All Stories

  1. Plant-Derived Hydrolysates Are a Suitable Replacement for Tryptone N1 in Recombinant Protein Expression Using Human Embryonic Kidney (HEK293-6E) Cells

    Article • BioTech, February 2026, MDPI AG

    Franco Falcone

  2. Galactomannan and Vicilin from Fenugreek Seeds (Trigonella foenum-graecum) Impair Early Pathogen-Host Interaction of Campylobacter jejuni with Intestinal Cells via JlpA

    Article • Planta Medica, February 2025, Thieme Publishing Group

    Franco Falcone

  3. Inverse Correlation of Th2-Specific Cytokines with Hepatic Egg Burden in S. mansoni-Infected Hamsters

    Article • Cells, September 2024, MDPI AG

    Franco Falcone

  4. Front Cover: Fragment‐Based Design, Synthesis, and Characterization of Aminoisoindole‐Derived Furin Inhibitors (ChemMedChem 9/2024)

    Article • ChemMedChem, May 2024, Wiley

    Franco Falcone

  5. Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against Schistosoma mansoni c-Jun N-terminal kinase SMJNK

    Article • Frontiers in Parasitology, April 2024, Frontiers

    Franco Falcone

  6. Multifunctional interaction of CihC/FbpC orthologs of relapsing fever spirochetes with host-derived proteins involved in adhesion, fibrinolysis, and complement evasion

    Article • Frontiers in Immunology, April 2024, Frontiers

    Franco Falcone

  7. Fragment‐Based Design, Synthesis, and Characterization of Aminoisoindole‐Derived Furin Inhibitors

    Article • ChemMedChem, March 2024, Wiley

    Franco Falcone

  8. Identification and characterisation of the tegument-expressed aldehyde dehydrogenase SmALDH_312 of Schistosoma mansoni, a target of disulfiram

    Article • European Journal of Medicinal Chemistry, May 2023, Elsevier

    Franco Falcone

  9. Multiplex Immunofluorescence: A Powerful Tool in Cancer Immunotherapy

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Franco Falcone

  10. Metabolic reprogramming of hepatocytes by Schistosoma mansoni eggs

    Article • JHEP Reports, February 2023, Elsevier

    Franco Falcone

  11. The Humanised NPY-mRFP RBL Reporter Cell Line Is a Fast and Inexpensive Tool for Detection of Allergen-Specific IgE in Human Sera

    Article • Diagnostics, August 2022, MDPI AG

    Franco Falcone

  12. CipA mediates complement resistance of Acinetobacter baumannii by formation of a factor I-dependent quadripartite assemblage

    Article • Frontiers in Immunology, July 2022, Frontiers

    Franco Falcone

  13. Docking-Based Virtual Screening Enables Prioritizing Protein Kinase Inhibitors With In Vitro Phenotypic Activity Against Schistosoma mansoni

    Article • Frontiers in Cellular and Infection Microbiology, July 2022, Frontiers

    Franco Falcone

  14. Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis

    Article • Molecules, February 2022, MDPI AG

    Franco Falcone

  15. CipA mediates complement resistance of Acinetobacter baumannii by formation of a Factor I-dependent quadripartite assemblage

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Franco Falcone

  16. Ascaris lumbricoides and ticks associated with sensitization to galactose α1,3-galactose and elicitation of the alpha-gal syndrome

    Article • Journal of Allergy and Clinical Immunology, February 2022, Elsevier

    Franco Falcone

  17. Introduction of a Hexalysine (6 K) Tag Can Protect from N-Terminal Cleavage and Increase Yield of Recombinant Proteins Expressed in the Periplasm of E. coli

    Article • January 2022, Springer Science + Business Media

    Franco Falcone

  18. Are humanized IgE reporter systems potential game changers in serological diagnosis of human parasitic infection?

    Article • Parasitology Research, November 2021, Springer Science + Business Media

    Franco Falcone

  19. Does Schistosoma Mansoni Facilitate Carcinogenesis?

    Article • Cells, August 2021, MDPI AG

    Franco Falcone

  20. Structural and binding characterization of the LacdiNAc-specific adhesin (LabA; HopD) exodomain from Helicobacter pylori

    Article • Current Research in Structural Biology, January 2021, Elsevier

    Franco Falcone

  21. IPSE, a urogenital parasite-derived immunomodulatory molecule, suppresses bladder pathogenesis and anti-microbial peptide gene expression in bacterial urinary tract infection

    Article • Parasites & Vectors, December 2020, Springer Science + Business Media

    Franco Falcone

  22. Campylobacter sp.: Pathogenicity factors and prevention methods—new molecular targets for innovative antivirulence drugs?

