineal Research, February 2016, Wiley

Professor Michael Hsiao
Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma

Article • Oncotarget, January 2016, Impact Journals, LLC

Professor Michael Hsiao
Evaluation of the intracellular uptake and cytotoxicity effect of TiO2 nanostructures for various human oral and lung cells under dark conditions

Article • Toxicology Research, January 2016, Oxford University Press (OUP)

Professor Michael Hsiao
Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells

Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

Professor Michael Hsiao
Suppression of fructose-bisphosphate aldolase C expression as a predictor of advanced oral squamous cell carcinoma

Article • Head & Neck, November 2015, Wiley

Professor Michael Hsiao
GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis

Article • Oncotarget, November 2015, Impact Journals, LLC

Professor Michael Hsiao
Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma

Article • Cancer Letters, November 2015, Elsevier

Professor Michael Hsiao
Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90–EGFR association

Article • Oncogene, October 2015, Nature

Professor Michael Hsiao
Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

Article • Proceedings of the National Academy of Sciences, October 2015, Proceedings of the National Academy of Sciences

Professor Michael Hsiao
4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype

Article • Toxicology and Applied Pharmacology, October 2015, Elsevier

Professor Michael Hsiao
Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation

Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, October 2015, Elsevier

Professor Michael Hsiao
By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

Article • Oncotarget, August 2015, Impact Journals, LLC

Professor Michael Hsiao
DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer

Article • Oncotarget, August 2015, Impact Journals, LLC

Professor Michael Hsiao
Plasminogen Activator Inhibitor-2 Plays a Leading Prognostic Role among Protease Families in Non-Small Cell Lung Cancer

Article • PLOS One, July 2015, PLOS

Professor Michael Hsiao
Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling

Article • Head & Neck, July 2015, Wiley

Professor Michael Hsiao
CARMA3 Represses Metastasis Suppressor NME2 to Promote Lung Cancer Stemness and Metastasis

Article • American Review of Respiratory Disease, July 2015, American Thoracic Society

Professor Michael Hsiao
Diverse Targets of -Catenin during the Epithelial-Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse

Article • Cancer Research, June 2015, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Keap1-Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein

Article • Clinical Cancer Research, June 2015, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Ghrelin promotes renal cell carcinoma metastasis via Snail activation and is associated with poor prognosis

Article • The Journal of Pathology, May 2015, Wiley

Professor Michael Hsiao
Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

Article • Scientific Reports, May 2015, Nature

Professor Michael Hsiao
Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β–Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System

Article • Diabetes, April 2015, American Diabetes Association

Professor Michael Hsiao
Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells

Article • Cell Cycle, March 2015, Taylor & Francis

Professor Michael Hsiao
GPCR dimerization in brainstem nuclei contributes to the development of hypertension

Article • British Journal of Pharmacology, March 2015, Wiley

Professor Michael Hsiao
The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression

Article • RNA Biology, March 2015, Taylor & Francis

Professor Michael Hsiao
Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Article • Oncotarget, February 2015, Impact Journals, LLC

Professor Michael Hsiao
Evaluations of the Chemical Stability and Cytotoxicity of CuInS2and CuInS2/ZnS Core/Shell Quantum Dots

Article • The Journal of Physical Chemistry C, February 2015, American Chemical Society (ACS)

Professor Michael Hsiao
The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer

Article • Annals of Surgical Oncology, January 2015, Springer Science + Business Media

Professor Michael Hsiao
Plasmon-induced hyperthermia: hybrid upconversion NaYF4:Yb/Er and gold nanomaterials for oral cancer photothermal therapy

Article • Journal of Materials Chemistry B, January 2015, Royal Society of Chemistry

Professor Michael Hsiao
Preclinical investigation of ibrutinib, a Bruton’s kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes

Article • Oncotarget, November 2014, Impact Journals, LLC

Professor Michael Hsiao
Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b

Article • Cancer Research, October 2014, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Squalene Synthase Induces Tumor Necrosis Factor Receptor 1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis

Article • American Review of Respiratory Disease, September 2014, American Thoracic Society

Professor Michael Hsiao
E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer

Article • Annals of Surgical Oncology, September 2014, Springer Science + Business Media

Professor Michael Hsiao
miR326 Maturation Is Crucial for VEGF-C-Driven Cortactin Expression and Esophageal Cancer Progression

Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

Professor Michael Hsiao
MTAP is an independent prognosis marker and the concordant loss of MTAP and p16 expression predicts short survival in non-small cell lung cancer patients

Article • European Journal of Surgical Oncology, September 2014, Elsevier

Professor Michael Hsiao
MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1

Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 2014, Elsevier

Professor Michael Hsiao
Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

Article • Archives of Toxicology, August 2014, Springer Science + Business Media

Professor Michael Hsiao
Involvement of two distinct signalling pathways in IGF-1-mediated central control of hypotensive effects in normotensive and hypertensive rats

Article • Acta Physiologica, August 2014, Wiley

Professor Michael Hsiao
Arsenic Trioxide Inhibits CXCR4-Mediated Metastasis by Interfering miR-520h/PP2A/NF-κB Signaling in Cervical Cancer

Article • Annals of Surgical Oncology, July 2014, Springer Science + Business Media

Professor Michael Hsiao
Resveratrol decreases fructose‐induced oxidative stress, mediated by NADPH oxidase via an AMPK‐dependent mechanism

Article • British Journal of Pharmacology, May 2014, Wiley

Professor Michael Hsiao
Different Impacts of α- and β-Blockers in Neurogenic Hypertension Produced by Brainstem Lesions in Rat

Article • Anesthesiology, May 2014, Wolters Kluwer Health

Professor Michael Hsiao
Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells

Article • Autophagy, April 2014, Taylor & Francis

Professor Michael Hsiao
MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo

Article • Oncogenesis, April 2014, Nature

Professor Michael Hsiao
Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

Article • Hepatology, March 2014, Wolters Kluwer Health

Professor Michael Hsiao
Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers

Article • Proceedings of the National Academy of Sciences, February 2014, Proceedings of the National Academy of Sciences

Professor Michael Hsiao
Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2

Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, February 2014, Elsevier

Professor Michael Hsiao
Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma

Article • Molecular Cancer, January 2014, Springer Science + Business Media

Professor Michael Hsiao
The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis

Article • Molecular Cancer, January 2014, Springer Science + Business Media

Professor Michael Hsiao
Integrative transcriptome sequencing identifies trans-splicing events with important roles in human embryonic stem cell pluripotency

Article • Genome Research, October 2013, Cold Spring Harbor Laboratory Press

Professor Michael Hsiao
Hispolon Induces Apoptosis through JNK1/2-Mediated Activation of a Caspase-8, -9, and -3-Dependent Pathway in Acute Myeloid Leukemia (AML) Cells and Inhibits AML Xenograft Tumor Growth in Vivo

Article • Journal of Agricultural and Food Chemistry, October 2013, American Chemical Society (ACS)

Professor Michael Hsiao
Baseline hypertension: New insight into the potential predictors of survival in patients with hepatocellular carcinoma

Article • International Journal of Cardiology, October 2013, Elsevier

Professor Michael Hsiao
Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation

Article • British Journal of Pharmacology, October 2013, Wiley

Professor Michael Hsiao
Array-Based High-Throughput Screening in Mouse Embryonic Stem Cells with shRNAs

Article • September 2013, Wiley

Professor Michael Hsiao
Gfi-1 is the transcriptional repressor of SOCS1 in acute myeloid leukemia cells

Article • Journal of Leukocyte Biology, September 2013, Wiley

Professor Michael Hsiao
Targeting the XIAP/caspase-7 complex selectively kills caspase-3–deficient malignancies

Article • Journal of Clinical Investigation, August 2013, American Society for Clinical Investigation

Professor Michael Hsiao
Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex

Article • Journal of Cell Science, August 2013, The Company of Biologists

Professor Michael Hsiao
Carboxyl-Terminal Modulator Protein Positively Regulates Akt Phosphorylation and Acts as an Oncogenic Driver in Breast Cancer

Article • Cancer Research, August 2013, American Association for Cancer Research (AACR)

Professor Michael Hsiao
A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells

Article • Carcinogenesis, July 2013, Oxford University Press (OUP)

Professor Michael Hsiao
Expression of GOLM1 Correlates with Prognosis in Human Hepatocellular Carcinoma

Article • Annals of Surgical Oncology, July 2013, Springer Science + Business Media

Professor Michael Hsiao
Loss of RUNX3 increases osteopontin expression and promotes cell migration in gastric cancer

