All Stories

  1. Guidance in the application of quality management in the field of chromatography in routine medical laboratories – EFLM Committee: Accreditation and ISO/CEN Standards point of view

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), June 2026, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  2. Grupo de Trabajo de la EFLM sobre Acreditación y Normas ISO/CEN sobre cómo abordar los requisitos de la norma ISO15189 sobre retención de documentación y muestras

    Article • Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, March 2024, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel, Professor Christos Kroupis

  3. EFLM Working Group Accreditation and ISO/CEN standards on dealing with ISO 15189 demands for retention of documents and examination objects

    Article • Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, January 2024, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel, Professor Christos Kroupis

  4. APS calculator: a data-driven tool for setting outcome-based analytical performance specifications for measurement uncertainty using specific clinical requirements and population data

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), November 2023, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  5. In-house diagnostic devices under the EU IVDR and unwanted side-effects of intentional transparency

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), July 2023, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  6. In reply to: Limitations in using the EFLM WG-A/ISO approach for assessment of reagent lot variability

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), June 2023, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  7. ISO 15189 is a sufficient instrument to guarantee high-quality manufacture of laboratory developed tests for in-house-use conform requirements of the European In-Vitro-Diagnostics Regulation

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2023, De Gruyter

    DR Matthias Orth, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  8. M133 An approach for determining allowable between reagent lot variation

    Article • Clinica Chimica Acta, May 2022, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  9. An approach for determining allowable between reagent lot variation

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), February 2022, De Gruyter

    Dr Marc HM Thelen, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  10. Improving the laboratory result release process in the light of ISO 15189:2012 standard

    Article • Clinica Chimica Acta, November 2021, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  11. Implementation of the new EU IVD regulation – urgent initiatives are needed to avert impending crisis

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), September 2021, De Gruyter

    Prof Christa CM Cobbaert, DR Matthias Orth, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  12. Organisation and quality monitoring for point-of-care testing (POCT) in Belgium: proposal for an expansion of the legal framework for POCT into primary health care

    Article • Acta Clinica Belgica, January 2021, Taylor & Francis

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  13. Validation and verification of examination procedures in medical laboratories: opinion of the EFLM Working Group Accreditation and ISO/CEN standards (WG-A/ISO) on dealing with ISO 15189:2012 demands for method verification and validation

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), February 2020, De Gruyter

    Dr Marc HM Thelen, Professor Christos Kroupis, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  14. Documenting metrological traceability as intended by ISO 15189:2012: A consensus statement about the practice of the implementation and auditing of this norm element

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), December 2018, De Gruyter

    Dr Marc HM Thelen, Professor Christos Kroupis, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  15. Corrigendum to: Recommendation for the review of biological reference intervals in medical laboratories

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2017, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  16. Monitoring glucose levels in critically ill patients

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2016, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  17. Practical approach for medical validation of therapeutic drug monitoring results

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2016, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  18. Accreditation process in European countries – an EFLM survey

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2016, De Gruyter

    Professor Christos Kroupis, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  19. Recommendation for the review of biological reference intervals in medical laboratories

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2016, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel, Professor Christos Kroupis

  20. Current Evidence and Future Perspectives on the Effective Practice of Patient-Centered Laboratory Medicine

    Article • Clinical Chemistry, April 2015, Oxford University Press (OUP)

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  21. Flexible Scope for ISO15189 accreditation

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2015, De Gruyter

    Professor Christos Kroupis, Dr Marc HM Thelen, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  22. Practice-Oriented Quality Specifications for Therapeutic Drug Monitoring

    Article • Clinical Chemistry, March 2014, Oxford University Press (OUP)

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  23. A safety study on single intravenous dose of tetrachloro-diphenyl glycoluril [iodogen] dissolved in dimethyl sulphoxide (DMSO)

    Article • Xenobiotica, January 2013, Taylor & Francis

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  24. Performance of cassette-based blood gas analyzers to monitor blood glucose and lactate levels in a surgical intensive care setting

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2013, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  25. Interference of ethylene glycol with lactate measurement: A comparison study on new generation cassette-based blood gas analyzers

