Dr Juan Francisco Leon

All Stories

1. 
   Design and Semisynthesis of Aminocannabinoids as Neurological Magic Shotguns

   Article • Journal of Natural Products, December 2025, American Chemical Society (ACS)

   Dr Juan Francisco Leon

2. 
   Dillapiole Dampens the Expression of the Major Virulence Genes of Francisella tularensis

   Article • Molecules, October 2025, MDPI AG

   Dr Juan Francisco Leon

3. 
   Cardio-pulmonary arrest in a patient revived with naloxone following reported use of 7-hydroxymitragynine

   Article • Journal of Toxicology Clinical Toxicology, September 2025, Taylor & Francis

   Dr Juan Francisco Leon

4. 
   From Kratom to Semi‐Synthetic Opioids: The Rise and Risks of MGM‐15

   Article • Drug Testing and Analysis, September 2025, Wiley

   Dr Juan Francisco Leon

5. 
   Uncaria attenuata and its main corynanthean alkaloid, villocarine A, exert antinociceptive effects in rats via activation of central μ-opioid receptors

   Article • Journal of Ethnopharmacology, September 2025, Elsevier

   Dr Juan Francisco Leon

6. 
   Effects of kratom alkaloids on mesolimbic dopamine release

   Article • Neuroscience Letters, February 2025, Elsevier

   Dr Juan Francisco Leon

7. 
   Semi-Synthesis of Dimeric Cannabidiol Derivatives and Evaluation of their Affinity at Neurological Targets

   Article • Journal of Natural Products, January 2025, American Chemical Society (ACS)

   Dr Juan Francisco Leon

8. 
   The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α2 receptor activity in vitro and in vivo

   Article • European Journal of Pharmacology, October 2024, Elsevier

   Dr Juan Francisco Leon

9. 
   Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones

   Article • ACS Medicinal Chemistry Letters, April 2024, American Chemical Society (ACS)

   Dr Juan Francisco Leon

10. 
    Therapeutics to Treat Psychiatric and Neurological Disorders: A Promising Perspective from Algerian Traditional Medicine

    Article • Plants, November 2023, MDPI AG

    Dr Juan Francisco Leon

11. 
    Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2023, Elsevier

    Dr Juan Francisco Leon

12. 
    The Polypharmacological Effects of Cannabidiol

    Article • Molecules, April 2023, MDPI AG

    Dr Juan Francisco Leon

13. 
    Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies

    Article • Metabolites, March 2023, MDPI AG

    Dr Juan Francisco Leon

14. 
    Directed Biosynthesis of Mitragynine Stereoisomers

    Article • Journal of the American Chemical Society, February 2023, American Chemical Society (ACS)

    Dr Juan Francisco Leon

15. 
    Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer

    Article • International Journal of Biological Sciences, January 2023, Ivyspring International Publisher

    Dr Juan Francisco Leon

16. 
    Interactive Effects of µ-Opioid and Adrenergic-α2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine

    Article • Journal of Pharmacology and Experimental Therapeutics, December 2022, Elsevier

    Dr Juan Francisco Leon

17. 
    Metabolism of Speciociliatine, an Overlooked Kratom Alkaloid for its Potential Pharmacological Effects

    Article • The AAPS Journal, July 2022, Springer Science + Business Media

    Dr Juan Francisco Leon

18. 
    Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma

    Article • Molecules, July 2022, MDPI AG

    Dr Juan Francisco Leon

19. 
    Plant growth and phytoactive alkaloid synthesis in kratom [Mitragyna speciosa (Korth.)] in response to varying radiance

    Article • PLOS One, April 2022, PLOS

    Dr Juan Francisco Leon

20. 
    The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study

    Article • Drug Metabolism and Disposition, February 2022, Elsevier

    Dr Juan Francisco Leon

21. 
    Plant growth and phytoactive alkaloid synthesis in Mitragyna speciosa (kratom) in response to varying radiance

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Dr Juan Francisco Leon

22. 
    Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors

    Article • Biomedicines, September 2021, MDPI AG

    Dr Juan Francisco Leon

23. 
    Activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors

    Article • Journal of Medicinal Chemistry, September 2021, American Chemical Society (ACS)

