All Stories

  1. Mastering Immunity: Antibody Feedback as a Driver of Germinal Center Fate and Vaccine Responses

    Article • European Journal of Immunology, December 2025, Wiley

    Dr Kai-Michael Toellner

  2. Time of day of vaccination does not influence antibody responses to pneumococcal and annual influenza vaccination in a cohort of healthy older adults

    Article • Vaccine, March 2025, Elsevier

    Dr Kai-Michael Toellner

  3. Regulation of BCR-mediated Ca 2+ mobilization by MIZ1-TMBIM4 safeguards IgG1 + GC B cell–positive selection

    Article • Science Immunology, April 2024, American Association for the Advancement of Science

    Dr Kai-Michael Toellner

  4. Time of Day of Vaccination Does Not Influence Antibody Responses to Pneumococcal and Annual Influenza Vaccination in a Cohort of Healthy Older Adults

    Article • January 2024, Elsevier

    Dr Kai-Michael Toellner

  5. IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation

    Article • Journal of Experimental Medicine, July 2023, Rockefeller University Press

    Dr Kai-Michael Toellner

  6. Regulation of BCR-mediated Ca2+mobilization by MIZ1-TIMBIM4 safeguards IgG1+GC B cell positive selection

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Kai-Michael Toellner

  7. Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses

    Article • Frontiers in Immunology, March 2023, Frontiers

    Dr Kai-Michael Toellner

  8. Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Dr Kai-Michael Toellner

  9. Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism

    Article • Science Immunology, September 2022, American Association for the Advancement of Science

    Dr Kai-Michael Toellner

  10. Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

    Article • Nature Communications, May 2022, Springer Science + Business Media

    Dr Kai-Michael Toellner

  11. Germinal center derived B cell memory without T cells

    Article • Journal of Experimental Medicine, February 2022, Rockefeller University Press

    Dr Kai-Michael Toellner

  12. Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Dr Kai-Michael Toellner

  13. Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death

    Article • iScience, February 2021, Elsevier

    Dr Kai-Michael Toellner

  14. Memory-like B cells emerging from germinal centres recycle through the subcapsular sinus

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Dr Kai-Michael Toellner

  15. Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration

    Article • Cell Reports, November 2020, Elsevier

    Dr Kai-Michael Toellner

  16. Enhanced BCR signalling inflicts early plasmablast and germinal centre B cell death

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Dr Kai-Michael Toellner

  17. Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Dr Kai-Michael Toellner

  18. Class-Switch Recombination Occurs Infrequently in Germinal Centers

    Article • Immunity, August 2019, Elsevier

    Dr Kai-Michael Toellner

  19. Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

    Article • Science Advances, May 2019, American Association for the Advancement of Science

    Dr Kai-Michael Toellner

  20. B cell receptor role during B cell development and the immune response

    Article • F1000Research, April 2018, Faculty of 1000, Ltd.

    Dr Kai-Michael Toellner, Juan Carlos Yam-Puc

  21. Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

    Article • Journal of Experimental Medicine, March 2018, Rockefeller University Press

    Dr Kai-Michael Toellner

  22. IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates

    Article • mBio, March 2018, ASM Journals

    Dr Kai-Michael Toellner

  23. CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

    Article • Mucosal Immunology, December 2017, Nature

    Dr Kai-Michael Toellner

  24. IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD fromSalmonellaTyphimurium

    Article • The Journal of Immunology, November 2017, The American Association of Immunologists

    Dr Kai-Michael Toellner

  25. TFR cells trump autoimmune antibody responses to limit sedition

    Article • Nature Immunology, October 2017, Nature

    Dr Kai-Michael Toellner

  26. What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination?

    Article • Cold Spring Harbor Perspectives in Biology, June 2017, Cold Spring Harbor Laboratory Press

    Dr Kai-Michael Toellner

  27. Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment

    Article • International Journal of Molecular Sciences, May 2017, MDPI AG

    Dr Kai-Michael Toellner

  28. Detecting Gene Expression in Lymphoid Microenvironments by Laser Microdissection and Quantitative RT-PCR

    Article • January 2017, Springer Science + Business Media

    Dr Kai-Michael Toellner

  29. Corrigendum to ‘Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial’ [Vaccine 34 (2016) 2679–2685]

    Article • Vaccine, September 2016, Elsevier

    Dr Kai-Michael Toellner

  30. Antagonizing Retinoic Acid Receptors Increases Myeloid Cell Production by Cultured Human Hematopoietic Stem Cells

    Article • Archivum Immunologiae et Therapiae Experimentalis, July 2016, Springer Science + Business Media

