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  1. Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3

    Article • Nature Communications, June 2026, Springer Science + Business Media

    Professor Jose Jalife

  2. NOD1 is a key mediator of atrial myopathy in heart failure

    Article • Theranostics, June 2026, Ivyspring International Publisher

    Professor Jose Jalife

  3. Ventricular fibrillation dynamics reveal regional asymmetry in resilience to cardiac arrest and predict clinical outcome

    Article • Cardiovascular Research, May 2026, Oxford University Press (OUP)

    Professor Jose Jalife

  4. Rescuing the heart from the tornadoes of sudden cardiac death

    Article • Trends in Cardiovascular Medicine, April 2026, Elsevier

    Professor Jose Jalife

  5. Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation

    Article • Cardiovascular Research, March 2026, Oxford University Press (OUP)

    Professor Jose Jalife

  6. Cardiac Macrophages and Fibroblasts Modulate Atrial Fibrillation Maintenance

    Article • Circulation Research, March 2026, Wolters Kluwer Health

    Professor Jose Jalife

  7. The Complex Interplay Between Aging, Cardiac Remodeling, and Atrial Fibrillation

    Article • JACC Clinical Electrophysiology, February 2026, Elsevier

    Professor Jose Jalife

  8. MOG1 L18F -mediated increase in late sodium current produces Long QT Syndrome

    Article • December 2025, openRxiv

    Professor Jose Jalife

  9. Transforming atrial fibrillation management by targeting comorbidities and reducing atrial fibrillation burden: the 10th AFNET/EHRA consensus conference

    Article • EP Europace, December 2025, Oxford University Press (OUP)

    Professor Jose Jalife

  10. Investigating the Risk of Arrhythmogenesis Associated With Fentanyl Abuse Using Human and Mouse Cardiomyocytes

    Article • Circulation, August 2025, Wolters Kluwer Health

    Professor Jose Jalife

  11. Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome

    Article • Cell Discovery, January 2025, Springer Science + Business Media

    Professor Jose Jalife

  12. Promising tools for future drug discovery and development in antiarrhythmic therapy

    Article • Pharmacological Reviews, January 2025, Elsevier

    Professor Jose Jalife

  13. Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome

    Article • December 2024, openRxiv

    Professor Jose Jalife

  14. The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development

    Article • Nature Communications, October 2024, Springer Science + Business Media

    Dr Joan Isern, Professor Jose Jalife

  15. The Impact of Extracellular Histones and Absence of Toll-like Receptors on Cardiac Functional and Electrical Disturbances in Mouse Hearts

    Article • International Journal of Molecular Sciences, August 2024, MDPI AG

    Professor Jose Jalife

  16. Practical approach for atrial cardiomyopathy characterization in patients with atrial fibrillation

    Article • Revista Española de Cardiología (English Edition), August 2024, Elsevier

    Professor Jose Jalife

  17. Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American He...

    Article • EP Europace, July 2024, Oxford University Press (OUP)

    Jean-Baptiste Guichard, Professor Jose Jalife

  18. Extracellular Kir2.1 C122Y Mutant Upsets Kir2.1-PIP 2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome

    Article • Circulation Research, April 2024, Wolters Kluwer Health

    Professor Jose Jalife

  19. The Kir2.1-NaV1.5 Channelosome and its role in Arrhythmias in Inheritable Cardiac Diseases

    Article • Heart Rhythm, January 2024, Elsevier

    Professor Jose Jalife

  20. p38γ/δ activation alters cardiac electrical activity and predisposes to ventricular arrhythmia

    Article • Nature Cardiovascular Research, November 2023, Springer Science + Business Media

    Professor Jose Jalife

  21. Intermediate Molecular Phenotypes to Identify Genetic Markers of Anthracycline-Induced Cardiotoxicity Risk

    Article • Cells, July 2023, MDPI AG

    Professor Jose Jalife

  22. SNTA1 Gene Rescues Ion Channel Function in Cardiomyocytes Derived from Induced Pluripotent Stem Cells Reprogrammed from Muscular Dystrophy Patients with Arrhythmias

    Article • January 2022, Cold Spring Harbor Laboratory Press

    Professor Jose Jalife

  23. Erratum to: Transcriptome and proteome mapping in the sheep atria reveal molecular features of atrial fibrillation progression

    Article • Cardiovascular Research, July 2021, Oxford University Press (OUP)

    Professor Jose Jalife

  24. Mapping Technologies for Catheter Ablation of Atrial Fibrillation Beyond Pulmonary Vein Isolation

    Article • European Cardiology Review, May 2021, Medical Media Communications, Ltd. T/A Radcliffe Cardiology

    Professor Jose Jalife

  25. Novel approaches to mechanism-based atrial fibrillation ablation

    Article • Cardiovascular Research, March 2021, Oxford University Press (OUP)

    Professor Jose Jalife

  26. Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson–Gilford progeria syndrome

    Article • Cardiovascular Research, February 2021, Oxford University Press (OUP)