    Dr Juan Francisco Leon

24. 
    Correction to “Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery”

    Article • Journal of Medicinal Chemistry, July 2021, American Chemical Society (ACS)

    Dr Juan Francisco Leon

25. 
    Structure–Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of rac-5β-Hydroxy-d-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action

    Article • Molecules, July 2021, MDPI AG

    Dr Juan Francisco Leon

26. 
    Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery

    Article • Journal of Medicinal Chemistry, May 2021, American Chemical Society (ACS)

    Dr Juan Francisco Leon

27. 
    Assessment of Contribution of 7‐Hydroxymitragynine and Mitragynine Pseudoindoxyl to the MU‐Opioid Activity of Mitragynine

    Article • The FASEB Journal, May 2021, Wiley

    Dr Juan Francisco Leon

28. 
    Mitragynine Attenuates the Development of Tolerance to and Withdrawal from Morphine in Rats

    Article • The FASEB Journal, May 2021, Wiley

    Dr Juan Francisco Leon

29. 
    Pharmacological Characterization of Mitragynine: Antinociception, Respiratory Depression, Self‐Administration, Drug Discrimination, Tolerance, and withdrawal in Rats

    Article • The FASEB Journal, May 2021, Wiley

    Dr Juan Francisco Leon

30. 
    Serotonin 5‐HT 1A Receptor Activity of Kratom Alkaloids Mitragynine, Paynantheine, and Speciogynine

    Article • The FASEB Journal, May 2021, Wiley

    Dr Juan Francisco Leon

31. 
    The Lofexidine‐Like Discriminative Effects of the Primary Kratom Alkaloid Mitragynine in Rats

    Article • The FASEB Journal, May 2021, Wiley

    Dr Juan Francisco Leon

32. 
    Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine

    Article • European Journal of Drug Metabolism and Pharmacokinetics, April 2021, Springer Science + Business Media

    Dr Juan Francisco Leon

33. 
    Coumarins and other constituents from Deverra battandieri

    Article • Phytochemistry Letters, April 2021, Elsevier

    Dr Juan Francisco Leon

34. 
    Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats

    Article • Journal of Pharmacology and Experimental Therapeutics, March 2021, Elsevier

    Dr Juan Francisco Leon

35. 
    Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors

    Article • Journal of Natural Products, February 2021, American Chemical Society (ACS)

    Dr Juan Francisco Leon

36. 
    Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats

    Article • Journal of Natural Products, February 2021, American Chemical Society (ACS)

    Dr Juan Francisco Leon

37. 
    Proposed Mechanism for the Antitrypanosomal Activity of Quercetin and Myricetin Isolated from Hypericum afrum Lam.: Phytochemistry, In Vitro Testing and Modeling Studies

    Article • Molecules, February 2021, MDPI AG

    Dr Juan Francisco Leon

38. 
    Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2021, Elsevier

    Dr Juan Francisco Leon

39. 
    Kratom (Mitragyna speciosa Korth.): A description on the ethnobotany, alkaloid chemistry, and neuropharmacology

    Article • January 2021, Elsevier

    Dr Juan Francisco Leon

40. 
    Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells

    Article • International Journal of Molecular Sciences, December 2020, MDPI AG

    Dr Juan Francisco Leon

41. 
    Effects of Nutrient Fertility on Growth and Alkaloidal Content in Mitragyna speciosa (Kratom)

    Article • Frontiers in Plant Science, December 2020, Frontiers

    Dr Juan Francisco Leon

42. 
    Challenges and future directions of potential natural products leads against 2019-nCoV outbreak

    Article • Current Plant Biology, December 2020, Elsevier

    Dr Juan Francisco Leon

43. 
    Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence

    Article • Drug and Alcohol Dependence, November 2020, Elsevier

    Dr Juan Francisco Leon

44. 
    Evaluation of the rewarding effects of mitragynine and 7‐hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats

    Article • Drug and Alcohol Dependence, October 2020, Elsevier

    Dr Juan Francisco Leon

45. 
    Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

    Article • ACS Pharmacology & Translational Science, July 2020, American Chemical Society (ACS)

    Dr Juan Francisco Leon

46. 
    Pharmacokinetics and Safety of Mitragynine in Beagle Dogs

    Article • Planta Medica, July 2020, Thieme Publishing Group

    Dr Juan Francisco Leon

47. 
    Characterization of Chemical Compounds and Antioxidant Activity of Centaurea solstitialis sp. schouwii (DC.) Q. et S. (Asteraceae)

    Article • Current Bioactive Compounds, July 2020, Bentham Science Publishers

    Djamel SARRI, Dr Juan Francisco Leon

48. 
    3-O-Formyl -27-Hydroxyfusidic Acid: A New Metabolite of Fusidic Acid by Cunninghamella echinulata

    Article • Records of Natural Products, March 2020, ACG Publications

    Dr Juan Francisco Leon

49. 
    Patterns and reasons for kratom (Mitragyna speciosa) use among current and former opioid poly-drug users

    Article • Journal of Ethnopharmacology, March 2020, Elsevier

    Dr Juan Francisco Leon

50. 
    Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids

    Article • Toxicology Letters, February 2020, Elsevier

    Dr Juan Francisco Leon

51. 
    Bioanalytical method development and validation of corynantheidine, a kratom alkaloid, using UPLC-MS/MS, and its application to preclinical pharmacokinetic studies

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2020, Elsevier

    Dr Juan Francisco Leon

52. 
    Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

    Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

    Dr Juan Francisco Leon

53. 
    Total Phenolic and Flavonoid Content and Biological Activities of Extracts and Isolated Compounds of Cytisus villosus Pourr.

    Article • Biomolecules, November 2019, MDPI AG

    Dr Juan Francisco Leon

54. 
    Perspective on the Therapeutics of Anti-Snake Venom

    Article • Molecules, September 2019, MDPI AG

    Dr Juan Francisco Leon

55. 
    The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats

    Article • Psychopharmacology, May 2019, Springer Science + Business Media

    Dr Juan Francisco Leon

56. 
    Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra‐performance liquid chromatography−tandem mass spectrometry

    Article • Drug Testing and Analysis, May 2019, Wiley

    Dr Juan Francisco Leon

57. 
    Motives for using Kratom (Mitragyna speciosa Korth.) among regular users in Malaysia

    Article • Journal of Ethnopharmacology, April 2019, Elsevier

    Dr Juan Francisco Leon

58. 
    Computationally aided stereochemical assignment of undescribed bisabolenes from Calea urticifolia

    Article • Phytochemistry, January 2019, Elsevier

    Dr Juan Francisco Leon

59. 
    Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)

    Article • Xenobiotica, December 2018, Taylor & Francis

    Dr Juan Francisco Leon, Shyam Kamble

60. 
    Centaurea microcarpa Coss. & Dur. (Asteraceae) extracts: New cyanogenic glucoside and other constituents

    Article • Natural Product Research, November 2018, Taylor & Francis

    thamere cheriet, Dr Juan Francisco Leon, Djamel SARRI

61. 
    Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats

    Article • Planta Medica, November 2018, Thieme Publishing Group

    Dr Juan Francisco Leon

62. 
    Humulene derivatives from Saharian Asteriscus graveolens

    Article • Tetrahedron Letters, July 2018, Elsevier

    Dr Juan Francisco Leon

63. 
    Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine

    Article • Addiction Biology, June 2018, Wiley

    Dr Juan Francisco Leon

64. 
    Secondary metabolites from two Hispaniola Ageratina species and their cytotoxic activity

    Article • Medicinal Chemistry Research, May 2018, Springer Science + Business Media

