All Stories

  1. Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells

    Article • PLoS ONE, May 2023, PLOS

    Professor Daniel F Legler

  2. Naïve T lymphocytes chemotax to CCL21 but not to S1P-rich serum

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Professor Daniel F Legler

  3. Heparin Specifically Interacts with Basic BBXB Motifs of the Chemokine CCL21 to Define CCR7 Signaling

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Professor Daniel F Legler

  4. Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation

    Article • BMC Biology, August 2022, Springer Science + Business Media

    Professor Daniel F Legler

  5. Distinct Fates of Chemokine and Surrogate Molecule Gradients: Consequences for CCR7-Guided Dendritic Cell Migration

    Article • Frontiers in Immunology, June 2022, Frontiers

    Professor Daniel F Legler

  6. Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake

    Article • Cells, April 2022, MDPI AG

    Professor Daniel F Legler

  7. Delineating the interactions between the cannabinoid CB 2 receptor and its regulatory effectors; β‐arrestins and GPCR kinases

    Article • British Journal of Pharmacology, February 2022, Wiley

    Professor Daniel F Legler

  8. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics

    Article • Cell Reports, February 2022, Elsevier

    Professor Daniel F Legler

  9. Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants

    Article • Scientific Reports, December 2021, Springer Science + Business Media

    Professor Daniel F Legler

  10. CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration

    Article • Frontiers in Immunology, September 2021, Frontiers

    Professor Daniel F Legler

  11. The dimeric form of CXCL12 binds to atypical chemokine receptor 1

    Article • Science Signaling, August 2021, American Association for the Advancement of Science

    Professor Daniel F Legler

  12. CCR7 signalosomes are preassembled on tips of lymphocyte microvilli in proximity to LFA-1

    Article • Biophysical Journal, August 2021, Elsevier

    Professor Daniel F Legler

  13. A Versatile Toolkit for Semi-Automated Production of Fluorescent Chemokines to Study CCR7 Expression and Functions

    Article • International Journal of Molecular Sciences, April 2021, MDPI AG

    Professor Daniel F Legler

  14. Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus

    Article • Blood Advances, January 2021, American Society of Hematology

    Professor Daniel F Legler

  15. Keratinocytes control skin immune homeostasis through de novo–synthesized glucocorticoids

    Article • Science Advances, January 2021, American Association for the Advancement of Science

    Professor Daniel F Legler

  16. Functional Heterogeneities in Biomembranes

    Article • January 2021, Frontiers

    Professor Daniel F Legler

  17. CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems

    Article • Frontiers in Immunology, October 2020, Frontiers

    Professor Daniel F Legler

  18. β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4

    Article • Frontiers in Immunology, September 2020, Frontiers

    Professor Daniel F Legler

  19. B cell zone reticular cell microenvironments shape CXCL13 gradient formation

    Article • Nature Communications, July 2020, Springer Science + Business Media

    Professor Daniel F Legler, Mariagrazia Uguccioni

  20. CCR 5 deficiency/ CCR 5Δ32: resistant to HIV infection at the cost of curtailed CD 4 + T cell memory responses

    Article • The EMBO Journal, July 2020, EMBO

    Professor Daniel F Legler

  21. CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity

    Article • Haematologica, July 2020, Ferrata Storti Foundation (Haematologica)

    Professor Daniel F Legler

  22. FAT10 localizes in dendritic cell aggresome-like induced structures and contributes to their disassembly

    Article • Journal of Cell Science, June 2020, The Company of Biologists

    Professor Daniel F Legler

  23. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4

    Article • Journal of Leukocyte Biology, June 2020, Wiley

    Professor Daniel F Legler

  24. Membrane Compartmentalization and Scaffold Proteins in Leukocyte Migration

    Article • Frontiers in Cell and Developmental Biology, April 2020, Frontiers

    Professor Daniel F Legler

  25. ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins

    Article • Frontiers in Immunology, April 2020, Frontiers

    Professor Daniel F Legler, Mariagrazia Uguccioni

  26. Atypical Functions of Leukocyte Chemoattractant Receptors

    Article • January 2020, Frontiers

    Professor Daniel F Legler

  27. ImmunoPhysics and ImmunoEngineering

    Article • January 2020, Frontiers

    Professor Daniel F Legler

  28. Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation

    Article • Cell Reports, October 2019, Elsevier

    Professor Daniel F Legler

  29. In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell–Mediated Host Surveillance

    Article • The Journal of Immunology, September 2019, The American Association of Immunologists

    Professor Daniel F Legler

  30. Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

    Article • Frontiers in Immunology, September 2019, Frontiers

    Professor Daniel F Legler

  31. Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7

    Article • International Journal of Molecular Sciences, May 2019, MDPI AG

    Professor Daniel F Legler

  32. Interleukin-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation

    Article • Journal of Allergy and Clinical Immunology, February 2019, Elsevier

    Professor Daniel F Legler

  33. CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70

    Article • Frontiers in Immunology, January 2019, Frontiers

    Professor Daniel F Legler

  34. Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions

    Article • International Journal of Molecular Sciences, December 2018, MDPI AG

    Professor Daniel F Legler

  35. Role of Mechanotransduction and Tension in T Cell Function

    Article • Frontiers in Immunology, November 2018, Frontiers

    Professor Daniel F Legler

  36. ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins

    Article • The FASEB Journal, September 2018, Federation of American Societies For Experimental Biology (FASEB)

    Professor Daniel F Legler

  37. CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells

    Article • Journal of Leukocyte Biology, May 2018, Wiley

    Professor Daniel F Legler

  38. Beyond migration-Chemokines in lymphocyte priming, differentiation, and modulating effector functions

    Article • Journal of Leukocyte Biology, April 2018, Wiley

    Professor Daniel F Legler

  39. A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking

    Article • Journal of Leukocyte Biology, March 2018, Wiley

    Professor Daniel F Legler

  40. Membrane lipid environment: Potential modulation of chemokine receptor function

    Article • Cytokine, February 2018, Elsevier

    Professor Daniel F Legler

  41. New insights in chemokine signaling

    Article • F1000Research, January 2018, Faculty of 1000, Ltd.

    Professor Daniel F Legler

  42. A structure–activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins

    Article • Archives of Toxicology, November 2017, Springer Science + Business Media

    Professor Daniel F Legler

  43. Chemokine activity modulation

    Article • The FASEB Journal, July 2017, Federation of American Societies For Experimental Biology (FASEB)

    Cesar Santiago, Mariagrazia Uguccioni, Dr Yoan R. Monneau, Professor Daniel F Legler, Mario Melado

  44. Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention

    Article • Molecular Pharmacology, January 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Daniel F Legler

  45. Chemokines: Chemistry, Biochemistry and Biological Function

    Article • CHIMIA International Journal for Chemistry, December 2016, Swiss Chemical Society

    Professor Daniel F Legler

  46. Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7-driven metastatic spread of luminal-A breast tumors

    Article • Journal of Leukocyte Biology, March 2016, Wiley

    Professor Daniel F Legler

  47. Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses

    Article • Journal of Leukocyte Biology, January 2016, Wiley

    Professor Daniel F Legler

  48. Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

    Article • Journal of Leukocyte Biology, January 2016, Wiley

    Professor Daniel F Legler

  49. Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration

    Article • Immunity, January 2016, Elsevier

    Professor Daniel F Legler

  50. The STEAP1262-270peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice-A new approach to immunotherapy against prostate carcinoma

    Article • The Prostate, December 2015, Wiley

    Professor Daniel F Legler

  51. Loss of Gadkin Affects Dendritic Cell Migration In Vitro

    Article • PLoS ONE, December 2015, PLOS

    Professor Daniel F Legler

  52. In vivo TCR Signaling in CD4+ T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity

    Article • Frontiers in Immunology, June 2015, Frontiers

    Professor Daniel F Legler

  53. Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity

    Article • Cell Cycle, April 2015, Taylor & Francis

    Professor Daniel F Legler

  54. Analysis of CCR7 mediated T cell transfectant migration using a microfluidic gradient generator

    Article • Journal of Immunological Methods, April 2015, Elsevier

    Professor Daniel F Legler

  55. On the move: endocytic trafficking in cell migration

    Article • Cellular and Molecular Life Sciences, February 2015, Springer Science + Business Media

    Professor Daniel F Legler

  56. Regulation of Sec16 levels and dynamics links proliferation and secretion

    Article • Journal of Cell Science, December 2014, The Company of Biologists

    Professor Daniel F Legler

  57. CCR7: Roles in cancer cell dissemination, migration and metastasis formation

    Article • The International Journal of Biochemistry & Cell Biology, September 2014, Elsevier

    Professor Daniel F Legler

  58. Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

    Article • Science, January 2013, American Association for the Advancement of Science

    Professor Daniel F Legler

  59. Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E2and liver X receptor activation

    Article • European Journal of Immunology, September 2012, Wiley

    Professor Daniel F Legler

  60. Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration

    Article • Journal of Cell Science, July 2012, The Company of Biologists

    Professor Daniel F Legler

  61. Surface Engineering of Biomembranes with GPI-Anchored Proteins and its Applications

    Article • March 2012, Bentham Science Publishers

    Professor Daniel F Legler

  62. Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E2

    Article • Cellular Immunology, March 2012, Elsevier

    Professor Daniel F Legler

  63. Cross-Talk Between TCR and CCR7 Signaling Sets a Temporal Threshold for Enhanced T Lymphocyte Migration

    Article • The Journal of Immunology, October 2011, The American Association of Immunologists

    Professor Daniel F Legler

  64. Definition of Key Variables for the Induction of Optimal NY-ESO-1-Specific T Cells in HLA Transgene Mice

    Article • The Journal of Immunology, August 2010, The American Association of Immunologists

    Professor Daniel F Legler

  65. Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

    Article • Immunity, May 2010, Elsevier

    Professor Daniel F Legler

  66. Prostaglandin E2 at new glance: Novel insights in functional diversity offer therapeutic chances

    Article • The International Journal of Biochemistry & Cell Biology, February 2010, Elsevier