    Professor Jose Jalife, Prof. Vicente Andrés

  27. Cardiac phenotype in familial partial lipodystrophy

    Article • Clinical Endocrinology, February 2021, Wiley

    Professor Jose Jalife

  28. Tbx5 variants disrupt Nav1.5 function differently in patients diagnosed with Brugada or Long QT Syndrome

    Article • Cardiovascular Research, February 2021, Oxford University Press (OUP)

    Professor Jose Jalife

  29. Anatomical targets and expected outcomes of catheter‐based ablation of atrial fibrillation in 2020

    Article • Pacing and Clinical Electrophysiology, January 2021, Wiley

    Professor Jose Jalife

  30. Transcriptome and proteome mapping in the sheep atria reveal molecular featurets of atrial fibrillation progression

    Article • Cardiovascular Research, October 2020, Oxford University Press (OUP)

    Professor Jose Jalife

  31. Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents

    Article • Molecular & Cellular Proteomics, September 2020, Elsevier

    Professor Jose Jalife

  32. The p.P888L SAP97 polymorphism increases the transient outward current (Ito,f) and abbreviates the action potential duration and the QT interval

    Article • Scientific Reports, July 2020, Springer Science + Business Media

    Professor Jose Jalife

  33. Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death

    Article • Cardiovascular Research, May 2020, Oxford University Press (OUP)

    Professor Jose Jalife

  34. Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices

    Article • EP Europace, December 2019, Oxford University Press (OUP)

    Professor Jose Jalife

  35. Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association

    Article • Circulation Research, October 2019, Wolters Kluwer Health

    Professor Jose Jalife

  36. Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation

    Article • Circulation Arrhythmia and Electrophysiology, October 2019, Wolters Kluwer Health

    Professor Jose Jalife

  37. Atrial Myopathy

    Article • JACC Basic to Translational Science, September 2019, Elsevier

    Professor Jose Jalife

  38. Instantaneous Amplitude and Frequency Modulations Detect the Footprint of Rotational Activity and Reveal Stable Driver Regions as Targets for Persistent Atrial Fibrillation Ablation

    Article • Circulation Research, August 2019, Wolters Kluwer Health

    Professor Jose Jalife

  39. A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources

    Article • The Journal of Physiology, July 2019, Wiley

    Professor Jose Jalife

  40. Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors

    Article • Nature Communications, May 2019, Springer Science + Business Media

    Professor Jose Jalife

  41. Lesion Index Titration Using Contact-Force Technology Enables Safe and Effective Radiofrequency Lesion Creation at the Root of the Aorta and Pulmonary Artery

    Article • Circulation Arrhythmia and Electrophysiology, March 2019, Wolters Kluwer Health

    Professor Jose Jalife

  42. Clinical Characteristics and Electrophysiological Mechanisms Underlying Brugada ECG in Patients With Severe Hyperkalemia

    Article • Journal of the American Heart Association, February 2019, Wolters Kluwer Health

    Professor Jose Jalife

  43. Three-dimensional cardiac fibre disorganization as a novel parameter for ventricular arrhythmia stratification after myocardial infarction

    Article • EP Europace, January 2019, Oxford University Press (OUP)

    Professor Jose Jalife

  44. Brugada syndrome trafficking–defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels

    Article • JCI Insight, September 2018, American Society for Clinical Investigation

    Professor Jose Jalife

  45. Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction

    Article • EP Europace, September 2018, Oxford University Press (OUP)

    Professor Jose Jalife

  46. Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

    Article • Nature Genetics, July 2018, Springer Science + Business Media

    Professor Jose Jalife

  47. Mechanisms and Drug Development in Atrial Fibrillation

    Article • Pharmacological Reviews, June 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Jose Jalife

  48. Cardiac Kir2.1 and Na V 1.5 Channels Traffic Together to the Sarcolemma to Control Excitability

    Article • Circulation Research, May 2018, Wolters Kluwer Health

    Professor Jose Jalife

  49. Factors affecting basket catheter detection of real and phantom rotors in the atria: A computational study

    Article • PLoS Computational Biology, March 2018, PLOS

    Professor Jose Jalife

  50. The tornadoes of sudden cardiac arrest

    Article • Nature, February 2018, Springer Science + Business Media

    Professor Jose Jalife

  51. Causality analysis of leading singular value decomposition modes identifies rotor as the dominant driving normal mode in fibrillation

    Article • Chaos An Interdisciplinary Journal of Nonlinear Science, January 2018, American Institute of Physics

    Professor Jose Jalife

  52. Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development

    Article • The American Journal of Human Genetics, January 2018, Elsevier

    Professor Jose Jalife

  53. Eplerenone Reduces Atrial Fibrillation Burden Without Preventing Atrial Electrical Remodeling

    Article • Journal of the American College of Cardiology, December 2017, Elsevier

    Professor Jose Jalife

  54. Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule

    Article • The FASEB Journal, November 2017, Federation of American Societies For Experimental Biology (FASEB)

    Professor Jose Jalife

  55. Synergistic Research Between the Center of Arrhythmia Research and the Michigan Biology of Cardiovascular Aging at the University of Michigan

