All Stories

  1. Age-related bone loss in mouse lumbar vertebrae is affected by region, sex, and level: Implications for spinal loading and analysis methods

    Article • Bone Reports, December 2025, Elsevier

    James Iatridis

  2. Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective

    Article • JOR Spine, July 2025, Wiley

    James Iatridis

  3. ZNF865 (BLST) Regulates Human Cell Senescence and DNA Damage

    Article • June 2025, Cold Spring Harbor Laboratory Press

    James Iatridis

  4. TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model

    Article • JOR Spine, May 2025, Wiley

    James Iatridis

  5. Myoblast-derived ADAMTS-like 2 promotes skeletal muscle regeneration after injury

    Article • npj Regenerative Medicine, December 2024, Springer Science + Business Media

    James Iatridis

  6. The role of the complement system in disc degeneration and Modic changes

    Article • JOR Spine, February 2024, Wiley

    James Iatridis

  7. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord—An In Vivo Rat Discogenic Pain Model

    Article • International Journal of Molecular Sciences, February 2024, MDPI AG

    James Iatridis

  8. Galectin‐3 and RAGE differentially control advanced glycation endproduct‐induced collagen damage in murine intervertebral disc organ culture

    Article • JOR Spine, March 2023, Wiley

    James Iatridis

  9. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    James Iatridis

  10. Teaching Tissue Repair Through an Inquiry-Based Learning Bioadhesives Module

    Article • Biomedical Engineering Education, November 2022, Springer Science + Business Media

    James Iatridis

  11. Genipin-crosslinked fibrin seeded with oxidized alginate microbeads as a novel composite biomaterial strategy for intervertebral disc cell therapy

    Article • Biomaterials, August 2022, Elsevier

    James Iatridis

  12. Ex vivo biomechanical evaluation of Acute lumbar endplate injury and comparison to annulus fibrosus injury in a rat model

    Article • Journal of the Mechanical Behavior of Biomedical Materials, July 2022, Elsevier

    James Iatridis

  13. Mechanisms and clinical implications of intervertebral disc calcification

    Article • Nature Reviews Rheumatology, May 2022, Springer Science + Business Media

    James Iatridis

  14. Accelerometry Data Delineate Phases of Recovery and Supplement Patient-Reported Outcome Measures Following Lumbar Laminectomy

    Article • World Neurosurgery, April 2022, Elsevier

    James Iatridis

  15. Does the neutral zone quantification method matter? Efficacy of evaluating neutral zone during destabilization and restabilization in human spine implant testing

    Article • Journal of Biomechanics, December 2021, Elsevier

    James Iatridis

  16. High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE‐KO mice

    Article • Journal of Orthopaedic Research®, October 2021, Wiley

    James Iatridis

  17. Single‐cell RNA‐sequencing atlas of bovine caudal intervertebral discs: Discovery of heterogeneous cell populations with distinct roles in homeostasis

    Article • The FASEB Journal, September 2021, Wiley

    James Iatridis

  18. Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration

    Article • Cartilage, September 2021, SAGE Publications

    James Iatridis

  19. Extracellular Vesicles as an Emerging Treatment Option for Intervertebral Disc Degeneration: Therapeutic Potential, Translational Pathways, and Regulatory Considerations

    Article • Advanced Healthcare Materials, July 2021, Wiley

    James Iatridis

  20. Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the ORS spine section

    Article • JOR Spine, June 2021, Wiley

    Jordy Schol, James Iatridis

  21. A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series

    Article • JOR Spine, June 2021, Wiley

    James Iatridis

  22. Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section

    Article • JOR Spine, May 2021, Wiley

    Jordy Schol, James Iatridis

  23. Prenatal muscle forces are necessary for vertebral segmentation and disc structure, but not for notochord involution in mice

    Article • May 2021, ECM Research Journal

    James Iatridis

  24. Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions

    Article • Bone Research, January 2021, Springer Science + Business Media

    James Iatridis

  25. Ingenuity during the COVID-19 pandemic: a controlled experiment for respirator mask efficacy testing

    Article • BMJ Innovations, December 2020, BMJ

    James Iatridis

  26. Advancing basic and preclinical spine research: Highlights from the ORS PSRS 5th International Spine Research Symposium

