All Stories

  1. Interleukin signatures as histology-aligned biomarkers in inflammatory bowel disease.

    Article • Inflammatory Intestinal Diseases, April 2026, Karger Publishers

    Professor Christos Kroupis

  2. Systemic Immune Signatures of Endoscopic–Histologic Discordance in Inflammatory Bowel Disease: A Pilot Study

    Article • Journal of Clinical Medicine, April 2026, MDPI AG

    Professor Christos Kroupis

  3. Serum Interleukin-10 as a Potential Biomarker for Deep Remission and Histologic Activity in Ulcerative Colitis

    Article • Biomedicines, April 2026, MDPI AG

    Professor Christos Kroupis

  4. Interleukin Signatures as Prognostic Biomarkers in Ulcerative Colitis: From Immune Pathways to Clinical Prediction

    Article • Current Issues in Molecular Biology, January 2026, MDPI AG

    Professor Christos Kroupis

  5. Molecular Studies of TCF4 Gene and Correlation with Late-Onset Fuchs Endothelial Corneal Dystrophy in the Greek Population: A Novel Cost-Effective Diagnostic Algorithm

    Article • International Journal of Molecular Sciences, November 2025, MDPI AG

    Professor Christos Kroupis

  6. APOE Genotyping in Cognitive Disorders: Preliminary Observations from the Greek Population

    Article • International Journal of Molecular Sciences, August 2025, MDPI AG

    Professor Christos Kroupis

  7. Correlation of intravitreal IL-6 with the formation of epiretinal membrane after successful retinal detachment repair

    Article • Therapeutic Advances in Ophthalmology, June 2025, SAGE Publications

    Professor Christos Kroupis

  8. PON1, APOE and SDF-1 Gene Polymorphisms and Risk of Retinal Vein Occlusion: A Case-Control Study

    Article • Genes, May 2024, MDPI AG

    Professor Christos Kroupis

  9. Risk factors for retinal vein occlusion: Multivariate approach in a case-control study

    Article • AJO International, April 2024, Elsevier

    Professor Christos Kroupis

  10. Grupo de Trabajo de la EFLM sobre Acreditación y Normas ISO/CEN sobre cómo abordar los requisitos de la norma ISO15189 sobre retención de documentación y muestras

    Article • Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, March 2024, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel, Professor Christos Kroupis

  11. EFLM Working Group Accreditation and ISO/CEN standards on dealing with ISO 15189 demands for retention of documents and examination objects

    Article • Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, January 2024, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel, Professor Christos Kroupis

  12. Association of PON1 , APOE and SDF-1 Gene Polymorphisms with Treatment Response to Intravitreal Anti-VEGF Treatment in Patients with Retinal Vein Occlusion

    Article • Seminars in Ophthalmology, November 2023, Taylor & Francis

    Professor Christos Kroupis

  13. Unravelling the Role of P300 and TMPRSS2 in Prostate Cancer: A Literature Review

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Professor Christos Kroupis

  14. Simultaneous determination of procalcitonin and interleukin-6 in human serum samples with a point-of-care biosensing device

    Article • Talanta, June 2023, Elsevier

    Professor Christos Kroupis

  15. Endothelial Injury Syndromes after Allogeneic Hematopoietic Stem Cell Transplantation: Angiopetin-2 as a Novel Predictor of the Outcome and the Role of Functional Autoantibodies against Angiotensin II Type 1 and Endothelin A Receptor

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Professor Christos Kroupis

  16. APOE Allele Frequency in Southern Greece: Exploring the Role of Geographical Gradient in the Greek Population

    Article • Geriatrics, December 2022, MDPI AG

    Professor Christos Kroupis

  17. Molecular biologic milieu in rhegmatogenous retinal detachment and proliferative vitreoretinopathy: a literature review

    Article • Ophthalmic Research, June 2022, Karger Publishers

    Professor Christos Kroupis

  18. The importance of aerobic capacity and nutrition in recreational master mountain runners’ performance and race-induced changes in body composition and biochemical blood indices

    Article • International Journal of Sports Science & Coaching, December 2021, SAGE Publications