    Article • Clinica Chimica Acta, December 2012, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  26. Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method

    Article • The Journal of Maternal-Fetal & Neonatal Medicine, February 2012, Taylor & Francis

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel, Professor karel allegaert

  27. Transient Catabolic State with Reduced IGF-I after Antenatal Glucocorticoids

    Article • Pediatric Research, September 2007, Nature

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  28. Model order selection for quantification of a multi-exponential magnetic resonance spectrum

    Article • August 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  29. Fructosamine 3-kinase-related protein and deglycation in human erythrocytes

    Article • Biochemical Journal, August 2004, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  30. Quantification of the glycogen13C-1 NMR signal during glycogen synthesis in perfused rat liver

    Article • NMR in Biomedicine, January 2003, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  31. Proton magnetization transfer effect in rat liver lactate

    Article • Magnetic Resonance in Medicine, April 2002, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  32. No-Flow Ischemia Inhibits Insulin Signaling in Heart by Decreasing Intracellular pH

    Article • Circulation Research, March 2001, Wolters Kluwer Health

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  33. Conversion of a synthetic fructosamine into its 3-phospho derivative in human erythrocytes

    Article • Biochemical Journal, December 2000, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  34. Conversion of a synthetic fructosamine into its 3-phospho derivative in human erythrocytes

    Article • Biochemical Journal, December 2000, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  35. Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.

    Article • Diabetes, October 2000, American Diabetes Association

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  36. BAY R3401: A Blood-Glucose Lowering Prodrug's Impact on Phosphorylase a and b Activities

    Article • Diabetes, September 2000, American Diabetes Association

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  37. Further observations on the uptake and effects of phosphonates in perfused rat liver studied by 31P‐NMR

    Article • NMR in Biomedicine, August 1999, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  38. Further observations on the uptake and effects of phosphonates in perfused rat liver studied by31P-NMR

    Article • NMR in Biomedicine, August 1999, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  39. On the inhibition of hepatic glycogenolysis by fructose. A31P-NMR study in perfused rat liver using the fructose analogue 2,5-anhydro-D-mannitol

    Article • NMR in Biomedicine, May 1999, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  40. Phosphocreatine resynthesis is not affected by creatine loading

    Article • Medicine & Science in Sports & Exercise, February 1999, Wolters Kluwer Health

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  41. 1H NMR spectroscopy study of the dynamic properties of glycogen in solution by steady-state magnetisation measurement with off-resonance irradiation

    Article • Carbohydrate Research, January 1998, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  42. Phosphonates as31P-NMR markers of extra- and intracellular space and pH in perfused rat liver

    Article • NMR in Biomedicine, September 1997, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  43. Phosphonates as 31P‐NMR markers of extra- and intracellular space and pH in perfused rat liver

    Article • NMR in Biomedicine, September 1997, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  44. Evaluation of signal processing methods for the quantification of a multi–exponential signal: the glycogen13C-1 NMR signal

    Article • NMR in Biomedicine, October 1996, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  45. 13C-NMR relaxation in glycogen

    Article • Magnetic Resonance in Medicine, July 1996, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  46. Modulation of basal hepatic glycogenolysis by nitric oxide

    Article • Hepatology, June 1996, Wolters Kluwer Health

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  47. Modulation of basal hepatic glycogenolysis by nitric oxide

    Article • Hepatology, June 1996, Wolters Kluwer Health

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  48. Caffeine counteracts the ergogenic action of muscle creatine loading

    Article • Journal of Applied Physiology, February 1996, American Physiological Society

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  49. Demonstration of a Glycogen/Glucose 1-Phosphate Cycle in Hepatocytes from Fasted Rats

    Article • Journal of Biological Chemistry, August 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  50. Evaluation of Signal Processing Methods for the Quantification of Strongly Overlapping Peaks in 31P NMR Spectra

    Article • Journal of Magnetic Resonance Series B, September 1994, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  51. New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heart.

    Article • Circulation, June 1994, Wolters Kluwer Health

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  52. Ischaemic ATP degradation studied by HPLC and31P-NMR spectroscopy: do the two techniques observe the same ATP pools?

