Uncertainty and variability in computational and mathematical models of cardiac physiology

What is it about?

There are many things that make us uncertain about how much to trust the results of simulations of the heart. Here we describe the many sources and how we might begin to quantify our certainty that the simulations capture the correct behaviour.

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Why is it important?

Cardiac simulations are beginning to be used for what are called 'safety criticial' predictions - for drug safety and for guiding doctors' treatments in the clinic. For these applications we really need to be able to assign probabilities to the different outcomes that may occur.