All Stories

  1. Sulfur dioxide extrusion: Exploring the mechanism behind the formation of highly reactive 5-(trifluoromethyl)azafulvenium methide intermediates

    Article • Journal of Analytical and Applied Pyrolysis, August 2025, Elsevier

    Maria Isabel Soares, Teresa Pinho e Melo

  2. Novel tetradentate N2O2 water-soluble Schiff Base and its Al(III) complex: Synthesis, structural characterization, and correlations between structure and stability against hydrolysis

    Article • Journal of Molecular Structure, June 2025, Elsevier

    Maria Isabel Soares, Teresa Pinho e Melo

  3. Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts macrophage immune response

    Article • Journal of Lipid Research, June 2025, Elsevier

    Maria Isabel Soares

  4. Chiral hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: the search for selective p53-activating agents for colorectal cancer therapy

    Article • RSC Medicinal Chemistry, January 2024, Royal Society of Chemistry

    Maria Isabel Soares, Teresa Pinho e Melo

  5. Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts

    Article • Cells, December 2023, MDPI AG

    Maria Isabel Soares, Teresa Pinho e Melo

  6. Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation

    Article • Journal of Lipid Research, September 2023, Elsevier

    Maria Isabel Soares, Teresa Pinho e Melo

  7. Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages

    Article • Traffic, May 2023, Wiley

    Maria Isabel Soares, Teresa Pinho e Melo

  8. Diels–Alder Cycloaddition Reactions in Sustainable Media

    Article • Molecules, February 2022, MDPI AG

    Teresa Pinho e Melo, Maria Isabel Soares

  9. Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cell homeostasis

    Article • Journal of Cell Science, October 2021, The Company of Biologists

    Teresa Pinho e Melo, Maria Isabel Soares

  10. Synthesis and structure-activity relationships of new chiral spiro-β-lactams highly active against HIV-1 and Plasmodium

    Article • European Journal of Medicinal Chemistry, July 2021, Elsevier

    Maria Isabel Soares, Teresa Pinho e Melo

  11. Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams

    Article • Advanced Synthesis & Catalysis, April 2021, Wiley

    Maria Isabel Soares, Teresa Pinho e Melo

  12. A selective p53 activator and anticancer agent to improve colorectal cancer therapy

    Article • Cell Reports, April 2021, Elsevier

    PhD Filipe Monteiro, Maria Isabel Soares, Teresa Pinho e Melo

  13. Synthesis of 5H-chromeno[3,4-b]pyridines via DABCO-catalyzed [3 + 3] annulation of 3-nitro-2H-chromenes and allenoates

    Article • Organic & Biomolecular Chemistry, January 2021, Royal Society of Chemistry

    Dr Joaquim Marçalo, Teresa Pinho e Melo, Maria Isabel Soares

  14. Strategies and methodologies for the construction of spiro-γ-lactams: an update

    Article • Organic Chemistry Frontiers, January 2021, Royal Society of Chemistry

    Teresa Pinho e Melo, Maria Isabel Soares

  15. Spiro-Lactams as Novel Antimicrobial Agents

    Article • Current Topics in Medicinal Chemistry, February 2020, Bentham Science Publishers

    Teresa Pinho e Melo, Maria Isabel Soares

  16. 1,3-Dipolar Cycloadditions Involving Allenes: Synthesis of Five-Membered Rings

    Article • Current Organic Chemistry, January 2020, Bentham Science Publishers

    Maria Isabel Soares

  17. Phosphane-Catalyzed [3+2] Annulation of Allenoates with 3-Nitro-2H -chromenes: Synthesis of Tetrahydrocyclopenta[c ]chromenes

    Article • European Journal of Organic Chemistry, June 2019, Wiley

    Maria Isabel Soares, Teresa Pinho e Melo

  18. Molecular and crystal structures and spectroscopic properties of 2-oxo-2-(Thiophen-2-yl) ethyl phosphonic acid

    Article • Journal of Molecular Structure, February 2019, Elsevier

    Maria Isabel Soares

  19. ONE-POT DIASTEREOSELECTIVE SYNTHESIS OF CHIRAL TRICYCLIC l-CYSTEINE AND d-PENICILLAMINE DERIVATIVES: A LABORATORY EXPERIMENT

    Article • Química Nova, January 2019, Sociedade Brasileira de Quimica (SBQ)

    Maria Isabel Soares, Teresa Pinho e Melo

  20. Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, February 2017, Elsevier

    Maria Isabel Soares, Teresa Pinho e Melo

  21. Conformational behaviour, photochemistry and flash vacuum pyrolysis of a 2-(1H-tetrazol-1-yl)thiophene

    Article • New Journal of Chemistry, January 2017, Royal Society of Chemistry

    Maria Isabel Soares, Teresa Pinho e Melo

  22. Synthesis of Thieno[2,3-d]pyrimidines via Microwave-Assisted Thermolysis of 1-(Thiophene-2-yl)-1H-tetrazoles

    Article • ChemistrySelect, September 2016, Wiley

    Maria Isabel Soares, Teresa Pinho e Melo

  23. Synthesis and thermal reactivity of thiazolo[3,4-a]benzimidazole-2,2-dioxides: approach to 1H-benzo[d]imidazoles via novel benzo-2,5-diazafulvenium methides

