All Stories

  1. Apobec2 deficiency causes mitochondrial defects and mitophagy in skeletal muscle

    Article • The FASEB Journal, March 2018, Federation of American Societies For Experimental Biology (FASEB)

    Dr Cristina Rada, Yusuke Sato

  2. CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex

    Article • Nucleic Acids Research, June 2015, Oxford University Press (OUP)

    Dr Cristina Rada

  3. Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

    Article • eLife, September 2014, eLife

    Benjamin Taylor, Dr Cristina Rada

  4. Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation

    Article • European Journal of Immunology, May 2014, Wiley

    Dr Cristina Rada

  5. Michael S. Neuberger 1953–2013

    Article • Nature Immunology, December 2013, Springer Science + Business Media

    Dr Cristina Rada

  6. Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo‐relative, karyopherin α

    Article • FEBS Letters, November 2013, Wiley

    Dr Cristina Rada

  7. Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

    Article • Epigenetics & Chromatin, November 2013, Springer Science + Business Media

    Dr Cristina Rada, Dr Wendy Dean

  8. DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

    Article • eLife, April 2013, eLife

    Benjamin Taylor, Dr Cristina Rada

  9. Abstract 611: AID/APOBEC cytidine deaminases can mimic the phenomenon of localized hypermutation in cancer or kataegis .

    Article • Cancer Research, April 2013, American Association for Cancer Research (AACR)

    Dr Cristina Rada

  10. Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice

    Article • Cell Cycle, March 2013, Taylor & Francis

    Dr Cristina Rada

  11. The cytoplasmic AID complex

    Article • Seminars in Immunology, August 2012, Elsevier

    Dr Cristina Rada

  12. ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma

    Article • Cancer Cell, May 2011, Elsevier

    Dr Cristina Rada

  13. A High-Throughput Assay for DNA Deaminases

    Article • January 2011, Springer Science + Business Media

    Dr Cristina Rada

  14. The dependence of Ig class‐switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin

    Article • European Journal of Immunology, December 2010, Wiley

    Dr Cristina Rada

  15. AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

    Article • Nature Structural & Molecular Biology, June 2009, Springer Science + Business Media

    Dr Cristina Rada

  16. AID and RPA: PKA makes the connection local

    Article • Nature Immunology, April 2009, Springer Science + Business Media

    Dr Cristina Rada

  17. Interaction between Antibody-Diversification Enzyme AID and Spliceosome-Associated Factor CTNNBL1

    Article • Molecular Cell, August 2008, Elsevier

    Dr Cristina Rada

  18. microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells

    Article • Immunity, December 2007, Elsevier

    Dr Cristina Rada, Dr Kai-Michael Toellner

  19. SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

    Article • The EMBO Journal, January 2006, Springer Science + Business Media

    Dr Cristina Rada

  20. Somatic hypermutation at A·T pairs: polymerase error versus dUTP incorporation

    Article • Nature Reviews Immunology, February 2005, Springer Science + Business Media

    Dr Cristina Rada

  21. The mechanism of somatic hypermutation at A·T pairs remains an open question

    Article • Nature Reviews Immunology, February 2005, Springer Science + Business Media

    Dr Cristina Rada

  22. Mismatch Recognition and Uracil Excision Provide Complementary Paths to Both Ig Switching and the A/T-Focused Phase of Somatic Mutation

    Article • Molecular Cell, October 2004, Elsevier

    Dr Cristina Rada

  23. Comparison of the Differential Context-dependence of DNA Deamination by APOBEC Enzymes: Correlation with Mutation Spectra in Vivo

    Article • Journal of Molecular Biology, March 2004, Elsevier

    Dr Cristina Rada

  24. Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

    Article • Current Biology, October 2002, Elsevier

    Dr Cristina Rada

  25. Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene

    Article • Proceedings of the National Academy of Sciences, July 2002, Proceedings of the National Academy of Sciences

    Dr Cristina Rada

  26. Epigenetics: Monoallelic Expression in the Immune System

    Article • Current Biology, February 2002, Elsevier

    Dr Cristina Rada

  27. Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting

    Article • Immunity, July 1998, Elsevier

    Dr Cristina Rada

  28. Monitoring and interpreting the intrinsic features of somatic hypermutation

    Article • Immunological Reviews, April 1998, Wiley

    Dr Cristina Rada

  29. The 5′ hypermutation boundary of x chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription

    Article • European Journal of Immunology, December 1997, Wiley

    Dr Cristina Rada, Dr Wendy Dean

  30. The targeting of somatic hypermutation

    Article • Seminars in Immunology, June 1996, Elsevier

    Dr Cristina Rada

  31. The maturation of the antibody response

    Article • January 1995, Elsevier

    Dr Cristina Rada

  32. The 5′ boundary of somatic hypermutation in a Vχ gene is in the leader intron

    Article • European Journal of Immunology, June 1994, Wiley

    Dr Cristina Rada

  33. Affinity maturation leads to differential expression of multiple copies of a κ light-chain transgene

    Article • Nature, May 1993, Springer Science + Business Media

    Dr Cristina Rada

  34. Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.

    Article • Proceedings of the National Academy of Sciences, March 1990, Proceedings of the National Academy of Sciences

    Dr Cristina Rada