All Stories

  1. Integrative analysis discovers Imidurea as dual multitargeted inhibitor of CD69, CD40, SHP2, lysozyme, GATA3, cCBL, and S-cysteinase from SARS-CoV-2 and M. tuberculosis

    Article • International Journal of Biological Macromolecules, May 2024, Elsevier

    Dr Guruprasad R Medigeshi, Dr Shaban Ahmad

  2. The Effective Inhibitory Concentration of Interferon-β Correlates with Infectivity and Replication Fitness of SARS-CoV-2 Variants

    Article • Journal of Interferon & Cytokine Research, April 2024, Mary Ann Liebert Inc

    Dr Guruprasad R Medigeshi

  3. Long-Term Kinetics of SARS-CoV-2 Neutralizing and Anti-Receptor Binding Domain Antibodies among Laboratory-Confirmed COVID-19 Cases in Delhi National Capital Region, India: A Prospective, One-Year Follow-Up Study

    Article • Journal of Clinical Medicine, January 2024, MDPI AG

    Dr Guruprasad R Medigeshi

  4. Neutralizing antibodies from prior exposure to dengue virus negatively correlate with viremia on re-infection

    Article • Communications Medicine, October 2023, Springer Science + Business Media

    Dr Guruprasad R Medigeshi

  5. Anti-SARS-CoV-2 Antibody Kinetics up to 6 months of follow-up: Result from a Nation-wide Population-based, Age Stratified Sero-Epidemiological Prospective Cohort Study in India

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  6. BA.1, BA.2 and BA.2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodies

    Article • PLoS Pathogens, February 2023, PLOS

    Dr Guruprasad R Medigeshi

  7. Antibody Response to SARS-CoV-2 among COVID-19 Confirmed Cases and Correlates with Neutralizing Assay in a Subgroup of Patients in Delhi National Capital Region, India

    Article • Vaccines, August 2022, MDPI AG

    Dr Guruprasad R Medigeshi

  8. A Vitamin D–RelB/NF-κB Pathway Limits Chandipura Virus Multiplication by Rewiring the Homeostatic State of Autoregulatory Type 1 IFN–IRF7 Signaling

    Article • The Journal of Immunology, August 2022, The American Association of Immunologists

    Dr Guruprasad R Medigeshi

  9. Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination

    Article • Nature Communications, June 2022, Springer Science + Business Media

    Dr Guruprasad R Medigeshi

  10. Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months

    Article • EBioMedicine, April 2022, Elsevier

    Dr Guruprasad R Medigeshi

  11. Selection of optimum formulation of RBD-based protein sub-unit covid19 vaccine (Corbevax) based on safety and immunogenicity in an open-label, randomized Phase-1 and 2 clinical studies

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  12. Antibody response after a single dose of BBV152 vaccine negatively correlates with pre-existing antibodies and induces a significant but low levels of neutralizing antibodies to Omicron variant

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  13. A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2

    Article • Molecular Therapy — Nucleic Acids, December 2021, Elsevier

    Dr Guruprasad R Medigeshi

  14. Immunophenotyping and Transcriptional Profiling of Human Plasmablasts in Dengue

    Article • Journal of Virology, November 2021, ASM Journals

    Dr Guruprasad R Medigeshi

  15. A vitamin D-RelB/NF-κB pathway limits Chandipura virus multiplication by rewiring the homeostatic state of autoregulatory type 1 interferon-IRF7 signaling

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  16. Dengue virus replication enhances labile zinc pools by modulation of ZIP8

    Article • Cellular Microbiology, October 2021, Hindawi Publishing Corporation

    Dr Guruprasad R Medigeshi

  17. Transcriptome analysis and connectivity mapping of Cissampelos pareira L. provides molecular links of ESR1 modulation to viral inhibition

    Article • Scientific Reports, October 2021, Springer Science + Business Media

    Dr Guruprasad R Medigeshi

  18. Humoral cross-reactivity towards SARS-CoV-2 in young children with acute respiratory infection with low-pathogenicity coronaviruses

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  19. Immune profile and responses of a novel Dengue DNA vaccine encoding EDIII-NS1 consensus design based on Indo-African sequences

    Article • September 2021, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  20. Oxidative stress specifically inhibits replication of dengue virus

    Article • Journal of General Virology, April 2021, Society for General Microbiology