    Article • Circulation Research, November 2017, Wolters Kluwer Health

    Professor Jose Jalife

  56. Triple threat: adiposity, aging, atrial fibrillation

    Article • Aging, November 2017, Impact Journals, LLC

    Professor Jose Jalife

  57. hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Professor Jose Jalife

  58. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

    Article • Journal of Arrhythmia, October 2017, Wiley

    Professor Jose Jalife

  59. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

    Article • Heart Rhythm, October 2017, Elsevier

    Professor Jose Jalife

  60. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

    Article • Heart Rhythm, October 2017, Elsevier

    Professor Jose Jalife

  61. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

    Article • EP Europace, September 2017, Oxford University Press (OUP)

    Professor Jose Jalife

  62. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

    Article • EP Europace, September 2017, Oxford University Press (OUP)

    Professor Jose Jalife

  63. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary

    Article • Journal of Interventional Cardiac Electrophysiology, September 2017, Springer Science + Business Media

    Professor Jose Jalife

  64. Propagation of Sinus Waves in the Atrial Architecture

    Article • Circulation Arrhythmia and Electrophysiology, September 2017, Wolters Kluwer Health

    Professor Jose Jalife

  65. Is TGF-β 1 (Transforming Growth Factor-β 1 ) an Enabler of Myofibroblast–Cardiomyocyte Cross Talk?

    Article • Circulation Arrhythmia and Electrophysiology, May 2017, Wolters Kluwer Health

    Professor Jose Jalife

  66. Selection of the Best of 2016 in Catheter Ablation

    Article • Revista Española de Cardiología (English Edition), April 2017, Elsevier

    Professor Jose Jalife

  67. Tbx20 controls the expression of the KCNH2 gene and of hERG channels

    Article • Proceedings of the National Academy of Sciences, January 2017, Proceedings of the National Academy of Sciences

    Professor Jose Jalife

  68. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication

    Article • Heart Rhythm, January 2017, Elsevier

    Professor Jose Jalife

  69. Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes

    Article • Journal of Molecular and Cellular Cardiology, October 2016, Elsevier

    Professor Jose Jalife

  70. Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro

    Article • The Journal of Immunology, September 2016, The American Association of Immunologists

    Professor Jose Jalife

  71. Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Structurally Normal Hearts

    Article • Cardiac Electrophysiology Clinics, September 2016, Elsevier

    Professor Jose Jalife

  72. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication

    Article • EP Europace, July 2016, European Society of Cardiology

    Professor Jose Jalife

  73. Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production

    Article • Journal of Molecular Endocrinology, July 2016, Bioscientifica

    Professor Jose Jalife

  74. Constitutive Intracellular Na + Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular Tachycardia

    Article • Circulation, June 2016, Wolters Kluwer Health

    Professor Jose Jalife

  75. Atrial Fibrillation Susceptibility in Obesity

    Article • Circulation Research, May 2016, Wolters Kluwer Health

    Professor Jose Jalife

  76. Extracellular Matrix–Mediated Maturation of Human Pluripotent Stem Cell–Derived Cardiac Monolayer Structure and Electrophysiological Function

    Article • Circulation Arrhythmia and Electrophysiology, April 2016, Wolters Kluwer Health

    Professor Jose Jalife

  77. Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes

    Article • JACC Basic to Translational Science, April 2016, Elsevier

    Professor Jose Jalife

  78. Mechanisms of Atrial Fibrillation

    Article • Heart Failure Clinics, April 2016, Elsevier

    Professor Jose Jalife

  79. Novel Upstream Approaches to Prevent Atrial Fibrillation Perpetuation

    Article • Heart Failure Clinics, April 2016, Elsevier

    Professor Jose Jalife

  80. Pulmonary vein triggers, focal sources, rotors and atrial cardiomyopathy: implications for the choice of the most effective ablation therapy

    Article • Journal of Internal Medicine, March 2016, Wiley

    Professor Jose Jalife

  81. Structural and Functional Bases of Cardiac Fibrillation

    Article • JACC Clinical Electrophysiology, February 2016, Elsevier

    Professor Jose Jalife

  82. Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels

    Article • Cardiovascular Research, January 2016, European Society of Cardiology

    Ricardo Caballero, Professor Jose Jalife

  83. Mechanistic Approaches to Detect, Target, and Ablate the Drivers of Atrial Fibrillation

    Article • Circulation Arrhythmia and Electrophysiology, January 2016, Wolters Kluwer Health

    Professor Jose Jalife

  84. Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of human and sheep atria

    Article • European Heart Journal, November 2015, European Society of Cardiology

    Professor Jose Jalife

  85. The elusive rotor electrogram footprint

    Article • EP Europace, November 2015, European Society of Cardiology

    Professor Jose Jalife

  86. Letter by Jalife et al Regarding Article, “Quantitative Analysis of Localized Sources Identified by Focal Impulse and Rotor Modulation Mapping in Atrial Fibrillation”

    Article • Circulation Arrhythmia and Electrophysiology, October 2015, Wolters Kluwer Health

    Professor Jose Jalife

  87. Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate

    Article • Circulation Arrhythmia and Electrophysiology, October 2015, Wolters Kluwer Health

    Professor Jose Jalife

  88. Atrial remodeling, fibrosis, and atrial fibrillation

    Article • Trends in Cardiovascular Medicine, August 2015, Elsevier

    Professor Jose Jalife

  89. Protein assemblies of sodium and inward rectifier potassium channels control cardiac excitability and arrhythmogenesis

