What is it about?
This work is to illustrate the critical role of innate immunity receptor in bacteria-induced NET formation, pro inflammatory cytokine production, and the development of gamma-delta TH17 cells.
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Why is it important?
While TLR2 is regarded as the PRR to Gram-positive bacteria, TLR2 KO mice are not more susceptible to Gram-Positive Listeria monocytogenes infection. This work demonstrate that CLEC5A, a Syk-coupled C-type lectin, is the key receptor for Listeria and Staphylococcus-induced NET formation and pro inflammatory cytokine secretion, and CLEC5A KO mice are highly susceptible to host defense against Listeria and Staphylococcus. This work unveils the critical functions f C-type lectin in host defense against bacterial infection.
Perspectives
Previous work shows that Lectin-1, a member of Syk-coupled receptors, is critical in host defense against fungal invasion. This work demonstrates that CLEC5A is the critical receptor in host defense against bacterial infection, and is co-activated with TLR2 by distinct PAMPs on pathogens. Previous we have shown that CLEC5A and TLR7 are co-activated by flaviviruses and influenza viruses, suggesting combination of CLEC5A with distinct members of TLR enable immune cells to recognize diverse antigens. Thus, CLEC5A is the potential target for the modulation of inflammatory reaction, and blocked of CLEC5A may attenuate tissue damages resulted from severe inflammatory reactions.
Dr Shie-Liang Hsieh
Genomics Research Center, Academia Sinica, Taipei, Taiwan
Read the Original
This page is a summary of: CLEC5A is a critical receptor in innate immunity against Listeria infection, Nature Communications, August 2017, Nature,
DOI: 10.1038/s41467-017-00356-3.
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