    Article • JOR Spine, December 2020, Wiley

    James Iatridis

  27. Ex-vivo biomechanics of repaired rat intervertebral discs using genipin crosslinked fibrin adhesive hydrogel

    Article • Journal of Biomechanics, December 2020, Elsevier

    James Iatridis

  28. Balancing biological and biomechanical performance in intervertebral disc repair: a systematic review of injectable cell delivery biomaterials

    Article • November 2020, Forum Multimedia Publishing LLC

    James Iatridis

  29. The Functional Role of Interface Tissue Engineering in Annulus Fibrosus Repair: Bridging Mechanisms of Hydrogel Integration with Regenerative Outcomes

    Article • ACS Biomaterials Science & Engineering, November 2020, American Chemical Society (ACS)

    James Iatridis

  30. Spatial mapping of collagen content and structure in human intervertebral disk degeneration

    Article • JOR Spine, November 2020, Wiley

    James Iatridis

  31. Development of a two-part biomaterial adhesive strategy for annulus fibrosus repair and ex vivo evaluation of implant herniation risk

    Article • Biomaterials, November 2020, Elsevier

    James Iatridis

  32. Advanced glycation end products cause RAGE‐dependent annulus fibrosus collagen disruption and loss identified using in situ second harmonic generation imaging in mice intervertebral disk in vivo and in organ culture models

    Article • JOR Spine, September 2020, Wiley

    James Iatridis

  33. Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model

    Article • Scientific Reports, September 2020, Springer Science + Business Media

    James Iatridis

  34. Letter to the Editor: Individual Patient-reported Activity Levels Before and After Joint Arthroplasty Are Neither Accurate nor Reproducible

    Article • Clinical Orthopaedics and Related Research, September 2020, Wolters Kluwer Health

    James Iatridis

  35. Crosslinker concentration controls TGFβ-3 release and annulus fibrosus cell apoptosis in genipin-crosslinked fibrin hydrogels

    Article • May 2020, Forum Multimedia Publishing LLC

    James Iatridis

  36. Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model

    Article • PLOS One, May 2020, PLOS

    James Iatridis

  37. The importance of diversity, equity, and inclusion in orthopedic research

    Article • Journal of Orthopaedic Research®, April 2020, Wiley

    James Iatridis

  38. Measuring the neutral zone of spinal motion segments: Comparison of multiple analysis methods to quantify spinal instability

    Article • JOR Spine, April 2020, Wiley

    James Iatridis

  39. Loss of tenomodulin expression is a risk factor for age‐related intervertebral disc degeneration

    Article • Aging Cell, February 2020, Wiley

    James Iatridis

  40. Physician Decision-making in Return to Play After Cervical Spine Injury

    Article • Clinical Spine Surgery A Spine Publication, January 2020, Wolters Kluwer Health

    James Iatridis

  41. Functional cell phenotype induction with TGF-β1 and collagen-polyurethane scaffold for annulus fibrosus rupture repair

    Article • January 2020, Forum Multimedia Publishing LLC

    James Iatridis

  42. Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model

    Article • December 2019, Cold Spring Harbor Laboratory Press

    James Iatridis

  43. Morphological and biomechanical effects of annulus fibrosus injury and repair in an ovine cervical model

    Article • JOR Spine, December 2019, Wiley

    James Iatridis

  44. Homeostasis disrupted by strain mechanosensing

    Article • Nature Biomedical Engineering, December 2019, Springer Science + Business Media

    James Iatridis

  45. Neonatal annulus fibrosus regeneration occurs via recruitment and proliferation of Scleraxis-lineage cells

    Article • npj Regenerative Medicine, December 2019, Springer Science + Business Media

    James Iatridis

  46. Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model

    Article • PLOS One, November 2019, PLOS

    James Iatridis

  47. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice

    Article • Cell Death and Disease, October 2019, Springer Science + Business Media

