All Stories

  1. <i>Ex vivo</i> correction of severe coagulation Factor VII deficiency in patient-derived 3D liver organoids

    Article • Haematologica, October 2025, Ferrata Storti Foundation (Haematologica)

    Dr gareth John sullivan

  2. Effect of hypoxia on aquaporins and hepatobiliary transport systems in human hepatic cells

    Article • Pediatric Research, June 2024, Springer Science + Business Media

    Dr gareth John sullivan

  3. Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

    Article • Biomaterials and Biosystems, June 2024, Elsevier

    Dr gareth John sullivan

  4. Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform

    Article • Journal of Pediatric Gastroenterology and Nutrition, March 2024, Wiley

    Dr gareth John sullivan

  5. Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids

    Article • Advanced Science, March 2024, Wiley

    Dr gareth John sullivan

  6. Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation

    Article • International Journal of Biological Sciences, January 2024, Ivyspring International Publisher

    Dr gareth John sullivan

  7. The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease

    Article • International Journal of Biological Sciences, January 2024, Ivyspring International Publisher

    Dr gareth John sullivan

  8. 3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation

    Article • Acta Biomaterialia, November 2023, Elsevier

    Akos Vegvari, Dr gareth John sullivan

  9. Cell line sourcing and characterization for cultured meat product development

    Article • October 2023, Burleigh Dodds Science Publishing Limited

    Dr gareth John sullivan

  10. A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment

    Article • Genome Biology, September 2023, Springer Science + Business Media

    Dr gareth John sullivan

  11. Scalable production of tissue-like vascularized liver organoids from human PSCs

    Article • Experimental & Molecular Medicine, September 2023, Springer Science + Business Media

    Dr gareth John sullivan

  12. Deoxyribonucleoside treatment rescues EtBr‐induced mtDNA depletion in iPSC‐derived neural stem cells with POLG mutations

    Article • The FASEB Journal, August 2023, Wiley

    Dr gareth John sullivan, Dr. Jessica Furriol

  13. Sensitivity of endogenous autofluorescence in HeLa cells to the application of external magnetic fields

    Article • Scientific Reports, July 2023, Springer Science + Business Media

    Dr gareth John sullivan

  14. POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia

    Article • Experimental Neurology, July 2023, Elsevier

    Dr gareth John sullivan

  15. Aagenaes syndrome/lymphedema cholestasis syndrome 1 is caused by a founder variant in the 5’-untranslated region of UNC45A

    Article • Journal of Hepatology, June 2023, Elsevier

    Dr gareth John sullivan

  16. “iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives”

    Article • Frontiers in Physiology, January 2023, Frontiers

    Dr gareth John sullivan

  17. “Organ-in-a-Column” Coupled On-line with Liquid Chromatography-Mass Spectrometry

    Article • Analytical Chemistry, December 2022, American Chemical Society (ACS)

    Dr gareth John sullivan

  18. Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations

    Article • Cell Cycle, July 2022, Taylor & Francis

    Dr gareth John sullivan

  19. Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview

    Article • Frontiers in Pharmacology, June 2022, Frontiers

    Dr gareth John sullivan

  20. POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition

    Article • Cell Cycle, March 2022, Taylor & Francis

    Dr gareth John sullivan

  21. Autophagy modulates cell fate decisions during lineage commitment

    Article • Autophagy, December 2021, Taylor & Francis

    Dr gareth John sullivan

  22. Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model

    Article • Frontiers in Cell and Developmental Biology, October 2021, Frontiers

    Dr gareth John sullivan

  23. 3D Printed Tooling for Injection Molded Microfluidics

    Article • Macromolecular Materials and Engineering, October 2021, Wiley

    Dr gareth John sullivan

  24. Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations

    Article • Frontiers in Cell and Developmental Biology, September 2021, Frontiers

    Dr gareth John sullivan

  25. Distinct mitochondrial remodeling during early cardiomyocyte development in a human-based stem cell model

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Dr gareth John sullivan

  26. ADVANCED PRECLINICAL MODELS FOR EVALUATION OF DRUG INDUCED LIVER INJURY - CONSENSUS STATEMENT BY THE EUROPEAN DRUG-INDUCED LIVER INJURY NETWORK [PRO-EURO-DILI-NET]

