All Stories

  1. Scale‐related process heterogeneities change properties of high‐cell‐density fermentation broths demonstrated with Escherichia coli B and K‐12 strains

    Article • Journal of Chemical Technology & Biotechnology, March 2023, Wiley

    Gerald Striedner

  2. Recombinant Peptide Production Softens Escherichia coli Cells and Increases Their Size during C-Limited Fed-Batch Cultivation

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Gerald Striedner

  3. Development and Validation of an Artificial Neural-Network-Based Optical Density Soft Sensor for a High-Throughput Fermentation System

    Article • Processes, January 2023, MDPI AG

    Gerald Striedner

  4. Fusion Tag Design Influences Soluble Recombinant Protein Production in Escherichia coli

    Article • International Journal of Molecular Sciences, July 2022, MDPI AG

    Gerald Striedner

  5. In-Depth Characterization of a Re-Engineered Cholera Toxin Manufacturing Process Using Growth-Decoupled Production in Escherichia coli

    Article • Toxins, June 2022, MDPI AG

    Gerald Striedner

  6. Bioprocess characterization of virus‐like particle production with the insect cell baculovirus expression system at nanoparticle level

    Article • Journal of Chemical Technology & Biotechnology, May 2022, Wiley

    Gerald Striedner

  7. Stable Sf9 cell pools as a system for rapid HIV‐1 virus‐like particle production

    Article • Journal of Chemical Technology & Biotechnology, September 2021, Wiley

    Gerald Striedner

  8. Digital Twin Application for Model-Based DoE to Rapidly Identify Ideal Process Conditions for Space-Time Yield Optimization

    Article • Processes, June 2021, MDPI AG

    Gerald Striedner

  9. Whole cell-based catalyst for enzymatic production of the osmolyte 2-O-α-glucosylglycerol

    Article • Microbial Cell Factories, April 2021, Springer Science + Business Media

    Gerald Striedner

  10. Native Hydrophobic Interaction Chromatography Hyphenated to Multi-Angle Light Scattering Detection for In-Process Control of SARS-CoV-2 Nucleocapsid Protein Produced in Escherichia Coli

    Article • March 2021, American Chemical Society (ACS)

    Gerald Striedner

  11. Holistic view on processes is essential for efficient production process development

    Article • Biotechnology Journal, March 2021, Wiley

    Mathias Fink, Gerald Striedner

  12. Tunable expression rate control of a growth-decoupled T7 expression system by l-arabinose only

    Article • Microbial Cell Factories, February 2021, Springer Science + Business Media

    Gerald Striedner

  13. Three-dimensional chromatography for purification and characterization of antibody fragments and related impurities from Escherichia coli crude extracts

    Article • Journal of Chromatography A, February 2021, Elsevier

    Gerald Striedner

  14. Advanced purification platform using circularly permuted caspase‐2 for affinity fusion‐tag removal to produce native fibroblast growth factor 2

    Article • Journal of Chemical Technology & Biotechnology, January 2021, Wiley

    Gerald Striedner

  15. Quantification of glycated IgG in CHO supernatants: A practical approach

    Article • Biotechnology Progress, January 2021, Wiley

    Gerald Striedner

  16. High-throughput microbioreactor provides a capable tool for early stage bioprocess development

    Article • Scientific Reports, January 2021, Springer Science + Business Media

    Gerald Striedner

  17. A comprehensive antigen production and characterization study for easy-to-implement, highly specific and quantitative SARS-CoV-2 antibody assays

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Gerald Striedner

  18. Accelerating HIV‐1 VLP production using stable High Five insect cell pools

    Article • Biotechnology Journal, December 2020, Wiley

    Gerald Striedner

  19. Production of Circularly Permuted Caspase-2 for Affinity Fusion-Tag Removal: Cloning, Expression in Escherichia coli, Purification, and Characterization