    Article • Applied Microbiology and Biotechnology, November 2020, Springer Science + Business Media

    Franco Falcone

  23. IPSE, a Urogenital Parasite-Derived Immunomodulatory Molecule, Suppresses Bladder Pathogenesis and Anti-Microbial Peptide Gene Expression in Bacterial Urinary Tract Infection

    Article • November 2020, Springer Science + Business Media

    Franco Falcone

  24. Development of a protein microarray-based diagnostic chip mimicking the skin prick test for allergy diagnosis

    Article • Scientific Reports, October 2020, Springer Science + Business Media

    Franco Falcone

  25. IPSE, an abundant egg-secreted protein of the carcinogenic helminth Schistosoma haematobium, promotes proliferation of bladder cancer cells and angiogenesis

    Article • Infectious Agents and Cancer, October 2020, Springer Science + Business Media

    Franco Falcone

  26. IPSE, an Abundant Egg-Secreted Protein of the Carcinogenic Helminth Schistosoma haematobium, Promotes Proliferation of Bladder Cancer Cells and Angiogenesis

    Article • October 2020, Springer Science + Business Media

    Franco Falcone

  27. The evolution of IgE‐mediated type I hypersensitivity and its immunological value

    Article • Allergy, September 2020, Wiley

    Franco Falcone

  28. IPSE, a Parasite-Derived, Host Immunomodulatory Infiltrin Protein, Alleviates Resiniferatoxin-Induced Bladder Pain

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Franco Falcone

  29. Author Correction: Antigenic cross-reactivity between Schistosoma mansoni and allergenic invertebrates putatively due to shared glycanic epitopes

    Article • Scientific Reports, May 2020, Springer Science + Business Media

    Franco Falcone

  30. Use of BODIPY-Labeled ATP Analogues in the Development and Validation of a Fluorescence Polarization-Based Assay for Screening of Kinase Inhibitors

    Article • ACS Omega, April 2020, American Chemical Society (ACS)

    Franco Falcone

  31. Antigenic cross-reactivity between Schistosoma mansoni and allergenic invertebrates putatively due to shared glycanic epitopes

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    Franco Falcone

  32. IPSE, a parasite-derived, host immunomodulatory infiltrin protein, alleviates resiniferatoxin-induced bladder pain

    Article • Molecular Pain, January 2020, SAGE Publications

    Franco Falcone

  33. NPY-mRFP Rat Basophilic Leukemia (RBL) Reporter: A Novel, Fast Reporter of Basophil/Mast Cell Degranulation

    Article • January 2020, Springer Science + Business Media

    Franco Falcone

  34. Purification of Basophils from Peripheral Human Blood

    Article • January 2020, Springer Science + Business Media

    Franco Falcone

  35. Use of Engineered Nanoparticles (ENPs) for the Study of High-Affinity IgE FcεRI Receptor Engagement and Rat Basophilic Leukemia (RBL) Cell Degranulation

    Article • January 2020, Springer Science + Business Media

    Franco Falcone

  36. Use of Humanized Fluorescent Reporter Cell Line RBL NFAT-DsRed for the Detection of Allergen-Specific IgE in Patient Sera Using Allergen Microarrays

    Article • January 2020, Springer Science + Business Media

    Franco Falcone

  37. Use of Humanized RBL Reporter Systems for the Detection of Allergen-Specific IgE Sensitization in Human Serum

    Article • January 2020, Springer Science + Business Media

    Franco Falcone

  38. BabA and LPS inhibitors against Helicobacter pylori: pectins and pectin-like rhamnogalacturonans as adhesion blockers

    Article • Applied Microbiology and Biotechnology, November 2019, Springer Science + Business Media

    Franco Falcone

  39. Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori

    Article • Protein Expression and Purification, November 2019, Elsevier

    Franco Falcone

  40. Profiling Transcriptional Regulation and Functional Roles of Schistosoma mansoni c-Jun N-Terminal Kinase

    Article • Frontiers in Genetics, October 2019, Frontiers

    Franco Falcone

  41. Corrigendum to “The Schistosoma mansoni cyclophilin a epitope 107–121 induces a protective immune response against schistosomiasis” [Mol. Immunol. 111(2019) 172–181]