    Article • Journal of Hepatology, June 2021, Elsevier

    Dr gareth John sullivan

  27. Liver Organoids: Recent Developments, Limitations and Potential

    Article • Frontiers in Medicine, May 2021, Frontiers

    Dr gareth John sullivan

  28. Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities

    Article • Cell Reports Medicine, April 2021, Elsevier

    Dr gareth John sullivan

  29. N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation

    Article • Experimental Neurology, March 2021, Elsevier

    Dr gareth John sullivan

  30. Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies

    Article • Analytical Chemistry, February 2021, American Chemical Society (ACS)

    Dr gareth John sullivan

  31. How well do brain organoids capture your brain?

    Article • iScience, February 2021, Elsevier

    Dr gareth John sullivan

  32. Stem cell derived astrocytes with POLG mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neurons

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Dr gareth John sullivan, Dr. Jessica Furriol

  33. Scalable production of tissue-like vascularised liver organoids from human PSCs

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Dr gareth John sullivan

  34. Characterizing Coagulation FVII from iPSC-Hepatocytes-like Cells: Setting the Basis for Cell Therapy Development

    Article • Blood, November 2020, American Society of Hematology

    Dr gareth John sullivan

  35. A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates

    Article • Scientific Reports, October 2020, Springer Science + Business Media

    Dr gareth John sullivan

  36. “Organoid-in-a-column” coupled on-line with liquid chromatography-mass spectrometry

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr gareth John sullivan

  37. Disease‐specific phenotypes in iPSC ‐derived neural stem cells with POLG mutations

    Article • EMBO Molecular Medicine, August 2020, EMBO

    Dr gareth John sullivan, Dr. Jessica Furriol

  38. Scalable small molecule derived mini-liver organoids from human pluripotent stem cells

    Article • Journal of Hepatology, August 2020, Elsevier

    Dr gareth John sullivan

  39. Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons

    Article • Molecular Cell, July 2020, Elsevier

    Dr gareth John sullivan

  40. Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr gareth John sullivan

  41. Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain

    Article • Cell Reports, February 2020, Elsevier

    Dr gareth John sullivan

  42. 3D cell culture models and organ‐on‐a‐chip: Meet separation science and mass spectrometry

    Article • Electrophoresis, September 2019, Wiley

    Dr gareth John sullivan

  43. Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties

    Article • Scientific Reports, September 2019, Springer Science + Business Media

    Dr gareth John sullivan

  44. Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells

    Article • Frontiers in Physiology, November 2018, Frontiers

    Dr gareth John sullivan

  45. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

    Article • Nature Communications, July 2018, Springer Science + Business Media

    Dr gareth John sullivan, Jonghwan Kim

  46. Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth

    Article • Scientific Reports, April 2018, Springer Science + Business Media

    Dr gareth John sullivan

  47. Rapid Screening of the Endodermal Differentiation Potential of Human Pluripotent Stem Cells

    Article • November 2017, Wiley

    Dr gareth John sullivan

  48. Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies

    Article • npj Regenerative Medicine, October 2017, Springer Science + Business Media

    Dr gareth John sullivan

  49. Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification

    Article • Journal of the American Heart Association, September 2017, Wolters Kluwer Health

    Dr gareth John sullivan, Arkady Rutkovskiy, Anna Malashicheva

  50. Future Challenges in the Generation of Hepatocyte-Like Cells From Human Pluripotent Stem Cells

    Article • Current Pathobiology Reports, July 2017, Springer Science + Business Media

    Dr gareth John sullivan

  51. Development of an inducible platform for intercellular protein delivery

    Article • International Journal of Pharmaceutics, April 2017, Elsevier

    Dr gareth John sullivan

  52. Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Dr gareth John sullivan

  53. Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines

    Article • Scientific Reports, November 2016, Springer Science + Business Media

    Dr gareth John sullivan

  54. Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells

    Article • August 2016, Wiley

    Dr gareth John sullivan

  55. Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly

    Article • Stem Cells Translational Medicine, July 2016, Wiley

    Dr gareth John sullivan

  56. Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

    Article • Stem Cell Reports, May 2015, Elsevier

    Dr gareth John sullivan

  57. Investigation of Rett syndrome using pluripotent stem cells

    Article • Journal of Cellular Biochemistry, September 2013, Wiley

    Dr gareth John sullivan

  58. Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells"