    Dr Kai-Michael Toellner

  31. Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial

    Article • Vaccine, May 2016, Elsevier

    Dr Kai-Michael Toellner

  32. Regulation of germinal center B-cell differentiation

    Article • Immunological Reviews, February 2016, Wiley

    Dr Kai-Michael Toellner

  33. Extrafollicular Antibody Responses

    Article • January 2016, Elsevier

    Dr Kai-Michael Toellner

  34. FOXP1 inhibits plasma cell differentiation

    Article • Blood, October 2015, American Society of Hematology

    Dr Kai-Michael Toellner

  35. IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

    Article • Proceedings of the National Academy of Sciences, August 2015, Proceedings of the National Academy of Sciences

    Dr Kai-Michael Toellner

  36. Inflammation-induced formation of fat-associated lymphoid clusters

    Article • Nature Immunology, June 2015, Nature

    Dr Kai-Michael Toellner, Dr Jorge Caamano

  37. Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production

    Article • European Journal of Immunology, June 2015, Wiley

    Dr Kai-Michael Toellner

  38. Robo4 vaccines induce antibodies that retard tumor growth

    Article • Angiogenesis, October 2014, Springer Science + Business Media

    Dr Kai-Michael Toellner

  39. Cognate interactions: Extrafollicular IL-4 drives germinal-center reactions, a new role for an old cytokine

    Article • European Journal of Immunology, July 2014, Wiley

    Dr Kai-Michael Toellner

  40. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis

    Article • Journal of Clinical Investigation, April 2014, American Society for Clinical Investigation

    Dr Kai-Michael Toellner

  41. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis

    Article • Journal of Clinical Investigation, November 2013, American Society for Clinical Investigation

    Dr Kai-Michael Toellner

  42. Dose-Dependent Induction of Murine Th1/Th2 Responses to Sheep Red Blood Cells Occurs in Two Steps: Antigen Presentation during Second Encounter Is Decisive

    Article • PLOS One, June 2013, PLOS

    Dr Kai-Michael Toellner

  43. Germinal center B cells govern their own fate via antibody feedback

    Article • Journal of Experimental Medicine, February 2013, Rockefeller University Press

    Dr Kai-Michael Toellner

  44. The Capsular Polysaccharide Vi from Salmonella Typhi Is a B1b Antigen

    Article • The Journal of Immunology, November 2012, The American Association of Immunologists

    Dr Kai-Michael Toellner

  45. CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines

    Article • Blood, October 2012, American Society of Hematology

    Dr Kai-Michael Toellner

  46. A Theory of Germinal Center B Cell Selection, Division, and Exit

    Article • Cell Reports, July 2012, Elsevier

    Dr Kai-Michael Toellner

  47. Cover Picture: Eur. J. Immunol. 12/11

    Article • European Journal of Immunology, November 2011, Wiley

    Dr Kai-Michael Toellner

  48. Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts

    Article • European Journal of Immunology, November 2011, Wiley

    Dr Kai-Michael Toellner

  49. Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

    Article • Annals of the Rheumatic Diseases, July 2011, BMJ

    Dr Kai-Michael Toellner

  50. Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression

    Article • PLOS One, June 2011, PLOS

    Dr Kai-Michael Toellner

  51. Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

    Article • Annals of the Rheumatic Diseases, February 2011, BMJ

    Dr Kai-Michael Toellner

  52. Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors

    Article • Blood, December 2010, American Society of Hematology

    Dr Kai-Michael Toellner

  53. Trypanosoma cruzi infection induces a massive extrafollicular and follicular splenic B-cell response which is a high source of non-parasite-specific antibodies

    Article • Immunology, September 2010, Wiley

    Dr Kai-Michael Toellner

  54. IFN-γ produced by CD8 T cells induces T-bet–dependent and –independent class switching in B cells in responses to alum-precipitated protein vaccine

    Article • Proceedings of the National Academy of Sciences, September 2010, Proceedings of the National Academy of Sciences

    Dr Kai-Michael Toellner

  55. SLC6A4 expression and anti-proliferative responses to serotonin transporter ligands chlomipramine and fluoxetine in primary B-cell malignancies

