All Stories

  1. Modulation of energetic and lipid pathways by curcumin as a potential chemopreventive strategy in human prostate cancer cells

    Article • Biochemical and Biophysical Research Communications, November 2024, Elsevier

    Fedora Grande

  2. Multivariate Approaches in Quantitative Structure–Property Relationships Study for the Photostability Assessment of 1,4-Dihydropyridine Derivatives

    Article • Pharmaceutics, January 2024, MDPI AG

    Fedora Grande

  3. Molecular Docking Studies and In Vitro Activity of Paliurus spina-christi Mill Extracts as Pancreatic Lipase Inhibitors

    Article • Antioxidants, January 2024, MDPI AG

    Fedora Grande

  4. Dissecting CYP1A2 Activation by Arylalkanoic Acid Prodrugs toward the Development of Anti-Inflammatory Agents

    Article • International Journal of Molecular Sciences, December 2023, MDPI AG

    Fedora Grande

  5. Multivariate Curve Resolution Methodology Applied to the ATR-FTIR Data for Adulteration Assessment of Virgin Coconut Oil

    Article • Molecules, June 2023, MDPI AG

    Fedora Grande

  6. Identification of Pinosylvin in Pinus nigra subsp. laricio: A Naturally Occurring Stilbenoid Suppressing LPS-Induced Expression of Pro-Inflammatory Cytokines and Mediators and Inhibiting the JAK/STAT Signaling Pathway

    Article • Pharmaceuticals, May 2023, MDPI AG

    Fedora Grande

  7. Multivariate Curve Resolution Methodology Applied to the ATR-FTIR Data for Adulteration Assessment of Virgin Coconut Oil

    Article • May 2023, MDPI AG

    Fedora Grande

  8. TiO2-NPs Toxicity and Safety: An Update of the Findings Published over the Last Six Years

    Article • Mini-Reviews in Medicinal Chemistry, May 2023, Bentham Science Publishers

    Fedora Grande

  9. Promising Perspectives of the Antiproliferative GPER Inverse Agonist ERα17p in Breast Cancer

    Article • Cells, February 2023, MDPI AG

    Fedora Grande

  10. Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents

    Article • European Journal of Medicinal Chemistry, January 2023, Elsevier

    Fedora Grande

  11. Carbazoles: Role and Functions in Fighting Diabetes

    Article • Applied Sciences, December 2022, MDPI AG

    Fedora Grande

  12. Anticancer Drugs: Recent Strategies to Improve Stability Profile, Pharmacokinetic and Pharmacodynamic Properties

    Article • Molecules, August 2022, MDPI AG

    Fedora Grande

  13. Palladium iodide catalyzed carbonylative double cyclization to a new class of S,O-bicyclic heterocycles

    Article • Catalysis Today, August 2022, Elsevier

    Fedora Grande

  14. Interaction of letrozole and its degradation products with aromatase: chemometric assessment of kinetics and structure-based binding validation

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, May 2022, Taylor & Francis

    Fedora Grande

  15. Photodegradation of Anti-Inflammatory Drugs: Stability Tests and Lipid Nanocarriers for Their Photoprotection

    Article • Molecules, October 2021, MDPI AG

    Fedora Grande

  16. Polyphenols from Citrus Tacle® Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy

    Article • Molecules, September 2021, MDPI AG

    Fedora Grande

  17. Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds

    Article • Pharmaceuticals, September 2021, MDPI AG

    Fedora Grande

  18. Toward Multitasking Pharmacological COX-Targeting Agents: Non-Steroidal Anti-Inflammatory Prodrugs with Antiproliferative Effects

    Article • Molecules, June 2021, MDPI AG

    Fedora Grande

  19. Carbazole and Simplified Derivatives: Novel Tools toward β-Adrenergic Receptors Targeting

    Article • Applied Sciences, June 2021, MDPI AG

    Vittoria Rago, Fedora Grande

  20. Cateslytin abrogates lipopolysaccharide-induced cardiomyocyte injury by reducing inflammation and oxidative stress through toll like receptor 4 interaction

