All Stories

  1. Improvement effect of synbiotics intake on stool frequency in constipation-prone healthy participants: placebo-controlled, randomised, double-blind, parallel-group comparison

    Article • Beneficial Microbes, August 2026, De Gruyter

    Dr Hirokazu Tsuji

  2. Viable gut bacterial metrics associated with intestinal eubiosis and dysbiosis

    Article • Gut Microbes Reports, March 2026, Taylor & Francis

    Dr Hirokazu Tsuji

  3. Early establishment of Bifidobacterium-dominant microbiome in planned cesarean-born infants via Bifidobacterium breve strain Yakult supplementation: A randomized, double-blind, placebo-controlled, parallel-group pilot study

    Article • Pediatrics & Neonatology, February 2026, Elsevier

    Dr Hirokazu Tsuji

  4. Prolonged Lacticaseibacillus paracasei strain Shirota intake modulates gut microbiota and colonic mucosal gene expression following colonic adenoma resection

    Article • Beneficial Microbes, December 2025, De Gruyter

    Dr Hirokazu Tsuji, Tomoaki Naito

  5. Effect of long-term consumption of <i>Lacticaseibacillus paracasei</i> strain Shirota-fermented milk on weight loss in the institutionalized oldest old: an exploratory study

    Article • Bioscience of Microbiota Food and Health, January 2025, BMFH Press

    Dr Hirokazu Tsuji

  6. Persistence of gut dysbiosis in individuals with anorexia nervosa

    Article • PLOS One, December 2023, PLOS

    Dr Hirokazu Tsuji

  7. Association between Isoflavones and Colorectal Cancer Risk: A Case-Control Study in Japanese

    Article • Journal of Oncology Research and Therapy, December 2022, Gavin Publishers

    Dr Hirokazu Tsuji

  8. Characteristics of gut microbiome, organic acid profiles and viral antibody indexes of healthy Japanese with live Lacticaseibacillus detected in stool

    Article • Beneficial Microbes, February 2022, Wageningen Academic Publishers

    Dr Hirokazu Tsuji

  9. Critical roles of a housekeeping sortase of probiotic Bifidobacterium bifidum in bacterium–host cell crosstalk

    Article • iScience, November 2021, Elsevier

    Dr Hirokazu Tsuji

  10. Stool preparation under anaerobic conditions contributes to retention of obligate anaerobes: potential improvement for fecal microbiota transplantation

    Article • BMC Microbiology, October 2021, Springer Science + Business Media

    Dr Hirokazu Tsuji

  11. Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes

    Article • Scientific Reports, June 2021, Springer Science + Business Media

    Dr Hirokazu Tsuji

  12. Development of a rapid and sensitive analytical system for Pseudomonas aeruginosa based on reverse transcription quantitative PCR targeting of rRNA molecules

    Article • Emerging Microbes & Infections, March 2021, Taylor & Francis

    Dr Hirokazu Tsuji

  13. Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life

    Article • The ISME Journal, March 2021, Springer Science + Business Media

    Dr Hirokazu Tsuji

  14. Multiple transporters and glycoside hydrolases are involved in arabinoxylan-derived oligosaccharide utilization in Bifidobacterium pseudocatenulatum

    Article • Applied and Environmental Microbiology, October 2020, ASM Journals

    Dr Hirokazu Tsuji

  15. Metabolomics profile of Japanese female patients with restricting-type anorexia nervosa

    Article • Physiology & Behavior, October 2020, Elsevier

    Dr Hirokazu Tsuji

  16. Impacts of Habitual Diets Intake on Gut Microbial Counts in Healthy Japanese Adults

    Article • Nutrients, August 2020, MDPI AG

    Dr Hirokazu Tsuji

  17. Gut microbiota and stroke

    Article • Journal of Cerebral Blood Flow & Metabolism, January 2020, SAGE Publications

    Associate Professor Kazuo Yamashiro, Dr Hirokazu Tsuji

  18. Association of life habits and fermented milk intake with stool frequency, defecatory symptoms and intestinal microbiota in healthy Japanese adults