    Article • Tetrahedron, June 2015, Elsevier

    Maria Isabel Soares, Teresa Pinho e Melo

  24. Thermolysis of 1-(thiophen-2-yl)-1H-tetrazoles: a route to thiophene-fused imidazoles and pyrimidines

    Article • Tetrahedron, May 2015, Elsevier

    Maria Isabel Soares, Teresa Pinho e Melo

  25. Pericyclic Reactions of Azafulvenium Methides Bearing Internal Dipolarophiles - Synthesis of Chromene and Chromane Derivatives

    Article • European Journal of Organic Chemistry, January 2015, Wiley

    Maria Isabel Soares, Teresa Pinho e Melo

  26. 742: Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer MCF7 and HCC1806 cell lines

    Article • European Journal of Cancer, July 2014, Elsevier

    Mafalda Laranjo, Maria Isabel Soares

  27. 741: PARP-inhibitor PJ34 potentiates the anticancer effect of chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles against breast cancer cell lines

    Article • European Journal of Cancer, July 2014, Elsevier

    Mafalda Laranjo, Maria Isabel Soares

  28. Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles

    Article • European Journal of Medicinal Chemistry, May 2014, Elsevier

    Teresa Pinho e Melo, Ana Cristina Gonçalves, Mafalda Laranjo, Maria Isabel Soares

  29. Microwave-induced Pericyclic Reactions of Aza- and Diazafulvenium Methides

    Article • Current Microwave Chemistry, March 2014, Bentham Science Publishers

    Teresa Pinho e Melo, Maria Isabel Soares

  30. Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-breast cancer properties

    Article • European Journal of Medicinal Chemistry, February 2013, Elsevier

    Teresa Pinho e Melo, Mafalda Laranjo, Maria Isabel Soares

  31. Thiazolo[3,4-b]indazole-2,2-dioxides as Masked Extended Dipoles: Pericyclic Reactions of Benzodiazafulvenium Methides

    Article • The Journal of Organic Chemistry, December 2012, American Chemical Society (ACS)

    Teresa Pinho e Melo, Maria Isabel Soares

  32. Nitrogen-bridged heterocycles via cycloaddition of non-classical heterocyclic-fused-[c]thiazoles

    Article • Tetrahedron, October 2011, Elsevier

    Teresa Pinho e Melo, Maria Isabel Soares

  33. Chiral 6-hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: Novel antitumor DNA monoalkylating agents

    Article • European Journal of Medicinal Chemistry, October 2010, Elsevier

    Teresa Pinho e Melo, Mafalda Laranjo, Maria Isabel Soares

  34. Novel antitumor DNA monoalkylating agents: Synthesis and biological evaluation

    Article • BMC Proceedings, September 2010, Springer Science + Business Media

    Maria Isabel Soares, Teresa Pinho e Melo

  35. Flash vacuum pyrolysis of 2,2-dioxo-1H,3H-pyrrolo[1,2-c]thiazoles and 2-vinyl-1H-pyrroles

    Article • Tetrahedron, October 2008, Elsevier

    Teresa Pinho e Melo, PhD Rui M Brito, Maria Isabel Soares

  36. Microwave-assisted generation and reactivity of aza- and diazafulvenium methides: heterocycles via pericyclic reactions

    Article • Tetrahedron Letters, August 2008, Elsevier

    Teresa Pinho e Melo, Maria Isabel Soares

  37. Chemistry of Diazafulvenium Methides in the Synthesis of Functionalized Pyrazoles

    Article • The Journal of Organic Chemistry, May 2007, American Chemical Society (ACS)

    Teresa Pinho e Melo, Maria Isabel Soares

  38. ‘Higher-order’ azomethine ylides in the synthesis of functionalized pyrroles and 5-oxo-5H-pyrrolizines

    Article • Tetrahedron, February 2007, Elsevier

    Teresa Pinho e Melo, Maria Isabel Soares

  39. Conformational Behavior of Dimethyl 5-Methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate 2,2-Dioxide Isolated in Low-Temperature Matrixes

    Article • The Journal of Physical Chemistry A, May 2006, American Chemical Society (ACS)

    Teresa Pinho e Melo, Maria Isabel Soares

  40. New chemistry of diazafulvenium methides: one way to pyrazoles

    Article • Tetrahedron Letters, January 2006, Elsevier

    Teresa Pinho e Melo, Maria Isabel Soares, Antonio Rocha Gonsalves

  41. N-Vinyl- and C-Vinylpyrroles from Azafulvenium Methides. Flash Vacuum Pyrolysis Route to 5-Oxo-5H-pyrrolizines and 1-Azabenzo[f]azulenes

    Article • The Journal of Organic Chemistry, July 2005, American Chemical Society (ACS)

    Teresa Pinho e Melo, Maria Isabel Soares, Antonio Rocha Gonsalves

  42. Reactivity of azafulvenium methides derived from pyrrolo[1,2-c]thiazole-2,2-dioxides: synthesis of functionalised pyrroles

    Article • Tetrahedron Letters, May 2004, Elsevier

    Teresa Pinho e Melo, Maria Isabel Soares, Antonio Rocha Gonsalves

  43. Synthesis of Chiral Pyrrolo[1,2-c]thiazoles via Intramolecular Dipolar Cycloaddition of Münchnones:  An Interesting Rearrangement to Pyrrolo[1,2-c]thiazines

    Article • The Journal of Organic Chemistry, May 2002, American Chemical Society (ACS)

    Teresa Pinho e Melo, Maria Isabel Soares, Antonio Rocha Gonsalves