    James Iatridis

  48. Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model

    Article • PLOS One, October 2019, PLOS

    James Iatridis

  49. Sex Differences in Rat Intervertebral Disc Structure and Function Following Annular Puncture Injury

    Article • Spine, September 2019, Wolters Kluwer Health

    James Iatridis

  50. Injectable cellulose-based hydrogels as nucleus pulposus replacements: Assessment of in vitro structural stability, ex vivo herniation risk, and in vivo biocompatibility

    Article • Journal of the Mechanical Behavior of Biomedical Materials, August 2019, Elsevier

    James Iatridis

  51. Biomechanical test protocols to detect minor injury effects in intervertebral discs

    Article • Journal of the Mechanical Behavior of Biomedical Materials, July 2019, Elsevier

    James Iatridis

  52. Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity

    Article • PLOS One, May 2019, PLOS

    James Iatridis

  53. Fibrin-Genipin Hydrogel for Cartilage Tissue Engineering in Nasal Reconstruction

    Article • Annals of Otology Rhinology & Laryngology, March 2019, SAGE Publications

    James Iatridis

  54. Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment

    Article • JBMR Plus, March 2019, Oxford University Press (OUP)

    James Iatridis

  55. Short-term foetal immobility temporally and progressively affects chick spinal curvature and anatomy and rib development

    Article • January 2019, Forum Multimedia Publishing LLC

    James Iatridis

  56. Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs

    Article • Disease Models & Mechanisms, November 2018, The Company of Biologists

    James Iatridis

  57. 3D printing a mechanically-tunable acrylate resin on a commercial DLP-SLA printer

    Article • Additive Manufacturing, October 2018, Elsevier

    James Iatridis

  58. Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies

    Article • Annals of the New York Academy of Sciences, September 2018, Wiley

    James Iatridis

  59. New horizons in spine research: Disc biology, tissue engineering, biomechanics, translational, and clinical research

    Article • JOR Spine, August 2018, Wiley

    James Iatridis

  60. Critical aspects and challenges for intervertebral disc repair and regeneration-Harnessing advances in tissue engineering

    Article • JOR Spine, July 2018, Wiley

    Dr Sibylle Grad, James Iatridis

  61. Effects of Level, Loading Rate, Injury and Repair on Biomechanical Response of Ovine Cervical Intervertebral Discs

    Article • Annals of Biomedical Engineering, June 2018, Springer Science + Business Media

    James Iatridis

  62. Dietary Advanced Glycation End-Product Consumption Leads to Mechanical Stiffening of Murine Intervertebral Discs

    Article • June 2018, Cold Spring Harbor Laboratory Press

    James Iatridis

  63. Thermoresponsive, redox-polymerized cellulosic hydrogels undergo in situ gelation and restore intervertebral disc biomechanics post discectomy

    Article • May 2018, Forum Multimedia Publishing LLC

    James Iatridis

  64. Inhibiting tumor necrosis factor-alpha at time of induced intervertebral disc injury limits long-term pain and degeneration in a rat model