Article • Carcinogenesis, June 2013, Oxford University Press (OUP)

Professor Michael Hsiao
Hexamethonium Reverses the Lethal Cardiopulmonary Damages in a Rat Model of Brainstem Lesions Mimicking Fatal Enterovirus 71 Encephalitis*

Article • Critical Care Medicine, May 2013, Wolters Kluwer Health

Professor Michael Hsiao
Glycogen synthase kinase 3 β activity is required for hBora/Aurora A-mediated mitotic entry

Article • Cell Cycle, March 2013, Taylor & Francis

Professor Michael Hsiao
Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling

Article • Arthritis & Rheumatism, February 2013, Wiley

Professor Michael Hsiao
Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

Article • Journal of Clinical Investigation, February 2013, American Society for Clinical Investigation

Professor Michael Hsiao
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

Article • Journal of Clinical Investigation, February 2013, American Society for Clinical Investigation

Professor Michael Hsiao
Analysis of Protein-Protein Interactions in Cross-talk Pathways Reveals CRKL Protein as a Novel Prognostic Marker in Hepatocellular Carcinoma

Article • Molecular & Cellular Proteomics, February 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

Professor Michael Hsiao
Chitosan-Modified Stable Colloidal Gold Nanostars for the Photothermolysis of Cancer Cells

Article • The Journal of Physical Chemistry C, January 2013, American Chemical Society (ACS)

Professor Michael Hsiao
Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78

Article • Oncogene, January 2013, Springer Science + Business Media

Professor Michael Hsiao
Targeting polymeric fluorescent nanodiamond-gold/silver multi-functional nanoparticles as a light-transforming hyperthermia reagent for cancer cells

Article • Nanoscale, January 2013, Royal Society of Chemistry

Professor Michael Hsiao
A Preclinical Evaluation of Antimycin A as a Potential Antilung Cancer Stem Cell Agent

Article • Evidence-based Complementary and Alternative Medicine, January 2013, Hindawi Publishing Corporation

Professor Michael Hsiao
BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells

Article • Evidence-based Complementary and Alternative Medicine, January 2013, Hindawi Publishing Corporation

Professor Michael Hsiao
Inhibition of Metastatic Potential in Breast CarcinomaIn VivoandIn Vitrothrough Targeting VEGFRs and FGFRs

Article • Evidence-based Complementary and Alternative Medicine, January 2013, Hindawi Publishing Corporation

Professor Michael Hsiao
Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer

Article • Proceedings of the National Academy of Sciences, December 2012, Proceedings of the National Academy of Sciences

Professor Michael Hsiao
Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer

Article • American Review of Respiratory Disease, December 2012, American Thoracic Society

Professor Michael Hsiao
CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation

Article • Cell Death and Differentiation, November 2012, Springer Science + Business Media

Professor Michael Hsiao
Cisplatin Selects for Multidrug-Resistant CD133+ Cells in Lung Adenocarcinoma by Activating Notch Signaling

Article • Cancer Research, November 2012, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Exercise-induced SPARC prevents tumorigenesis of colon cancer

Article • Gut, October 2012, BMJ

Professor Michael Hsiao
Central hypotensive effects of neuropeptide Y are modulated by endothelial nitric oxide synthase after activation by ribosomal protein S6 kinase

Article • British Journal of Pharmacology, October 2012, Wiley

Professor Michael Hsiao
A shRNA Functional Screen Reveals Nme6 and Nme7 Are Crucial for Embryonic Stem Cell Renewal

Article • Stem Cells, September 2012, Wiley

Professor Michael Hsiao
Adenylate Kinase-4 Is a Marker of Poor Clinical Outcomes That Promotes Metastasis of Lung Cancer by Downregulating the Transcription Factor ATF3

Article • Cancer Research, September 2012, American Association for Cancer Research (AACR)

Professor Michael Hsiao
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

Article • Journal of Clinical Investigation, August 2012, American Society for Clinical Investigation

Professor Michael Hsiao
Activation of Robo1 Signaling of Breast Cancer Cells by Slit2 from Stromal Fibroblast Restrains Tumorigenesis via Blocking PI3K/Akt/ -Catenin Pathway

Article • Cancer Research, July 2012, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Renin activates PI3K-Akt-eNOS signalling through the angiotensin AT1 and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii

Article • British Journal of Pharmacology, July 2012, Wiley

Professor Michael Hsiao
ASK1 promotes apoptosis of normal and malignant plasma cells

Article • Blood, June 2012, American Society of Hematology

Professor Michael Hsiao
Expression of gremlin 1 correlates with increased angiogenesis and progression-free survival in patients with pancreatic neuroendocrine tumors

Article • Journal of Gastroenterology, June 2012, Springer Science + Business Media

Professor Michael Hsiao
Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury

Article • Critical Care Medicine, April 2012, Wolters Kluwer Health

Professor Michael Hsiao
MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol

Article • Oncogene, March 2012, Springer Science + Business Media

Professor Michael Hsiao
Meiotic Competent Human Germ Cell-like Cells Derived from Human Embryonic Stem Cells Induced by BMP4/WNT3A Signaling and OCT4/EpCAM (Epithelial Cell Adhesion Molecule) Selection

Article • Journal of Biological Chemistry, March 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

Professor Michael Hsiao
RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells

Article • Oncogene, January 2012, Springer Science + Business Media

Professor Michael Hsiao
Seedless, silver-induced synthesis of star-shaped gold/silver bimetallic nanoparticles as high efficiency photothermal therapy reagent

Article • Journal of Materials Chemistry, January 2012, Royal Society of Chemistry

Professor Michael Hsiao
WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β

Article • Cell Death and Differentiation, December 2011, Springer Science + Business Media

Professor Michael Hsiao
Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to down-regulate Akt and MMP-2

Article • British Journal of Pharmacology, December 2011, Wiley

Professor Michael Hsiao
Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan

Article • Archives of Oral Biology, October 2011, Elsevier

Professor Michael Hsiao
NAT2 slow acetylation haplotypes are associated with the increased risk of betel quid–related oral and pharyngeal squamous cell carcinoma

Article • Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, October 2011, Elsevier

Professor Michael Hsiao
TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer

Article • Oncogene, September 2011, Springer Science + Business Media

Professor Michael Hsiao
FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization

Article • Cancer Research, September 2011, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Biocompatible transferrin-conjugated sodium hexametaphosphate-stabilized gold nanoparticles: synthesis, characterization, cytotoxicity and cellular uptake

Article • Nanotechnology, September 2011, Institute of Physics Publishing

Professor Michael Hsiao
miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans

Article • Journal of Clinical Investigation, September 2011, American Society for Clinical Investigation

Professor Michael Hsiao
The novel DNA alkylating agent BO-1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models

Article • International Journal of Cancer, July 2011, Wiley

Professor Michael Hsiao
Central nicotinic acetylcholine receptor involved in Ca2+-calmodulin-endothelial nitric oxide synthase pathway modulated hypotensive effects

Article • British Journal of Pharmacology, June 2011, Wiley

Professor Michael Hsiao
Epi process margin improvement using co-implantation to control Phosphorus diffusion in a DRAM manufacturing

Article • June 2011, Institute of Electrical & Electronics Engineers (IEEE)

Professor Michael Hsiao
Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer

Article • Journal of Hepatology, April 2011, Elsevier

Professor Michael Hsiao
X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors

Article • Materials Chemistry and Physics, March 2011, Elsevier

Professor Michael Hsiao
N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity

Article • Cancer Cell, February 2011, Elsevier

Professor Michael Hsiao
Minocycline inhibits the growth of glioma by inducing autophagy

Article • Autophagy, February 2011, Taylor & Francis

Professor Michael Hsiao
Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas

Article • Head & Neck, January 2011, Wiley

Professor Michael Hsiao
Modulating cell-uptake behavior of Au-based nanomaterials via quantitative biomolecule modification

Article • Journal of Materials Chemistry, January 2011, Royal Society of Chemistry

Professor Michael Hsiao
IL-10 Promoter Genetic Polymorphisms and Risk of Kawasaki Disease in Taiwan

Article • Disease Markers, January 2011, Hindawi Publishing Corporation

Professor Michael Hsiao
IL-6 Trans-Signaling in Formation and Progression of Malignant Ascites in Ovarian Cancer

Article • Cancer Research, December 2010, American Association for Cancer Research (AACR)

Professor Michael Hsiao
H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

Article • Cancer Research, October 2010, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Polyethylenimine-mediated PUMA gene delivery to orthotopic oral cancer: Suppression of tumor growth through apoptosis induction in situ and prolonged survival

Article • Head & Neck, August 2010, Wiley

Professor Michael Hsiao
hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

Article • Journal of Clinical Investigation, August 2010, American Society for Clinical Investigation

Professor Michael Hsiao
CYR61 Regulates BMP-2-dependent Osteoblast Differentiation through the αvβ3Integrin/Integrin-linked Kinase/ERK Pathway

Article • Journal of Biological Chemistry, July 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

Professor Michael Hsiao
Downregulation of MicroRNA miR-520h by E1A Contributes to Anticancer Activity

Article • Cancer Research, May 2010, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Dermcidin identification from exhaled air for lung cancer diagnosis

Article • European Respiratory Journal, May 2010, European Respiratory Society (ERS)

Professor Michael Hsiao
Angiotensin II Inhibits Neuronal Nitric Oxide Synthase Activation Through the ERK1/2-RSK Signaling Pathway to Modulate Central Control of Blood Pressure

Article • Circulation Research, March 2010, Wolters Kluwer Health

Professor Michael Hsiao
Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: A therapeutic benefit for arthritis

Article • Arthritis & Rheumatism, February 2010, Wiley

Professor Michael Hsiao
Biocompatibility of Fe3O4nanoparticles evaluated byin vitrocytotoxicity assays using normal, glia and breast cancer cells

Article • Nanotechnology, January 2010, Institute of Physics Publishing

Professor Michael Hsiao
Enhancement of cell radiation sensitivity by pegylated gold nanoparticles

Article • Physics in Medicine and Biology, January 2010, Institute of Physics Publishing

Professor Michael Hsiao
Diagnosis of Gastric Malignancy Using Gastric Juice 1-antitrypsin

Article • Cancer Epidemiology Biomarkers & Prevention, January 2010, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Cytokine Genetic Polymorphisms and Susceptibility to Kawasaki Disease in Taiwanese Children

Article • Circulation Journal, January 2010, Japanese Circulation Society

Professor Michael Hsiao
Gastric juice acidity in upper gastrointestinal diseases

Article • World Journal of Gastroenterology, January 2010, Baishideng Publishing Group Co., Limited (formerly WJG Press)

Professor Michael Hsiao
Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/ AP-1 pathway

Article • Carcinogenesis, October 2009, Oxford University Press (OUP)

Professor Michael Hsiao
MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer

Article • Experimental Cell Research, September 2009, Elsevier

Professor Michael Hsiao
Suberoylanilide hydroxamic acid sensitizes human oral cancer cells to TRAIL-induced apoptosis through increase DR5 expression

Article • Molecular Cancer Therapeutics, September 2009, American Association for Cancer Research (AACR)

Professor Michael Hsiao
MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation

Article • Oncogene, July 2009, Springer Science + Business Media

Professor Michael Hsiao
Biosensing, Cytotoxicity, and Cellular Uptake Studies of Surface-Modified Gold Nanorods

Article • The Journal of Physical Chemistry C, April 2009, American Chemical Society (ACS)

Professor Michael Hsiao
Loss of RUNX3 Expression Correlates with Differentiation, Nodal Metastasis, and Poor Prognosis of Gastric Cancer

Article • Annals of Surgical Oncology, March 2009, Springer Science + Business Media

Professor Michael Hsiao
Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma

Article • Oncology Reports, March 2009, Spandidos Publications

Professor Michael Hsiao
Neuronal Nitric Oxide Synthase Activation Is Involved in Insulin-Mediated Cardiovascular Effects in the Nucleus Tractus Solitarii of Rats

Article • Neuroscience, March 2009, Elsevier

Professor Michael Hsiao
MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma

Article • Hepatology, December 2008, Wiley

Professor Michael Hsiao
Investigation of the Growth Mechanism of Iron Oxide Nanoparticles via a Seed-Mediated Method and Its Cytotoxicity Studies

Article • The Journal of Physical Chemistry C, September 2008, American Chemical Society (ACS)

Professor Michael Hsiao
Essential roles of caspases and their upstream regulators in rotenone-induced apoptosis

Article • Biochemical and Biophysical Research Communications, June 2008, Elsevier

Professor Michael Hsiao
Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma

Article • Oncogene, May 2008, Springer Science + Business Media

Professor Michael Hsiao
Octadecaborane implant technology for 72nm node stack DRAM p+ poly gate doping process