    Article • Molecular Immunology, October 2019, Elsevier

    Franco Falcone

  42. Characterization of human FcεRIα chain expression and gene copy number in humanized rat basophilic leukaemia (RBL) reporter cell lines

    Article • PLOS One, August 2019, PLOS

    Franco Falcone

  43. The Schistosoma mansoni cyclophilin A epitope 107-121 induces a protective immune response against schistosomiasis

    Article • Molecular Immunology, July 2019, Elsevier

    Franco Falcone

  44. IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis

    Article • AJP Renal Physiology, June 2019, American Physiological Society

    Franco Falcone, Abdulaziz Alouffi

  45. IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Franco Falcone, Abdulaziz Alouffi

  46. IPSE, a parasite-derived host immunomodulatory protein, is a promising therapeutic for hemorrhagic cystitis

    Article • August 2018, Cold Spring Harbor Laboratory Press

    Abdulaziz Alouffi , Franco Falcone

  47. Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis

    Article • The FASEB Journal, August 2018, Federation of American Societies For Experimental Biology (FASEB)

    Michael Hsieh, Franco Falcone, Abdulaziz Alouffi

  48. IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways

    Article • July 2018, Cold Spring Harbor Laboratory Press

    Abdulaziz Alouffi , Franco Falcone

  49. Polyionic Tags as Enhancers of Protein Solubility in Recombinant Protein Expression

    Article • Microorganisms, May 2018, MDPI AG

    Franco Falcone

  50. Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery

    Article • International Journal of Pharmaceutics, April 2018, Elsevier

    Franco Falcone

  51. RBL cells as models for in vitro studies of mast cells and basophils

    Article • Immunological Reviews, February 2018, Wiley

    Franco Falcone

  52. Screening natural libraries of human milk oligosaccharides against lectins using CaR-ESI-MS

    Article • The Analyst, January 2018, Royal Society of Chemistry

    Franco Falcone

  53. H-IPSE Is a Pathogen-Secreted Host Nucleus-Infiltrating Protein (Infiltrin) Expressed Exclusively by the Schistosoma haematobium Egg Stage

    Article • Infection and Immunity, September 2017, ASM Journals

    Franco Falcone, Abdulaziz Alouffi

  54. Use of Humanized RS-ATL8 Reporter System for Detection of Allergen-Specific IgE Sensitization in Human Food Allergy

    Article • January 2017, Springer Science + Business Media

    Franco Falcone

  55. Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

    Article • World Allergy Organization Journal, January 2016, Elsevier

    Franco Falcone

  56. Use of Humanized Rat Basophilic Leukemia Reporter Cell Lines as a Diagnostic Tool for Detection of Allergen-Specific IgE in Allergic Patients: Time for a Reappraisal?

    Article • Current Allergy and Asthma Reports, October 2015, Springer Science + Business Media

    Franco Falcone

  57. Live Imaging of Cellular Internalization of Single Colloidal Particle by Combined Label-Free and Fluorescence Total Internal Reflection Microscopy

    Article • Molecular Pharmaceutics, October 2015, American Chemical Society (ACS)

    Franco Falcone

  58. Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA

    Article • Science Advances, August 2015, American Association for the Advancement of Science

    Franco Falcone

  59. Correction: PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs

    Article • PLOS One, June 2015, PLOS

    Franco Falcone

  60. Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag

    Article • Protein Expression and Purification, February 2015, Elsevier

    Franco Falcone

  61. The search for mast cell and basophil models - are we getting closer to pathophysiological relevance?

    Article • Allergy, December 2014, Wiley

    Dr Ekaterini Tiligada, Franco Falcone

  62. High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites

    Article • Carbohydrate Polymers, November 2014, Elsevier

    Franco Falcone

  63. Use of Humanised Rat Basophilic Leukaemia Cell Line RS-ATL8 for the Assessment of Allergenicity of Schistosoma mansoni Proteins