    Dr Juan Francisco Leon

65. 
    3′-Hydroxy-3,4′-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK

    Article • Chemico-Biological Interactions, May 2018, Elsevier

    Dr Juan Francisco Leon

66. 
    Isolation, Antioxidant and Antimicrobial Activities of Ecdysteroids from Serratula cichoracea

    Article • Current Bioactive Compounds, April 2018, Bentham Science Publishers

    habiba larguet, Dr Juan Francisco Leon

67. 
    Secondary metabolites from the aerial parts of Cytisus villosus Pourr.

    Article • Phytochemistry Letters, April 2018, Elsevier

    Dr Juan Francisco Leon

68. 
    Evaluation of triazole and isoxazole derivatives as potential anti-infective agents

    Article • Medicinal Chemistry Research, February 2018, Springer Science + Business Media

    Dr Juan Francisco Leon

69. 
    Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants

    Article • Phytomedicine, February 2018, Elsevier

    Dr Juan Francisco Leon

70. 
    3′-Hydroxy-3,4′-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells

    Article • Bioorganic & Medicinal Chemistry, November 2017, Elsevier

    Dr Juan Francisco Leon

71. 
    Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor

    Article • Journal of Chemical Information and Modeling, January 2017, American Chemical Society (ACS)

    Dr Juan Francisco Leon

72. 
    Interactions of Desmethoxyyangonin, a Secondary Metabolite fromRenealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B

    Article • Evidence-based Complementary and Alternative Medicine, January 2017, Hindawi Publishing Corporation

    Dr Juan Francisco Leon, Babu Tekwani

73. 
    Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B

    Article • Journal of Natural Products, October 2016, American Chemical Society (ACS)

    Dr Juan Francisco Leon

74. 
    Components and antioxidant, anti-inflammatory, anti-ulcer and antinociceptive activities of the endemic species Stachys mialhesi de Noé

    Article • Arabian Journal of Chemistry, September 2016, Elsevier

    Dr Juan Francisco Leon

75. 
    Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance

    Article • Journal of Natural Products, May 2016, American Chemical Society (ACS)

    Dr Juan Francisco Leon

76. 
    Secondary Metabolites, Evaluation of the DPPH Free-Radical Scavenging Effect by Electron Spin Resonance and Antibacterial Activity of the Endemic Species Stachys circinata

    Article • Chemistry of Natural Compounds, April 2016, Springer Science + Business Media

    Dr Juan Francisco Leon

77. 
    Secondary Metabolites and Antioxidant Activity of Limonium duriusculum (de Girard) Kuntze Extracts

    Article • Asian Journal of Chemistry, January 2016, Asian Journal of Chemistry

    Dr Juan Francisco Leon

78. 
    In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower

    Article • Journal of Ethnopharmacology, November 2015, Elsevier

    Dr Juan Francisco Leon

79. 
    Secondary Metabolites from Linaria tingitana

    Article • Chemistry of Natural Compounds, November 2015, Springer Science + Business Media

    Dr Juan Francisco Leon

80. 
    In vitro opioid receptor displacement affinity and in vitro behavioral studies by tetrad assay of Nelumbo nucifera flower

    Article • Planta Medica, June 2015, Thieme Publishing Group

    Dr Juan Francisco Leon

81. 
    Isolation of acacetin from Calea urticifolia as a potent inhibitor of human monoamine oxidase-A and B

    Article • Planta Medica, June 2015, Thieme Publishing Group

    Dr Juan Francisco Leon

82. 
    Isolation, chemical profiling, and standardization of betaine, choline, acetylcholine, and 20-hydroxyecdysone from Atriplex species

    Article • Planta Medica, June 2015, Thieme Publishing Group

    Dr Juan Francisco Leon

83. 
    Secondary metabolites isolated from Salvia bogotensis

    Article • Planta Medica, June 2015, Thieme Publishing Group

    Dr Juan Francisco Leon

84. 
    Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors

    Article • Journal of Natural Products, June 2015, American Chemical Society (ACS)

