All Stories

  1. An automated platform for tailored late-stage halogenation of pharmaceuticals

    Article • February 2026, American Chemical Society (ACS)

    Dr Jesus Alcazar

  2. Electrochemical C−O and C−N Arylation using Alternating Polarity in flow for Compound Libraries

    Article • Angewandte Chemie, November 2024, Wiley

    Dr Jesus Alcazar

  3. Electrochemical C−O and C−N Arylation using Alternating Polarity in flow for Compound Libraries

    Article • Angewandte Chemie, November 2024, Wiley

    Dr Jesus Alcazar

  4. Multistep and multivectorial assembly line library synthesis in flow

    Article • Chem Catalysis, October 2024, Elsevier

    Dr Jesus Alcazar

  5. Structure–Activity Relationship of Oxacyclo- and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors

    Article • ACS Medicinal Chemistry Letters, August 2024, American Chemical Society (ACS)

    Dr Jesus Alcazar

  6. Automated One-pot Library Synthesis with Aldehydes as Radical Precursors

    Article • June 2024, American Chemical Society (ACS)

    Dr Jesus Alcazar

  7. Enabling Electrochemical C-O and C-N Arylation Libraries using Alternating Polarity in Flow

    Article • June 2024, American Chemical Society (ACS)

    Dr Jesus Alcazar

  8. Assembly line library synthesis in flow: A multistep and multivectorial approach

    Article • June 2024, American Chemical Society (ACS)

    Dr Jesus Alcazar

  9. Multistep Library Synthesis in Flow: Production of Matrix Libraries in an Assembly Line

    Article • May 2024, American Chemical Society (ACS)

    Dr Jesus Alcazar

  10. Alcohol-alcohol cross-coupling enabled by S H 2 radical sorting

    Article • Science, March 2024, American Association for the Advancement of Science

    Dr Jesus Alcazar

  11. Better Together: Catalyzing Innovation in Organic Synthesis via Academic-Industrial Consortia

    Article • Organic Letters, January 2024, American Chemical Society (ACS)

    Dr Jesus Alcazar

  12. Fully Automated Flow Protocol for C(sp3)–C(sp3) Bond Formation from Tertiary Amides and Alkyl Halides

    Article • Organic Letters, May 2023, American Chemical Society (ACS)

    Dr Jesus Alcazar

  13. Development of an Automated Platform for C(sp3)−C(sp3) Bond Formation via XAT Chemistry

    Article • ChemCatChem, January 2023, Wiley

    Dr Jesus Alcazar

  14. A biomimetic S H 2 cross-coupling mechanism for quaternary sp 3 -carbon formation

    Article • Science, December 2021, American Association for the Advancement of Science

    Dr Jesus Alcazar

  15. 7 Flow chemistry in fine chemical production

    Article • October 2021, De Gruyter

    Dr Jesus Alcazar

  16. C(sp3)−C(sp3) Bond Formation via Electrochemical Alkoxylation and Subsequent Lewis Acid Promoted Reactions

    Article • Advanced Synthesis & Catalysis, August 2021, Wiley

    Dr Jesus Alcazar

  17. Flow Chemistry in Drug Discovery

    Article • January 2021, Springer Science + Business Media

    Dr Jesus Alcazar

  18. Flow Chemistry in Drug Discovery: Challenges and Opportunities

    Article • January 2021, Springer Science + Business Media

    Dr Jesus Alcazar

  19. Flow Chemistry As a Tool to Access Novel Chemical Space for Drug Discovery

    Article • Future Medicinal Chemistry, August 2020, Taylor & Francis

    Dr Jesus Alcazar

  20. Synergy between supported ionic liquid-like phases and immobilized palladium N-heterocyclic carbene–phosphine complexes for the Negishi reaction under flow conditions

    Article • Beilstein Journal of Organic Chemistry, August 2020, Beilstein Institut

    Dr Jesus Alcazar

  21. Formation of quaternary carbons through cobalt-catalyzed C(sp3)–C(sp3) Negishi cross-coupling

    Article • Chemical Communications, January 2020, Royal Society of Chemistry

    Dr Jesus Alcazar

  22. Organometallic Chemistry in Flow in the Pharmaceutical Industry

    Article • September 2019, Royal Society of Chemistry

    Dr Jesus Alcazar

  23. Visible‐Light‐Promoted Iron‐Catalyzed C(sp 2 )–C(sp 3 ) Kumada Cross‐Coupling in Flow

    Article • Angewandte Chemie, July 2019, Wiley

    Dr Carlo Sambiagio, Dr Jesus Alcazar

  24. Flow Chemistry in Drug Discovery

    Article • July 2019, Royal Society of Chemistry

    Dr Jesus Alcazar

  25. De novo Design of Organic Photocatalysts: Bithiophene Derivatives for the Visible‐light Induced C−H Functionalization of Heteroarenes