    Professor Christos Kroupis

  19. Genotyping and Plasma/Cerebrospinal Fluid Profiling of a Cohort of Frontotemporal Dementia–Amyotrophic Lateral Sclerosis Patients

    Article • Brain Sciences, September 2021, MDPI AG

    Professor Christos Kroupis

  20. Global Longitudinal Strain of the Systemic Ventricle Is Correlated with Plasma Galectin-3 and Predicts Major Cardiovascular Events in Adult Patients with Congenital Heart Disease

    Article • Medicina, June 2020, MDPI AG

    Professor Christos Kroupis

  21. Validation and verification of examination procedures in medical laboratories: opinion of the EFLM Working Group Accreditation and ISO/CEN standards (WG-A/ISO) on dealing with ISO 15189:2012 demands for method verification and validation

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), February 2020, De Gruyter

    Dr Marc HM Thelen, Professor Christos Kroupis, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  22. Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system

    Article • Human Mutation, March 2019, Wiley

    Professor Christos Kroupis

  23. Frontotemporal dementia spectrum: first genetic screen in a Greek cohort

    Article • Neurobiology of Aging, March 2019, Elsevier

    Professor Christos Kroupis

  24. Th17 serum cytokines in relation to laboratory‐confirmed respiratory viral infection: A pilot study

    Article • Journal of Medical Virology, February 2019, Wiley

    Professor Christos Kroupis

  25. Documenting metrological traceability as intended by ISO 15189:2012: A consensus statement about the practice of the implementation and auditing of this norm element

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), December 2018, De Gruyter

    Dr Marc HM Thelen, Professor Christos Kroupis, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  26. A pilot plasma-ctDNA ring trial for the Cobas® EGFR Mutation Test in clinical diagnostic laboratories

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), September 2018, De Gruyter

    Professor Christos Kroupis

  27. Lazaroid (U-74389G) ameliorates lung injury due to lipid peroxidation and nitric oxide synthase-dependent reactive oxygen species generation caused by remote systematic ischemia-reperfusion following thoracoabdominal aortic occlusion

    Article • International Journal of Surgery, July 2018, Elsevier

    Professor Christos Kroupis

  28. Brain-derived neurotrophic factor (BDNF) in children with ASD and their parents: a 3-year follow-up

    Article • Acta Psychiatrica Scandinavica, March 2018, Wiley

    Professor Christos Kroupis

  29. Response to the letter to editor: Copeptin and its clinical implications in the setting of vasovagal syncope

    Article • International Journal of Cardiology, September 2017, Elsevier

    Professor Christos Kroupis

  30. Investigation of associations of ARMS2, CD14, and TLR4 gene polymorphisms with wet age-related macular degeneration in a Greek population

    Article • Clinical Ophthalmology, July 2017, Dove Medical Press

    Professor Christos Kroupis, IOSIF SKALIDAKIS

  31. Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-fluorouracil with or without docetaxel: a subset analysis of EORTC 24971 study

    Article • Annals of Oncology, June 2017, Oxford University Press (OUP)

    Professor Christos Kroupis

  32. Copeptin levels in patients with vasovagal syncope

    Article • International Journal of Cardiology, March 2017, Elsevier

    Professor Christos Kroupis

  33. AKT2 Gene Polymorphisms, sRANKL/OPG and Hormone Measurements in Polycystic Ovarian Syndrome (PCOS) Women

    Article • Clinical & Medical Biochemistry Open Access, January 2017, OMICS Publishing Group

    Professor Christos Kroupis

  34. Development and validation of molecular methodologies to assess PALB2 expression in sporadic breast cancer

    Article • Clinical Biochemistry, February 2016, Elsevier

    Professor Christos Kroupis

  35. Accreditation process in European countries – an EFLM survey

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2016, De Gruyter

    Professor Christos Kroupis, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  36. Recommendation for the review of biological reference intervals in medical laboratories

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2016, De Gruyter

    Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel, Professor Christos Kroupis

