All Stories

  1. Whole-genome sequencing of ocular Chlamydia trachomatis isolates from Gadarif State, Sudan
  2. Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal
  3. The conjunctival transcriptome in Ethiopians after trichiasis surgery: associations with the development of eyelid contour abnormalities and the effect of oral doxycycline treatment
  4. Conjunctival Microbiome-Host Responses Are Associated With Impaired Epithelial Cell Health in Both Early and Late Stages of Trachoma
  5. Influenza Vaccination Primes Human Myeloid Cell Cytokine Secretion and NK Cell Function
  6. Ocular immune responses, Chlamydia trachomatis infection and clinical signs of trachoma before and after azithromycin mass drug administration in a treatment naïve trachoma-endemic Tanzanian community
  7. Pathway-Wide Genetic Risks in Chlamydial Infections Overlap between Tissue Tropisms: A Genome-Wide Association Scan
  8. Is Trachoma disease severity linked to ocular Chlamydia trachomatis pathogen strain variation
  9. Conjunctival transcriptome profiling of Solomon Islanders with active trachoma in the absence of Chlamydia trachomatis infection
  10. Evaluation of a Chlamydia trachomatis-specific, commercial, real-time PCR for use with ocular swabs
  11. Active Trachoma Cases in the Solomon Islands Have Varied Polymicrobial Community Structures but Do Not Associate with Individual Non-Chlamydial Pathogens of the Eye
  12. An outbreak of acute haemorrhagic conjunctivitis associated with coxsackievirus A24 variant in The Gambia, West Africa
  13. The impact of a single round of community mass treatment with azithromycin on disease severity and ocular Chlamydia trachomatis load in treatment-naïve trachoma-endemic island communities in West Africa
  14. Pathways-wide genetic risks in Chlamydial infections overlap between tissue tropisms: A genome-wide association scan
  15. Immunofibrogenic Gene Expression Patterns in Tanzanian Children with Ocular Chlamydia trachomatis Infection, Active Trachoma and Scarring: Baseline Results of a 4-Year Longitudinal Study
  16. Genome-wide profiling of humoral immunity and pathogen genes under selection identifies immune evasion tactics of Chlamydia trachomatis during ocular infection
  17. Reduced-cost Chlamydia trachomatis -specific multiplex real-time PCR diagnostic assay evaluated for ocular swabs and use by trachoma research programmes
  18. Population-based prevalence survey of follicular trachoma and trachomatous trichiasis in the Casamance region of Senegal
  19. Persistence of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis: Results from a Comparative Transcriptome Analysis
  20. Spatial clustering of high load ocular Chlamydia trachomatis infection in trachoma: a cross-sectional population-based study
  21. Short-term increase in prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus following mass drug administration with azithromycin for trachoma control
  22. Profiling and validation of individual and patterns of Chlamydia trachomatis-specific antibody responses in trachomatous trichiasis
  23. miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease
  24. Defining Seropositivity Thresholds for Use in Trachoma Elimination Studies
  25. The Relationship between Active Trachoma and Ocular Chlamydia trachomatis Infection before and after Mass Antibiotic Treatment
  26. Blinding Trachoma: Systematic Review of Rates and Risk Factors for Progressive Disease
  27. Mycobacterium leprae Activates Toll-Like Receptor-4 Signaling and Expression on Macrophages Depending on Previous Bacillus Calmette-Guerin Vaccination
  28. Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data
  29. Increased Epithelial Expression of CTGF and S100A7 with Elevated Subepithelial Expression of IL-1β in Trachomatous Trichiasis
  30. Immunohistochemical Analysis of Scarring Trachoma Indicates Infiltration by Natural Killer and Undefined CD45 Negative Cells
  31. Can corneal pannus with trachomatous inflammation – follicular be used in combination as an improved specific clinical sign for current ocular Chlamydia trachomatis infection?