    Article • PLoS Neglected Tropical Diseases, September 2014, PLOS

    Franco Falcone

  64. Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a

    Article • Journal of Allergy and Clinical Immunology, September 2014, Elsevier

    Franco Falcone

  65. Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules

    Article • Experimental Cell Research, April 2014, Elsevier

    Franco Falcone

  66. Serological Screening of the Schistosoma mansoni Adult Worm Proteome

    Article • PLoS Neglected Tropical Diseases, March 2014, PLOS

    Franco Falcone

  67. Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human Immunity

    Article • Frontiers in Immunology, January 2014, Frontiers

    Franco Falcone

  68. Myeloid-Derived microRNAs, miR-223, miR27a, and miR-652, Are Dominant Players in Myeloid Regulation

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Franco Falcone

  69. Basophils and Mast Cells

    Article • January 2014, Springer Science + Business Media

    Franco Falcone

  70. Purification of Basophils from Peripheral Human Blood

    Article • January 2014, Springer Science + Business Media

    Franco Falcone

  71. Use of Humanized Rat Basophil Leukemia (RBL) Reporter Systems for Detection of Allergen-Specific IgE Sensitization in Human Serum

    Article • January 2014, Springer Science + Business Media

    Franco Falcone

  72. Uptake and transport of B 12 -conjugated nanoparticles in airway epithelium

    Article • Journal of Controlled Release, November 2013, Elsevier

    Franco Falcone

  73. Evidence Supporting a Role for Mammalian Chitinases in Efficacy of Caspofungin against Experimental Aspergillosis in Immunocompromised Rats

    Article • PLOS One, October 2013, PLOS

    Franco Falcone

  74. The history of mast cell and basophil research - some lessons learnt from the last century

    Article • Allergy, August 2013, Wiley

    Franco Falcone

  75. Optimisation and Use of Humanised RBL NF-AT-GFP and NF-AT-DsRed Reporter Cell Lines Suitable for High-Throughput Scale Detection of Allergic Sensitisation in Array Format and Identification of the ECM–Integrin Interaction as Critical Factor

    Article • Molecular Biotechnology, July 2013, Springer Science + Business Media

    Franco Falcone

  76. Basophilic histamine content and release during venom immunotherapy: Insights by flow cytometry

    Article • Cytometry Part B Clinical Cytometry, February 2013, Wiley

    Franco Falcone

  77. PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs

    Article • PLOS One, February 2013, PLOS

    Franco Falcone

  78. Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils

    Article • Leukemia & Lymphoma, October 2012, Taylor & Francis

    Franco Falcone

  79. Prediction of tolerance in children with IgE mediated cow's milk allergy by microarray profiling and chemometric approach

    Article • Journal of Immunological Methods, August 2012, Elsevier

    Franco Falcone

  80. Ligand density and clustering effects on endocytosis of folate modified nanoparticles

    Article • RSC Advances, January 2012, Royal Society of Chemistry

    Franco Falcone

  81. Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria

    Article • Journal of Allergy and Clinical Immunology, December 2011, Elsevier

    Franco Falcone

  82. The role of basophils in the pathogenesis of allergic disease

    Article • Clinical & Experimental Allergy, May 2011, Wiley

    Franco Falcone

  83. Multiple protein extract microarray for profiling human food-specific immunoglobulins A, M, G and E

    Article • Journal of Immunological Methods, February 2011, Elsevier

    Franco Falcone

  84. Interleukin-4-Inducing Principle fromSchistosoma mansoniEggs Contains a Functional C-Terminal Nuclear Localization Signal Necessary for Nuclear Translocation in Mammalian Cells but Not for Its Uptake

    Article • Infection and Immunity, January 2011, ASM Journals

    Franco Falcone

  85. Experimental hookworm infection: a randomized placebo-controlled trial in asthma

    Article • Clinical & Experimental Allergy, February 2010, Wiley

    Franco Falcone

  86. Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients

    Article • Journal of Allergy and Clinical Immunology, December 2009, Elsevier

    Franco Falcone

  87. Alginate encapsulation technology supports embryonic stem cells differentiation into insulin-producing cells

    Article • Journal of Biotechnology, December 2009, Elsevier

    Franco Falcone

  88. Basophils as critical orchestrators of Th2-type immune responses

    Article • Expert Review of Clinical Immunology, November 2009, Taylor & Francis

    Franco Falcone

  89. Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study

    Article • Clinical & Experimental Allergy, July 2009, Wiley

    Franco Falcone

  90. Total internal reflection microscopy for live imaging of cellular uptake of sub-micron non-fluorescent particles

    Article • Journal of Microscopy, July 2008, Wiley

    Franco Falcone

  91. A comparison of procedures for purifying human basophils to near homogeneity

    Article • Inflammation Research, March 2008, Springer Science + Business Media

    Franco Falcone

  92. A rapid two-step procedure for the purification of human peripheral blood basophils to near homogeneity

    Article • Clinical & Experimental Allergy, March 2008, Wiley

    Franco Falcone

  93. Human chitotriosidase is expressed in the eye and lacrimal gland and has an antimicrobial spectrum different from lysozyme

