All Stories

  1. A novel Dual-guide CRISPR–Cas13 strategy improves specificity for single-nucleotide variant detection
  2. Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA‐122 in hospital clinical laboratories
  3. Applying click chemistry principles to the design of tumor-targeted nanosystems
  4. A novel colorimetric assay for early differentiation of mucocutaneous and cutaneous leishmaniasis via species-specific identification
  5. A Novel Dual-Guide CRISPR-Cas13 Strategy Improves Specificity for Single-Nucleotide Variant Detection
  6. Tracker Nanocatalyst for Screening of Intracellular Copper‐Catalyzed Azide‐Alkyne Cycloadditions
  7. Amplification-Free Testing of microRNA Biomarkers in Cancer
  8. Exploring Trisubstituted adenine derivatives as adenosine A1 receptor ligands with antagonist activity: Synthesis, biological evaluation and molecular modelling
  9. Short communication: miRNA122 interrogation via PCR-Free method to track liver recovery
  10. Click chemistry-based dual nanosystem for microRNA-122 detection with single-base specificity from tumour cells
  11. Multiplexed MicroRNA biomarker detection by bridging lifetime filtering imaging and dynamic chemical labeling
  12. Click Chemistry-Driven Dual Nanosystem for miR-122 Detection with Single-Base Specificity from Tumour Cells
  13. A Novel Colorimetric Assay for Early Differentiation of Mucocutaneous and Cutaneous Leishmaniasis Via Species-Specific Identification
  14. Spatial Transcriptomics: Emerging Technologies in Tissue Gene Expression Profiling
  15. Symmetric 4,6-Dialkyl/arylamino-5-nitropyrimidines: Theoretical Explanation of Why Aminolysis of Alkoxy Groups Is Favoured over Chlorine Aminolysis in Nitro-Activated Pyrimidines.
  16. SARS-CoV-2 viral RNA detection using the novel CoVradar device associated with the CoVreader smartphone app
  17. Symmetric 4,6-Dialkyl/arylamino-5-nitropyrimidines: Theoretical Explanation of Why Aminolysis of Alkoxy Groups Is Favoured over Chlorine Aminolysis in Nitro-Activated Pyrimidines.
  18. Spatial Transcriptomics: Emerging Technologies in Tissue Gene Expression Profiling
  19. Evaluation of diagnostic and prognostic candidate biomarkers in drug‐induced liver injury vs. other forms of acute liver damage
  20. Identification of compounds with activity against Trypanosoma cruzi within a collection of synthetic nucleoside analogs
  21. Direct detection of alpha satellite DNA with single-base resolution by using abasic Peptide Nucleic Acids and Fluorescent in situ Hybridization
  22. MAGPIX and FLEXMAP 3D Luminex platforms for direct detection of miR-122-5p through dynamic chemical labelling
  23. Symmetric 4,6-dialkyl/arylamino-5-nitropyrimidines: theoretical explanation of why aminolysis of alkoxy groups is favoured over chlorine aminolysis in nitro-activated pyrimidines
  24. Hybrid Fluorescent Mass-Tag Nanotrackers as Universal Reagents for Long-Term Live-Cell Barcoding
  25. Open a new window in the world of circulating microRNAs by merging ChemiRNA Tech with a Luminex platform
  26. Simultaneous Detection of Drug-Induced Liver Injury Protein and microRNA Biomarkers Using Dynamic Chemical Labelling on a Luminex MAGPIX System
  27. Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi
  28. Synthesis and screening of 6‐alkoxy purine analogs as cell type‐selective apoptotic inducers in Jurkat cells
  29. Development of a nanotechnology-based approach for capturing and detecting nucleic acids by using flow cytometry
  30. Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation
  31. Insulin Crystals Grown in Short-Peptide Supramolecular Hydrogels Show Enhanced Thermal Stability and Slower Release Profile
  32. Design and Synthesis of 9-Dialkylamino-6-[(1H-1,2,3-triazol-4-yl)methoxy]-9H-purines