    Article • Leukemia Research, August 2010, Elsevier

    Dr Kai-Michael Toellner, Professor Ruth Frances Jarrett

  56. B1 Cells Promote Pancreas Infiltration by Autoreactive T Cells

    Article • The Journal of Immunology, July 2010, The American Association of Immunologists

    Dr Kai-Michael Toellner

  57. Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation

    Article • Immunity, July 2010, Elsevier

    Dr Kai-Michael Toellner

  58. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

    Article • Journal of Experimental Medicine, February 2010, Rockefeller University Press

    Dr Kai-Michael Toellner

  59. Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central‐memory‐like CD4 T cells

    Article • European Journal of Immunology, June 2009, Wiley

    Dr Kai-Michael Toellner

  60. Germinal centres seen through the mathematical eye: B-cell models on the catwalk

    Article • Trends in Immunology, April 2009, Elsevier

    Dr Kai-Michael Toellner

  61. Deriving a germinal center lymphocyte migration model from two-photon data

    Article • Journal of Experimental Medicine, December 2008, Rockefeller University Press

    Dr Kai-Michael Toellner

  62. Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella

    Article • Molecular Immunology, August 2008, Elsevier

    Dr Kai-Michael Toellner

  63. Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues

    Article • Immunology, June 2008, Wiley

    Dr Kai-Michael Toellner

  64. Ly49H+ NK Cells Migrate to and Protect Splenic White Pulp Stroma from Murine Cytomegalovirus Infection

    Article • The Journal of Immunology, May 2008, The American Association of Immunologists

    Dr Kai-Michael Toellner

  65. microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells

    Article • Immunity, December 2007, Elsevier

    Dr Cristina Rada, Dr Kai-Michael Toellner

  66. Axon growth and guidance genes identify T‐dependent germinal centre B cells

    Article • Immunology and Cell Biology, October 2007, Wiley

    Dr Kai-Michael Toellner

  67. Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells

    Article • European Journal of Immunology, June 2007, Wiley

    Dr Kai-Michael Toellner

  68. Salmonella Induces a Switched Antibody Response without Germinal Centers That Impedes the Extracellular Spread of Infection

    Article • The Journal of Immunology, May 2007, The American Association of Immunologists

    Dr Kai-Michael Toellner

  69. Neonatal and Adult CD4+CD3- Cells Share Similar Gene Expression Profile, and Neonatal Cells Up-Regulate OX40 Ligand in Response to TL1A (TNFSF15)

    Article • The Journal of Immunology, August 2006, The American Association of Immunologists

    Dr Kai-Michael Toellner

  70. Type I cytokine profiles of human naive and memory B lymphocytes: a potential for memory cells to impact polarization

    Article • Immunology, May 2006, Wiley

    Dr Kai-Michael Toellner

  71. B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responses

    Article • Proceedings of the National Academy of Sciences, April 2006, Proceedings of the National Academy of Sciences

    Dr Kai-Michael Toellner

  72. Responses to the soluble flagellar protein FliC are Th2, while those to FliC onSalmonella are Th1

    Article • European Journal of Immunology, November 2004, Wiley

    Dr Kai-Michael Toellner

  73. Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction

    Article • Immunology, October 2004, Wiley

    Dr Kai-Michael Toellner

  74. Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells

    Article • European Journal of Immunology, February 2004, Wiley

    Dr Kai-Michael Toellner

  75. Analysis of the Germinal Center Reaction and In Vivo Long-Lived Plasma Cells

    Article • January 2004, Springer Science + Business Media

    Dr Kai-Michael Toellner

  76. A non-voltage-gated calcium channel with L-type characteristics activated by B cell receptor ligation

    Article • Biochemical Pharmacology, November 2003, Elsevier

    Dr Kai-Michael Toellner

  77. Extrafollicular antibody responses

    Article • Immunological Reviews, August 2003, Wiley

    Dr Kai-Michael Toellner

  78. Naive and memory B cells respond differentially to T-dependent signaling but display an equal potential for differentiation toward the centroblast-restricted CD77/globotriaosylceramide phenotype

    Article • European Journal of Immunology, July 2003, Wiley

    Dr Kai-Michael Toellner

  79. Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens

    Article • European Journal of Immunology, February 2003, Wiley

    Dr Kai-Michael Toellner

  80. Rapid Development of Th2 Activity During T Cell Priming

    Article • Clinical and Developmental Immunology, January 2003, Hindawi Publishing Corporation