    Article • JOR Spine, May 2018, Wiley

    James Iatridis

  65. Elevated glycohemoglobin HbA1c is associated with low back pain in nonoverweight diabetics

    Article • The Spine Journal, May 2018, Elsevier

    James Iatridis

  66. Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration

    Article • Cartilage, March 2018, SAGE Publications

    James Iatridis

  67. Neonatal mouse intervertebral discs heal with restored function following herniation injury

    Article • The FASEB Journal, March 2018, Wiley

    Olivia Torre, James Iatridis

  68. Animal models for studying the etiology and treatment of low back pain

    Article • Journal of Orthopaedic Research®, March 2018, Wiley

    James Iatridis, Dr. Andre J van Wijnen

  69. Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine

    Article • JOR Spine, March 2018, Wiley

    James Iatridis

  70. A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring

    Article • February 2018, Forum Multimedia Publishing LLC

    James Iatridis

  71. Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration

    Article • The Spine Journal, February 2018, Elsevier

    James Iatridis

  72. Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs

    Article • Tissue Engineering Part A, February 2018, Mary Ann Liebert Inc

    James Iatridis

  73. Dietary Advanced Glycation End Products Have Sex- and Age-Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice

    Article • Journal of Bone and Mineral Research, November 2017, Wiley

    James Iatridis

  74. Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression

    Article • Journal of Orthopaedic Research®, September 2017, Wiley

    James Iatridis

  75. Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain

    Article • Annals of the New York Academy of Sciences, August 2017, Wiley

    James Iatridis

  76. Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks

    Article • Journal of Biomechanical Engineering, June 2017, ASME International

    James Iatridis

  77. Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape

    Article • Journal of Orthopaedic Research®, May 2017, Wiley

    James Iatridis

  78. In vitro and biomechanical screening of polyethylene glycol and poly(trimethylene carbonate) block copolymers for annulus fibrosus repair

    Article • Journal of Tissue Engineering and Regenerative Medicine, March 2017, Wiley

    James Iatridis

  79. Intervertebral Disk Degeneration and Repair

    Article • Neurosurgery, February 2017, Oxford University Press (OUP)

    James Iatridis

  80. New horizons in spine research: Intervertebral disc repair and regeneration

    Article • Journal of Orthopaedic Research®, January 2017, Wiley

    James Iatridis

  81. AGEs induce ectopic endochondral ossification in intervertebral discs

    Article • November 2016, ECM Research Journal

    James Iatridis

  82. Molecular mechanisms of biological aging in intervertebral discs

    Article • Journal of Orthopaedic Research®, August 2016, Wiley

    James Iatridis

  83. New Horizons in Spine Research: Disc biology, spine biomechanics and pathomechanisms of back pain

    Article • Journal of Orthopaedic Research®, August 2016, Wiley

    James Iatridis

  84. Does type 2 diabetes mellitus promote intervertebral disc degeneration?

    Article • European Spine Journal, June 2016, Springer Science + Business Media

    James Iatridis

  85. Do mechanical strain and TNF-α interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells?

    Article • Journal of Biomechanics, May 2016, Elsevier

    James Iatridis

  86. Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo

    Article • The Spine Journal, March 2016, Elsevier

    James Iatridis

  87. Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair

    Article • Journal of Biomechanical Engineering, January 2016, ASME International

    James Iatridis

  88. Mechanical restoration and failure analyses of a hydrogel and scaffold composite strategy for annulus fibrosus repair

    Article • Acta Biomaterialia, January 2016, Elsevier

    James Iatridis

  89. Development of a bovine decellularized extracellular matrix-biomaterial for nucleus pulposus regeneration

    Article • Journal of Orthopaedic Research®, December 2015, Wiley

    James Iatridis

  90. Association Between BMP-2 and Carcinogenicity

    Article • Spine, December 2015, Wolters Kluwer Health

    James Iatridis

  91. Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug

    Article • The Spine Journal, September 2015, Elsevier

    James Iatridis

  92. Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells

    Article • Spine, July 2015, Wolters Kluwer Health

    James Iatridis

  93. Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability

    Article • The Spine Journal, May 2015, Elsevier

    James Iatridis

  94. Assessment of functional and behavioral changes sensitive to painful disc degeneration

    Article • Journal of Orthopaedic Research®, March 2015, Wiley

    James Iatridis

  95. Correction: Combined Anti-Inflammatory and Anti-AGE Drug Treatments Have a Protective Effect on Intervertebral Discs in Mice with Diabetes

    Article • PLOS One, March 2015, PLOS

    James Iatridis

  96. TNFα Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs

    Article • PLOS One, March 2015, PLOS

    James Iatridis

  97. Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines

    Article • Osteoarthritis and Cartilage, March 2015, Elsevier

    James Iatridis

  98. Chronic Ingestion of Advanced Glycation End Products Induces Degenerative Spinal Changes and Hypertrophy in Aging Pre-Diabetic Mice

    Article • PLOS One, February 2015, PLOS

    James Iatridis

  99. Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

    Article • Journal of Orthopaedic Research®, January 2015, Wiley

    James Iatridis

  100. Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study

    Article • Journal of Anatomy, November 2014, Wiley

    James Iatridis

  101. Cellular bone matrices: viable stem cell-containing bone graft substitutes

    Article • The Spine Journal, November 2014, Elsevier

    James Iatridis

  102. Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model

    Article • The Spine Journal, November 2014, Elsevier

    James Iatridis

  103. Characterization of Mechanics and Cytocompatibility of Fibrin-Genipin Annulus Fibrosus Sealant with the Addition of Cell Adhesion Molecules

    Article • Tissue Engineering Part A, September 2014, Mary Ann Liebert Inc

    James Iatridis

  104. Outcomes and Complications of Diabetes Mellitus on Patients Undergoing Degenerative Lumbar Spine Surgery

    Article • Spine, September 2014, Wolters Kluwer Health

    James Iatridis

  105. The Impact of Diabetes Mellitus on Patients Undergoing Degenerative Cervical Spine Surgery

    Article • Spine, September 2014, Wolters Kluwer Health

    James Iatridis

  106. Nonoperative Management of Discogenic Back Pain

    Article • Spine, July 2014, Wolters Kluwer Health

    James Iatridis

  107. Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment

    Article • PLOS One, June 2014, PLOS

    James Iatridis

  108. Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture

    Article • Journal of Biomechanics, June 2014, Elsevier

    James Iatridis

  109. Notochordal Cell-Derived Therapeutic Strategies for Discogenic Back Pain

    Article • Global Spine Journal, July 2013, Thieme Publishing Group

    James Iatridis

  110. Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair

    Article • June 2013, Springer Science + Business Media

    James Iatridis

  111. Combined Anti-Inflammatory and Anti-AGE Drug Treatments Have a Protective Effect on Intervertebral Discs in Mice with Diabetes

    Article • PLOS One, May 2013, PLOS

    James Iatridis

  112. Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3

    Article • Journal of Spinal Disorders & Techniques, May 2013, Wolters Kluwer Health

    James Iatridis, Dr. Rosalyn Delia Abbott

  113. Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration

    Article • Journal of Magnetic Resonance Imaging, April 2013, Wiley

    James Iatridis

  114. A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift

    Article • Biochemical and Biophysical Research Communications, March 2013, Elsevier

    James Iatridis

  115. Genetic polymorphisms associated with intervertebral disc degeneration

    Article • The Spine Journal, March 2013, Elsevier

    James Iatridis

  116. Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?

    Article • The Spine Journal, March 2013, Elsevier

    James Iatridis

  117. Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses

    Article • PLOS One, January 2013, PLOS

    James Iatridis

  118. Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development

    Article • Arthritis Research & Therapy, January 2013, Springer Science + Business Media

    James Iatridis

  119. Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux–Lamy syndrome)

    Article • Journal of Orthopaedic Research®, November 2012, Wiley

    James Iatridis

  120. Stress and matrix-responsive cytoskeletal remodeling in fibroblasts

    Article • Journal of Cellular Physiology, October 2012, Wiley

    James Iatridis, Dr. Rosalyn Delia Abbott

  121. Genipin-Crosslinked Fibrin Hydrogels Modified With Collagen or Fibronectin as an Annulus Fibrosus Sealant

    Article • June 2012, ASME International

    James Iatridis

  122. Height and torsional stiffness are most sensitive to annular injury in large animal intervertebral discs

    Article • The Spine Journal, May 2012, Elsevier

    James Iatridis

  123. Live free or die: Stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted

    Article • Biochemical and Biophysical Research Communications, May 2012, Elsevier

    James Iatridis, Dr. Rosalyn Delia Abbott

  124. Commentary: Does needle injection cause disc degeneration? News in the continuing debate regarding pathophysiology associated with intradiscal injections