    Article • Science Translational Medicine, June 2013, American Association for the Advancement of Science

    Dr gareth John sullivan

  59. Modelling Human Disease with Pluripotent Stem Cells

    Article • Current Gene Therapy, March 2013, Bentham Science Publishers

    Dr gareth John sullivan

  60. FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA

    Article • Cell Reports, October 2012, Elsevier

    Dr gareth John sullivan

  61. Cellular reprogramming: a novel tool for investigating autism spectrum disorders

    Article • Trends in Molecular Medicine, August 2012, Elsevier

    Dr gareth John sullivan

  62. Role of Pluripotent Stem Cells in Regenerative Medicine

    Article • April 2012, Taylor & Francis

    Dr gareth John sullivan

  63. Regenerative Medicine, Stem Cells and the Liver

    Article • April 2012, Taylor & Francis

    Dr gareth John sullivan

  64. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

    Article • Proceedings of the National Academy of Sciences, March 2012, Proceedings of the National Academy of Sciences

    Dr gareth John sullivan

  65. Humanized murine model for HBV and HCV using human induced pluripotent stem cells

    Article • Archives of Pharmacal Research, February 2012, Springer Science + Business Media

    Dr gareth John sullivan

  66. Lineage-specific distribution of high levels of genomic

    Article • BDJ, July 2011, Springer Science + Business Media

    Dr gareth John sullivan

  67. The evolving biology of cell reprogramming

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, July 2011, Royal Society Publishing

    Dr gareth John sullivan

  68. Biomedical and social contributions to sustainability

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, April 2011, Royal Society Publishing

    Dr gareth John sullivan

  69. Induced pluripotent stem cells: epigenetic memories and practical implications

    Article • Molecular Human Reproduction, November 2010, Oxford University Press (OUP)

    Dr gareth John sullivan

  70. Hepatic Endoderm Differentiation from Human Embryonic Stem Cells

    Article • Current Stem Cell Research & Therapy, September 2010, Bentham Science Publishers

    Dr gareth John sullivan

  71. What are the limits to cell plasticity?

    Article • BDJ, May 2010, Nature

    Dr gareth John sullivan

  72. Generation of functional human hepatic endoderm from human induced pluripotent stem cells

    Article • Hepatology, September 2009, Wiley

    Dr gareth John sullivan

  73. A decade of progress since the birth of Dolly

    Article • Reproduction Fertility and Development, January 2009, CSIRO Publishing

    Dr gareth John sullivan

  74. UBF Binding In Vivo Is Not Restricted to Regulatory Sequences within the Vertebrate Ribosomal DNA Repeat

    Article • Molecular and Cellular Biology, January 2002, ASM Journals

    Dr gareth John sullivan

  75. Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli

    Article • The EMBO Journal, June 2001, Wiley

    Dr gareth John sullivan

  76. Dimerization and HMG box domains 1-3 present in Xenopus UBF are sufficient for its role in transcriptional enhancement

    Article • Nucleic Acids Research, August 1998, Oxford University Press (OUP)

    Dr gareth John sullivan

  77. The Xenopus RNA polymerase I transcription factor, UBF, has a role in transcriptional enhancement distinct from that at the promoter

    Article • The EMBO Journal, January 1997, Wiley

    Dr gareth John sullivan

  78. Nucleotide sequence of a repetitive element isolated from Leptospira interrogans serovar hardjo type hardjo-bovis

    Article • Journal of General Microbiology, May 1991, Society for General Microbiology

    Dr gareth John sullivan

  79. Development of a PCR test specific for Leptospira hardjo genotype bovis

    Article • Veterinary Record, March 1991, Wiley

    Dr gareth John sullivan