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  1. Biological Aging and Uterine Fibrosis in Cattle: Reproductive Trade-Offs from Enhanced Productivity

    Article • Cells, June 2025, MDPI AG

    Kazuhiko Imakawa

  2. Epithelial–Mesenchymal Transitions Leading to Conceptus Adhesion in Ruminants: Early Pregnancy Events in Cattle

    Article • International Journal of Molecular Sciences, April 2025, MDPI AG

    Kazuhiko Imakawa

  3. Buccal Swab Samples from Japanese Brown Cattle Fed with Limonite Reveal Altered Rumen Microbiome

    Article • Animals, July 2024, MDPI AG

    Kazuhiko Imakawa

  4. Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle

    Article • Biomolecules, November 2023, MDPI AG

    Kazuhiko Imakawa

  5. Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle

    Article • October 2023, MDPI AG

    Kazuhiko Imakawa

  6. Endogenous Retroviruses and Placental Evolution, Development, and Diversity

    Article • Cells, August 2022, MDPI AG

    Kazuhiko Imakawa

  7. Characterization of Serum Metabolome and Proteome Profiles Identifies SNX5 Specific for Pregnancy Failure in Holstein Heifers

    Article • Life, February 2022, MDPI AG

    Kazuhiko Imakawa

  8. Characterization of lncRNA functioning in ovine conceptuses and endometria during the peri-implantation period

    Article • Biochemical and Biophysical Research Communications, February 2022, Elsevier

    Kazuhiko Imakawa

  9. Epithelial-mesenchymal transition process during embryo implantation

    Article • Cell and Tissue Research, January 2022, Springer Science + Business Media

    Kazuhiko Imakawa

  10. Epithelial-mesenchymal transition and bi- and multi-nucleated trophoblast cell formation in ovine conceptuses during the peri-implantation period

    Article • Journal of Reproduction and Development, January 2022, Japanese Society of Animal Reproduction

    Kazuhiko Imakawa

  11. The effect of bta-miR-26b in intrauterine extracellular vesicles on maternal immune system during the implantation period

    Article • Biochemical and Biophysical Research Communications, October 2021, Elsevier

    Kazuhiko Imakawa

  12. Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions

    Article • Frontiers in Genetics, June 2021, Frontiers

    Kazuhiko Imakawa

  13. Formation of fibrin at sites of conceptus adhesion in the ewe

    Article • Reproduction, June 2021, Bioscientifica

    Kazuhiko Imakawa

  14. Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy

    Article • Biochemical and Biophysical Research Communications, May 2021, Elsevier

    Kazuhiko Imakawa

  15. A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP

    Article • Scientific Reports, February 2021, Springer Science + Business Media

    Kazuhiko Imakawa

  16. Genetic variation in Japanese Holstein cattle for EBL development

    Article • BMC Veterinary Research, October 2020, Springer Science + Business Media

    Kazuhiko Imakawa

  17. Peptidoglycan disrupts early embryo-maternal crosstalk via suppression of ISGs expression induced by interferon-tau in the bovine endometrium

    Article • Biochemical and Biophysical Research Communications, October 2020, Elsevier

    Kazuhiko Imakawa

  18. Emerging Role of Extracellular Vesicles in Embryo–Maternal Communication throughout Implantation Processes

    Article • International Journal of Molecular Sciences, August 2020, MDPI AG

    Kazuhiko Imakawa, Hiroshi Fujiwara

  19. Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune crosstalk in the corpus luteum, oviduct, and uterus

    Article • Theriogenology, July 2020, Elsevier

    Kazuhiko Imakawa

  20. IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle

    Article • Reproduction, May 2020, Bioscientifica

    Kazuhiko Imakawa

  21. Increasing Bovine leukemia virus (BLV) proviral load is a risk factor for progression of Enzootic bovine leucosis: A prospective study in Japan

    Article • Preventive Veterinary Medicine, May 2020, Elsevier

    Kazuhiko Imakawa

  22. Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

    Article • International Journal of Molecular Sciences, March 2020, MDPI AG

    Kazuhiko Imakawa, Hiroshi Fujiwara

  23. Effects of miR-98 in intrauterine extracellular vesicles on maternal immune regulation during the peri-implantation period in cattle

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Kazuhiko Imakawa

  24. Bovine endometrium responds to sperm via TLR2/4 pathway

    Article • PLOS One, April 2019, PLOS

    Mohamed Ezz, Kazuhiko Imakawa

  25. Implantation and Placentation in cattle and other mammals

    Article • Bioscientifica Proceedings, April 2019, Bioscientifica

    Kazuhiko Imakawa

  26. Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems

    Article • Current Pharmaceutical Biotechnology, November 2018, Bentham Science Publishers