    Article • International Immunopharmacology, May 2021, Elsevier

    Fedora Grande

  21. Efficacy of Red Glass in Protecting 1,4-Dihydropyridine Antihypertensive Drugs in Liquid Formulations

    Article • Applied Sciences, April 2021, MDPI AG

    Fedora Grande

  22. Use of Pluronic Surfactants in Gel Formulations of Photosensitive 1,4-Dihydropyridine Derivatives: A Potential Approach in the Treatment of Neuropathic Pain

    Article • Pharmaceutics, April 2021, MDPI AG

    Fedora Grande

  23. Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs

    Article • Biomedicines, April 2021, MDPI AG

    Fedora Grande

  24. The chromogranin A1‐373 fragment reveals how a single change in the protein sequence exerts strong cardioregulatory effects by engaging neuropilin‐1

    Article • Acta Physiologica, November 2020, Wiley

    Vittoria Rago, Fedora Grande

  25. Assessment of Surface Water Quality Using Multivariate Analysis: Case Study of the Crati River, Italy

    Article • Water, August 2020, MDPI AG

    Fedora Grande

  26. Computational Approaches for the Discovery of GPER Targeting Compounds

    Article • Frontiers in Endocrinology, August 2020, Frontiers

    Fedora Grande

  27. Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents

    Article • European Journal of Medicinal Chemistry, August 2020, Elsevier

    Dr Simone Brogi, Fedora Grande

  28. Photostability study of multicomponent drug formulations via MCR-ALS: The case of the hydrochlorothiazide-amiloride mixture

    Article • Journal of Pharmaceutical and Biomedical Analysis, July 2020, Elsevier

    Fedora Grande

  29. Carbazole Derivatives as Kinase-Targeting Inhibitors for Cancer Treatment

    Article • Mini-Reviews in Medicinal Chemistry, May 2020, Bentham Science Publishers

    Fedora Grande, Pasquale Longo

  30. Gel Formulation of Nabumetone and a Newly Synthesized Analog: Microemulsion as a Photoprotective Topical Delivery System

    Article • Pharmaceutics, May 2020, MDPI AG

    Fedora Grande

  31. Leptin Signaling Contributes to Aromatase Inhibitor Resistant Breast Cancer Cell Growth and Activation of Macrophages

    Article • Biomolecules, April 2020, MDPI AG

    Fedora Grande

  32. Cyclodextrins in topical gel formulation as photoprotective system for Nabumetone

    Article • IOP Conference Series Materials Science and Engineering, February 2020, Institute of Physics Publishing

    Fedora Grande

  33. Virtual screening in drug discovery: a precious tool for a still-demanding challenge

    Article • January 2020, Elsevier

    Fedora Grande

  34. Benzothienoquinazolinones as new multi-target scaffolds: Dual inhibition of human Topoisomerase I and tubulin polymerization

    Article • European Journal of Medicinal Chemistry, November 2019, Elsevier

    Fedora Grande

  35. AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)

    Article • Journal of Experimental & Clinical Cancer Research, August 2019, Springer Science + Business Media

    Fedora Grande

  36. Quercetin and its derivative Q2 modulate chromatin dynamics in adipogenesis and Q2 prevents obesity and metabolic disorders in rats

    Article • The Journal of Nutritional Biochemistry, July 2019, Elsevier

    Fedora Grande

  37. The Peptide ERα17p Is a GPER Inverse Agonist that Exerts Antiproliferative Effects in Breast Cancer Cells

    Article • Cells, June 2019, MDPI AG

    Fedora Grande

  38. Cryptotanshinone and tanshinone IIA from Salvia milthorrhiza Bunge (Danshen) as a new class of potential pancreatic lipase inhibitors