    Article • Beneficial Microbes, December 2019, Wageningen Academic Publishers

    Dr Hirokazu Tsuji

  19. Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants

    Article • Biomedicine Hub, September 2019, Karger Publishers

    Dr Hirokazu Tsuji

  20. F usicatenibacter

    Article • September 2019, Wiley

    Dr Hirokazu Tsuji

  21. Independent and Interactive Effects of Habitually Ingesting Fermented Milk Products Containing Lactobacillus casei Strain Shirota and of Engaging in Moderate Habitual Daily Physical Activity on the Intestinal Health of Older People

    Article • Frontiers in Microbiology, July 2019, Frontiers

    Dr Hirokazu Tsuji

  22. Bifidobacterium and Lactobacillus Counts in the Gut Microbiota of Patients With Bipolar Disorder and Healthy Controls

    Article • Frontiers in Psychiatry, January 2019, Frontiers

    Dr Hirokazu Tsuji

  23. Counting the Countless: Bacterial Quantification by Targeting rRNA Molecules to Explore the Human Gut Microbiota in Health and Disease

    Article • Frontiers in Microbiology, June 2018, Frontiers

    Dr Hirokazu Tsuji

  24. Identification of phenol- and p-cresol-producing intestinal bacteria by using media supplemented with tyrosine and its metabolites

    Article • FEMS Microbiology Ecology, June 2018, Oxford University Press (OUP)

    Dr Hirokazu Tsuji

  25. Higher enterococcus counts indicate a lower risk of colorectal adenomas: a prospective cohort study

    Article • Oncotarget, April 2018, Impact Journals, LLC

    Dr Hirokazu Tsuji

  26. Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study

    Article • PLOS One, November 2017, PLOS

    Dr Hirokazu Tsuji

  27. Gut dysbiosis induces lipopolysaccharide-mediated inflammation after cerebral ischemia in type 2 diabetic mice

    Article • Journal of the Neurological Sciences, October 2017, Elsevier

    Dr Hirokazu Tsuji

  28. Evolution of gut Bifidobacterium population in healthy Japanese infants over the first three years of life: a quantitative assessment

    Article • Scientific Reports, August 2017, Nature

    Dr Hirokazu Tsuji

  29. Ontogenesis of the Gut Microbiota Composition in Healthy, Full-Term, Vaginally Born and Breast-Fed Infants over the First 3 Years of Life: A Quantitative Bird’s-Eye View

    Article • Frontiers in Microbiology, July 2017, Frontiers

    Dr Hirokazu Tsuji

  30. Gut dysbiosis following C-section instigates higher colonisation of toxigenic Clostridium perfringens in infants

    Article • Beneficial Microbes, May 2017, Wageningen Academic Publishers

    Dr Ravinder Nagpal, Dr Hirokazu Tsuji

  31. Association between Yogurt Consumption and Intestinal Microbiota in Healthy Young Adults Differs by Host Gender

    Article • Frontiers in Microbiology, May 2017, Frontiers

    Dr Hirokazu Tsuji

  32. Correction: Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke

    Article • PLOS One, April 2017, PLOS

    Dr Hirokazu Tsuji

  33. Habitual intake of fermented milk products containing Lactobacillus casei strain Shirota and a reduced risk of hypertension in older people

    Article • Beneficial Microbes, February 2017, Wageningen Academic Publishers

    Dr Hirokazu Tsuji

  34. Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke

    Article • PLOS One, February 2017, PLOS

    Dr Hirokazu Tsuji

  35. Yakult Intestinal Flora-SCAN: A Novel Culture-Independent Analytical Method for Detection of Bacteria in the Bloodstream

    Article • Annals of Nutrition and Metabolism, January 2017, Karger Publishers

    Dr Hirokazu Tsuji

  36. Sensitive Quantitative Analysis of the Meconium Bacterial Microbiota in Healthy Term Infants Born Vaginally or by Cesarean Section

    Article • Frontiers in Microbiology, December 2016, Frontiers

    Dr Hirokazu Tsuji

  37. A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients

    Article • Inflammatory Bowel Diseases, December 2016, Wolters Kluwer Health

    Dr Hirokazu Tsuji

  38. Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder

    Article • Journal of Affective Disorders, September 2016, Elsevier

    Dr Hirokazu Tsuji

  39. Relationship of serum levels and dietary intake of isoflavone, and the novel bacterium Slackia sp. strain NATTS with the risk of prostate cancer: a case–control study among Japanese men

