All Stories

  1. A range of voltage-clamp protocol designs for rapid capture of hERG kinetics

    Article • Wellcome Open Research, November 2024, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  2. Ten simple rules for training scientists to make better software

    Article • PLoS Computational Biology, September 2024, PLOS

    Dr Gary R Mirams

  3. Geometrically-derived action potential markers for model development: a principled approach?

    Article • September 2024, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  4. Optimising experimental designs for model selection of ion channel drug binding mechanisms

    Article • August 2024, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  5. Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs

    Article • August 2024, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  6. A range of voltage-clamp protocol designs for rapid capture of hERG kinetics

    Article • August 2024, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  7. Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  8. Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics

    Article • Mathematics in Medical and Life Sciences, July 2024, Taylor & Francis

    Dr Gary R Mirams

  9. An experimental investigation of rundown of the L-type calcium current

    Article • Wellcome Open Research, May 2024, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  10. Variability in reported midpoints of (in)activation of cardiac INa

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  11. Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies

    Article • eLife, April 2024, eLife

    Dr Gary R Mirams

  12. Understanding the impact of numerical solvers on inference for differential equation models

    Article • Journal of The Royal Society Interface, March 2024, Royal Society Publishing

    Dr Gary R Mirams

  13. Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies

    Article • December 2023, eLife

    Dr Gary R Mirams

  14. Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics

    Article • The Bulletin of Mathematical Biophysics, November 2023, Springer Science + Business Media

    Dr Gary R Mirams

  15. The impact of uncertainty in hERG binding mechanism on in silico predictions of drug‐induced proarrhythmic risk

    Article • British Journal of Pharmacology, November 2023, Wiley

    Dr Gary R Mirams

  16. Model-driven optimal experimental design for calibrating cardiac electrophysiology models

    Article • Computer Methods and Programs in Biomedicine, October 2023, Elsevier

    Dr Gary R Mirams

  17. Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

    Article • EP Europace, August 2023, Oxford University Press (OUP)

    Dr Gary R Mirams

  18. Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models

    Article • Journal of Theoretical Biology, February 2023, Elsevier

    Dr Gary R Mirams

  19. Nuanced Interactions between AKAP79 and STIM1 with Orai1 Ca 2+ Channels at Endoplasmic Reticulum-Plasma Membrane Junctions Sustain NFAT Activation

    Article • Molecular and Cellular Biology, November 2022, Taylor & Francis

    Dr Gary R Mirams

  20. Models of the cardiac L‐type calcium current: A quantitative review

    Article • WIREs Mechanisms of Disease, August 2022, Wiley

    Dr Gary R Mirams

  21. Ion channel model reduction using manifold boundaries

    Article • Journal of The Royal Society Interface, August 2022, Royal Society Publishing

    Dr Gary R Mirams

  22. cellmlmanip and chaste_codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians

    Article • Wellcome Open Research, June 2022, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  23. A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models

    Article • Frontiers in Physiology, April 2022, Frontiers

    Dr Gary R Mirams

  24. A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability

    Article • The Bulletin of Mathematical Biophysics, February 2022, Springer Science + Business Media

    Dr Gary R Mirams

  25. A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer

    Article • Wellcome Open Research, November 2021, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  26. chaste codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians

    Article • Wellcome Open Research, October 2021, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  27. Models of the cardiac L-type calcium current: a quantitative review

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  28. Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243

    Article • Journal of General Physiology, August 2021, Rockefeller University Press

    Dr Gary R Mirams

  29. Neural Network Differential Equations For Ion Channel Modelling

    Article • Frontiers in Physiology, August 2021, Frontiers

    Dr Gary R Mirams

  30. Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia

    Article • Frontiers in Physiology, May 2021, Frontiers

    Dr Gary R Mirams

  31. Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine

    Article • Royal Society Open Science, April 2021, Royal Society Publishing

    Dr Gary R Mirams

  32. Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

    Article • Cell Reports Medicine, August 2020, Elsevier

    Dr Gary R Mirams

  33. A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer

    Article • Wellcome Open Research, July 2020, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  34. Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, May 2020, Royal Society Publishing