    Article • Basic Research in Cardiology, January 1994, Springer Science + Business Media

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  53. In Situ13C NMR quantification of hepatic glycogen

    Article • NMR in Biomedicine, November 1993, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  54. Bilirubin diglucuronide and monoglucuronides are formed at a single, lumenally oriented site of microsomal UDP-glucuronyltransferase

    Article • Hepatology, October 1993, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  55. Metabolic response to halothane in piglets susceptible to malignant hyperthermia: an in vivo 31P-NMR study

    Article • Journal of Applied Physiology, August 1993, American Physiological Society

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  56. In vivo muscle 31P nuclear magnetic resonance spectroscopy during treatment of halothane-sensitive and halothane-nonsensitive pigs

    Article • American Journal of Veterinary Research, April 1992, American Veterinary Medical Association (AVMA)

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  57. Modulation of maximal glycogenolysis in perfused rat liver by adenosine and ATP

    Article • Biochemical Journal, August 1991, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  58. 31P-NMR study of cardiac preservation: St. Thomas' Hospital cardioplegic solution versus UW preservation solution

    Article • Transplant International, June 1991, Frontiers

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  59. The cytosolic concentration of phosphate determines the maximal rate of glycogenolysis in perfused rat liver

    Article • Biochemical Journal, February 1990, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  60. Double-tuned resonator designs for NMR spectroscopy

    Article • Journal of Magnetic Resonance (1969), August 1989, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  61. Properties of membrane-bound bilirubin UDP-glucuronyltransferase in rough and smooth endoplasmic reticulum and in the nuclear envelope from rat liver

    Article • Biochemical Journal, May 1989, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  62. Bile pigment metabolism

    Article • Bailliére&#x027 s Clinical Gastroenterology, April 1989, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  63. Carrier-mediated translocation of uridine diphosphate glucose into the lumen of endoplasmic reticulum-derived vesicles from rat liver.

    Article • Journal of Clinical Investigation, September 1988, American Society for Clinical Investigation

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  64. Phosphate metabolites in rat skin

    Article • Biochemical Society Transactions, June 1988, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  65. Topology and regulation of bilirubin UDP-glucuronyltransferase in sealed native microsomes from rat liver

    Article • Archives of Biochemistry and Biophysics, May 1988, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  66. Phosphate metabolites in rat skin

    Article • NMR in Biomedicine, February 1988, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  67. On the binding of bilirubin and its structural analogs to hepatic microsomal bilirubin UDPglucuronyltransferase

    Article • Biochemistry, September 1987, American Chemical Society (ACS)

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  68. Endogenous esterification of bilirubin by liver microsomes. Evidence for an intramicrosomal pool of UDP-glucose and lumenal orientation of bilirubin UDP-glycosyltransferase.

    Article • Journal of Biological Chemistry, April 1987, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  69. Assay of mannose-6-phosphatase in untreated and detergent-disrupted rat-liver microsomes for assessment of integrity of microsomal preparations

    Article • FEBS Journal, April 1986, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  70. Radioassay of UDP-glucuronyltransferase-catalysed formation of bilirubin monoglucuronides and bilirubin diglucuronide in liver microsomes

    Article • Biochemical Journal, October 1984, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  71. Free Ionised Calcium—A Critical Survey

    Article • Annals of Clinical Biochemistry International Journal of Laboratory Medicine, September 1984, SAGE Publications

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  72. Induction of hepatic glycogen synthesis by glucocorticoids is not mediated by insulin

    Article • Molecular and Cellular Endocrinology, June 1982, Elsevier

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  73. The role of glycogen synthase phosphatase in the glucocorticoid-induced deposition of glycogen in foetal rat liver

    Article • Biochemical Journal, November 1980, Portland Press Ltd.

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  74. Glycogen-Synthase Phosphatase Activity in Rat Liver. Two Protein Components and Their Requirement for the Activation of Different Types of Substrate

    Article • FEBS Journal, February 1980, Wiley

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel