Prolonged Lacticaseibacillus paracasei strain Shirota intake modulates gut microbiota and colonic mucosal gene expression following colonic adenoma resection

What is it about?

Lacticaseibacillus paracasei strain Shirota (LcS) helps keep the gut healthy, affects immune cells, and reduces stress. Taking BLP (Biolactis powder: LcS preparation) for four years can lower the chance of polyps coming back in people who had colorectal adenoma removed. Also, people who took BLP for over 15 years after adenoma removal had tend to be fewer new adenomas and less weight loss with age. But, we don't fully understand how long-term BLP use affects the gut milieu and bacteria. So, we studied the gut bacteria and gene activity in the colon tissue of people who took BLP for over 20 years and those who didn't. The BLP group had more Coprococcus bacteria and butyrate-producing bacteria. The control group had more harmful and environmental bacteria, like Pseudomonadaceae and Brachyspiraceae. In BLP users, genes related to the oxidative phosphorylation (OXPHOS) pathway and mitochondrial electron transfer were more active. Genes related to T cells and G-protein-coupled receptors were also more active. These results suggest that long-term BLP use increases butyrate-producing bacteria and activates the OXPHOS pathway in the colon, which changes the gut environment and reduces harmful bacteria. This may help prevent colorectal cancer and support healthy aging.

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