    Dr Gary R Mirams

  35. The fickle heart: uncertainty quantification in cardiac and cardiovascular modelling and simulation

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, May 2020, Royal Society Publishing

    Dr Gary R Mirams

  36. Considering discrepancy when calibrating a mechanistic electrophysiology model

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, May 2020, Royal Society Publishing

    Dr Gary R Mirams

  37. A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

    Article • Toxicology and Applied Pharmacology, May 2020, Elsevier

    Dr Gary R Mirams

  38. Chaste: Cancer, Heart and Soft Tissue Environment

    Article • The Journal of Open Source Software, March 2020, The Open Journal

    Valentina Carapella, Dr Gary R Mirams

  39. Calibration of ionic and cellular cardiac electrophysiology models

    Article • WIREs Systems Biology and Medicine, February 2020, Wiley

    Dr Gary R Mirams

  40. Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

    Article • December 2019, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  41. Four Ways to Fit an Ion Channel Model

    Article • Biophysical Journal, December 2019, Elsevier

    Dr Gary R Mirams

  42. Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System

    Article • Biophysical Journal, December 2019, Elsevier

    Dr Gary R Mirams

  43. Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

    Article • Biophysical Journal, December 2019, Elsevier

    Dr Gary R Mirams

  44. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

    Article • Clinical Pharmacology & Therapeutics, November 2019, Wiley

    Dr Gary R Mirams

  45. High-throughput measurement and modeling of hERG kinetics using an automated platform

    Article • Journal of Pharmacological and Toxicological Methods, September 2019, Elsevier

    Dr Gary R Mirams

  46. Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters

    Article • Nature Communications, June 2019, Springer Science + Business Media

    Dr Gary R Mirams

  47. Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective

    Article • The Journal of Steroid Biochemistry and Molecular Biology, June 2019, Elsevier

    Dr Gary R Mirams

  48. Four ways to fit an ion channel model

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  49. Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  50. Rapid characterisation of hERG channel kinetics II: temperature dependence

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  51. Probabilistic Inference on Noisy Time Series (PINTS)

    Article • Journal of Open Research Software, January 2019, Ubiquity Press, Ltd.

    Dr Gary R Mirams

  52. Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology

    Article • The Bulletin of Mathematical Biophysics, October 2018, Springer Science + Business Media

    Dr Gary R Mirams

  53. Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative

    Article • Clinical Pharmacology & Therapeutics, August 2018, Wiley

    Dr Gary R Mirams

  54. Reproducible model development in the cardiac electrophysiology Web Lab

    Article • Progress in Biophysics and Molecular Biology, May 2018, Elsevier

    Dr Gary R Mirams

  55. Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

    Article • The Journal of Physiology, April 2018, Wiley

    Dr Gary R Mirams

  56. Reproducible model development in the Cardiac Electrophysiology Web Lab

    Article • January 2018, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  57. Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria

    Article • Nature Communications, January 2018, Nature

    Dr Gary R Mirams

  58. Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology

    Article • Frontiers in Physiology, December 2017, Frontiers

    Dr Gary R Mirams

  59. Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

    Article • Frontiers in Physiology, November 2017, Frontiers

    Dr Gary R Mirams

  60. Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro‐arrhythmia Assay initiative studies

    Article • British Journal of Pharmacology, October 2017, Wiley

    Dr Gary R Mirams

  61. Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

    Article • August 2017, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  62. Systems Toxicology: Real World Applications and Opportunities

    Article • Chemical Research in Toxicology, March 2017, American Chemical Society (ACS)

    Dr Gary R Mirams

  63. Sinusoidal Voltage Protocols For Rapid Characterisation Of Ion Channel Kinetics

    Article • March 2017, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  64. Hierarchical Bayesian inference for ion channel screening dose-response data

    Article • Wellcome Open Research, March 2017, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  65. High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Dr Gary R Mirams

  66. Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

    Article • Toxicology Research, January 2017, Oxford University Press (OUP)