    Article • Natural Product Research, May 2019, Taylor & Francis

    Fedora Grande

  39. Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery

    Article • Pharmaceutics, April 2019, MDPI AG

    Fedora Grande

  40. CCR5/CXCR4 Dual Antagonism for the Improvement of HIV Infection Therapy

    Article • Molecules, February 2019, MDPI AG

    Fedora Grande

  41. A New Generation of Dihydropyridine Calcium Channel Blockers: Photostabilization of Liquid Formulations Using Nonionic Surfactants

    Article • Pharmaceutics, January 2019, MDPI AG

    Fedora Grande

  42. A pilot study on the nutraceutical properties of the Citrus hybrid Tacle® as a dietary source of polyphenols for supplementation in metabolic disorders

    Article • Journal of Functional Foods, January 2019, Elsevier

    Fedora Grande

  43. Photo and thermal stress of linseed oil and stabilization strategies

    Article • Journal of Food Science and Technology, December 2018, Springer Science + Business Media

    Fedora Grande

  44. Benzopyrroloxazines containing a bridgehead nitrogen atom as promising scaffolds for the achievement of biologically active agents

    Article • European Journal of Medicinal Chemistry, May 2018, Elsevier

    Fedora Grande

  45. Identification by Molecular Docking ofHomoisoflavones from Leopoldia comosa as Ligands of Estrogen Receptors

    Article • Molecules, April 2018, MDPI AG

    Fedora Grande

  46. Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity

    Article • Molecules, January 2018, MDPI AG

    Fedora Grande

  47. New insights for the use of quercetin analogs in cancer treatment

    Article • Future Medicinal Chemistry, October 2017, Future Science

    Fedora Grande

  48. An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics

    Article • European Journal of Medicinal Chemistry, October 2017, Elsevier

    Fedora Grande

  49. Liquid crystalline microspheres for 5-fluorouracil specific release

    Article • Journal of Drug Delivery Science and Technology, October 2017, Elsevier

    Fedora Grande

  50. Synthesis and photodegradation studies of analogues of muscle relaxant 1,4-dihydropyridine compounds

    Article • Acta Pharmaceutica, January 2017, De Gruyter

    Fedora Grande

  51. Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression

    Article • Oncotarget, August 2016, Impact Journals, LLC

    Fedora Grande

  52. Titanium Dioxide Nanoparticles: a Risk for Human Health?

    Article • Mini-Reviews in Medicinal Chemistry, April 2016, Bentham Science Publishers

    Fedora Grande

  53. Identification and Preclinical Evaluation of SC144, a Novel Pyrroloquinoxaline Derivative with Broad-Spectrum Anticancer Activity

    Article • Mini-Reviews in Medicinal Chemistry, March 2016, Bentham Science Publishers

    PhD Francesca F Aiello , Fedora Grande

  54. Identification of novel 2-(1H-indol-1-yl)-benzohydrazides CXCR4 ligands impairing breast cancer growth and motility

    Article • Future Medicinal Chemistry, February 2016, Future Science

    Fedora Grande, PhD Francesca F Aiello

  55. Quercetin derivatives as novel antihypertensive agents: Synthesis and physiological characterization

    Article • European Journal of Pharmaceutical Sciences, January 2016, Elsevier

    Fedora Grande

  56. Antihypertensive effects of novel Quercetin derivatives

    Article • Vascular Pharmacology, December 2015, Elsevier

    Fedora Grande

  57. Dual inhibition of survivin and MAOA synergistically impairs growth of PTEN-negative prostate cancer

    Article • British Journal of Cancer, June 2015, Springer Science + Business Media

    Fedora Grande

  58. Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts

    Article • Future Medicinal Chemistry, March 2015, Future Science

    Fedora Grande, PhD Francesca F Aiello

  59. Outdoor Air Pollutants

    Article • January 2015, Springer Science + Business Media

    PhD Francesca F Aiello , Fedora Grande

  60. Active manganese dioxide promoted cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids to 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one derivatives

