All Stories

  1. Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model
  2. Homeostasis disrupted by strain mechanosensing
  3. Neonatal annulus fibrosus regeneration occurs via recruitment and proliferation of Scleraxis-lineage cells
  4. Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
  5. Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity
  6. Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs
  7. 3D printing a mechanically-tunable acrylate resin on a commercial DLP-SLA printer
  8. Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies
  9. Neonatal mouse intervertebral discs heal with restored function following herniation injury
  10. New horizons in spine research: Disc biology, tissue engineering, biomechanics, translational, and clinical research
  11. Critical aspects and challenges for intervertebral disc repair and regeneration-Harnessing advances in tissue engineering
  12. Effects of Level, Loading Rate, Injury and Repair on Biomechanical Response of Ovine Cervical Intervertebral Discs
  13. Dietary Advanced Glycation End-Product Consumption Leads to Mechanical Stiffening of Murine Intervertebral Discs
  14. Inhibiting tumor necrosis factor-alpha at time of induced intervertebral disc injury limits long-term pain and degeneration in a rat model
  15. Elevated glycohemoglobin HbA1c is associated with low back pain in nonoverweight diabetics
  16. Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine
  17. Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration
  18. Dietary Advanced Glycation End Products Have Sex- and Age-Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice
  19. Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression
  20. Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain
  21. Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks
  22. Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape
  23. In vitro and biomechanical screening of polyethylene glycol and poly(trimethylene carbonate) block copolymers for annulus fibrosus repair
  24. Intervertebral Disk Degeneration and Repair
  25. New horizons in spine research: Intervertebral disc repair and regeneration
  26. AGEs induce ectopic endochondral ossification in intervertebral discs
  27. Molecular mechanisms of biological aging in intervertebral discs
  28. New Horizons in Spine Research: Disc biology, spine biomechanics and pathomechanisms of back pain
  29. Does type 2 diabetes mellitus promote intervertebral disc degeneration?
  30. Do mechanical strain and TNF-α interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells?
  31. Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo
  32. Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair
  33. Mechanical restoration and failure analyses of a hydrogel and scaffold composite strategy for annulus fibrosus repair
  34. Development of a bovine decellularized extracellular matrix-biomaterial for nucleus pulposus regeneration
  35. Association Between BMP-2 and Carcinogenicity
  36. Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug
  37. Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells
  38. Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability
  39. Assessment of functional and behavioral changes sensitive to painful disc degeneration
  40. Correction: Combined Anti-Inflammatory and Anti-AGE Drug Treatments Have a Protective Effect on Intervertebral Discs in Mice with Diabetes
  41. TNFα Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs
  42. Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines
  43. Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting
  44. Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study
  45. Cellular bone matrices: viable stem cell-containing bone graft substitutes
  46. Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model
  47. Characterization of Mechanics and Cytocompatibility of Fibrin-Genipin Annulus Fibrosus Sealant with the Addition of Cell Adhesion Molecules
  48. Outcomes and Complications of Diabetes Mellitus on Patients Undergoing Degenerative Lumbar Spine Surgery
  49. The Impact of Diabetes Mellitus on Patients Undergoing Degenerative Cervical Spine Surgery
  50. Nonoperative Management of Discogenic Back Pain
  51. Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment
  52. Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture
  53. Notochordal Cell-Derived Therapeutic Strategies for Discogenic Back Pain
  54. Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair
  55. Combined Anti-Inflammatory and Anti-AGE Drug Treatments Have a Protective Effect on Intervertebral Discs in Mice with Diabetes
  56. Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3
  57. Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration
  58. A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift
  59. Genetic polymorphisms associated with intervertebral disc degeneration
  60. Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?
  61. Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses
  62. Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development
  63. Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux–Lamy syndrome)
  64. Stress and matrix-responsive cytoskeletal remodeling in fibroblasts
  65. Genipin-Crosslinked Fibrin Hydrogels Modified With Collagen or Fibronectin as an Annulus Fibrosus Sealant
  66. Height and torsional stiffness are most sensitive to annular injury in large animal intervertebral discs
  67. Live free or die: Stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted
  68. Commentary: Does needle injection cause disc degeneration? News in the continuing debate regarding pathophysiology associated with intradiscal injections
  69. Large residual strains are present in the intervertebral disc annulus fibrosus in the unloaded state
  70. Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells
  71. Complex loading affects intervertebral disc mechanics and biology
  72. Effects of Torsion on Intervertebral Disc Gene Expression and Biomechanics, Using a Rat Tail Model
  73. Fibroblast cytoskeletal remodeling contributes to connective tissue tension
  74. Erratum to: Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently
  75. Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells
  76. Penetrating Annulus Fibrosus Injuries Affect Dynamic Compressive Behaviors of the Intervertebral Disc Via Altered Fluid Flow: An Analytical Interpretation
  77. The effects of needle puncture injury on microscale shear strain in the intervertebral disc annulus fibrosus
  78. Refinement of Elastic, Poroelastic, and Osmotic Tissue Properties of Intervertebral Disks to Analyze Behavior in Compression
  79. Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently
  80. Effects of enzymatic digestion on compressive properties of rat intervertebral discs
  81. Limitation of Finite Element Analysis of Poroelastic Behavior of Biological Tissues Undergoing Rapid Loading
  82. Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype
  83. Function follows form
  84. Measurement of local strains in intervertebral disc anulus fibrosus tissue under dynamic shear: Contributions of matrix fiber orientation and elastin content
  85. In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression
  86. Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis
  87. An Analytical Model Describing Intervertebral Disc Mechanics Following a Needle Puncture Injury
  88. Asymmetric Loading Promotes Early Signs of Intervertebral Disc Degeneration in Large Animal Organ Culture
  89. Intervertebral disc cell response to dynamic compression is age and frequency dependent
  90. MSC response to pH levels found in degenerating intervertebral discs
  91. Spatially Resolved Streaming Potentials of Human Intervertebral Disk Motion Segments Under Dynamic Axial Compression
  92. Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity
  93. Behavior of Mesenchymal Stem Cells in the Chemical Microenvironment of the Intervertebral Disc
  94. Frequency-Dependent Behavior of the Intervertebral Disc in Response to Each of Six Degree of Freedom Dynamic Loading
  95. Dynamic Compression Effects on Intervertebral Disc Mechanics and Biology
  96. Mechanical homeostasis is altered in uterine leiomyoma
  97. Needle Puncture Injury Affects Intervertebral Disc Mechanics and Biology in an Organ Culture Model
  98. Evaluation of quantitative magnetic resonance imaging, biochemical and mechanical properties of trypsin-treated intervertebral discs under physiological compression loading
  99. In vivo intervertebral disc remodeling: Kinetics of mRNA expression in response to a single loading event
  100. Different Effects of Static Versus Cyclic Compressive Loading on Rat Intervertebral Disc Height and Water Loss In Vitro
  101. Measurements of Proteoglycan and Water Content Distribution in Human Lumbar Intervertebral Discs
  102. Characterization of an in vitro intervertebral disc organ culture system
  103. A numerical study to determine pericellular matrix modulus and evaluate its effects on the micromechanical environment of chondrocytes
  104. A Removable Precision Device for In-Vivo Mechanical Compression of Rat Tail Intervertebral Discs
  105. Direct measurement of intervertebral disc maximum shear strain in six degrees of freedom: Motions that place disc tissue at risk of injury
  106. Role of endplates in contributing to compression behaviors of motion segments and intervertebral discs
  107. Correlating Material Properties with Tissue Composition in Enzymatically Digested Bovine Annulus Fibrosus and Nucleus Pulposus Tissue
  108. Effects of Mechanical Loading on Intervertebral Disc Metabolism In Vivo
  109. In Vitro Organ Culture of the Bovine Intervertebral Disc
  110. Assessment of compressive modulus, hydraulic permeability and matrix content of trypsin-treated nucleus pulposus using quantitative MRI
  111. Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability
  112. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc
  113. Effect of mechanical loading on mRNA levels of common endogenous controls in articular chondrocytes and intervertebral disk
  114. Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo
  115. Mechanical damage to the intervertebral disc annulus fibrosus subjected to tensile loading
  116. Introduction
  117. Mechanical Conditions That Accelerate Intervertebral Disc Degeneration: Overload Versus Immobilization
  118. Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression
  119. Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus
  120. Influence of Fixed Charge Density Magnitude and Distribution on the Intervertebral Disc: Applications of a Poroelastic and Chemical Electric (PEACE) Model
  121. Mechanical Damage to the Intervertebral Disc Annulus Fibrosus Subjected to Cyclic Tensile Loading
  122. Streaming potential of human lumbar anulus fibrosus is anisotropic and affected by disc degeneration
  123. Shear mechanical properties of human lumbar annulus fibrosus
  124. Mechanical modulation of growth for the correction of vertebral wedge deformities
  125. Compression-Induced Changes in Intervertebral Disc Properties in a Rat Tail Model
  126. Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression
  127. The viscoelastic behavior of the non-degenerate human lumbar nucleus pulposus in shear
  128. Alterations in the mechanical behavior of the human lumbar nucleus pulposus with degeneration and aging
  129. Determination of collagen-proteoglycan interactions in vitro
  130. Is the Nucleus Pulposus a Solid or a Fluid? Mechanical Behaviors of the Nucleus Pulposus of the Human Intervertebral Disc
  131. Tensile Properties of Nondegenerate Human Lumbar Anulus Fibrosus