    Article • Biomolecules, November 2020, MDPI AG

    Gerald Striedner

  20. Adaptive Evolution in Producing Microtiter Cultivations Generates Genetically Stable Escherichia coli Production Hosts for Continuous Bioprocessing

    Article • Biotechnology Journal, November 2020, Wiley

    Gerald Striedner

  21. Fast and antibiotic free genome integration into Escherichia coli chromosome

    Article • Scientific Reports, October 2020, Springer Science + Business Media

    Gerald Striedner

  22. PEI-Mediated Transient Transfection of High Five Cells at Bioreactor Scale for HIV-1 VLP Production

    Article • Nanomaterials, August 2020, MDPI AG

    Gerald Striedner

  23. Hybrid Modeling and Intensified DoE: An Approach to Accelerate Upstream Process Characterization

    Article • Biotechnology Journal, June 2020, Wiley

    Gerald Striedner

  24. Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in Escherichia coli

    Article • ACS Synthetic Biology, April 2020, American Chemical Society (ACS)

    Gerald Striedner

  25. Extraction of recombinant periplasmic proteins under industrially relevant process conditions: Selectivity and yield strongly depend on protein titer and methodology

    Article • Biotechnology Progress, April 2020, Wiley

    Gerald Striedner

  26. Escherichia coli σ70 promoters allow expression rate control at the cellular level in genome-integrated expression systems

    Article • Microbial Cell Factories, March 2020, Springer Science + Business Media

    Gerald Striedner

  27. Comparison of Modeling Methods for DoE‐Based Holistic Upstream Process Characterization

    Article • Biotechnology Journal, February 2020, Wiley

    Gerald Striedner

  28. Evaluation of screening platforms for virus-like particle production with the baculovirus expression vector system in insect cells

    Article • Scientific Reports, January 2020, Springer Science + Business Media

    Gerald Striedner

  29. Soft sensor based on 2D‐fluorescence and process data enabling real‐time estimation of biomass in Escherichia coli cultivations

    Article • Engineering in Life Sciences, November 2019, Wiley

    Gerald Striedner

  30. The shortcomings of accurate rate estimations in cultivation processes and a solution for precise and robust process modeling

    Article • Bioprocess and Biosystems Engineering, September 2019, Springer Science + Business Media

    Gerald Striedner

  31. Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development

    Article • Journal of Industrial Microbiology & Biotechnology, August 2019, Oxford University Press (OUP)

    Gerald Striedner

  32. Microbioreactor Cultivations of Fab‐Producing Escherichia coli Reveal Genome‐Integrated Systems as Suitable for Prospective Studies on Direct Fab Expression Effects

    Article • Biotechnology Journal, July 2019, Wiley

    Mathias Fink, Gerald Striedner

  33. Implementation of a Fully Automated Microbial Cultivation Platform for Strain and Process Screening

    Article • Biotechnology Journal, June 2019, Wiley

    Gerald Striedner

  34. Lectin bio‐layer interferometry for assessing product quality of Fc‐ glycosylated immunoglobulin G

    Article • Biotechnology Progress, June 2019, Wiley

    Gerald Striedner

  35. Application of the Bradford Assay for Cell Lysis Quantification: Residual Protein Content in Cell Culture Supernatants

    Article • Biotechnology Journal, May 2019, Wiley

    Gerald Striedner

  36. Finished Genome Sequence of Escherichia coli K-12 Strain HMS174 (ATCC 47011)

    Article • Genome Announcements, November 2014, ASM Journals

    Gerald Striedner

  37. Online prediction of product titer and solubility of recombinant proteins in Escherichia colifed-batch cultivations

    Article • Journal of Chemical Technology & Biotechnology, July 2014, Wiley

    Gerald Striedner

  38. Comparative Transcription Profiling and In-Depth Characterization of Plasmid-Based and Plasmid-Free Escherichia coli Expression Systems under Production Conditions

    Article • Applied and Environmental Microbiology, April 2013, ASM Journals

    Gerald Striedner