    Dr Guruprasad R Medigeshi

  21. Immunophenotyping and transcriptional profiling of human plasmablasts in dengue

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  22. Kupyaphores are counter regulatory zinc homeostatic metallophores required for Mycobacterium tuberculosis colonization

    Article • February 2021, Research Square

    Dr Guruprasad R Medigeshi

  23. Transcriptome analysis and connectivity mapping of Cissampelos pareira L. provides molecular links of ESR1 modulation to viral inhibition

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  24. Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  25. Visual Detection of SARS-CoV-2 RNA by Conventional PCR-Induced Generation of DNAzyme Sensor

    Article • Frontiers in Molecular Biosciences, December 2020, Frontiers

    Dr Guruprasad R Medigeshi

  26. Community prevalence of antibodies to SARS-CoV-2 and correlates of protective immunity in an Indian metropolitan city

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  27. Kinetics of viral load, immunological mediators and characterization of a SARS-CoV-2 isolate in mild COVID-19 patients during acute phase of infection

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Dr Guruprasad R Medigeshi

  28. Epidemiology of Coronavirus Infection in Children and Their Impact on Lung Health: Finding From a Birth Cohort Study

    Article • The Pediatric Infectious Disease Journal, September 2020, Wolters Kluwer Health

    Dr Guruprasad R Medigeshi

  29. Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort

    Article • PLoS Neglected Tropical Diseases, June 2020, PLOS

    Dr Guruprasad R Medigeshi

  30. Respiratory Syncytial Virus-Induced Oxidative Stress Leads to an Increase in Labile Zinc Pools in Lung Epithelial Cells

    Article • mSphere, June 2020, ASM Journals

    Dr Guruprasad R Medigeshi

  31. Effect of acute respiratory infections in infancy on pulmonary function test at 3 years of age: a prospective birth cohort study

    Article • BMJ Open Respiratory Research, February 2020, BMJ

    Dr Guruprasad R Medigeshi

  32. Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India

    Article • International Journal of Microbiology Research, January 2020, Medknow

    Dr Guruprasad R Medigeshi

  33. Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-κB and Induction of Antiviral Response in Epithelial Cells

    Article • Frontiers in Immunology, October 2019, Frontiers

    Dr Guruprasad R Medigeshi

  34. Chandipura Virus Utilizes the Prosurvival Function of RelA NF-κB for Its Propagation

    Article • Journal of Virology, July 2019, ASM Journals

    Dr Guruprasad R Medigeshi

  35. Isolation and molecular characterization of dengue virus clinical isolates from pediatric patients in New Delhi

    Article • International Journal of Infectious Diseases, July 2019, Elsevier

    Dr Guruprasad R Medigeshi

  36. Position Paper on Road Map for RNA Virus Research in India

    Article • Frontiers in Microbiology, July 2018, Frontiers

    Dr Guruprasad R Medigeshi

  37. Dengue Virus Capsid Interacts with DDX3X–A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection

    Article • Frontiers in Cellular and Infection Microbiology, January 2018, Frontiers

    Dr Guruprasad R Medigeshi

  38. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum

    Article • Science Translational Medicine, September 2017, American Association for the Advancement of Science

    Dr Guruprasad R Medigeshi

  39. CD8 T cells protect adult naive mice from JEV-induced morbidity via lytic function

    Article • PLoS Neglected Tropical Diseases, February 2017, PLOS

    Dr Guruprasad R Medigeshi

  40. Platelet activation determines the severity of thrombocytopenia in dengue infection

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Dr Guruprasad R Medigeshi

  41. Dengue Virus Entry and Replication Does Not Lead to Productive Infection in Platelets

    Article • Open Forum Infectious Diseases, January 2017, Oxford University Press (OUP)

    Dr Guruprasad R Medigeshi

  42. Etiology of Acute Respiratory Infections in Infants

    Article • The Pediatric Infectious Disease Journal, January 2017, Wolters Kluwer Health