  32. Inverse relationship between microRNA-155 and -184 expression with increasing conjunctival inflammation during ocular Chlamydia trachomatis infection
  33. Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study
  34. Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies
  35. Pathogenesis of Progressive Scarring Trachoma in Ethiopia and Tanzania and Its Implications for Disease Control: Two Cohort Studies
  36. Costs of Testing for Ocular Chlamydia trachomatis Infection Compared to Mass Drug Administration for Trachoma in The Gambia: Application of Results from the PRET Study
  37. Serology for Trachoma Surveillance after Cessation of Mass Drug Administration
  38. Trachoma and Ocular Chlamydial Infection in the Era of Genomics
  39. Anthropometric indices of Gambian children after one or three annual rounds of mass drug administration with azithromycin for trachoma control
  40. Whole-genome enrichment and sequencing of Chlamydia trachomatisdirectly from clinical samples
  41. The conjunctival microbiome in health and trachomatous disease: a case control study
  42. Non-Participation during Azithromycin Mass Treatment for Trachoma in The Gambia: Heterogeneity and Risk Factors
  43. Risk Factors for Active Trachoma and Ocular Chlamydia trachomatis Infection in Treatment-Naïve Trachoma-Hyperendemic Communities of the Bijagós Archipelago, Guinea Bissau
  44. Mass administration of azithromycin and Streptococcus pneumoniae carriage: cross-sectional surveys in the Gambia
  45. Will droplet digital PCR become the test of choice for detecting and quantifying ocularChlamydia trachomatisinfection? Maybe
  46. Conjunctival Scarring in Trachoma Is Associated with the HLA-C Ligand of KIR and Is Exacerbated by Heterozygosity at KIR2DL2/KIR2DL3
  47. Towards a safe and effective chlamydial vaccine: Lessons from the eye
  48. Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children
  49. Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR
  50. Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection
  51. In vivo confocal microscopy and histopathology of the conjunctiva in trachomatous scarring and normal tissue: a systematic comparison
  52. Association between Ocular Bacterial Carriage and Follicular Trachoma Following Mass Azithromycin Distribution in The Gambia
  53. Mass Treatment with Azithromycin for Trachoma: When Is One Round Enough? Results from the PRET Trial in The Gambia
  54. Development and Evaluation of a Next-Generation Digital PCR Diagnostic Assay for Ocular Chlamydia trachomatis Infections
  55. Conjunctival MicroRNA Expression in Inflammatory Trachomatous Scarring
  56. Trachoma: Protective and Pathogenic Ocular Immune Responses to Chlamydia trachomatis
  57. Biogeography of the ecosystems of the healthy human body
  58. Eyescores: an open platform for secure electronic data and photographic evidence collection in ophthalmological field studies
  59. Post-Operative Recurrent Trachomatous Trichiasis Is Associated with Increased Conjunctival Expression of S100A7 (Psoriasin)
  60. A Diagnostics Platform for the Integrated Mapping, Monitoring, and Surveillance of Neglected Tropical Diseases: Rationale and Target Product Profiles
  61. Genome-Wide Identification ofChlamydia trachomatisAntigens Associated with Trachomatous Trichiasis
  62. Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing
  63. Innate Immune Responses and Modified Extracellular Matrix Regulation Characterize Bacterial Infection and Cellular/Connective Tissue Changes in Scarring Trachoma
  64. Active Trachoma Is Associated with Increased Conjunctival Expression ofIL17Aand Profibrotic Cytokines
  65. Diagnostic Accuracy of a Prototype Point-of-Care Test for Ocular Chlamydia trachomatis under Field Conditions in The Gambia and Senegal
  66. Trachoma Prevalence and Associated Risk Factors in The Gambia and Tanzania: Baseline Results of a Cluster Randomised Controlled Trial
  67. Conjunctival Transcriptome in Scarring Trachoma
  68. Profound and Sustained Reduction in Chlamydia trachomatis in The Gambia: A Five-Year Longitudinal Study of Trachoma Endemic Communities
  69. Trichiasis Surgery in The Gambia: A 4-Year Prospective Study
  70. Human Conjunctival Transcriptome Analysis Reveals the Prominence of Innate Defense in Chlamydia trachomatis Infection
  71. Pathway-Focused Arrays Reveal Increased Matrix Metalloproteinase-7 (Matrilysin) Transcription in Trachomatous Trichiasis
  72. Phylogenetic Analysis of Chlamydia trachomatis Tarp and Correlation with Clinical Phenotype
  73. Conjunctival Expression of Matrix Metalloproteinase and Proinflammatory Cytokine Genes after Trichiasis Surgery
  74. Haptoglobin and Sickle Cell Polymorphisms and Risk of Active Trachoma in Gambian Children
  75. Active Trachoma and Ocular Chlamydia trachomatis Infection in Two Gambian Regions: On Course for Elimination by 2020?