    Article • Advanced Synthesis & Catalysis, January 2019, Wiley

    Dr Jesus Alcazar

  26. Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring

    Article • The Journal of Organic Chemistry, October 2018, American Chemical Society (ACS)

    Dr Jesus Alcazar

  27. Photoinduced Palladium‐Catalyzed Negishi Cross‐Couplings Enabled by the Visible‐Light Absorption of Palladium–Zinc Complexes

    Article • Angewandte Chemie, September 2018, Wiley

    Dr Jesus Alcazar

  28. Back Cover: Visible‐Light‐Induced Nickel‐Catalyzed Negishi Cross‐Couplings by Exogenous‐Photosensitizer‐Free Photocatalysis (Angew. Chem. Int. Ed. 28/2018)

    Article • Angewandte Chemie, May 2018, Wiley

    Dr Jesus Alcazar

  29. Rücktitelbild: Visible‐Light‐Induced Nickel‐Catalyzed Negishi Cross‐Couplings by Exogenous‐Photosensitizer‐Free Photocatalysis (Angew. Chem. 28/2018)

    Article • Angewandte Chemie, May 2018, Wiley

    Dr Jesus Alcazar

  30. Visible‐Light‐Induced Nickel‐Catalyzed Negishi Cross‐Couplings by Exogenous‐Photosensitizer‐Free Photocatalysis

    Article • Angewandte Chemie, April 2018, Wiley

    Dr Jesus Alcazar

  31. On-demand synthesis of organozinc halides under continuous flow conditions

    Article • Nature Protocols, January 2018, Springer Science + Business Media

    Dr Jesus Alcazar

  32. Negishi coupling reactions with [11C]CH3I: a versatile method for efficient 11C–C bond formation

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Dr Jesus Alcazar

  33. Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)...

    Article • Bioorganic & Medicinal Chemistry, December 2017, Elsevier

    Dr Jesus Alcazar

  34. Visible-Light-Induced Trifluoromethylation of Highly Functionalized Arenes and Heteroarenes in Continuous Flow

    Article • Synthesis, August 2017, Thieme Publishing Group

    Dr Jesus Alcazar

  35. Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

    Article • Organic Letters, June 2017, American Chemical Society (ACS)

    Dr Jesus Alcazar

  36. Sustainable Flow Chemistry in Drug Discovery

    Article • January 2017, Wiley

    Dr Jesus Alcazar

  37. Front cover

    Article • Green Chemistry, January 2017, Royal Society of Chemistry

    Dr Jesus Alcazar

  38. Increasing global access to the high-volume HIV drug nevirapine through process intensification

    Article • Green Chemistry, January 2017, Royal Society of Chemistry

    Dr Jesus Alcazar

  39. Recent Advances of Microfluidics Technologies in the Field of Medicinal Chemistry

    Article • January 2017, Elsevier

    Dr Jesus Alcazar

  40. Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

    Article • Green Chemistry, January 2017, Royal Society of Chemistry

    Dr Jesus Alcazar

  41. What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2

    Article • Journal of Nuclear Medicine, July 2016, Society of Nuclear Medicine

    Guy Bormans, Dr Jesus Alcazar

  42. Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

    Article • Journal of Nuclear Medicine, May 2016, Society of Nuclear Medicine

    Guy Bormans, Dr Jesus Alcazar

  43. Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807

    Article • Molecular Imaging, January 2016, SAGE Publications

    Guy Bormans, Dr Jesus Alcazar

  44. Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia

    Article • Bioorganic & Medicinal Chemistry Letters, January 2016, Elsevier

    Dr Jesus Alcazar

  45. Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound

    Article • Bioorganic & Medicinal Chemistry Letters, September 2015, Elsevier

    Dr Jesus Alcazar

  46. Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, August 2015, Elsevier

    Dr Jesus Alcazar

  47. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

    Article • ACS Medicinal Chemistry Letters, May 2015, American Chemical Society (ACS)

    Dr Jesus Alcazar

  48. Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents

    Article • Neuron, May 2015, Elsevier

    Dr Jesus Alcazar

  49. First Example of Alkyl–Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups

    Article • Journal of Flow Chemistry, March 2015, Akademiai Kiado

    Professor Wim M De Borggraeve, Dr Jesus Alcazar

  50. Cover Picture: Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions (Adv. Synth. Catal. 18/2014)

    Article • Advanced Synthesis & Catalysis, November 2014, Wiley

    Dr Jesus Alcazar

  51. Microwave-assisted medicinal chemistry: examples from a pharmaceutical company

    Article • October 2014, Taylor & Francis

    Dr Jesus Alcazar

  52. First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

    Article • Journal of Flow Chemistry, September 2014, Akademiai Kiado

    Professor Wim M De Borggraeve, Dr Jesus Alcazar

  53. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1 H )-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