    Article • AJP Heart and Circulatory Physiology, June 2015, American Physiological Society

    Professor Jose Jalife

  90. Ion Channel Macromolecular Complexes in Cardiomyocytes: Roles in Sudden Cardiac Death

    Article • Circulation Research, June 2015, Wolters Kluwer Health

    Professor Jose Jalife

  91. Spectral analysis-based risk score enables early prediction of mortality and cerebral performance in patients undergoing therapeutic hypothermia for ventricular fibrillation and comatose status

    Article • International Journal of Cardiology, May 2015, Elsevier

    Professor Jose Jalife, Jose Millet

  92. Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

    Article • Proceedings of the National Academy of Sciences, March 2015, Proceedings of the National Academy of Sciences

    Professor Jose Jalife

  93. A device for rapid and quantitative measurement of cardiac myocyte contractility

    Article • Review of Scientific Instruments, March 2015, American Institute of Physics

    Professor Jose Jalife

  94. Role of extracellular histones in the cardiomyopathy of sepsis

    Article • The FASEB Journal, February 2015, Wiley

    Professor Jose Jalife

  95. Comparison of Radiofrequency Catheter Ablation of Drivers and Circumferential Pulmonary Vein Isolation in Atrial Fibrillation

    Article • Journal of the American College of Cardiology, December 2014, Elsevier

    Professor Jose Jalife

  96. Spectral analysis of electrograms in a substrate modified by radiofrequency ablation reveals similarities between organized and disorganized atrial rhythms

    Article • Heart Rhythm, December 2014, Elsevier

    Professor Jose Jalife

  97. Mechanisms of Atrial Fibrillation

    Article • Cardiology Clinics, November 2014, Elsevier

    Professor Jose Jalife

  98. Novel Upstream Approaches to Prevent Atrial Fibrillation Perpetuation

    Article • Cardiology Clinics, November 2014, Elsevier

    Professor Jose Jalife

  99. Scn1b deletion leads to increased tetrodotoxin‐sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

    Article • The Journal of Physiology, September 2014, Wiley

    Professor Jose Jalife

  100. CrossTalk proposal: Rotors have been demonstrated to drive human atrial fibrillation

    Article • The Journal of Physiology, August 2014, Wiley

    Professor Jose Jalife

  101. Rebuttal from Sanjiv M. Narayan and José Jalife

    Article • The Journal of Physiology, August 2014, Wiley

    Professor Jose Jalife

  102. Dominant Frequency Increase Rate Predicts Transition from Paroxysmal to Long-Term Persistent Atrial Fibrillation

    Article • Circulation, April 2014, Wolters Kluwer Health

    Professor Jose Jalife

  103. Mechanisms of persistent atrial fibrillation

    Article • Current Opinion in Cardiology, January 2014, Wolters Kluwer Health

    Professor Jose Jalife

  104. Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes

    Article • Stem Cell Research, November 2013, Elsevier

    Professor Jose Jalife

  105. Modulated parasystole: Still relevant after all these years!

    Article • Heart Rhythm, October 2013, Elsevier

    Professor Jose Jalife

  106. And the beat goes on ... the beat goes on: organization and quasi-periodicity in ventricular fibrillation

    Article • Cardiovascular Research, July 2013, European Society of Cardiology

    Professor Jose Jalife

  107. Inhibition of platelet-derived growth factor-AB signaling prevents electromechanical remodeling of adult atrial myocytes that contact myofibroblasts

    Article • Heart Rhythm, July 2013, Elsevier

    Professor Jose Jalife

  108. Neuroanatomy of the murine cardiac conduction system

    Article • Autonomic Neuroscience, June 2013, Elsevier

    Professor Jose Jalife

  109. Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function

    Article • Cardiovascular Research, April 2013, European Society of Cardiology

    Professor Jose Jalife

  110. Noninvasive Localization of Maximal Frequency Sites of Atrial Fibrillation by Body Surface Potential Mapping

    Article • Circulation Arrhythmia and Electrophysiology, April 2013, Wolters Kluwer Health

    Professor Jose Jalife, Jose Millet

  111. Introduction to the Series on Computational Approaches to Cardiac Arrhythmias

    Article • Circulation Research, March 2013, Wolters Kluwer Health

    Professor Jose Jalife

  112. Mechanoelectric Feedback in the Ischemic Myocardium: An Interplay That Modulates Susceptibility to Fibrillation

    Article • Revista Española de Cardiología (English Edition), March 2013, Elsevier

    Professor Jose Jalife

  113. Rotors and the Dynamics of Cardiac Fibrillation

    Article • Circulation Research, March 2013, Wolters Kluwer Health

    Professor Jose Jalife

  114. KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia

    Article • Proceedings of the National Academy of Sciences, February 2013, Proceedings of the National Academy of Sciences

    Professor Jose Jalife

  115. Genetically Engineered Excitable Cardiac Myofibroblasts Coupled to Cardiomyocytes Rescue Normal Propagation and Reduce Arrhythmia Complexity in Heterocellular Monolayers