    Article • The Spine Journal, April 2012, Elsevier

    James Iatridis

  125. Large residual strains are present in the intervertebral disc annulus fibrosus in the unloaded state

    Article • Journal of Biomechanics, April 2012, Elsevier

    James Iatridis

  126. Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells

    Article • Journal of Orthopaedic Research®, August 2011, Wiley

    James Iatridis, Dr. Rosalyn Delia Abbott

  127. Complex loading affects intervertebral disc mechanics and biology

    Article • Osteoarthritis and Cartilage, August 2011, Elsevier

    James Iatridis

  128. Effects of Torsion on Intervertebral Disc Gene Expression and Biomechanics, Using a Rat Tail Model

    Article • Spine, April 2011, Wolters Kluwer Health

    James Iatridis

  129. Fibroblast cytoskeletal remodeling contributes to connective tissue tension

    Article • Journal of Cellular Physiology, February 2011, Wiley

    James Iatridis

  130. Region-Dependent Aggrecan Degradation Patterns in the Rat Intervertebral Disc Are Affected by Mechanical Loading In Vivo

    Article • Spine, February 2011, Wolters Kluwer Health

    James Iatridis

  131. Erratum to: Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently

    Article • European Spine Journal, January 2011, Springer Science + Business Media

    James Iatridis

  132. Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells

    Article • Arthritis Research & Therapy, January 2011, Springer Science + Business Media

    James Iatridis, Dr. Rosalyn Delia Abbott

  133. Penetrating Annulus Fibrosus Injuries Affect Dynamic Compressive Behaviors of the Intervertebral Disc Via Altered Fluid Flow: An Analytical Interpretation

    Article • Journal of Biomechanical Engineering, January 2011, ASME International

    James Iatridis

  134. The effects of needle puncture injury on microscale shear strain in the intervertebral disc annulus fibrosus

    Article • The Spine Journal, December 2010, Elsevier

    James Iatridis

  135. Refinement of Elastic, Poroelastic, and Osmotic Tissue Properties of Intervertebral Disks to Analyze Behavior in Compression

    Article • Annals of Biomedical Engineering, August 2010, Springer Science + Business Media

    James Iatridis

  136. Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently

    Article • European Spine Journal, June 2010, Springer Science + Business Media

    James Iatridis

  137. Effects of enzymatic digestion on compressive properties of rat intervertebral discs

    Article • Journal of Biomechanics, April 2010, Elsevier

    James Iatridis, Dr. Rosalyn Delia Abbott

  138. Limitation of Finite Element Analysis of Poroelastic Behavior of Biological Tissues Undergoing Rapid Loading

    Article • Annals of Biomedical Engineering, March 2010, Springer Science + Business Media

    James Iatridis

  139. Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype

    Article • Stem Cell Research & Therapy, January 2010, Springer Science + Business Media

    James Iatridis

  140. Function follows form

    Article • Nature Materials, December 2009, Springer Science + Business Media

    James Iatridis

  141. Measurement of local strains in intervertebral disc anulus fibrosus tissue under dynamic shear: Contributions of matrix fiber orientation and elastin content

    Article • Journal of Biomechanics, October 2009, Elsevier

    James Iatridis

  142. In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression

    Article • Journal of Orthopaedic Research®, September 2009, Wiley

    James Iatridis

  143. Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis

    Article • Cellular and Molecular Bioengineering, July 2009, Springer Science + Business Media

    James Iatridis

  144. An Analytical Model Describing Intervertebral Disc Mechanics Following a Needle Puncture Injury

    Article • June 2009, ASME International

    James Iatridis

  145. Asymmetric Loading Promotes Early Signs of Intervertebral Disc Degeneration in Large Animal Organ Culture

    Article • June 2009, ASME International

    James Iatridis

  146. Measurement of Local Strains in Intervertebral Disc Anulus Fibrosus Tissue Under Dynamic Shear: Contributions of Matrix Fiber Orientation and Elastin Content

    Article • June 2009, ASME International

    James Iatridis

  147. Intervertebral disc cell response to dynamic compression is age and frequency dependent

    Article • Journal of Orthopaedic Research®, June 2009, Wiley

    James Iatridis

  148. MSC response to pH levels found in degenerating intervertebral discs

    Article • Biochemical and Biophysical Research Communications, February 2009, Elsevier

    James Iatridis

  149. Spatially Resolved Streaming Potentials of Human Intervertebral Disk Motion Segments Under Dynamic Axial Compression

    Article • Journal of Biomechanical Engineering, January 2009, ASME International

    James Iatridis

  150. Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity

    Article • European Spine Journal, November 2008, Springer Science + Business Media