    Article • Journal of Medicinal Chemistry, July 2014, American Chemical Society (ACS)

    Dr Jesus Alcazar

  54. Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

    Article • Advanced Synthesis & Catalysis, June 2014, Wiley

    Dr Jesus Alcazar

  55. Formation of amides when other approaches have failed

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Dr Jesus Alcazar, Professor Wim M De Borggraeve

  56. ChemInform Abstract: Microwave‐Assisted Continuous Flow Organic Synthesis (MACOS)

    Article • ChemInform, July 2013, Wiley

    Dr Jesus Alcazar

  57. Microwave‐Assisted Continuous Flow Organic Synthesis (MACOS)

    Article • December 2012, Wiley

    Dr Jesus Alcazar

  58. Cross‐Coupling in Flow using Supported Catalysts: Mild, Clean, Efficient and Sustainable Suzuki–Miyaura Coupling in a Single Pass

    Article • Advanced Synthesis & Catalysis, November 2012, Wiley

    Dr Jesus Alcazar

  59. Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

    Article • Journal of Medicinal Chemistry, October 2012, American Chemical Society (ACS)

    Guy Bormans, Dr Jesus Alcazar

  60. Recent Advances in Positron Emission Tomography (PET) Radiotracers for Imaging Phosphodiesterases

    Article • Current Topics in Medicinal Chemistry, May 2012, Bentham Science Publishers

    Guy Bormans, Dr Jesus Alcazar

  61. Preparation of amides mediated by isopropylmagnesium chloride under continuous flow conditions

    Article • Green Chemistry, January 2012, Royal Society of Chemistry

    Dr Jesus Alcazar

  62. Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes

    Article • European Journal of Organic Chemistry, December 2011, Wiley

    Dr Jesus Alcazar

  63. Application of flow chemistry to the reduction of nitriles to aldehydes

    Article • Tetrahedron Letters, November 2011, Elsevier

    Dr Jesus Alcazar

  64. Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging

    Article • Journal of Medicinal Chemistry, August 2011, American Chemical Society (ACS)

    Dr Jesus Alcazar

  65. Reproducibility and Scalability of Microwave-Assisted Reactions

    Article • July 2011, IntechOpen

    Dr Jesus Alcazar

  66. Influence of Polarity on the Scalability and Reproducibility of Solvent-Free Microwave-Assisted Reactions

    Article • Combinatorial Chemistry & High Throughput Screening, February 2011, Bentham Science Publishers

    Dr Jesus Alcazar

  67. Preclinical Evaluation of 18F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain

    Article • Journal of Nuclear Medicine, September 2010, Society of Nuclear Medicine

    Dr Jesus Alcazar

  68. ChemInform Abstract: Recent Applications of Microwave Irradiation to Medicinal Chemistry

    Article • ChemInform, May 2010, Wiley

    Dr Jesus Alcazar

  69. Recent Applications of Microwave Irradiation to Medicinal Chemistry

    Article • Future Medicinal Chemistry, February 2010, Taylor & Francis

    Dr Jesus Alcazar

  70. Novel Approach for Chemotype Hopping Based on Annotated Databases of Chemically Feasible Fragments and a Prospective Case Study: New Melanin Concentrating Hormone Antagonists

    Article • Journal of Medicinal Chemistry, March 2009, American Chemical Society (ACS)

    Dr Jesus Alcazar

  71. TRES: Multiradar-multisensor data processing assessment using opportunity targets

    Article • May 2008, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Jesus Alcazar

  72. Blocking melanin-concentrating hormone MCH1 receptor affects rat sleep–wake architecture

    Article • European Journal of Pharmacology, January 2008, Elsevier

    Dr Jesus Alcazar

  73. Applications of the Combination of Microwave and Parallel Synthesis in Medicinal Chemistry

    Article • Combinatorial Chemistry & High Throughput Screening, December 2007, Bentham Science Publishers

    Dr Jesus Alcazar

  74. Microwave‐Assisted Medicinal Chemistry

    Article • ChemInform, July 2007, Wiley

    Dr Jesus Alcazar

  75. Tricyclic isoxazolines: Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonism

    Article • Bioorganic & Medicinal Chemistry, June 2007, Elsevier

    Dr Anton AHP Megens, Dr Jesus Alcazar

  76. Microwave Assisted Medicinal Chemistry

    Article • Mini-Reviews in Medicinal Chemistry, April 2007, Bentham Science Publishers

    Dr Jesus Alcazar

  77. Reproducibility and Scalability of Solvent-Free Microwave-Assisted Reactions:From Domestic Ovens to Controllable Parallel Applications

    Article • Combinatorial Chemistry & High Throughput Screening, March 2007, Bentham Science Publishers

    Dr Jesus Alcazar

  78. Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined α2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

    Article • Bioorganic & Medicinal Chemistry, July 2006, Elsevier

    Dr Anton AHP Megens, Dr Jesus Alcazar

  79. Reproducibility Across Microwave Instruments: Preparation of a Set of 24 Compounds on a Multiwell Plate under Temperature‐Controlled Conditions.