    Kazuhiko Imakawa, Hiroshi Fujiwara

  27. Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis

    Article • Cell Death and Differentiation, November 2018, Springer Science + Business Media

    Kazuhiko Imakawa

  28. Day‐7 embryos generate an anti‐inflammatory immune response in peripheral blood immune cells in superovulated cows

    Article • American Journal of Reproductive Immunology, November 2018, Wiley

    Kazuhiko Imakawa

  29. Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus

    Article • Biochemical and Biophysical Research Communications, June 2018, Elsevier

    Kazuhiko Imakawa

  30. Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells

    Article • Scientific Reports, May 2018, Springer Science + Business Media

    Kazuhiko Imakawa

  31. Integration of molecules to construct the processes of conceptus implantation to the maternal endometrium

    Article • Journal of Animal Science, March 2018, Oxford University Press (OUP)

    Kazuhiko Imakawa

  32. Regulation of human trophoblast cell syncytialization by transcription factors STAT5B and NR4A3

    Article • Journal of Cellular Biochemistry, March 2018, Wiley

    Kazuhiko Imakawa

  33. Events associated with pregnancy establishment

    Article • The FASEB Journal, February 2018, Wiley

    Kazuhiko Imakawa

  34. Induction of immune-related gene expression by seminal exosomes in the porcine endometrium

    Article • Biochemical and Biophysical Research Communications, January 2018, Elsevier

    Kazuhiko Imakawa

  35. Intrauterine exosomes are required for bovine conceptus implantation

    Article • Biochemical and Biophysical Research Communications, January 2018, Elsevier

    Kazuhiko Imakawa

  36. Potential roles of metalloproteinases of endometrium-derived exosomes in embryo-maternal crosstalk during implantation

    Article • Journal of Cellular Physiology, December 2017, Wiley

    Kazuhiko Imakawa

  37. Transcriptional control of IFNT expression

    Article • Reproduction, October 2017, Bioscientifica

    Kazuhiko Imakawa

  38. Increase in complement iC3b is associated with anti-inflammatory cytokine expression during late pregnancy in mice

    Article • PLOS One, May 2017, PLOS

    Kazuhiko Imakawa

  39. Thirty years of interferon-tau research; Past, present and future perspective

    Article • Animal Science Journal, May 2017, Wiley

    Kazuhiko Imakawa

  40. Not one event, but a series of events required for pregnancy establishment

    Article • Journal of Endocrinology, February 2017, Bioscientifica

    Kazuhiko Imakawa, Hiroshi Fujiwara

  41. The Phylogeny of Placental Evolution Through Dynamic Integrations of Retrotransposons

    Article • January 2017, Elsevier

    Kazuhiko Imakawa

  42. Regulation of epithelial to mesenchymal transition in bovine conceptuses through the interaction between follistatin and activin A

    Article • Molecular and Cellular Endocrinology, October 2016, Elsevier

    Kazuhiko Imakawa

  43. CITED2 modulation of trophoblast cell differentiation: insights from global transcriptome analysis

    Article • Reproduction, February 2016, Bioscientifica

    Kazuhiko Imakawa

  44. Retroviral genes could be endogenized repeatedly during mammalian evolution.

    Article • Genes to Cells, September 2015, Wiley

    Kazuhiko Imakawa

  45. The localization of GATA2 in the nuclear and cytoplasmic regions of ovine conceptuses

    Article • Animal Science Journal, August 2014, Wiley

    Kazuhiko Imakawa

  46. Involvement of VCAM1 in the bovine conceptus adhesion to the uterine endometrium

    Article • May 2014, Bioscientifica

    Kazuhiko Imakawa, Hiroshi Fujiwara

  47. Establishment and characterization of immortalized bovine endometrial epithelial cells

    Article • Animal Science Journal, April 2014, Wiley

    Kazuhiko Imakawa

  48. Expression andin situlocalization ofGATA4, 5and6 mRNAs in ovine conceptuses and uterine endometria during the peri-implantation period

    Article • Animal Science Journal, December 2013, Wiley

    Kazuhiko Imakawa

  49. Bovine conceptuses express endogenous retrovirus-derived genes during pregnancy establishment.

    Article • Genome Biology and Evolution, January 2013, Oxford University Press (OUP)

    Yuki Nakaya, Kazuhiko Imakawa

  50. Expression of mesenchymal-related genes by the bovine trophectoderm following conceptus attachment to the endometrial epithelium

    Article • December 2011, Bioscientifica

    Kazuhiko Imakawa