  33. DatAC: A visual analytics platform to explore climate and air quality indicators associated with the COVID-19 pandemic in Spain
  34. An effective polymeric nanocarrier that allows for active targeting and selective drug delivery in cell coculture systems
  35. Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy
  36. Amplification-free profiling of microRNA-122 biomarker in DILI patient serums, using the luminex MAGPIX system
  37. Corrigendum to “Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)” [Crit. Rev. Oncol. Hematol. 151 (July) (2020) 102978]
  38. Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)
  39. Characterization and Therapeutic Effect of a pH Stimuli Responsive Polymeric Nanoformulation for Controlled Drug Release
  40. Mitochondrial pH Nanosensors for Metabolic Profiling of Breast Cancer Cell Lines
  41. A versatile theranostic nanodevice based on an orthogonal bioconjugation strategy for efficient targeted treatment and monitoring of triple negative breast cancer
  42. Direct Detection of miR-122 in Hepatotoxicity Using Dynamic Chemical Labeling Overcomes Stability and isomiR Challenges
  43. Direct detection of circulating microRNA-122 using dynamic chemical labelling with single molecule detection overcomes stability and isomiR challenges for biomarker qualification
  44. PCR-free and chemistry-based technology for miR-21 rapid detection directly from tumour cells
  45. A soft 3D polyacrylate hydrogel recapitulates the cartilage niche and allows growth-factor free tissue engineering of human articular cartilage
  46. New Platform for the Direct Profiling of microRNAs in Biofluids
  47. Liquid biopsy beyond of cancer: Circulating pulmonary cells as biomarkers of COPD aggressivity
  48. A colorimetric strategy based on dynamic chemistry for direct detection of Trypanosomatid species
  49. miR-122 direct detection in human serum by time-gated fluorescence imaging
  50. Time-Gated Luminescence Acquisition for Biochemical Sensing: miRNA Detection
  51. Smartphone-Based Diagnosis of Parasitic Infections With Colorimetric Assays in Centrifuge Tubes
  52. Catalytic and Electron Conducting Carbon Nanotube–Reinforced Lysozyme Crystals
  53. 1 H and 13 C assignments of 6-, 8-, 9- substituted purines
  54. Metallofluorescent Nanoparticles for Multimodal Applications
  55. Identification of Trypanosomatids by detecting Single Nucleotide Fingerprints using DNA analysis by dynamic chemistry with MALDI-ToF
  56. A PCR-free technology to detect and quantify microRNAs directly from human plasma
  57. Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury
  58. Tracking cell proliferation using a nanotechnology-based approach
  59. Poly(ethylmethacrylate-co-diethylaminoethyl acrylate) coating improves endothelial re-population, bio-mechanical and anti-thrombogenic properties of decellularized carotid arteries for blood vessel replacement
  60. Novel bead-based platform for direct detection of unlabelled nucleic acids through Single Nucleobase Labelling
  61. Bacterial rhyaluronidase id and production
  62. Number of Nanoparticles per Cell through a Spectrophotometric Method - A key parameter to Assess Nanoparticle-based Cellular Assays
  63. miRNA in situ hybridization in circulating tumor cells - MishCTC
  64. Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity
  65. Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
  66. Influence of the chirality of short peptide supramolecular hydrogels in protein crystallogenesis
  67. Synthesis of 6,8,9 poly-substituted purine analogue libraries as pro-apoptotic inducers of human leukemic lymphocytes and DAPK-1 inhibitors
  68. Protein crystallization in short-peptide supramolecular hydrogels: a versatile strategy towards biotechnological composite materials