    Dr Juan Francisco Leon

85. 
    Antinociceptive activity of extracts and secondary metabolites from wild growing and micropropagated plants of Renealmia alpinia

    Article • Journal of Ethnopharmacology, May 2015, Elsevier

    Dr Juan Francisco Leon

86. 
    Phytochemistry of Mitragyna speciosa

    Article • October 2014, Taylor & Francis

    Dr Juan Francisco Leon

87. 
    Cannabinoid and opioid radioligand displacement by secondary metabolites from Banisteriopsis caapi

    Article • Planta Medica, July 2014, Thieme Publishing Group

    Dr Juan Francisco Leon

88. 
    Investigation of Nelumbo nucifera flower for human opioid receptor displacement affinity

    Article • Planta Medica, July 2014, Thieme Publishing Group

    Dr Juan Francisco Leon

89. 
    Phenolic compounds, antioxidant activity and ultrastructural study from Protea hybrid ‘Susara’

    Article • Industrial Crops and Products, April 2014, Elsevier

    Dr Juan Francisco Leon

90. 
    Flavanones from Miconia prasina

    Article • Phytochemistry Letters, February 2014, Elsevier

    Dr Juan Francisco Leon

91. 
    Secondary Metabolites from Eupenicillium parvum and Their in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors

    Article • Planta Medica, November 2013, Thieme Publishing Group

    Dr Juan Francisco Leon

92. 
    Fatty Acids with in Vitro Binding Affinity for Human Opioid Receptors from the Fungus Emericella nidulans

    Article • Journal of Agricultural and Food Chemistry, October 2013, American Chemical Society (ACS)

    Dr Juan Francisco Leon

93. 
    Correction to Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors

    Article • Journal of Natural Products, October 2013, American Chemical Society (ACS)

    Dr Juan Francisco Leon

94. 
    A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands

    Article • Phytochemistry, August 2013, Elsevier

    Dr Juan Francisco Leon

95. 
    New strategy toward the diverted synthesis of oxidized abietane diterpenes via oxidation of 6,7-dehydroferruginol methyl ether with dimethyldioxirane

    Article • Tetrahedron Letters, August 2013, Elsevier

    Dr Juan Francisco Leon, Dr. José M. Padrón

96. 
    Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors

    Article • Journal of Natural Products, May 2013, American Chemical Society (ACS)

    Dr Juan Francisco Leon

97. 
    A New Flavonoid C-Glycoside from Solanum elaeagnifolium with Hepatoprotective and Curative Activities against Paracetamol- Induced Liver Injury in Mice

    Article • Zeitschrift für Naturforschung C, February 2013, De Gruyter

    Dr Juan Francisco Leon

98. 
    A New Flavonoid C-Glycoside from Solanum elaeagnifolium with Hepatoprotective and Curative Activities against Paracetamol-Induced Liver Injury in Mice

    Article • Zeitschrift für Naturforschung C, January 2013, De Gruyter

    Dr Juan Francisco Leon

99. 
    Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells

    Article • Biochemical and Biophysical Research Communications, November 2012, Elsevier

    Dr Juan Francisco Leon

100. 
     Secondary Metabolites from Two Species of Tolpis and Their Biological Activities

     Article • Molecules, November 2012, MDPI AG

     Dr Juan Francisco Leon

101. 
     Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

     Article • European Journal of Medicinal Chemistry, September 2012, Elsevier

     Dr Juan Francisco Leon

102. 
     Cytotoxic sesquiterpene lactones and other constituents of Centaurea omphalotricha

     Article • Journal of the Brazilian Chemical Society, May 2012, FapUNIFESP (SciELO)

     Dr Juan Francisco Leon

103. 
     A new flavonoid and other constituents fromCentaurea nicaeensisAll. var.wallianaM.

     Article • Natural Product Research, February 2012, Taylor & Francis

     Dr Juan Francisco Leon

104. 
     Phytochemical study of Halimium halimifolium

     Article • Chemistry of Natural Compounds, January 2012, Springer Science + Business Media