  37. Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease

    Article • Biomarkers, December 2015, Informa Healthcare

    Professor Christos Kroupis, Professor Maria Dalamaga

  38. Evaluation of a particle enhanced turbidimetric assay for the measurement of neutrophil gelatinase-associated lipocalin in plasma and urine on Architect-8000: Analytical performance and establishment of reference values

    Article • Clinical Biochemistry, December 2015, Elsevier

    Professor Christos Kroupis

  39. Development of a novel PTT assay for mutation detection in PALB2 large exons and PALB2 screening in medullary breast cancer

    Article • Familial Cancer, November 2015, Springer Science + Business Media

    Professor Christos Kroupis

  40. Development of novel real-time PCR methodology for quantification of COL11A1 mRNA variants and evaluation in breast cancer tissue specimens

    Article • BMC Cancer, October 2015, Springer Science + Business Media

    Professor Christos Kroupis

  41. Non-invasive prenatal testing (NIPT): limitations on the way to become diagnosis

    Article • Diagnosis, September 2015, De Gruyter

    Professor Christos Kroupis

  42. Novel association of FCGR2A polymorphism with age-related macular degeneration (AMD) and development of a novel CFH real-time genotyping method

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2015, De Gruyter

    Professor Christos Kroupis

  43. Flexible Scope for ISO15189 accreditation

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2015, De Gruyter

    Professor Christos Kroupis, Dr Marc HM Thelen, Prof Dr em MD PhD EuSpLM Florent JLA Vanstapel

  44. Oxidative stress in dry age-related macular degeneration and exfoliation syndrome

    Article • Critical Reviews in Clinical Laboratory Sciences, October 2014, Taylor & Francis

    Professor Christos Kroupis

  45. Validation of a Real-Time Quantitative Polymerase Chain Reaction Method for the Quantification of 3 Survivin Transcripts and Evaluation in Breast Cancer Tissues

    Article • Clinical Breast Cancer, April 2014, Elsevier

    Professor Christos Kroupis, Professor Maria Dalamaga

  46. Association of survivin splice variants with prognosis and treatment of breast cancer

    Article • World Journal of Clinical Oncology, January 2014, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Professor Christos Kroupis

  47. Molecular Genetics of Pseudoexfoliation Syndrome (PXFS) and Glaucoma(PXFG)

    Article • Journal of Genetic Syndromes & Gene Therapy, January 2013, OMICS Publishing Group

    Professor Christos Kroupis

  48. Serum markers of deranged myocardial collagen turnover: Their relation to malignant ventricular arrhythmias in cardioverter-defibrillator recipients with heart failure

    Article • American Heart Journal, October 2012, Elsevier

    Professor Christos Kroupis

  49. Cancer epigenomics: moving slowly, but at a steady pace from laboratory bench to clinical practice

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2012, De Gruyter

    Professor Christos Kroupis

  50. Hereditary breast cancer: beyond BRCA genetic analysis; PALB2 emerges

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2012, De Gruyter

    Professor Christos Kroupis

  51. Biomarkers in primary open angle glaucoma

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2012, De Gruyter

    Professor Christos Kroupis

  52. Human papilloma virus (HPV) molecular diagnostics

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2011, De Gruyter

    Professor Christos Kroupis

  53. Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR

    Article • World Journal of Gastroenterology, January 2011, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Professor Christos Kroupis, Professor Maria Dalamaga

  54. Increased inflammatory Response in Patients With Dilated Cardiomyopathy Is Associated With Dyslipidemia: Effects of Statin Therapy

    Article • Angiology, December 2010, SAGE Publications

    Professor Christos Kroupis

  55. The Association Between a CommonFCGR2APolymorphism and C-Reactive Protein and Coronary Artery Disease Revisited

    Article • Genetic Testing and Molecular Biomarkers, December 2010, Mary Ann Liebert Inc

    Professor Christos Kroupis, Professor Maria Dalamaga

  56. PIK3CA Hotspot Mutation Scanning by a Novel and Highly Sensitive High-Resolution Small Amplicon Melting Analysis Method

    Article • Journal of Molecular Diagnostics, September 2010, Elsevier

    Professor Christos Kroupis, Panagiotis Vorkas

  57. P374 EPIGENETIC MODIFICATIONS IN HUMAN CAROTID ATHEROMATOUS PLAQUES

    Article • Atherosclerosis Supplements, June 2010, Elsevier

    Professor Christos Kroupis, Professor Maria Dalamaga

  58. Mutation scanning of exon 20 of the BRCA1 gene by high-resolution melting curve analysis

    Article • Clinical Biochemistry, January 2010, Elsevier

    Professor Christos Kroupis, Panagiotis Vorkas

  59. PI3K Pathway Activity and Response to First-Line Chemotherapy in Combination with Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer.