    Professor Daniel F Legler

  67. Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process

    Article • Microvascular Research, December 2009, Elsevier

    Professor Daniel F Legler

  68. Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

    Article • British Journal of Cancer, August 2009, Nature

    Professor Daniel F Legler

  69. Prostaglandin E2 enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

    Article • Blood, November 2008, American Society of Hematology

    Professor Daniel F Legler

  70. Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis

    Article • Journal of Cell Science, July 2008, The Company of Biologists

    Professor Daniel F Legler

  71. Reduced Expression of Cyclooxygenase-2 in Primary Breast Cancer

    Article • JNCI Journal of the National Cancer Institute, July 2008, Oxford University Press (OUP)

    Professor Daniel F Legler

  72. Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition

    Article • Journal of Biological Chemistry, June 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Daniel F Legler

  73. Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon

    Article • Oncogene, June 2008, Nature

    Professor Daniel F Legler

  74. V domain of RAGE interacts with AGEs on prostate carcinoma cells

    Article • The Prostate, January 2008, Wiley

    Professor Daniel F Legler

  75. A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

    Article • EMBO Reports, September 2007, Wiley

    Professor Daniel F Legler

  76. Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO

    Article • Journal of Leukocyte Biology, August 2007, Wiley

    Professor Daniel F Legler

  77. Opposite Fate of Endocytosed CCR7 and Its Ligands: Recycling versus Degradation

    Article • The Journal of Immunology, August 2006, The American Association of Immunologists

    Professor Daniel F Legler

  78. Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts

    Article • Blood, April 2006, American Society of Hematology

    Professor Daniel F Legler

  79. Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells

    Article • The FASEB Journal, February 2006, Federation of American Societies For Experimental Biology (FASEB)

    Professor Daniel F Legler

  80. Prostaglandin E2 Is Generally Required for Human Dendritic Cell Migration and Exerts Its Effect via EP2 and EP4 Receptors

    Article • The Journal of Immunology, January 2006, The American Association of Immunologists

    Professor Daniel F Legler

  81. Differential insertion of GPI-anchored GFPs into lipid rafts of live cells

    Article • The FASEB Journal, October 2004, Federation of American Societies For Experimental Biology (FASEB)

    Professor Daniel F Legler

  82. PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction

    Article • The FASEB Journal, September 2004, Federation of American Societies For Experimental Biology (FASEB)

    Professor Daniel F Legler

  83. Theα vβ 3 integrin as a tumor homing ligand for lymphocytes

    Article • European Journal of Immunology, June 2004, Wiley

    Professor Daniel F Legler

  84. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2

    Article • Blood, March 2004, American Society of Hematology

    Professor Daniel F Legler

  85. Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation

    Article • Immunity, May 2003, Elsevier

    Professor Daniel F Legler

  86. The β1and β3Integrins Promote T Cell Receptor-mediated Cytotoxic T Lymphocyte Activation

    Article • Journal of Biological Chemistry, April 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Daniel F Legler

  87. Soluble Major Histocompatibility Complex-Peptide Octamers with Impaired CD8 Binding Selectively Induce Fas-dependent Apoptosis

    Article • Journal of Biological Chemistry, October 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Daniel F Legler

  88. CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

    Article • Nature Immunology, August 2002, Nature

    Professor Daniel F Legler

  89. Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region

    Article • Cellular and Molecular Life Sciences, January 2002, Springer Science + Business Media

    Professor Daniel F Legler

  90. Selective inhibition of CTL activation by a dipalmitoyl-phospholipid that prevents the recruitment of signaling molecules to lipid rafts

    Article • The FASEB Journal, May 2001, Federation of American Societies For Experimental Biology (FASEB)

    Professor Daniel F Legler

  91. CTL activation is induced by cross-linking of TCR/MHC-peptide-CD8/p56lck adducts in rafts

    Article • European Journal of Immunology, May 2001, Wiley

    Professor Daniel F Legler

  92. Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes

    Article • European Journal of Immunology, February 2001, Wiley

    Dr Kai-Michael Toellner, Professor Daniel F Legler

  93. Activation-dependent modulation of B lymphocyte migration to chemokines

    Article • International Immunology, September 2000, Oxford University Press (OUP)

    Professor Daniel F Legler

  94. The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7

    Article • European Journal of Immunology, June 1998, Wiley

    Professor Daniel F Legler

  95. B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

    Article • The Journal of Experimental Medicine, February 1998, Rockefeller University Press

    Professor Daniel F Legler

  96. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function

    Article • Current Biology, September 1997, Elsevier

    Professor Daniel F Legler

  97. Identification of CCR8, the Receptor for the Human CC Chemokine I-309

    Article • Journal of Biological Chemistry, July 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Daniel F Legler

  98. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

    Article • Nature, August 1996, Nature

    Professor Daniel F Legler

  99. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1

    Article • European Journal of Immunology, April 1996, Wiley

    Professor Daniel F Legler