    Article • Tetrahedron, November 2013, Elsevier

    Fedora Grande, PhD Francesca F Aiello

  61. Stabilization of MDA-7/IL-24 for colon cancer therapy

    Article • Cancer Letters, July 2013, Elsevier

    Fedora Grande

  62. Discovery of a Novel Orally Active Small-Molecule gp130 Inhibitor for the Treatment of Ovarian Cancer

    Article • Molecular Cancer Therapeutics, March 2013, American Association for Cancer Research (AACR)

    Fedora Grande

  63. Small Molecule Inhibitors of CXCR4

    Article • Theranostics, January 2013, Ivyspring International Publisher

    Fedora Grande

  64. Design and Synthesis of 3-Carbamoylbenzoic Acid Derivatives as Inhibitors of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1)

    Article • ChemMedChem, September 2012, Wiley

    PhD Francesca F Aiello , Fedora Grande

  65. Abstract 1927: Mechanistic characterization of SC144 in colon cancer

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Fedora Grande

  66. Cytotoxic potential of novel 6,7-dimethoxyquinazolines

    Article • European Journal of Medicinal Chemistry, February 2012, Elsevier

    Fedora Grande

  67. Convenient synthesis of fluorazone derivatives by one-pot pyrrolation/cyclization of anthranilic acids

    Article • Tetrahedron Letters, November 2011, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  68. Small-Molecule Inhibitors of p53-MDM2 Interaction: the 2006-2010 Update

    Article • Current Pharmaceutical Design, February 2011, Bentham Science Publishers

    Fedora Grande

  69. Direct cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids into fused pyrrolizinones

    Article • Tetrahedron Letters, December 2010, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  70. Efficient synthesis of 9H-pyrrolo[1,2-a]indol-9-one derivatives based on active manganese dioxide promoted intramolecular cyclization

    Article • Tetrahedron, January 2010, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  71. Combination effects of SC144 and cytotoxic anticancer agents

    Article • Anti-Cancer Drugs, June 2009, Wolters Kluwer Health

    Fedora Grande

  72. Synthesis and biological evaluation of novel hydrazide based cytotoxic agents

    Article • Expert Opinion on Investigational Drugs, April 2009, Informa Healthcare

    PhD Francesca F Aiello , Fedora Grande

  73. Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity

    Article • Cancer Biology & Therapy, March 2009, Taylor & Francis

    PhD Francesca F Aiello , Fedora Grande

  74. Discovery of Novel Anticancer Compounds Based on a Quinoxalinehydrazine Pharmacophore

    Article • ChemMedChem, November 2008, Wiley

    Fedora Grande, PhD Francesca F Aiello

  75. Naphthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation

    Article • ChemMedChem, June 2008, Wiley

    Fedora Grande, PhD Francesca F Aiello

  76. Small Molecules Anti-HIV Therapeutics Targeting CXCR4

    Article • Current Pharmaceutical Design, February 2008, Bentham Science Publishers

    Fedora Grande

  77. Small Molecule Inhibitors of Stat3 Signaling Pathway

    Article • Current Cancer Drug Targets, February 2007, Bentham Science Publishers

    Fedora Grande

  78. Synthesis and antitumor activities of a series of novel quinoxalinhydrazides

    Article • Bioorganic & Medicinal Chemistry, January 2007, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  79. Recent advances in the design and discovery of small-molecule therapeutics targeting HER2/neu

    Article • Expert Opinion on Therapeutic Patents, January 2007, Informa Healthcare

    Fedora Grande

  80. A critical study on the application of the zero-crossing derivative spectrophotometry to the photodegradation monitoring of lacidipine

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2006, Elsevier

    Fedora Grande

  81. An approach to the stereo-controlled synthesis of polycyclic derivatives of l-4-thiazolidinecarboxylic acid active against HIV-1 integrase

    Article • European Journal of Medicinal Chemistry, August 2006, Elsevier

    Fedora Grande, PhD Francesca F Aiello

  82. Synthesis of novel thiazolothiazepine based HIV-1 integrase inhibitors

    Article • Bioorganic & Medicinal Chemistry, August 2004, Elsevier

    PhD Francesca F Aiello , Fedora Grande