    Article • Cancer Research, December 2009, American Association for Cancer Research (AACR)

    Professor Christos Kroupis

  60. The Effect of Plasma Homocysteine Levels on Clinical Outcomes of Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome

    Article • The American Journal of the Medical Sciences, December 2009, Elsevier

    Pantelis Bagos, Professor Christos Kroupis

  61. Development of a real-time PCR detection method for a FCGR2A polymorphism in the LightCycler and application in the heparin-induced thrombocytopenia syndrome

    Article • Clinical Biochemistry, November 2009, Elsevier

    Professor Christos Kroupis

  62. Serum oxidizability, total antioxidant status and albumin serum levels in patients with aneurysmal or arterial occlusive disease

    Article • Clinical Biochemistry, June 2008, Elsevier

    Professor Christos Kroupis, Professor Maria Dalamaga

  63. Asymmetric real-time PCR detection of BRCA1 5382insC mutation by melting curve analysis in the LightCycler

    Article • Clinica Chimica Acta, April 2008, Elsevier

    Professor Christos Kroupis

  64. Population-based study of human papillomavirus infection and cervical neoplasia in Athens, Greece

    Article • Epidemiology and Infection, June 2007, Cambridge University Press

    Professor Christos Kroupis

  65. The beneficial effects of the combined methods in investigating heparin-induced thrombocytopenia

    Article • Critical Care, January 2007, Springer Science + Business Media

    Professor Christos Kroupis

  66. Presence of high-risk human papillomavirus sequences in breast cancer tissues and association with histopathological characteristics

    Article • Clinical Biochemistry, July 2006, Elsevier

    Professor Christos Kroupis, Professor Maria Dalamaga

  67. Antiinflammatory Effects of Cardiac Resynchronization Therapy in Patients with Chronic Heart Failure

    Article • Pacing and Clinical Electrophysiology, March 2006, Wiley

    Professor Christos Kroupis

  68. Coronary and peripheral blood flow changes following biventricular pacing and their relation to heart failure improvement

    Article • EP Europace, January 2006, European Society of Cardiology

    Professor Christos Kroupis

  69. Real-Time Reverse Transcription-PCR Quantification of Vascular Endothelial Growth Factor Splice Variants

    Article • Clinical Chemistry, August 2005, AACC

    Professor Christos Kroupis

  70. Development and applications of a real-time quantitative RT-PCR method (QRT-PCR) for BRCA1 mRNA

    Article • Clinical Biochemistry, January 2005, Elsevier

    Professor Christos Kroupis

  71. Familial clustering of autoimmune diseases in patients with dilated cardiomyopathy

    Article • The American Journal of Cardiology, May 2004, Elsevier

    Professor Christos Kroupis

  72. Genetic counseling of medullary breast cancer patients

    Article • Clinical Genetics, March 2004, Wiley

    Professor Christos Kroupis

  73. P-470 Sustained improvement in peripheral immune responses by biventricular pacing and its association with exercise tolerance and quality of life

    Article • EP Europace, December 2003, European Society of Cardiology

    Professor Christos Kroupis

  74. P-230 The effect of biventricularpacing on serum levels of soluble cellular adhesion molecules is sustained following 3 months of therapy discontinuation

    Article • EP Europace, December 2003, European Society of Cardiology

    Professor Christos Kroupis

  75. P-168 BNP in biventricular pacing: Its association with functional status and inflammatory markers

    Article • EP Europace, December 2003, European Society of Cardiology

    Professor Christos Kroupis

  76. Prognostic significance of soluble interleukin-2 receptor levels in patients with dilated cardiomyopathy

    Article • European Journal of Clinical Investigation, June 2003, Wiley

    Professor Christos Kroupis

  77. 158 Growth hormone treatment reduces circulating inflammatory cytokines and improves left ventricular contractile performance in patients with dilated cardiomyopathy