    Article • International Urology and Nephrology, June 2016, Springer Science + Business Media

    Dr Hirokazu Tsuji

  40. Correction: Diversity of Intestinal Clostridium coccoides Group in the Japanese Population, as Demonstrated by Reverse Transcription-Quantitative PCR

    Article • PLOS One, March 2016, PLOS

    Dr Hirokazu Tsuji

  41. Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in PD

    Article • Parkinsonism & Related Disorders, January 2016, Elsevier

    Dr Hirokazu Tsuji

  42. Serum Isoflavone Concentrations and Equol-Producing Intestinal Flora in Prostate Cancer in Japanese-American in Hawaii

    Article • Journal of Nutrition & Food Sciences, January 2016, OMICS Publishing Group

    Dr Hirokazu Tsuji

  43. Gut Dysbiosis in Patients with Anorexia Nervosa

    Article • PLOS One, December 2015, PLOS

    Dr Hirokazu Tsuji

  44. Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

    Article • PLOS One, November 2015, PLOS

    Dr Hirokazu Tsuji

  45. Sensitive quantification of Clostridium perfringens in human feces by quantitative real-time PCR targeting alpha-toxin and enterotoxin genes

    Article • BMC Microbiology, October 2015, Springer Science + Business Media

    Dr Hirokazu Tsuji

  46. Sensitive and rapid RT-qPCR quantification of pathogenic Candida species in human blood

    Article • Journal of Microbiological Methods, October 2015, Elsevier

    Dr Hirokazu Tsuji

  47. Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size

    Article • Bioconjugate Chemistry, August 2015, American Chemical Society (ACS)

    Dr Hirokazu Tsuji

  48. Diversity of Intestinal Clostridium coccoides Group in the Japanese Population, as Demonstrated by Reverse Transcription-Quantitative PCR

    Article • PLOS One, May 2015, PLOS

    Dr Hirokazu Tsuji

  49. Establishment of a sensitive system for analysis of human vaginal microbiota on the basis of rRNA-targeted reverse transcription-quantitative PCR

    Article • Journal of Microbiological Methods, April 2015, Elsevier

    Dr Hirokazu Tsuji

  50. Diversity in gut bacterial community of school-age children in Asia

    Article • Scientific Reports, February 2015, Nature

    Dr Hirokazu Tsuji

  51. Characterization of the Gut Microbiota of Papua New Guineans Using Reverse Transcription Quantitative PCR

    Article • PLOS One, February 2015, PLOS

    Dr Hirokazu Tsuji

  52. Synthesis and Immunestimulating Activity of Lactobacilli-Originated Polysaccharide–Polymeric Microparticle Conjugates

    Article • Langmuir, February 2015, American Chemical Society (ACS)

    Dr Hirokazu Tsuji

  53. Intestinal Microbiota Profiles of Healthy Pre-School and School-Age Children and Effects of Probiotic Supplementation

    Article • Annals of Nutrition and Metabolism, January 2015, Karger Publishers

    Dr Hirokazu Tsuji

  54. Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

    Article • Asian Pacific Journal of Cancer Prevention, March 2014, Asian Pacific Organization for Cancer Prevention

    Dr Hirokazu Tsuji

  55. Isoflavones in Japanese and Caucasian men with prostate cancer in Hawaii.

    Article • Journal of Clinical Oncology, February 2014, American Society of Clinical Oncology (ASCO)

    Dr Hirokazu Tsuji

  56. Transposon Mutagenesis of Probiotic Lactobacillus casei Identifies asnH, an Asparagine Synthetase Gene Involved in Its Immune-Activating Capacity

    Article • PLOS One, January 2014, PLOS

    Dr Hirokazu Tsuji

  57. Fusicatenibacter saccharivorans gen. nov., sp. nov., isolated from human faeces

    Article • INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, April 2013, Society for General Microbiology

    Dr Hirokazu Tsuji

  58. Intestinal Enterobacteriaceae and Escherichia coli populations in Japanese adults demonstrated by the reverse transcription-quantitative PCR and the clone library analyses