    Article • PLOS One, February 2013, PLOS

    Professor Jose Jalife

  116. TGF-β1, Released by Myofibroblasts, Differentially Regulates Transcription and Function of Sodium and Potassium Channels in Adult Rat Ventricular Myocytes

    Article • PLOS One, February 2013, PLOS

    Professor Jose Jalife

  117. Heterogeneity of Ryanodine Receptor Dysfunction in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

    Article • Circulation Research, January 2013, Wolters Kluwer Health

    Professor Jose Jalife

  118. The ionic bases of the action potential in isolated mouse cardiac Purkinje cell

    Article • Heart Rhythm, January 2013, Elsevier

    Professor Jose Jalife

  119. Long-Term Frequency Gradients During Persistent Atrial Fibrillation in Sheep Are Associated With Stable Sources in the Left Atrium

    Article • Circulation Arrhythmia and Electrophysiology, December 2012, Wolters Kluwer Health

    Professor Jose Jalife

  120. Translational Research in Atrial Fibrillation

    Article • Circulation Arrhythmia and Electrophysiology, December 2012, Wolters Kluwer Health

    Professor Jose Jalife

  121. Spatial gradients in action potential duration created by regional magnetofection of hERG are a substrate for wavebreak and turbulent propagation in cardiomyocyte monolayers

    Article • The Journal of Physiology, November 2012, Wiley

    Professor Jose Jalife

  122. Extracellular Matrix Promotes Highly Efficient Cardiac Differentiation of Human Pluripotent Stem Cells

    Article • Circulation Research, October 2012, Wolters Kluwer Health

    Professor Jose Jalife

  123. Elevated Pre-Operative Serum Peptides for Collagen I and III Synthesis Result in Post-Surgical Atrial Fibrillation

    Article • Journal of the American College of Cardiology, October 2012, Elsevier

    Professor Jose Jalife

  124. Venice Chart International Consensus Document on Atrial Fibrillation Ablation: 2011 Update

    Article • Journal of Cardiovascular Electrophysiology, August 2012, Wiley

    Professor Jose Jalife

  125. Biological pacemakers: The oscillatory road ahead

    Article • Heart Rhythm, August 2012, Elsevier

    Professor Jose Jalife

  126. High-rate pacing-induced atrial fibrillation effectively reveals properties of spontaneously occurring paroxysmal atrial fibrillation in humans

    Article • EP Europace, June 2012, European Society of Cardiology

    Professor Jose Jalife

  127. Simultaneous Voltage and Calcium Mapping of Genetically Purified Human Induced Pluripotent Stem Cell–Derived Cardiac Myocyte Monolayers

    Article • Circulation Research, June 2012, Wolters Kluwer Health

    Professor Jose Jalife

  128. Chloroquine Terminates Stretch-Induced Atrial Fibrillation More Effectively Than Flecainide in the Sheep Heart

    Article • Circulation Arrhythmia and Electrophysiology, June 2012, Wolters Kluwer Health

    Professor Jose Jalife

  129. Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    Professor Jose Jalife

  130. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design

    Article • Heart Rhythm, April 2012, Elsevier

    Professor Jose Jalife

  131. Radiofrequency catheter ablation of pulmonary vein roots results in axonal degeneration of distal epicardial nerves

    Article • Autonomic Neuroscience, April 2012, Elsevier

    Professor Jose Jalife

  132. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design: A...

    Article • EP Europace, March 2012, European Society of Cardiology

    Professor Jose Jalife

  133. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design

    Article • Journal of Interventional Cardiac Electrophysiology, March 2012, Springer Science + Business Media

    Professor Jose Jalife

  134. Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues

    Article • Circulation Research, February 2012, Wolters Kluwer Health

    Professor Jose Jalife

  135. Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts

    Article • Heart Rhythm, January 2012, Elsevier

    Professor Jose Jalife

  136. Left-to-right ventricular differences in IKATP underlie epicardial repolarization gradient during global ischemia

    Article • Heart Rhythm, November 2011, Elsevier

    Professor Jose Jalife

  137. Time- and frequency-domain analyses of atrial fibrillation activation rate: The optical mapping reference

    Article • Heart Rhythm, November 2011, Elsevier

    Professor Jose Jalife

  138. Human Atrial Action Potential and Ca 2+ Model

    Article • Circulation Research, October 2011, Wolters Kluwer Health

    Professor Jose Jalife

  139. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing

    Article • Progress in Biophysics and Molecular Biology, October 2011, Elsevier

    Dr Gary R Mirams, Professor Jose Jalife

  140. A null mutation of the neuronal sodium channel Na V 1.6 disrupts action potential propagation and excitation‐contraction coupling in the mouse heart

    Article • The FASEB Journal, September 2011, Wiley

    Professor Jose Jalife

  141. Complex Fractionated Atrial Electrograms

    Article • Circulation Arrhythmia and Electrophysiology, August 2011, Wolters Kluwer Health