  69. Generation of Autologous Multipotent Endothelial-Like Cells from Lipoaspirates of Human Adipose-Derived Stem Cells and Polymer Microarrays Technology: Potential Cardiovascular Regeneration
  70. Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices
  71. The Use of Solid Supports to Generate Nucleic Acid Carriers
  72. Novel Biochip Platform for Nucleic Acid Analysis
  73. Decoding a PNA Encoded Peptide Library by PCR: The Discovery of New Cell Surface Receptor Ligands
  74. Microarray Generation of Thousand-Member Oligonucleotide Libraries
  75. Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery
  76. Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery
  77. Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism
  78. Dynamic chemistry for enzyme-free allele discrimination in genotyping by MALDI-TOF mass spectrometry
  79. Encoded peptide libraries and the discovery of new cell binding ligands
  80. Polymer Microarrays for Cellular High-Content Screening
  81. DNA Analysis by Dynamic Chemistry
  82. DNA Analysis by Dynamic Chemistry
  83. Fingerprinting Polymer Microarrays
  84. 844 POLYMER LIBRARY SCREENING IDENTIFIES AN EXTRACELLULAR MATRIX THAT PROMOTES AND STABILISES HUMAN EMBRYONIC STEM CELL-DERIVED HEPATOCYTE FUNCTION
  85. A cooperative polymer-DNA microarray approach to biomaterial investigation
  86. From 10,000 to 1: Selective synthesis and enzymatic evaluation of fluorescence resonance energy transfer peptides as specific substrates for chymopapain
  87. Microwave-assisted orthogonal synthesis of PNA–peptide conjugates
  88. Deciphering cellular morphology and biocompatibility using polymer microarrays
  89. Combining Nebulization-Mediated Transfection and Polymer Microarrays for the Rapid Determination of Optimal Transfection Substrates
  90. Inkjet fabrication of hydrogel microarrays using in situ nanolitre-scale polymerisation
  91. Screening for Polymorphs on Polymer Microarrays
  92. Peptoid dendrimers—microwave-assisted solid-phase synthesis and transfection agent evaluation
  93. A 10,000 Member PNA-Encoded Peptide Library for Profiling Tyrosine Kinases
  94. Flexible Fabrication of Microarrays of Microwells
  95. Microarray Platforms for Enzymatic and Cell-Based Assays
  96. Design, Syntheses, Biological Evaluation, and Docking Studies of 2-Substituted 5-Methylsulfonyl-1-Phenyl-1H-Indoles: Potent and Selective in vitro Cyclooxygenase-2 Inhibitors
  97. Microarray platforms for enzymatic and cell-based assays
  98. Polymer microarrays: Identification of substrates for phagocytosis assays
  99. Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides—a gentle heat goes a long way
  100. Dual colour, microarray-based, analysis of 10 000 protease substrates
  101. Regioselective One-Pot Synthesis of 9-Alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazines. Reactivity of Aliphatic and Aromatic Hydrazides.
  102. Dde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA–peptide conjugates
  103. Regioselective One-Pot Synthesis of 9-Alkyl-6-chloropyrido[3,2- e ][1,2,4]triazolo[4,3- a ]pyrazines. Reactivity of Aliphatic and Aromatic Hydrazides
  104. Synthesis and cellular uptake of cell delivering PNA–peptide conjugates
  105. Combinatorial libraries – from solution to 2D microarrays
  106. Dendrimers and combinatorial chemistry—tools for fluorescent enhancement in protease assays
  107. Polyplexes and Lipoplexes for Mammalian Gene Delivery: From Traditional to Microarray Screening
  108. Full Orthogonality between Dde and Fmoc: The Direct Synthesis of PNA−Peptide Conjugates
  109. Parallel and Multiplexed Bead-Based Assays and Encoding Strategies
  110. An efficient one-pot synthesis of 6-alkoxy-8,9-dialkylpurines via reaction of 5-amino-4-chloro-6-alkylaminopyrimidines with N,N-dimethylalkaneamides and alkoxide ions
  111. 1H and13C chemical shifts for bis(benzopyridinium) dibromides with semirigid aromatic linkers