All Stories

  1. The ISSLS VERTEBRA initiative: establishing reporting standards for regenerative medicine trials in disc degeneration and low back pain
  2. Tie2-enriched nucleus pulposus cell transplantation enables severity-independent disc repair in a canine model with induced and controlled disc degeneration severity
  3. Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)
  4. Adapt, Mitigate, and Target: The Role of Oxidative Stress in Intervertebral Disc Homeostasis and Disc Degeneration
  5. Comparative Efficacy and Safety of Osteobiologics in Posterior Lumbar Fusion: A Network Meta-Analysis of Randomized Controlled Trials
  6. TIE2-positive cells in the nucleus pulposus with a purpose: the who, what and why
  7. The Gut-Disc Axis: Unraveling the Microbiome’s Role in Lumbar Disc Herniation
  8. Efficacy and Safety of Osteobiologics for Lumbar Spinal Fusion
  9. The Vicious Cycle of Obesity and Low Back Pain: A Comprehensive Review
  10. The forgotten spine score: study protocol for a novel patient-centered outcome measure in lumbar spine fusion surgery
  11. Extracellular vesicles for intervertebral disc regeneration
  12. Alginate vs. Hyaluronic Acid as Carriers for Nucleus Pulposus Cells: A Study on Regenerative Outcomes in Disc Degeneration
  13. Assessment of Tie2-Rejuvenated Nucleus Pulposus Cell Transplants from Young and Old Patient Sources Demonstrates That Age Still Matters
  14. Getting to the Core: Exploring the Embryonic Development from Notochord to Nucleus Pulposus
  15. Cell Therapy for Intervertebral Disc Regeneration: Progress and Hurdles in Clinical Translation
  16. Enzymatic chemonucleolysis for lumbar disc herniation—an assessment of historical and contemporary efficacy and safety: a systematic review and meta-analysis
  17. A comprehensive review of cell transplantation and platelet‐rich plasma therapy for the treatment of disc degeneration‐related back and neck pain: A systematic evidence‐based analysis
  18. SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential
  19. Revisiting the Newest Vital Sign Survey: Addressing Concerns About This Health Literacy Assessment Tool
  20. ISSLS PRIZE in Basic Science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain
  21. Threats and opportunities of using ChatGPT in scientific writing—The risk of getting spineless
  22. Recombinant Laminin-511 Fragment (iMatrix-511) Coating Supports Maintenance of Human Nucleus Pulposus Progenitor Cells In Vitro
  23. Investigation of the Mitigation of DMSO-Induced Cytotoxicity by Hyaluronic Acid following Cryopreservation of Human Nucleus Pulposus Cells
  24. Adolescent Idiopathic Scoliotic Deformity Correction Surgery Assisted by Smart-Glasses Can Enhance Correction Outcomes and Accuracy, While Also Improving Surgeon Fatigue
  25. Low Radiation Protocol for Intraoperative Robotic C-Arm Can Enhance Adolescent Idiopathic Scoliosis Deformity Correction Accuracy and Safety
  26. Harmonization and standardization of nucleus pulposus cell extraction and culture methods
  27. Comprehensive Narrative Review on the Analysis of Outcomes from Cell Transplantation Clinical Trials for Discogenic Low Back Pain
  28. Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study
  29. N ‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass production
  30. Multicenter Retrospective Analysis of Intradiscal Condoliase Injection Therapy for Lumbar Disc Herniation
  31. Predictive Factors for Successful Treatment of Deep Incisional Surgical Site Infections following Instrumented Spinal Surgeries: Retrospective Review of 1832 Cases
  32. Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease
  33. Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the ORS spine section
  34. Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section
  35. Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells
  36. Screening for Growth-Factor Combinations Enabling Synergistic Differentiation of Human MSC to Nucleus Pulposus Cell-Like Cells
  37. Optimization of Spheroid Colony Culture and Cryopreservation of Nucleus Pulposus Cells for the Development of Intervertebral Disc Regenerative Therapeutics
  38. Simultaneous translation on two rods improves the correction and apex translocation in adolescent patients with hypokyphotic scoliosis
  39. Rubinstein-Taybi syndrome with scoliosis treated with single-stage posterior spinal fusion: illustrative case
  40. Cobalt-chromium versus titanium alloy rods for correction of adolescent idiopathic scoliosis based on 1-year follow-up: a multicenter randomized controlled clinical trial
  41. Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review
  42. FACS is more potent to fish IVD progenitor cells than magnetic and bead-based methods
  43. Annulus Fibrosus Cell Sheets Limit Disc Degeneration in a Rat Annulus Fibrosus Injury Model
  44. Minimal Sustainability of Dedifferentiation Effected by ROCK Inhibitor on Nucleus Pulposus Cells In Vitro
  45. Summary of​ clinical trials investigating cell transplantation for intervertebral disc repair
  46. Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species
  47. Discogenic cell transplantation directly from a cryopreserved state in an induced intervertebral disc degeneration canine model
  48. Corrigendum to ‘Regenerative technologies to bed side: Evolving the regulatory’ [J Orthop Translat 9 (2017) 1–7]
  49. Cell therapy for intervertebral disc repair: Clinical perspective
  50. Regenerative technologies to bed side: Evolving the regulatory framework
  51. Sciatic nerve regeneration by transplantation of in vitro differentiated nucleus pulposus progenitor cells
  52. Biological Approaches to Spinal Disc Repair and Regeneration for Clinicians