    Professor Jose Jalife

  142. High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

    Article • Journal of Visualized Experiments, July 2011, MyJove Corporation

    Professor Jose Jalife

  143. Guidance for the Heart Rhythm Society Pertaining to Interactions with Industry

    Article • Heart Rhythm, July 2011, Elsevier

    Professor Jose Jalife

  144. Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes

    Article • Journal of Clinical Investigation, July 2011, American Society for Clinical Investigation

    Professor Jose Jalife

  145. Immunohistochemical characterization of the intrinsic cardiac neural plexus in whole-mount mouse heart preparations

    Article • Heart Rhythm, May 2011, Elsevier

    Professor Jose Jalife

  146. Mammalian enabled (Mena) is a critical regulator of cardiac function

    Article • AJP Heart and Circulatory Physiology, May 2011, American Physiological Society

    Professor Jose Jalife

  147. Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers

    Article • The Journal of Physiology, April 2011, Wiley

    Professor Jose Jalife

  148. Complement dependency of cardiomyocyte release of mediators during sepsis

    Article • The FASEB Journal, April 2011, Wiley

    Professor Jose Jalife

  149. Morphologic pattern of the intrinsic ganglionated nerve plexus in mouse heart

    Article • Heart Rhythm, March 2011, Elsevier

    Professor Jose Jalife

  150. Left atrial pressure and dominant frequency of atrial fibrillation in humans

    Article • Heart Rhythm, February 2011, Elsevier

    Professor Jose Jalife

  151. Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine

    Article • Cardiovascular Research, January 2011, European Society of Cardiology

    Professor Jose Jalife

  152. A Major Role for hERG in Determining Frequency of Reentry in Neonatal Rat Ventricular Myocyte Monolayer

    Article • Circulation Research, December 2010, Wolters Kluwer Health

    Professor Jose Jalife

  153. Deja vu in the theories of atrial fibrillation dynamics

    Article • Cardiovascular Research, November 2010, European Society of Cardiology

    Professor Jose Jalife

  154. Targeting atrioventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs

    Article • Cardiovascular Research, November 2010, European Society of Cardiology

    Professor Jose Jalife

  155. Purkinje cell calcium dysregulation is the cellular mechanism that underlies catecholaminergic polymorphic ventricular tachycardia

    Article • Heart Rhythm, August 2010, Elsevier

    Professor Jose Jalife

  156. Epicardial neural ganglionated plexus of ovine heart: Anatomic basis for experimental cardiac electrophysiology and nerve protective cardiac surgery

    Article • Heart Rhythm, July 2010, Elsevier

    Professor Jose Jalife

  157. Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets

    Article • The FASEB Journal, June 2010, Wiley

    Professor Jose Jalife

  158. Mechanisms Underlying the Antifibrillatory Action of Hyperkalemia in Guinea Pig Hearts

    Article • Biophysical Journal, May 2010, Elsevier

    Alena Talkachova, Professor Jose Jalife

  159. Letter by Berenfeld and Jalife Regarding Article “Dominant Frequency of Atrial Fibrillation Correlates Poorly With Atrial Fibrillation Cycle Length”

    Article • Circulation Arrhythmia and Electrophysiology, February 2010, Wolters Kluwer Health

    Professor Jose Jalife

  160. Inward rectifier potassium channels control rotor frequency in ventricular fibrillation

    Article • Heart Rhythm, November 2009, Elsevier

    Professor Jose Jalife

  161. Complex fractionated atrial electrograms: Properties of time-domain versus frequency-domain methods

    Article • Heart Rhythm, October 2009, Elsevier

    Professor Jose Jalife

  162. Left versus right atrial difference in dominant frequency, K+ channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery

    Article • Heart Rhythm, October 2009, Elsevier

    Professor Jose Jalife

  163. Paroxysmal atrioventricular block: Are phase 3 and phase 4 block mechanisms or misnomers?

    Article • Heart Rhythm, October 2009, Elsevier

    Professor Jose Jalife

  164. Mechanisms of stretch-induced atrial fibrillation in the presence and the absence of adrenocholinergic stimulation: Interplay between rotors and focal discharges

    Article • Heart Rhythm, July 2009, Elsevier

    Professor Jose Jalife

  165. A Single-Cell Model of Phase-Driven Control of Ventricular Fibrillation Frequency

    Article • Biophysical Journal, April 2009, Elsevier

    Professor Jose Jalife

  166. Prevention of Atrial Fibrillation

    Article • Circulation, February 2009, Wolters Kluwer Health

    Professor Jose Jalife

  167. Nerve Supply of the Human Pulmonary Veins: An Anatomical Study

    Article • Heart Rhythm, February 2009, Elsevier

    Professor Jose Jalife

  168. Real-time dominant frequency mapping and ablation of dominant frequency sites in atrial fibrillation with left-to-right frequency gradients predicts long-term maintenance of sinus rhythm

    Article • Heart Rhythm, January 2009, Elsevier

    Professor Jose Jalife

  169. Electrotonic Myofibroblast-to-Myocyte Coupling Increases Propensity to Reentrant Arrhythmias in Two-Dimensional Cardiac Monolayers

    Article • Biophysical Journal, November 2008, Elsevier

    Professor Jose Jalife

  170. Reentry in an accessory atrioventricular pathway as a trigger for atrial fibrillation initiation in manifest Wolff-Parkinson-White syndrome: A matter of reflection?