    Article • Journal of Microbiological Methods, February 2013, Elsevier

    Dr Hirokazu Tsuji

  59. Influence of Isoflavone Intake and Equol-producing Intestinal Flora on Prostate Cancer Risk

    Article • Asian Pacific Journal of Cancer Prevention, January 2013, Asian Pacific Organization for Cancer Prevention

    Dr Hirokazu Tsuji

  60. Up to Species-level Community Analysis of Human Gut Microbiota by 16S rRNA Amplicon Pyrosequencing

    Article • Bioscience of Microbiota Food and Health, January 2013, BMFH Press

    Dr Hirokazu Tsuji

  61. Molecular monitoring of the development of intestinal microbiota in Japanese infants

    Article • Beneficial Microbes, June 2012, Wageningen Academic Publishers

    Dr Hirokazu Tsuji

  62. Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

    Article • PLoS Pathogens, May 2012, PLOS

    Dr Hirokazu Tsuji

  63. Sensitive Quantification of Clostridium difficile Cells by Reverse Transcription-Quantitative PCR Targeting rRNA Molecules

    Article • Applied and Environmental Microbiology, May 2012, ASM Journals

    Dr Hirokazu Tsuji

  64. Development of a sensitive rRNA-targeted reverse transcription-quantitative polymerase chain reaction for detection of Vibrio cholerae/mimicus, V. parahaemolyticus/alginolyticus and Campylobacter jejuni/coli

    Article • Microbiology and Immunology, January 2012, Wiley

    Dr Hirokazu Tsuji

  65. Identification of an Enzyme System for Daidzein-to-Equol Conversion in Slackia sp. Strain NATTS

    Article • Applied and Environmental Microbiology, December 2011, ASM Journals

    Dr Hirokazu Tsuji

  66. Prostate Cancer Chemoprevention Study: An investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen

    Article • Cancer Science, November 2011, Wiley

    Dr Hirokazu Tsuji

  67. Role of probiotic in preventing acute diarrhoea in children: a community-based, randomized, double-blind placebo-controlled field trial in an urban slum

    Article • Epidemiology and Infection, July 2010, Cambridge University Press

    Dr Hirokazu Tsuji

  68. Detection of Human Intestinal Catalase-Negative, Gram-Positive Cocci by rRNA-Targeted Reverse Transcription-PCR

    Article • Applied and Environmental Microbiology, June 2010, ASM Journals

    Dr Hirokazu Tsuji

  69. Bacterial rRNA-Targeted Reverse Transcription-PCR Used To Identify Pathogens Responsible for Fever with Neutropenia

    Article • Journal of Clinical Microbiology, March 2010, ASM Journals

    Dr Hirokazu Tsuji

  70. Isolation and characterization of the equol-producing bacterium Slackia sp. strain NATTS

    Article • Archives of Microbiology, February 2010, Springer Science + Business Media

    Dr Hirokazu Tsuji

  71. A practical random mutagenesis system for probioticLactobacillus caseiusing Tn5transposition complexes

    Article • Journal of Applied Microbiology, February 2010, Wiley

    Dr Hirokazu Tsuji

  72. Establishment of an Analytical System for the Human Fecal Microbiota, Based on Reverse Transcription-Quantitative PCR Targeting of Multicopy rRNA Molecules

    Article • Applied and Environmental Microbiology, February 2009, ASM Journals

    Dr Hirokazu Tsuji

  73. Genetic Modification of Probiotic Microorganisms

    Article • July 2008, Wiley

    Dr Hirokazu Tsuji

  74. Repeated-batch production of galactooligosaccharides from lactose at high concentration by using alginate-immobilized cells of Sporobolomyces singularis YIT 10047

    Article • The Journal of General and Applied Microbiology, January 2008, Microbiology Research Foundation

    Dr Hirokazu Tsuji

  75. Sensitive Quantitative Detection of Commensal Bacteria by rRNA-Targeted Reverse Transcription-PCR

    Article • Applied and Environmental Microbiology, October 2006, ASM Journals

    Dr Hirokazu Tsuji

  76. A Hydrogen Peroxide-Forming NADH Oxidase That Functions as an Alkyl Hydroperoxide Reductase in Amphibacillus xylanus

    Article • Journal of Bacteriology, September 2000, ASM Journals

    Dr Hirokazu Tsuji