    James Iatridis

  151. Behavior of Mesenchymal Stem Cells in the Chemical Microenvironment of the Intervertebral Disc

    Article • Spine, August 2008, Wolters Kluwer Health

    James Iatridis

  152. Frequency-Dependent Behavior of the Intervertebral Disc in Response to Each of Six Degree of Freedom Dynamic Loading

    Article • Spine, July 2008, Wolters Kluwer Health

    James Iatridis

  153. Dynamic Compression Effects on Intervertebral Disc Mechanics and Biology

    Article • Spine, June 2008, Wolters Kluwer Health

    James Iatridis

  154. Mechanical homeostasis is altered in uterine leiomyoma

    Article • American Journal of Obstetrics and Gynecology, April 2008, Elsevier

    James Iatridis

  155. Needle Puncture Injury Affects Intervertebral Disc Mechanics and Biology in an Organ Culture Model

    Article • Spine, February 2008, Wolters Kluwer Health

    James Iatridis

  156. Evaluation of quantitative magnetic resonance imaging, biochemical and mechanical properties of trypsin-treated intervertebral discs under physiological compression loading

    Article • Journal of Magnetic Resonance Imaging, January 2008, Wiley

    James Iatridis

  157. In vivo intervertebral disc remodeling: Kinetics of mRNA expression in response to a single loading event

    Article • Journal of Orthopaedic Research®, January 2008, Wiley

    James Iatridis

  158. Different Effects of Static Versus Cyclic Compressive Loading on Rat Intervertebral Disc Height and Water Loss In Vitro

    Article • Spine, August 2007, Wolters Kluwer Health

    James Iatridis

  159. Measurements of Proteoglycan and Water Content Distribution in Human Lumbar Intervertebral Discs

    Article • Spine, June 2007, Wolters Kluwer Health

    James Iatridis

  160. Characterization of an in vitro intervertebral disc organ culture system

    Article • European Spine Journal, February 2007, Springer Science + Business Media

    James Iatridis

  161. A numerical study to determine pericellular matrix modulus and evaluate its effects on the micromechanical environment of chondrocytes

    Article • Journal of Biomechanics, January 2007, Elsevier

    James Iatridis

  162. A Removable Precision Device for In-Vivo Mechanical Compression of Rat Tail Intervertebral Discs

    Article • Journal of Medical Devices, January 2007, ASME International

    James Iatridis

  163. Direct measurement of intervertebral disc maximum shear strain in six degrees of freedom: Motions that place disc tissue at risk of injury

    Article • Journal of Biomechanics, January 2007, Elsevier

    James Iatridis

  164. Role of endplates in contributing to compression behaviors of motion segments and intervertebral discs

    Article • Journal of Biomechanics, January 2007, Elsevier

    James Iatridis

  165. Correlating Material Properties with Tissue Composition in Enzymatically Digested Bovine Annulus Fibrosus and Nucleus Pulposus Tissue

    Article • Annals of Biomedical Engineering, April 2006, Springer Science + Business Media

    James Iatridis

  166. Effects of Mechanical Loading on Intervertebral Disc Metabolism In Vivo

    Article • Journal of Bone and Joint Surgery, April 2006, The Journal of Bone and Joint Surgery, Inc.

    James Iatridis

  167. In Vitro Organ Culture of the Bovine Intervertebral Disc

    Article • Spine, March 2006, Wolters Kluwer Health

    James Iatridis

  168. Assessment of compressive modulus, hydraulic permeability and matrix content of trypsin-treated nucleus pulposus using quantitative MRI

    Article • Journal of Biomechanics, January 2006, Elsevier

    James Iatridis

  169. Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability

    Article • Journal of Biomechanics, November 2005, Elsevier

    James Iatridis

  170. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc

    Article • Journal of Orthopaedic Research®, September 2005, Wiley

    James Iatridis

  171. Effect of mechanical loading on mRNA levels of common endogenous controls in articular chondrocytes and intervertebral disk