Article • May 2008, Institute of Electrical & Electronics Engineers (IEEE)

Professor Michael Hsiao
Adenosine Modulates Cardiovascular Functions Through Activation of Extracellular Signal-Regulated Kinases 1 and 2 and Endothelial Nitric Oxide Synthase in the Nucleus Tractus Solitarii of Rats

Article • Circulation, February 2008, Wolters Kluwer Health

Professor Michael Hsiao
Correction

Article • Hepatology, January 2008, Wiley

Professor Michael Hsiao
Defective Phosphatidylinositol 3-Kinase Signaling in Central Control of Cardiovascular Effects in the Nucleus Tractus Solitarii of Spontaneously Hypertensive Rats

Article • Hypertension Research, January 2008, Japanese Society of Hypertension

Professor Michael Hsiao
Observation of peptide differences between cancer and control in gastric juice

Article • PROTEOMICS - CLINICAL APPLICATIONS, January 2008, Wiley

Professor Michael Hsiao
The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer

Article • Journal of Surgical Oncology, January 2008, Wiley

Professor Michael Hsiao
Glycine N-methyltransferase−/− mice develop chronic hepatitis and glycogen storage disease in the liver

Article • Hepatology, October 2007, Wiley

Professor Michael Hsiao
Effect of theVP3gene of chicken anemia virus on canine mammary tumor cells

Article • American Journal of Veterinary Research, April 2007, American Veterinary Medical Association (AVMA)

Professor Michael Hsiao
Exogenous nitric oxide stimulated collagen type I expression and TGF-β1 production in keloid fibroblasts by a cGMP-dependent manner

Article • Nitric Oxide, March 2007, Elsevier

Professor Michael Hsiao
Nitric oxide promotes the progression of periapical lesion via inducing macrophage and osteoblast apoptosis

Article • Oral Microbiology and Immunology, February 2007, Wiley

Professor Michael Hsiao
1-Antitrypsin Precursor in Gastric Juice Is a Novel Biomarker for Gastric Cancer and Ulcer

Article • Clinical Cancer Research, February 2007, American Association for Cancer Research (AACR)

Professor Michael Hsiao
Nitric oxide produced by iNOS is associated with collagen synthesis in keloid scar formation

Article • Nitric Oxide, June 2006, Elsevier

Professor Michael Hsiao
Induction of Heme Oxygenase-1 Is Involved in Carbon Monoxide-Mediated Central Cardiovascular Regulation

Article • Journal of Pharmacology and Experimental Therapeutics, March 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Michael Hsiao
The Interleukin-1 RN Polymorphism and Helicobacter pylori Infection in the Development of Duodenal Ulcer

Article • Helicobacter, December 2004, Wiley

Professor Michael Hsiao
In Situ Akt Phosphorylation in the Nucleus Tractus Solitarii Is Involved in Central Control of Blood Pressure and Heart Rate

Article • Circulation, October 2004, Wolters Kluwer Health

Professor Michael Hsiao
COX-2 Regulates the Insulin-Like Growth Factor I-Induced Potentiation of Zn2+-Toxicity in Primary Cortical Culture

Article • Molecular Pharmacology, September 2004, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Michael Hsiao
The cardiovascular effects of nitric oxide and carbon monoxide in the nucleus tractus solitarii of rats

Article • Journal of Hypertension, June 2004, Wolters Kluwer Health

Professor Michael Hsiao
Gene delivery of endothelial nitric oxide synthase into nucleus tractus solitarii induces biphasic response in cardiovascular functions of hypertensive rats

Article • American Journal of Hypertension, January 2004, Oxford University Press (OUP)

Professor Michael Hsiao
Interactions of Carbon Monoxide and Metabotropic Glutamate Receptor Groups in the Nucleus Tractus Solitarii of Rats

Article • Journal of Pharmacology and Experimental Therapeutics, November 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Michael Hsiao
Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas

Article • Cancer Letters, November 2003, Elsevier

Professor Michael Hsiao
Interaction of Carbon Monoxide and Adenosine in the Nucleus Tractus Solitarii of Rats

Article • Hypertension, September 2003, Wolters Kluwer Health

Professor Michael Hsiao
Enhanced gene delivery to HER-2-overexpressing breast cancer cells by modified immunolipoplexes conjugated with the anti-HER-2 antibody

