All Stories

  1. Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments
  2. Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters
  3. Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective
  4. Four ways to fit an ion channel model
  5. Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system
  6. Rapid characterisation of hERG channel kinetics II: temperature dependence
  7. Probabilistic Inference on Noisy Time Series (PINTS)
  8. Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology
  9. Reproducible model development in the cardiac electrophysiology Web Lab
  10. Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics
  11. Reproducible model development in the Cardiac Electrophysiology Web Lab
  12. Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies
  13. Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator
  14. Sinusoidal Voltage Protocols For Rapid Characterisation Of Ion Channel Kinetics
  15. Hierarchical Bayesian inference for ion channel screening dose-response data
  16. Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator
  17. Hierarchical Bayesian inference for ion channel screening dose-response data
  18. Hierarchical Bayesian Modelling of Variability and Uncertainty in Synthetic Action Potential Traces
  19. Exploring temperature-dependence of hERG channel kinetics using sine wave voltage protocols
  20. Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?
  21. Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century
  22. Uncertainty and variability in computational and mathematical models of cardiac physiology
  23. Recent developments in using mechanistic cardiac modelling for drug safety evaluation
  24. The Cardiac Electrophysiology Web Lab
  25. Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential
  26. Voltage protocol design for determining hERG channel kinetics
  27. A web portal for in-silico action potential predictions
  28. Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression
  29. Cardiac tissue slices: preparation, handling, and successful optical mapping
  30. Cellular cardiac electrophysiology modeling with Chaste and CellML
  31. Novel Voltage Protocols for Determining hERG Channel Kinetics
  32. Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue
  33. Prediction of Thorough QT study results using action potential simulations based on ion channel screens
  34. In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted?
  35. Ten Simple Rules for Effective Computational Research
  36. Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures
  37. Evaluation of computational modelling as a preclinical proarrhythmic safety assay
  38. Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
  39. Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge
  40. Chaste: An Open Source C++ Library for Computational Physiology and Biology
  41. mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study
  42. A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling
  43. Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials
  44. Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings
  45. A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
  46. Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing
  47. Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG
  48. Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates
  49. Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets
  50. Is it time for in silico simulation of drug cardiac side effects?
  51. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing
  52. High-throughput functional curation of cellular electrophysiology models
  53. Functional Curation: Potential Future Directions for SED-ML
  54. Functional Curation: Potential Future Directions for SED-ML
  55. Novel Approaches to Assessing Cardiac Safety – Proceedings of a Workshop
  56. The significant effect of the choice of ionic current integration method in cardiac electro-physiological simulations
  57. Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk
  58. Multiscale Modeling of Colonic Crypts and Early Colorectal Cancer
  59. A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L-type Calcium Channel Modelling
  60. A hybrid approach to multi-scale modelling of cancer
  61. Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes
  62. Modelling Spatially Regulated β-Catenin Dynamics and Invasion in Intestinal Crypts
  63. Chaste: A test-driven approach to software development for biological modelling
  64. An integrative computational model for intestinal tissue renewal
  65. A computational study of discrete mechanical tissue models
  66. A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway
  67. Towards a multiscale model of colorectal cancer