     Dr Juan Francisco Leon

105. 
     Antifungal Metabolites from the Roots of Diospyros virginiana by Overpressure Layer Chromatography

     Article • Chemistry & Biodiversity, December 2011, Wiley

     Dr Juan Francisco Leon

106. 
     Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens

     Article • Medicinal Chemistry Research, November 2011, Springer Science + Business Media

     Dr Juan Francisco Leon

107. 
     Secondary Metabolites from Two Species of Pulicaria and Their Cytotoxic Activity

     Article • Chemistry & Biodiversity, November 2011, Wiley

     Dr Juan Francisco Leon

108. 
     Benzyl Derivatives within VitroBinding Affinity for Human Opioid and Cannabinoid Receptors from the FungusEurotium repens

     Article • Journal of Natural Products, July 2011, American Chemical Society (ACS)

     Dr Juan Francisco Leon

109. 
     Flavonoid aglycones and sterol from Chrysanthemum fontanesii

     Article • Chemistry of Natural Compounds, March 2011, Springer Science + Business Media

     Dr Juan Francisco Leon

110. 
     Flavonoid aglycones from Centaurea maroccana

     Article • Chemistry of Natural Compounds, March 2011, Springer Science + Business Media

     Dr Juan Francisco Leon

111. 
     Chemotaxonomy of Gonospermum and related genera

     Article • Phytochemistry, April 2010, Elsevier

     Dr Juan Francisco Leon

112. 
     Four flavonoids from the aerial part of Ononis angustissima species

     Article • Chemistry of Natural Compounds, November 2009, Springer Science + Business Media

     Dr Juan Francisco Leon

113. 
     A flavonoid with cytotoxic activity and other constituents from Centaurea africana

     Article • Phytochemistry Letters, August 2009, Elsevier

     Dr Juan Francisco Leon

114. 
     Sesquiterpene Lactones fromGonospermum gomeraeandG. fruticosumand Their Cytotoxic Activities

     Article • Journal of Natural Products, December 2008, American Chemical Society (ACS)

     Dr Juan Francisco Leon

115. 
     Mycophenolic Derivatives fromEupenicilliumparvum

     Article • Journal of Natural Products, December 2008, American Chemical Society (ACS)

     Dr Juan Francisco Leon

116. 
     Induction of G2-M phase arrest and apoptosis by α-methylene-γ-butyrolactones in human leukemia cells

     Article • Cancer Letters, September 2008, Elsevier

     Dr Juan Francisco Leon

117. 
     A new guaianolide and other constituents from Achillea ligustica

     Article • Biochemical Systematics and Ecology, May 2008, Elsevier

     Dr Juan Francisco Leon

118. 
     Synthesis of novel spirostanic saponins and their cytotoxic activity

     Article • Bioorganic & Medicinal Chemistry, February 2008, Elsevier

     Dr Juan Francisco Leon

119. 
     The Presence of Capsule in Cryptococcus neoformans Influences the Gene Expression Profile in Dendritic Cells during Interaction with the Fungus

     Article • Infection and Immunity, February 2008, ASM Journals

     Dr Juan Francisco Leon

120. 
     A New Ceramide fromSuillus luteus and Its Cytotoxic Activity against Human Melanoma Cells

     Article • Chemistry & Biodiversity, January 2008, Wiley

     Dr Juan Francisco Leon

121. 
     Sesquiterpene lactones and other constituents from Matricaria chamomilla L.

     Article • Biochemical Systematics and Ecology, August 2007, Elsevier

     Dr Juan Francisco Leon

122. 
     Revisiting the Reaction Between Diaminomaleonitrile and Aromatic Aldehydes: a Green Chemistry Approach

     Article • Molecules, November 2006, MDPI AG

     Dr Juan Francisco Leon

123. 
     Synthesis and antiproliferative activity of novel sugiol β-amino alcohol analogs

     Article • European Journal of Medicinal Chemistry, November 2006, Elsevier

     Dr Juan Francisco Leon, Dr. José M. Padrón

124. 
     Isolation, Structure Elucidation, Total Synthesis, and Evaluation of New Natural and Synthetic Ceramides on Human SK-MEL-1 Melanoma Cells