    Article • Heart Rhythm, September 2008, Elsevier

    Professor Jose Jalife

  171. RXP-E

    Article • Circulation Research, August 2008, Wolters Kluwer Health

    Professor Jose Jalife

  172. Atrial Septopulmonary Bundle of the Posterior Left Atrium Provides a Substrate for Atrial Fibrillation Initiation in a Model of Vagally Mediated Pulmonary Vein Tachycardia of the Structurally Normal Heart

    Article • Circulation Arrhythmia and Electrophysiology, August 2008, Wolters Kluwer Health

    Professor Jose Jalife

  173. Role of Conduction Velocity Restitution and Short-Term Memory in the Development of Action Potential Duration Alternans in Isolated Rabbit Hearts

    Article • Circulation, July 2008, Wolters Kluwer Health

    Alena Talkachova, Professor Jose Jalife

  174. Cardiac fibrillation: From ion channels to rotors in the human heart

    Article • Heart Rhythm, June 2008, Elsevier

    Professor Jose Jalife

  175. Universal scaling law of electrical turbulence in the mammalian heart

    Article • Proceedings of the National Academy of Sciences, December 2007, Proceedings of the National Academy of Sciences

    Professor Jose Jalife

  176. Spatial Distribution of Fibrosis Governs Fibrillation Wave Dynamics in the Posterior Left Atrium During Heart Failure

    Article • Circulation Research, October 2007, Wolters Kluwer Health

    Professor Jose Jalife

  177. Arrhythmogenic Mechanisms in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

    Article • Circulation Research, September 2007, Wolters Kluwer Health

    Alena Talkachova, Professor Jose Jalife

  178. Three distinct phases of VF during global ischemia in the isolated blood-perfused pig heart

    Article • AJP Heart and Circulatory Physiology, September 2007, American Physiological Society

    Professor Jose Jalife

  179. Adenoviral Expression of I Ks Contributes to Wavebreak and Fibrillatory Conduction in Neonatal Rat Ventricular Cardiomyocyte Monolayers

    Article • Circulation Research, August 2007, Wolters Kluwer Health

    Professor Jose Jalife

  180. Endoscopic fluorescence mapping of the left atrium: A novel experimental approach for high resolution endocardial mapping in the intact heart

    Article • Heart Rhythm, July 2007, Elsevier

    Professor Jose Jalife

  181. Optical mapping of Langendorff-perfused human hearts: establishing a model for the study of ventricular fibrillation in humans

    Article • AJP Heart and Circulatory Physiology, July 2007, American Physiological Society

    Professor Jose Jalife

  182. Reentry and atrial fibrillation

    Article • Heart Rhythm, March 2007, Elsevier

    Professor Jose Jalife

  183. Aging and atrial fibrillation research: Where we are and where we should go

    Article • Heart Rhythm, February 2007, Elsevier

    Professor Jose Jalife

  184. Up‐regulation of the inward rectifier K+ current (IK1) in the mouse heart accelerates and stabilizes rotors

    Article • The Journal of Physiology, December 2006, Wiley

    Professor Jose Jalife

  185. Activation of Inward Rectifier Potassium Channels Accelerates Atrial Fibrillation in Humans

    Article • Circulation, December 2006, Wolters Kluwer Health

    Professor Jose Jalife

  186. Action Potential Duration Restitution Portraits of Mammalian Ventricular Myocytes: Role of Calcium Current

    Article • Biophysical Journal, October 2006, Elsevier

    Alena Talkachova, Professor Jose Jalife

  187. Tiempo, espacio y frecuencia en la fibrilación ventricular

    Article • Revista Española de Cardiología, September 2006, Elsevier

    Professor Jose Jalife

  188. Mechanisms of Wave Fractionation at Boundaries of High-Frequency Excitation in the Posterior Left Atrium of the Isolated Sheep Heart During Atrial Fibrillation

    Article • Circulation, February 2006, Wolters Kluwer Health

    Professor Jose Jalife

  189. Altered Right Atrial Excitation and Propagation in Connexin40 Knockout Mice

    Article • Circulation, October 2005, Wolters Kluwer Health

    Professor Jose Jalife

  190. Spectral Analysis Identifies Sites of High-Frequency Activity Maintaining Atrial Fibrillation in Humans

    Article • Circulation, August 2005, Wolters Kluwer Health

    Professor Jose Jalife

  191. Ionic Determinants of Functional Reentry in a 2-D Model of Human Atrial Cells During Simulated Chronic Atrial Fibrillation

    Article • Biophysical Journal, June 2005, Elsevier

    Professor Jose Jalife

  192. Ionic mechanisms of wavebreak in fibrillation

    Article • Heart Rhythm, June 2005, Elsevier

    Professor Jose Jalife

  193. A Novel Form of Short QT Syndrome (SQT3) Is Caused by a Mutation in the KCNJ2 Gene

    Article • Circulation Research, April 2005, Wolters Kluwer Health

    Professor Jose Jalife

  194. Mechanisms of Atrial Fibrillation Termination by Pure Sodium Channel Blockade in an Ionically-Realistic Mathematical Model