    Article • ChemInform, September 2005, Wiley

    Dr Jesus Alcazar

  80. Reproducibility Across Microwave Instruments:  Preparation of a Set of 24 Compounds on a Multiwell Plate under Temperature-Controlled Conditions

    Article • Journal of Combinatorial Chemistry, April 2005, American Chemical Society (ACS)

    Dr Jesus Alcazar

  81. Novel Approach towards the Synthesis of 3,3a,4,5-Tetrahydroquinolino[4,3-c]isoxazole Derivatives: Application to the Preparation of Previously Unattainable 3a,4-Dihydroazabenzopyrano[4,3-c]isoxazole Scaffolds

    Article • Synlett, January 2005, Thieme Publishing Group

    Dr Jesus Alcazar

  82. Reproducibility across Microwave Instruments: First Example of Genuine Parallel Scale up of Compounds under Microwave Irradiation

    Article • QSAR & Combinatorial Science, December 2004, Wiley

    Dr Jesus Alcazar

  83. Discovery of a New Series of Centrally Active Tricyclic Isoxazoles Combining Serotonin (5-HT) Reuptake Inhibition with α2-Adrenoceptor Blocking Activity

    Article • Journal of Medicinal Chemistry, November 2004, American Chemical Society (ACS)

    Dr Anton AHP Megens, Dr Jesus Alcazar

  84. Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety

    Article • Bioorganic & Medicinal Chemistry Letters, June 2004, Elsevier

    Dr Anton AHP Megens, Dr Jesus Alcazar

  85. Synthesis of novel 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines as potential new scaffolds for drug discovery: selective introduction of substituents on the pyridine ring

    Article • Tetrahedron Letters, December 2003, Elsevier

    Dr Jesus Alcazar

  86. Novel analogues of 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines: modifications in the dioxane ring

    Article • Tetrahedron Letters, November 2003, Elsevier

    Dr Jesus Alcazar

  87. Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities: a novel series of potential antidepressants

    Article • Bioorganic & Medicinal Chemistry Letters, August 2003, Elsevier

    Dr Anton AHP Megens, Dr Jesus Alcazar

  88. Synthesis of novel aza analogues of 2-substituted-2,3-dihydro-1,4-benzodioxins as potential new scaffolds for drug discovery

    Article • Tetrahedron Letters, March 2003, Elsevier

    Dr Jesus Alcazar

  89. Synthesis and structure–activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT2A/2C receptor antagonists. Part 1

    Article • Bioorganic & Medicinal Chemistry Letters, January 2002, Elsevier

    Dr Anton AHP Megens, Dr Jesus Alcazar

  90. Synthesis and structure–Activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT2A/2C receptor antagonists. Part 2

    Article • Bioorganic & Medicinal Chemistry Letters, January 2002, Elsevier

    Dr Anton AHP Megens, Dr Jesus Alcazar

  91. Carbon-13 NMR spectra of imidazole 1-oxides. Comparison with the parent imidazoles

    Article • Magnetic Resonance in Chemistry, April 1998, Wiley

    Dr Jesus Alcazar

  92. Selective Synthesis of 2-, 4-, and 5-Cyano Substituted Imidazoles from Imidazole N-Oxides and Trimethylsilyl Cyanide

    Article • The Journal of Organic Chemistry, January 1996, American Chemical Society (ACS)

    Dr Jesus Alcazar

  93. Synthesis of Imidazole N-Oxides in Solvent-free Conditions

    Article • Heterocycles, January 1996, CLOCKSS Archive

    Dr Jesus Alcazar

  94. Synthesis of 4-hydroxylamino-1-azabuta-1,3-dienes and their cyclization to 2-substituted pyrazole 1-oxides

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1995, Royal Society of Chemistry

    Dr Jesus Alcazar

  95. Synthesis of imidazole 1-oxides from 1,2-diimines

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1995, Royal Society of Chemistry

    Dr Jesus Alcazar

  96. Enhancement of hands-free telecommunications

    Article • Annals of Telecommunications, July 1994, Springer Science + Business Media

    Dr Jesus Alcazar