Article • Journal of Biomedical Science, May 2003, Springer Science + Business Media

Professor Michael Hsiao
Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes

Article • Oral Oncology, January 2003, Elsevier

Professor Michael Hsiao
Enhanced Gene Delivery to HER-2-Overexpressing Breast Cancer Cells by Modified Immunolipoplexes Conjugated with the Anti-HER-2 Antibody

Article • Journal of Biomedical Science, January 2003, Springer Science + Business Media

Professor Michael Hsiao
Article • Clinical & Experimental Metastasis, January 2003, Springer Science + Business Media

Professor Michael Hsiao
Nitric Oxide Promotes Infectious Bone Resorption by Enhancing Cytokine-Stimulated Interstitial Collagenase Synthesis in Osteoblasts

Article • Journal of Bone and Mineral Research, January 2003, Wiley

Professor Michael Hsiao
Parietal Contusion and Transient Superior Sagittal Sinus Occlusion Presenting with Cortical Blindness

Article • Journal of Trauma and Acute Care Surgery, November 2002, Wolters Kluwer Health

Professor Michael Hsiao
Inducible Cyclooxygenase and Interleukin 6 Gene Expressions in Nasal Polyp Fibroblasts

Article • Archives of Otolaryngology - Head and Neck Surgery, August 2002, American Medical Association (AMA)

Professor Michael Hsiao
Article • Acta Neurochirurgica, July 2002, Springer Science + Business Media

Professor Michael Hsiao
Sequential expressions of MMP-1, TIMP-1, IL-6, and COX-2 genes in induced periapical lesions in rats

Article • European Journal Of Oral Sciences, June 2002, Wiley

Professor Michael Hsiao
Mutation in the FGFR2 gene in a Taiwanese patient with Beare-Stevenson cutis gyrata syndrome

Article • Clinical Genetics, May 2002, Wiley

Professor Michael Hsiao
Article • Clinical & Experimental Metastasis, January 2002, Springer Science + Business Media

Professor Michael Hsiao
Clinical characteristics of double pylorus

Article • Gastrointestinal Endoscopy, October 2001, Elsevier

Professor Michael Hsiao
Comparisons of Tumor Suppressor p53, p21, and p16 Gene Therapy Effects on Glioblastoma Tumorigenicity in Situ

Article • Biochemical and Biophysical Research Communications, September 2001, Elsevier

Professor Michael Hsiao
Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac

Article • International Journal of Cancer, January 2001, Wiley

Professor Michael Hsiao
Norcantharidin-Induced Post-G2/M Apoptosis Is Dependent on Wild-Type p53 Gene

Article • Biochemical and Biophysical Research Communications, September 2000, Elsevier

Professor Michael Hsiao
Expression of p16INK4A Induces Dominant Suppression of Glioblastoma Growth in Situ through Necrosis and Cell Cycle Arrest

Article • Biochemical and Biophysical Research Communications, March 2000, Elsevier

Professor Michael Hsiao
Genetic organization of alpha-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of alpha- bungarotoxin isotoxins is not derived from edited mRNAs

Article • Nucleic Acids Research, October 1999, Oxford University Press (OUP)

Professor Michael Hsiao
Functional Expression of Human p21WAF1/CIP1Gene in Rat Glioma Cells Suppresses Tumor Growthin Vivoand Induces Radiosensitivity

Article • Biochemical and Biophysical Research Communications, April 1997, Elsevier

Professor Michael Hsiao
Intracavitary Liposome-Mediated p53 Gene Transfer into Glioblastoma with Endogenous Wild-Type p53in VivoResults in Tumor Suppression and Long-Term Survival

Article • Biochemical and Biophysical Research Communications, April 1997, Elsevier

Professor Michael Hsiao
Dissemination and tissue invasiveness in murine acute leukemia associated with acquisition ofp53 mutation and loss of wild-typep53

Article • Molecular Carcinogenesis, June 1995, Wiley

Professor Michael Hsiao
Characterization of Functional Nanomaterials in Cosmetics and its Cytotoxic Effects

Article • Springer Science + Business Media

Professor Michael Hsiao
The Synthesis of Iron Oxide Nanoparticles via Seed-Mediated Process and its Cytotoxicity Studies

Article • Springer Science + Business Media

Professor Michael Hsiao

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