All Stories

  1. Organoid-in-Bead (OrB): vortex-based compartmentalization enables scalable, high-density intestinal organoid culture

    Article • June 2026, openRxiv

    Kazuki Hattori

  2. Microfluidic Core–Shell Encapsulation Enables Scalable Generation of Apical-Out Intestinal Spheroids

    Article • June 2026, openRxiv

    Kazuki Hattori

  3. Emulsion-Templated Gel Embedding: A Microfluidics-Free Method for Scalable Cell Encapsulation in Hydrogel Microcapsules

    Article • ACS Biomaterials Science & Engineering, May 2026, American Chemical Society (ACS)

    Kazuki Hattori

  4. Large-Scale Production of Uniform, Small Adipocyte Spheroids in Hydrogel Microcapsules Using a Microfluidic Flow-Focusing Device

    Article • ACS Biomaterials Science & Engineering, March 2026, American Chemical Society (ACS)

    Kazuki Hattori

  5. Cell assays in microcompartments driven by droplet microfluidics and hydrogel technologies

    Article • The Journal of Biochemistry, February 2026, Oxford University Press (OUP)

    Kazuki Hattori

  6. Space-efficient method for high-throughput generation of uniform cell-laden hollow agarose microcapsules

    Article • October 2025, openRxiv

    Kazuki Hattori

  7. Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Kazuki Hattori

  8. Large-scale generation of uniform sub-100 μm adipocyte spheroids in hydrogel microcapsules using a flow-focusing microfluidic device

    Article • June 2024, openRxiv

    Kazuki Hattori

  9. Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis/release regulators

    Article • September 2023, openRxiv

    Kazuki Hattori

  10. High-throughput 3D imaging flow cytometry of adherent 3D cell cultures

    Article • July 2023, openRxiv

    Kazuki Hattori

  11. A 50 µm acoustic resonator microchannel enables focusing 100 nm polystyrene beads and sub-micron bioparticles

    Article • Sensors and Actuators B Chemical, February 2023, Elsevier

    Kazuki Hattori

  12. mTOR-AKT Signaling in Cellular Clock Resetting Triggered by Osmotic Stress

    Article • Antioxidants & Redox Signaling, October 2022, Mary Ann Liebert Inc

    PhD Isao Naguro, Kazuki Hattori

  13. Droplet Array-Based Platform for Parallel Optical Analysis of Dynamic Extracellular Vesicle Secretion from Single Cells

    Article • Analytical Chemistry, July 2022, American Chemical Society (ACS)

    Kazuki Hattori

  14. Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

    Article • April 2022, openRxiv

    Kazuki Hattori

  15. Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation

    Article • Nature Biomedical Engineering, March 2022, Springer Science + Business Media

    Kazuki Hattori

  16. ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

    Article • Scientific Reports, November 2021, Springer Science + Business Media

    PhD Isao Naguro, Kazuki Hattori

  17. The mitochondrial Ca 2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis

    Article • EMBO Reports, April 2021, Springer Science + Business Media

    PhD Isao Naguro, Kazuki Hattori

  18. β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes

    Article • PLOS One, October 2020, PLOS

    Kazuki Hattori

  19. High-throughput organoid screening enables engineering of intestinal epithelial composition

    Article • April 2020, openRxiv

    Kazuki Hattori

  20. β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes

    Article • April 2020, openRxiv

    Kazuki Hattori

  21. The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1

    Article • Journal of Biological Chemistry, April 2020, Elsevier

    Kazuki Hattori

  22. ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

    Article • Life Science Alliance, February 2020, Life Science Alliance, LLC

    Kazuki Hattori

  23. β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2018, Elsevier

    PhD Isao Naguro, Kazuki Hattori

  24. ASK family kinases mediate cellular stress and redox signaling to circadian clock

    Article • Proceedings of the National Academy of Sciences, March 2018, Proceedings of the National Academy of Sciences

    PhD Isao Naguro, Kazuki Hattori

  25. Apoptosis signal-regulating kinase 1 in regulated necrosis

    Article • Cell Cycle, January 2018, Taylor & Francis

    Kazuki Hattori

  26. The regulatory and signaling mechanisms of the ASK family

    Article • Advances in Biological Regulation, December 2017, Elsevier

    Kazuki Hattori

  27. Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway

    Article • EMBO Reports, September 2017, EMBO

    PhD Isao Naguro, Kazuki Hattori

  28. Pleiotropic properties of ASK1

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, January 2017, Elsevier

    Kazuki Hattori

  29. ASK1 signalling regulates brown and beige adipocyte function

    Article • Nature Communications, April 2016, Springer Science + Business Media

    PhD Isao Naguro, Kazuki Hattori

  30. The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress

    Article • EBioMedicine, March 2016, Elsevier

    PhD Isao Naguro, Kazuki Hattori

  31. ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

    Article • Nature Communications, December 2012, Springer Science + Business Media

    PhD Isao Naguro, Kazuki Hattori

  32. The roles of ASK family proteins in stress responses and diseases

    Article • Cell Communication and Signaling, April 2009, Springer Science + Business Media

    PhD Isao Naguro, Kazuki Hattori