     Article • Journal of Medicinal Chemistry, September 2006, American Chemical Society (ACS)

     Dr Juan Francisco Leon

125. 
     A Homo-Isoflavonoid and a Cytotoxic Saponin fromDracaena draco

     Article • Chemistry & Biodiversity, January 2006, Wiley

     Dr Juan Francisco Leon

126. 
     A new guaianolide and other sesquiterpene lactones from Centaurea acaulis L. (Asteraceae)

     Article • Biochemical Systematics and Ecology, October 2005, Elsevier

     Dr Juan Francisco Leon

127. 
     Sesquiterpenoids fromPulicariacanariensisand Their Cytotoxic Activities#

     Article • Journal of Natural Products, April 2005, American Chemical Society (ACS)

     Dr Juan Francisco Leon

128. 
     Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity

     Article • Phytochemistry, March 2005, Elsevier

     Dr Juan Francisco Leon

129. 
     Lanostanoid Triterpenes fromLaetiporussulphureusand Apoptosis Induction on HL-60 Human Myeloid Leukemia Cells

     Article • Journal of Natural Products, December 2004, American Chemical Society (ACS)

     Dr Juan Francisco Leon

130. 
     Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

     Article • Bioorganic & Medicinal Chemistry, August 2004, Elsevier

     Dr Juan Francisco Leon

131. 
     Isolation fromEucalyptusoccidentalisand Identification of a New Kaempferol Derivative that Induces Apoptosis in Human Myeloid Leukemia Cells

     Article • Journal of Natural Products, April 2004, American Chemical Society (ACS)

     Dr Juan Francisco Leon

132. 
     Flavans of dragon’s blood from Dracaena draco and Dracaena tamaranae

     Article • Biochemical Systematics and Ecology, February 2004, Elsevier

     Dr Juan Francisco Leon

133. 
     Novel Cytostatic Lanostanoid Triterpenes fromGanoderma australe

     Article • Helvetica Chimica Acta, September 2003, Wiley

     Dr Juan Francisco Leon

134. 
     Sesquiterpenoid Derivatives fromGonospermumelegansand Their Cytotoxic Activity for HL-60 Human Promyelocytic Cells#

     Article • Journal of Natural Products, July 2003, American Chemical Society (ACS)

     Dr Juan Francisco Leon

135. 
     Synthesis and Antiproliferative Activity of a New Compound Containing an α-Methylene-γ-Lactone Group

     Article • Journal of Medicinal Chemistry, June 2002, American Chemical Society (ACS)

     Dr Juan Francisco Leon

136. 
     New Lanostanoids from the FungusGanodermaconcinna

     Article • Journal of Natural Products, March 2002, American Chemical Society (ACS)

     Dr Juan Francisco Leon

137. 
     A facile chemoselective deacetylation in the presence of benzoyl and p-bromobenzoyl groups using p-toluenesulfonic acid

     Article • Tetrahedron Letters, April 2001, Elsevier

     Dr Juan Francisco Leon

138. 
     Phenolic Compounds of Dragon's Blood fromDracaenadraco

     Article • Journal of Natural Products, September 2000, American Chemical Society (ACS)

     Dr Juan Francisco Leon

139. 
     Synthesis of 2t-Substituted-1r,3c-BIS(2′-Hydroxy-5-Substituted-Benzyl)-Imidazolidines by Reaction of 1,3-BIS(2′-Hydroxy-5′-Substituted-Benzyl)-Imidazolidines with Aromatic Aldehydes

     Article • Synthetic Communications, June 2000, Taylor & Francis

     Dr Juan Francisco Leon

140. 
     Lanostanoid Triterpenes fromGanodermalucidum

     Article • Journal of Natural Products, December 1999, American Chemical Society (ACS)

     Dr Juan Francisco Leon