    Dr Kai-Michael Toellner

  81. Established T Cell-Driven Germinal Center B Cell Proliferation Is Independent of CD28 Signaling but Is Tightly Regulated Through CTLA-4

    Article • The Journal of Immunology, January 2003, The American Association of Immunologists

    Dr Kai-Michael Toellner

  82. HL60 Cells Halted in G1 or S Phase Differentiate Normally

    Article • Experimental Cell Research, November 2002, Elsevier

    Dr Kai-Michael Toellner

  83. Th2 Activities Induced During Virgin T Cell Priming in the Absence of IL-4, IL-13, and B Cells

    Article • The Journal of Immunology, September 2002, The American Association of Immunologists

    Dr Kai-Michael Toellner

  84. CDK Inhibitor p18INK4c Is Required for the Generation of Functional Plasma Cells

    Article • Immunity, August 2002, Elsevier

    Dr Josie Ursini-Siegel, Dr Kai-Michael Toellner

  85. Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

    Article • Journal of Experimental Medicine, February 2002, Rockefeller University Press

    Dr Kai-Michael Toellner

  86. Tracking the response of Xid B cells in vivo: TI-2 antigen induces migration and proliferation but Btk is essential for terminal differentiation

    Article • European Journal of Immunology, May 2001, Wiley

    Dr Kai-Michael Toellner

  87. Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes

    Article • European Journal of Immunology, February 2001, Wiley

    Dr Kai-Michael Toellner, Professor Daniel F Legler

  88. Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival

    Article • Journal of Experimental Medicine, September 2000, Rockefeller University Press

    Dr Kai-Michael Toellner

  89. T-independent type 2 antigens induce B cell proliferation in multiple splenic sites, but exponential growth is confined to extrafollicular foci

    Article • European Journal of Immunology, April 1999, Wiley

    Dr Kai-Michael Toellner

  90. Interplays between mouse mammary tumor virus and the cellular and humoral immune response

    Article • Immunological Reviews, April 1999, Wiley

    Dr Kai-Michael Toellner

  91. Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help

    Article • European Journal of Immunology, February 1999, Wiley

    Dr Kai-Michael Toellner

  92. CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1

    Article • Journal of Experimental Medicine, July 1998, Rockefeller University Press

    Dr Kai-Michael Toellner

  93. T Helper 1 (Th1) and Th2 Characteristics Start to Develop During T Cell Priming and Are Associated with an Immediate Ability to Induce Immunoglobulin Class Switching

    Article • Journal of Experimental Medicine, April 1998, Rockefeller University Press

    Dr Kai-Michael Toellner

  94. Memory B-cell clones and the diversity of their members

    Article • Seminars in Immunology, August 1997, Elsevier

    Dr Kai-Michael Toellner

  95. PROPERTIES OF MULTINUCLEATED GIANT CELLS IN A NEWIN VITRO MODEL FOR HUMAN GRANULOMA FORMATION

    Article • The Journal of Pathology, May 1997, Wiley

    Dr Kai-Michael Toellner

  96. The changing preference of T and B cells for partners as T-dependent antibody responses develop

    Article • Immunological Reviews, April 1997, Wiley

    Dr Kai-Michael Toellner

  97. Immunoglobulin switch transcript production in vivo related to the site and time of antigen-specific B cell activation

    Article • Journal of Experimental Medicine, May 1996, Rockefeller University Press

    Dr Kai-Michael Toellner

  98. The use of reverse transcription polymerase chain reaction to analyse large numbers of mRNA species from a single cell

    Article • Journal of Immunological Methods, January 1996, Elsevier

    Dr Kai-Michael Toellner

  99. Follicular dendritic cells productively infected with immunodeficiency viruses transmit infection to T cells

    Article • Medical Microbiology and Immunology, October 1995, Springer Science + Business Media

    Dr Kai-Michael Toellner

  100. The human germinal centre cells, follicular dendritic cells and germinal centre T cells produce B cell-stimulating cytokines

    Article • Cytokine, May 1995, Elsevier

    Dr Kai-Michael Toellner

  101. Durchflußzytometrische Analytik von Liquor cerebrospinalis

    Article • LaboratoriumsMedizin, January 1991, De Gruyter

    Dr Kai-Michael Toellner