    Article • Analytical Biochemistry, June 2005, Elsevier

    James Iatridis

  172. Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo

    Article • AJP Cell Physiology, March 2005, American Physiological Society

    James Iatridis

  173. Mechanical damage to the intervertebral disc annulus fibrosus subjected to tensile loading

    Article • Journal of Biomechanics, March 2005, Elsevier

    James Iatridis

  174. Introduction

    Article • Spine, December 2004, Wolters Kluwer Health

    James Iatridis

  175. Mechanical Conditions That Accelerate Intervertebral Disc Degeneration: Overload Versus Immobilization

    Article • Spine, December 2004, Wolters Kluwer Health

    James Iatridis

  176. Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression

    Article • Journal of Orthopaedic Research®, November 2004, Wiley

    James Iatridis

  177. Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus

    Article • Journal of Biomechanics, August 2004, Elsevier

    James Iatridis

  178. Organ Culture System for Mechanobiology Studies of the Intervertebral Disc

    Article • January 2004, ASME International

    James Iatridis

  179. Article • Spine, May 2003, Wolters Kluwer Health

    James Iatridis

  180. Influence of Fixed Charge Density Magnitude and Distribution on the Intervertebral Disc: Applications of a Poroelastic and Chemical Electric (PEACE) Model

    Article • Journal of Biomechanical Engineering, February 2003, ASME International

    James Iatridis

  181. Mechanical Damage to the Intervertebral Disc Annulus Fibrosus Subjected to Cyclic Tensile Loading

    Article • January 2003, ASME International

    James Iatridis

  182. Growth Plate Chondrocyte Enlargement Modulated by Mechanical Loading

    Article • January 2002, IOS Press

    James Iatridis

  183. Streaming potential of human lumbar anulus fibrosus is anisotropic and affected by disc degeneration

    Article • Journal of Biomechanics, November 1999, Elsevier

    James Iatridis

  184. Shear mechanical properties of human lumbar annulus fibrosus

    Article • Journal of Orthopaedic Research®, September 1999, Wiley

    James Iatridis

  185. Mechanical modulation of growth for the correction of vertebral wedge deformities

    Article • Journal of Orthopaedic Research®, July 1999, Wiley

    James Iatridis

  186. Compression-Induced Changes in Intervertebral Disc Properties in a Rat Tail Model

    Article • Spine, May 1999, Wolters Kluwer Health

    James Iatridis

  187. Creation and Correction of Vertebral Wedge Deformity by Mechanical Modulation of Growth

    Article • January 1999, IOS Press

    James Iatridis

  188. Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression

    Article • Journal of Biomechanics, June 1998, Elsevier

    James Iatridis

  189. The viscoelastic behavior of the non-degenerate human lumbar nucleus pulposus in shear

    Article • Journal of Biomechanics, October 1997, Elsevier

    James Iatridis

  190. Alterations in the mechanical behavior of the human lumbar nucleus pulposus with degeneration and aging

    Article • Journal of Orthopaedic Research®, March 1997, Wiley

    James Iatridis

  191. Determination of collagen-proteoglycan interactions in vitro

    Article • Journal of Biomechanics, June 1996, Elsevier

    James Iatridis

  192. Is the Nucleus Pulposus a Solid or a Fluid? Mechanical Behaviors of the Nucleus Pulposus of the Human Intervertebral Disc

    Article • Spine, May 1996, Wolters Kluwer Health

    James Iatridis

  193. Tensile Properties of Nondegenerate Human Lumbar Anulus Fibrosus

    Article • Spine, February 1996, Wolters Kluwer Health

    James Iatridis

  194. Degeneration and Aging Affect the Tensile Behavior of Human Lumbar Anulus Fibrosus

    Article • Spine, December 1995, Wolters Kluwer Health

    James Iatridis

  195. Regional Variation in Tensile Properties and Biochemical Composition of the Human Lumbar Anulus Fibrosus

    Article • Spine, June 1994, Wolters Kluwer Health

    James Iatridis

  196. Development of an At-home Metal Corrosion Laboratory Experiment for STEM Outreach in Biomaterials During the Covid-19 Pandemic

    Article • American Society for Engineering Education

    James Iatridis