    Dr Gary R Mirams

  67. Hierarchical Bayesian inference for ion channel screening dose-response data

    Article • Wellcome Open Research, November 2016, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  68. Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca 2+ Signals

    Article • Molecular Cell, November 2016, Elsevier

    Dr Gary R Mirams

  69. Hierarchical Bayesian Modelling of Variability and Uncertainty in Synthetic Action Potential Traces

    Article • September 2016, Computing in Cardiology

    Dr Gary R Mirams

  70. Exploring temperature-dependence of hERG channel kinetics using sine wave voltage protocols

    Article • Journal of Pharmacological and Toxicological Methods, September 2016, Elsevier

    Dr Gary R Mirams

  71. Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

    Article • Journal of Molecular and Cellular Cardiology, July 2016, Elsevier

    Dr Gary R Mirams

  72. Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

    Article • The Journal of Physiology, June 2016, Wiley

    Dr Gary R Mirams

  73. Uncertainty and variability in computational and mathematical models of cardiac physiology

    Article • The Journal of Physiology, June 2016, Wiley

    Dr Gary R Mirams

  74. Recent developments in using mechanistic cardiac modelling for drug safety evaluation

    Article • Drug Discovery Today, June 2016, Elsevier

    Dr Gary R Mirams

  75. Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart

    Article • Scientific Reports, May 2016, Springer Science + Business Media

    Dr Gary R Mirams

  76. The Cardiac Electrophysiology Web Lab

    Article • Biophysical Journal, January 2016, Elsevier

    Dr Gary R Mirams

  77. Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential

    Article • Heart Rhythm, October 2015, Elsevier

    Dr Gary R Mirams

  78. Voltage protocol design for determining hERG channel kinetics

    Article • Journal of Pharmacological and Toxicological Methods, September 2015, Elsevier

    Dr Gary R Mirams

  79. A web portal for in-silico action potential predictions

    Article • Journal of Pharmacological and Toxicological Methods, September 2015, Elsevier

    Dr Gary R Mirams

  80. Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression

    Article • Cell Reports, July 2015, Elsevier

    Dr Gary R Mirams

  81. Cardiac tissue slices: preparation, handling, and successful optical mapping

    Article • AJP Heart and Circulatory Physiology, January 2015, American Physiological Society

    Dr Gary R Mirams

  82. Cellular cardiac electrophysiology modeling with Chaste and CellML

    Article • Frontiers in Physiology, January 2015, Frontiers

    Dr Gary R Mirams

  83. Novel Voltage Protocols for Determining hERG Channel Kinetics

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Gary R Mirams

  84. Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue

    Article • Journal of Theoretical Biology, January 2015, Elsevier

    Dr Gary R Mirams

  85. Prediction of Thorough QT study results using action potential simulations based on ion channel screens

    Article • Journal of Pharmacological and Toxicological Methods, November 2014, Elsevier

    Dr Gary R Mirams

  86. In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted?

    Article • Journal of Pharmacological and Toxicological Methods, November 2014, Elsevier

    Dr Gary R Mirams

  87. Ten Simple Rules for Effective Computational Research

    Article • PLoS Computational Biology, March 2014, PLOS

    Derek Groen, Dr Alexander G Fletcher, Dr Gary R Mirams, Dr Derek Groen, Dr Christian Adam Yates

  88. Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Gary R Mirams

  89. Evaluation of computational modelling as a preclinical proarrhythmic safety assay

    Article • Journal of Pharmacological and Toxicological Methods, July 2013, Elsevier

    Dr Gary R Mirams

  90. Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

    Article • Journal of Pharmacological and Toxicological Methods, July 2013, Elsevier

    Dr Gary R Mirams

  91. Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

    Article • Journal of Pharmacological and Toxicological Methods, July 2013, Elsevier

    Dr Gary R Mirams

  92. Chaste: An Open Source C++ Library for Computational Physiology and Biology

    Article • PLoS Computational Biology, March 2013, PLOS

    Dr Alexander G Fletcher, Dr Nejib Zemzemi, Dr Gary R Mirams

  93. mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study

    Article • PLOS One, February 2013, PLOS

    Dr Gary R Mirams

  94. A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling

    Article • Future Generation Computer Systems, February 2013, Elsevier

    Dr Gary R Mirams

  95. Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials

    Article • British Journal of Pharmacology, January 2013, Wiley

    Dr Nejib Zemzemi, Dr Gary R Mirams

  96. Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings

    Article • January 2013, Springer Science + Business Media

    Dr Gary R Mirams

  97. A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt

    Article • Journal of Theoretical Biology, November 2012, Elsevier

    Dr Alexander G Fletcher, Dr Gary R Mirams

  98. Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing

    Article • British Journal of Pharmacology, October 2012, Wiley

    Dr Gary R Mirams

  99. Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG

    Article • Journal of Molecular and Cellular Cardiology, May 2012, Elsevier

    Dr Gary R Mirams

  100. Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Gary R Mirams

  101. Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets

    Article • Mathematical Biosciences, January 2012, Elsevier

    Dr Gary R Mirams

  102. Is it time for in silico simulation of drug cardiac side effects?

    Article • Annals of the New York Academy of Sciences, December 2011, Wiley

    Dr Gary R Mirams

  103. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing

    Article • Progress in Biophysics and Molecular Biology, October 2011, Elsevier

    Dr Gary R Mirams, Professor Jose Jalife

  104. High-throughput functional curation of cellular electrophysiology models

    Article • Progress in Biophysics and Molecular Biology, October 2011, Elsevier

    Dr Gary R Mirams

  105. Functional Curation: Potential Future Directions for SED-ML

    Article • Nature Reports Climate Change, September 2011, Nature

    Dr Gary R Mirams

  106. Functional Curation: Potential Future Directions for SED-ML

    Article • Nature Reports Climate Change, September 2011, Nature

    Dr Gary R Mirams

  107. Novel Approaches to Assessing Cardiac Safety – Proceedings of a Workshop

    Article • Drug Safety, May 2011, Springer Science + Business Media

    Dr Gary R Mirams

  108. The significant effect of the choice of ionic current integration method in cardiac electro-physiological simulations

    Article • International Journal for Numerical Methods in Biomedical Engineering, March 2011, Wiley

    Dr Gary R Mirams

  109. Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

    Article • Cardiovascular Research, February 2011, European Society of Cardiology

    Dr Gary R Mirams

  110. Multiscale Modeling of Colonic Crypts and Early Colorectal Cancer

    Article • December 2010, Taylor & Francis

    Dr Gary R Mirams

  111. A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L-type Calcium Channel Modelling

    Article • December 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Gary R Mirams

  112. A hybrid approach to multi-scale modelling of cancer

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, October 2010, Royal Society Publishing

    Oliver Jensen, Dr Gary R Mirams

  113. Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes

    Article • August 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Gary R Mirams

  114. Modelling Spatially Regulated β-Catenin Dynamics and Invasion in Intestinal Crypts

    Article • Biophysical Journal, August 2010, Elsevier

    Dr Gary R Mirams

  115. Chaste: A test-driven approach to software development for biological modelling

    Article • Computer Physics Communications, December 2009, Elsevier

    Dr Alexander G Fletcher, Dr Gary R Mirams

  116. An integrative computational model for intestinal tissue renewal

    Article • Cell Proliferation, October 2009, Wiley

    Dr Alexander G Fletcher, Oliver Jensen, Dr Gary R Mirams

  117. A computational study of discrete mechanical tissue models

    Article • Physical Biology, April 2009, Institute of Physics Publishing

    Dr Alexander G Fletcher, Dr Gary R Mirams

  118. A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway

    Article • Journal of Mathematical Biology, March 2009, Springer Science + Business Media

    Dr Gary R Mirams

  119. Towards a multiscale model of colorectal cancer

    Article • Journal of Biomechanics, January 2006, Elsevier

    Dr Gary R Mirams