    Article • Microbes and Infection, January 2008, Elsevier

    Franco Falcone

  94. A novel tool for the detection of allergic sensitization combining protein microarrays with human basophils

    Article • Clinical & Experimental Allergy, December 2007, Wiley

    Franco Falcone

  95. Chitotriosidase deficiency is not associated with human hookworm infection in a Papua New Guinean population

    Article • Infection Genetics and Evolution, December 2007, Elsevier

    Franco Falcone

  96. The 21st century renaissance of the basophil? Current insights into its role in allergic responses and innate immunity

    Article • Experimental Dermatology, November 2006, Wiley

    Franco Falcone

  97. Lack of protease activated receptor (PAR) expression in purified human basophils

    Article • Inflammation Research, April 2005, Springer Science + Business Media

    Franco Falcone

  98. Parasite role reversal: worms on trial

    Article • Trends in Parasitology, April 2005, Elsevier

    Franco Falcone

  99. Le polynucléaire basophile et immunité anti-parasitaire : une mise à jour

    Article • Revue Française d Allergologie et d Immunologie Clinique, January 2004, Elsevier

    Franco Falcone

  100. The Innate Allergenicity of Helminth Parasites

    Article • Clinical Reviews in Allergy & Immunology, January 2004, Springer Science + Business Media

    Franco Falcone

  101. Molecular Characterization of an Interleukin-4-inducing Factor fromSchistosoma mansoniEggs

    Article • Journal of Biological Chemistry, March 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Franco Falcone

  102. A Brugia malayi Homolog of Macrophage Migration Inhibitory Factor Reveals an Important Link Between Macrophages and Eosinophil Recruitment During Nematode Infection

    Article • The Journal of Immunology, November 2001, The American Association of Immunologists

    Franco Falcone

  103. A glycoprotein from Schistosoma mansoni eggs binds non-antigen-specific immunoglobulin E and releases interleukin-4 from human basophils

    Article • Parasite Immunology, August 2001, Wiley

    Franco Falcone

  104. Ascaris suum-Derived Products Induce Human Neutrophil Activation via a G Protein-Coupled Receptor That Interacts with the Interleukin-8 Receptor Pathway

    Article • Infection and Immunity, June 2001, ASM Journals

    Franco Falcone

  105. Do basophils play a role in immunity against parasites?

    Article • Trends in Parasitology, March 2001, Elsevier

    Franco Falcone

  106. The New Subfamily of Cathepsin-Z-like Protease Genes Includes Tc-cpz-1, a Cysteine Protease Gene Expressed in Toxocara canis Adults and Infective Stage Larvae

    Article • Experimental Parasitology, March 2000, Elsevier

    Franco Falcone

  107. A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA

    Article • RNA, February 2000, Cold Spring Harbor Laboratory Press

    Franco Falcone

  108. Vaccination against helminth parasites - the ultimate challenge for vaccinologists?

    Article • Immunological Reviews, October 1999, Wiley

    Dr Martin Holland, Franco Falcone

  109. Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils

    Article • European Journal of Immunology, March 1999, Wiley

    Franco Falcone

  110. Early Interleukin–4: Its Role in the Switch towards a Th2 Response and IgE–Mediated Allergy

    Article • International Archives of Allergy and Immunology, January 1999, Karger Publishers

    Dr Martin Holland, Franco Falcone

  111. A three-step procedure for the purification of human basophils from buffy coat blood

    Article • Inflammation Research, April 1997, Springer Science + Business Media

    Franco Falcone

  112. Purified human peripheral blood basophils release interleukin-13 and preformed interleukin-4 following immunological activation

    Article • European Journal of Immunology, October 1996, Wiley

    Franco Falcone

  113. Human basophils release interleukin-4 after stimulation withSchistosoma mansoni egg antigen

    Article • European Journal of Immunology, May 1996, Wiley

    Franco Falcone