    Dr Guruprasad R Medigeshi

  43. Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India

    Article • Journal of Virology, October 2016, ASM Journals

    Dr. Anil Verma, Dr Guruprasad R Medigeshi

  44. Dengue Inhibitors

    Article • Antimicrobial Agents and Chemotherapy, August 2016, ASM Journals

    Dr Guruprasad R Medigeshi

  45. Identification and characterization of the role of c-terminal Src kinase in dengue virus replication

    Article • Scientific Reports, July 2016, Springer Science + Business Media

    Dr Guruprasad R Medigeshi

  46. Role of human GRP75 in miRNA mediated regulation of dengue virus replication

    Article • Gene, July 2016, Elsevier

    Dr Guruprasad R Medigeshi

  47. Correction: Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India—Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity

    Article • PLoS Neglected Tropical Diseases, April 2016, PLOS

    Dr Guruprasad R Medigeshi

  48. Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India—Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity

    Article • PLoS Neglected Tropical Diseases, March 2016, PLOS

    Dr Guruprasad R Medigeshi

  49. Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum

    Article • Scientific Reports, January 2016, Springer Science + Business Media

    Dr Guruprasad R Medigeshi, Prof. Sarman Singh

  50. Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner

    Article • Biochemical Journal, September 2015, Portland Press Ltd.

    Dr Guruprasad R Medigeshi

  51. Correction: Corrigendum: Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle

    Article • Scientific Reports, June 2014, Springer Science + Business Media

    Dr Guruprasad R Medigeshi

  52. Japanese Encephalitis Virus Disrupts Cell-Cell Junctions and Affects the Epithelial Permeability Barrier Functions

    Article • PLOS One, July 2013, PLOS

    Dr Guruprasad R Medigeshi

  53. Role of RNA Interference (RNAi) in Dengue Virus Replication and Identification of NS4B as an RNAi Suppressor

    Article • Journal of Virology, June 2013, ASM Journals

    sunil mukherjee, Dr Guruprasad R Medigeshi

  54. Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle

    Article • Scientific Reports, May 2013, Springer Science + Business Media

    Dr Guruprasad R Medigeshi

  55. Bispidine-Amino Acid Conjugates Act as a Novel Scaffold for the Design of Antivirals That Block Japanese Encephalitis Virus Replication

    Article • PLoS Neglected Tropical Diseases, January 2013, PLOS

    Dr Guruprasad R Medigeshi

  56. Mosquito-borne flaviviruses: overview of viral life-cycle and host–virus interactions

    Article • Future Virology, September 2011, Future Medicine

    Dr Guruprasad R Medigeshi

  57. Immune Response to the West Nile Virus in Aged Non-Human Primates

    Article • PLOS One, December 2010, PLOS

    Dr Guruprasad R Medigeshi

  58. P58IPK: A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection

    Article • PLoS Pathogens, May 2009, PLOS

    Dr Guruprasad R Medigeshi

  59. West Nile Virus Capsid Degradation of Claudin Proteins Disrupts Epithelial Barrier Function

    Article • Journal of Virology, April 2009, ASM Journals

    Dr Guruprasad R Medigeshi

  60. West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of αvβ3 Integrin

    Article • Journal of Virology, April 2008, ASM Journals

    Dr Guruprasad R Medigeshi

  61. AP-1 Membrane–Cytoplasm Recycling Regulated by μ1A-Adaptin

    Article • Traffic, January 2008, Wiley

    Dr Guruprasad R Medigeshi

  62. West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP Induction and Apoptosis

    Article • Journal of Virology, August 2007, ASM Journals

    Dr Guruprasad R Medigeshi

  63. Regulation of AP-1 membrane recycling by µ1A-adaptin

    Article • March 2007, Elsevier

    Dr Guruprasad R Medigeshi

  64. A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking

    Article • The EMBO Journal, September 2006, Wiley

    Dr Guruprasad R Medigeshi

  65. The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles

    Article • Journal of Virology, September 2005, ASM Journals

    Dr Guruprasad R Medigeshi

  66. Characterization of the in Vitro Retrograde Transport of MPR46

    Article • Traffic, September 2003, Wiley

    Dr Guruprasad R Medigeshi

  67. Protein kinase C regulates transcription of the human guanylate cyclase C gene

    Article • European Journal of Biochemistry, April 2001, Wiley

    Dr Guruprasad R Medigeshi

  68. Biochemical Characterization of the Intracellular Domain of the Human Guanylyl Cyclase C Receptor Provides Evidence for a Catalytically Active Homotrimer

    Article • Biochemistry, November 2000, American Chemical Society (ACS)

    Dr Guruprasad R Medigeshi