  76. Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians
  77. When Can Antibiotic Treatments for Trachoma Be Discontinued? Graduating Communities in Three African Countries
  78. The Development of an Age-Structured Model for Trachoma Transmission Dynamics, Pathogenesis and Control
  79. Revealing the History of Sheep Domestication Using Retrovirus Integrations
  80. Estimating Household and Community Transmission of Ocular Chlamydia trachomatis
  81. Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain
  82. Risk factors for active trachoma in The Gambia
  83. Chlamydia trachomatis ompA Variants in Trachoma: What Do They Tell Us?
  84. Analysis of flow cytometry data using an automatic processing tool
  85. Two Doses of Azithromycin to Eliminate Trachoma in a Tanzanian Community
  86. Pathogenic Diversity amongChlamydia trachomatisOcular Strains in Nonhuman Primates Is Affected by Subtle Genomic Variations
  87. Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation
  88. FOXP3 gene expression in a tuberculosis case contact study
  89. Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians
  90. Chlamydial Positivity of Nasal Discharge at Baseline Is Associated with Ocular Chlamydial Positivity 2 Months following Azithromycin Treatment
  91. Conjunctival FOXP3 Expression in Trachoma: Do Regulatory T Cells Have a Role in Human Ocular Chlamydia trachomatis Infection?
  92. A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatisinfection
  93. The Frequency of Chlamydia trachomatis Major Outer Membrane Protein-Specific CD8+ T Lymphocytes in Active Trachoma Is Associated with Current Ocular Infection
  94. Conjunctival Chlamydial 16S Ribosomal RNA Expression in Trachoma: Is Chlamydial Metabolic Activity Required for Disease to Develop?
  95. Temporal cytokine gene expression patterns in subjects with trachoma identify distinct conjunctival responses associated with infection
  96. Infection with Chlamydia trachomatis after mass treatment of a trachoma hyperendemic community in Tanzania: a longitudinal study
  97. Re-emergence of Chlamydia trachomatis infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal study
  98. Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci
  99. An index of community ocular Chlamydia trachomatis load for control of trachoma
  100. Mass Treatment and the Effect on the Load ofChlamydia trachomatisInfection in a Trachoma-Hyperendemic Community
  101. Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors
  102. Cytokine and Fibrogenic Gene Expression in the Conjunctivas of Subjects from a Gambian Community Where Trachoma Is Endemic
  103. Mass Treatment with Single-Dose Azithromycin for Trachoma
  104. Selective maturation of dendritic cells byNippostrongylus brasiliensis-secreted proteins drives Th2 immune responses
  105. Which Members of a Community Need Antibiotics to Control Trachoma? ConjunctivalChlamydia trachomatisInfection Load in Gambian Villages
  106. Plasmodium falciparum infection of the placenta affects newborn immune responses
  107. Strategies for control of trachoma: observational study with quantitative PCR
  108. Proteins secreted by the parasitic nematodeNippostrongylus brasiliensis act as adjuvants for Th2 responses
  109. Vaccination against helminth parasites - the ultimate challenge for vaccinologists?
  110. Early Interleukin–4: Its Role in the Switch towards a Th2 Response and IgE–Mediated Allergy
  111. Parasite immunity: Pathways for expelling intestinal helminths
  112. Antibody Response to the 60‐kDa Chlamydial Heat‐Shock Protein Is Associated with Scarring Trachoma
  113. Synthetic peptides based on Chlamydia trachomatis antigens identify cytotoxic T lymphocyte responses in subjects from a trachoma‐endemic population
  114. Jaagsiekte retrovirus establishes a disseminated infection of the lymphoid tissues of sheep affected by pulmonary adenomatosis
  115. T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring