Bacterial rhyaluronidase id and production
What is it about?
This article: is about the identification and characterization of a bacterial hyaluronidase from S.koganeiensis and its production in recombinant form in E.coli. The purification of the recombinant form has allowed for the total characterization and the study of its 3D structure.
Why is it important?
This new protein has never before been isolated and totally characterized, therefore rendering this new discovery unique and important. This breakthrough by Italian researchers represents the future driving force of Pharmacology. In addition, hyaluronidase – as a carrier able to promote the dispersion and absorption of the therapeutically active ingredients it delivers – enables avant-garde applications in areas with high socio-economic impact (such as oncology, diabetes, immunodeficiency) and to optimise the efficacy of gene therapies, as well as the subcutaneous bioavailability of biologicals, thereby reducing the use of the intravenous route.
The following have contributed to this page: Dr. Jose A. Gavira, Luciano Messina, and Dr Juan J Diaz-Mochon