    Article • Circulation Research, March 2005, Wolters Kluwer Health

    Professor Jose Jalife

  195. The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis

    Article • Heart Rhythm, March 2005, Elsevier

    Professor Jose Jalife

  196. Atrioventricular conduction in mammalian species: Hemodynamic and electrical scaling

    Article • Heart Rhythm, February 2005, Elsevier

    Professor Jose Jalife

  197. Effect of remodelling, stretch and ischaemia on ventricular fibrillation frequency and dynamics in a heart failure model

    Article • Cardiovascular Research, January 2005, European Society of Cardiology

    Professor Jose Jalife

  198. From Mouse to Whale

    Article • Circulation, November 2004, Wolters Kluwer Health

    Professor Jose Jalife

  199. Molecular mechanisms and global dynamics of fibrillation: an integrative approach to the underlying basis of vortex-like reentry

    Article • Journal of Theoretical Biology, October 2004, Elsevier

    Professor Jose Jalife

  200. Swapping Connexin Genes

    Article • Circulation Research, January 2004, Wolters Kluwer Health

    Professor Jose Jalife

  201. Cholinergic atrial fibrillation: IK,ACh gradients determine unequal left/right atrial frequencies and rotor dynamics

    Article • Cardiovascular Research, October 2003, European Society of Cardiology

    Professor Jose Jalife

  202. Proceedings of the Third International Workshop on Computer Simulation and Experimental Assessment of Cardiac Electrical Function

    Article • Journal of Cardiovascular Electrophysiology, October 2003, Wiley

    Professor Jose Jalife

  203. Synthesis of Voltage-Sensitive Fluorescence Signals from Three-Dimensional Myocardial Activation Patterns

    Article • Biophysical Journal, October 2003, Elsevier

    Professor Jose Jalife

  204. Intra-Atrial Pressure Increases Rate and Organization of Waves Emanating From the Superior Pulmonary Veins During Atrial Fibrillation

    Article • Circulation, August 2003, Wolters Kluwer Health

    Professor Jose Jalife

  205. Blockade of the Inward Rectifying Potassium Current Terminates Ventricular Fibrillation in the Guinea Pig Heart

    Article • Journal of Cardiovascular Electrophysiology, June 2003, Wiley

    Professor Jose Jalife

  206. Wavebreak Formation During Ventricular Fibrillation in the Isolated, Regionally Ischemic Pig Heart

    Article • Circulation Research, March 2003, Wolters Kluwer Health

    Professor Jose Jalife

  207. Article • Journal of Interventional Cardiac Electrophysiology, January 2003, Springer Science + Business Media

    Professor Jose Jalife

  208. Article • Journal of Interventional Cardiac Electrophysiology, January 2003, Springer Science + Business Media

    Professor Jose Jalife

  209. WAVES IN EXCITABLE MEDIA: EFFECTS OF WAVE GEOMETRY

    Article • International Journal of Bifurcation and Chaos, September 2002, World Scientific Pub Co Pte Lt

    Professor Jose Jalife

  210. Frequency-Dependent Breakdown of Wave Propagation Into Fibrillatory Conduction Across the Pectinate Muscle Network in the Isolated Sheep Right Atrium

    Article • Circulation Research, June 2002, Wolters Kluwer Health

    Professor Jose Jalife

  211. Minimal principle for rotor filaments

    Article • Proceedings of the National Academy of Sciences, June 2002, Proceedings of the National Academy of Sciences

    Professor Jose Jalife

  212. Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillation

    Article • Cardiovascular Research, May 2002, European Society of Cardiology

    Professor Jose Jalife

  213. Rectification of the Background Potassium Current

    Article • Circulation Research, December 2001, Wolters Kluwer Health

    Professor Jose Jalife

  214. New approaches to antiarrhythmic therapy; emerging therapeutic applications of the cell biology of cardiac arrhythmias

    Article • European Heart Journal, December 2001, European Society of Cardiology

    Professor Jose Jalife

  215. Standing Excitation Waves in the Heart Induced by Strong Alternating Electric Fields

    Article • Physical Review Letters, October 2001, American Physical Society (APS)

    Professor Jose Jalife

  216. Report of the NASPE/NHLBI Round Table on Future Research Directions in Atrial Fibrillation

    Article • Pacing and Clinical Electrophysiology, September 2001, Wiley

    Professor Jose Jalife

  217. Action Potential Characteristics and Arrhythmogenic Properties of the Cardiac Conduction System of the Murine Heart

    Article • Circulation Research, August 2001, Wolters Kluwer Health

    Professor Jose Jalife

  218. Null Mutation of Connexin43 Causes Slow Propagation of Ventricular Activation in the Late Stages of Mouse Embryonic Development

    Article • Circulation Research, June 2001, Wolters Kluwer Health

    Professor Jose Jalife

  219. Shaping of a scroll wave filament by cardiac fibers

    Article • May 2001, American Physical Society (APS)

    Professor Jose Jalife

  220. Mechanisms underlying ventricular tachycardia and its transition to ventricular fibrillation in the structurally normal heart

    Article • Cardiovascular Research, May 2001, European Society of Cardiology

    Professor Jose Jalife