    Article • European Journal of Heart Failure Supplements, June 2003, Oxford University Press (OUP)

    Professor Christos Kroupis

  78. Atypical Medullary Breast Carcinoma in a Family Carrying the 5382insC BRCA-1 Mutation

    Article • The Breast Journal, May 2003, Wiley

    Professor Christos Kroupis

  79. Sustained improvement in peripheral immune response by biventricular pacing and its association with exercise tolerance and quality of life

    Article • Journal of the American College of Cardiology, March 2003, Elsevier

    Professor Christos Kroupis

  80. Physical training-induced reduction of peripheral monocyte-related inflammatory markers is associated with improvement in endothelial function of chronic heart failure patients

    Article • Journal of the American College of Cardiology, March 2003, Elsevier

    Professor Christos Kroupis

  81. Immunomodulatory effects of growth hormone administration are associated with improvement in myocardial contractile performance in dilated cardiomyopathy patients

    Article • Journal of the American College of Cardiology, March 2003, Elsevier

    Professor Christos Kroupis

  82. Article • Cardiovascular Drugs and Therapy, January 2003, Springer Science + Business Media

    Professor Christos Kroupis

  83. Germ line BRCA1 & BRCA2 mutations in Greek breast/ovarian cancer families: 5382insC is the most frequent mutation observed

    Article • Cancer Letters, November 2002, Elsevier

    Professor Christos Kroupis

  84. Growth hormone administration reduces circulating proinflammatory cytokines and soluble Fas/soluble Fas ligand system in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy

    Article • American Heart Journal, August 2002, Elsevier

    Professor Christos Kroupis

  85. Physical training modulates proinflammatory cytokines and soluble fas-soluble fas ligand system in patients with chronic heart failure

    Article • Journal of the American College of Cardiology, March 2002, Elsevier

    Professor Christos Kroupis

  86. Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fasligand system in patients with chronic heart failure

    Article • Journal of the American College of Cardiology, February 2002, Elsevier

    Professor Christos Kroupis

  87. Hyperprolactinaemia in patients with heart failure: clinical and immunogenetic correlations

    Article • European Journal of Clinical Investigation, February 2002, Wiley

    Professor Christos Kroupis

  88. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure

    Article • European Heart Journal, May 2001, European Society of Cardiology

    Professor Christos Kroupis

  89. Immune-genetic control of hyperprolactinemia in patients with heart failure and correlation with ventricular function Dennis Cokkinos, Constantinos Limas, Christos Kroupis, Antigoni Haidaroglou. Onassis Cardiac Surgery Center, Athens, Greece

    Article • Journal of the American College of Cardiology, February 2001, Elsevier

    Professor Christos Kroupis

  90. Cell adhesion molecules in relation to simvastatin and hormone replacement therapy in coronary artery disease

    Article • European Heart Journal, June 2000, European Society of Cardiology

    Professor Christos Kroupis

  91. Physical training reduces circulating monocyte-endothelial cell adhesive interaction markers in patients with chronic heart failure

    Article • European Journal of Heart Failure, June 2000, Wiley

    Professor Christos Kroupis

  92. Effects of growth hormone treatment on circulating proinflammatory cytokines and soluble apoptosis receptor Fas in patients with dilated cardiomyopathy

    Article • European Journal of Heart Failure, June 2000, Wiley

    Professor Christos Kroupis

  93. BRCA1 mutation analysis in breast/ovarian cancer families from Greece

    Article • Human Mutation, January 2000, Wiley

    Professor Christos Kroupis

  94. Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in a Greek population of blood donors

    Article • American Journal of Hematology, August 1999, Wiley

    Professor Christos Kroupis

  95. Effect of Cyclosporine and Sirolimus on Interleukin-15–Driven Proliferation of OKT3-Preactivated Human Lymphocytes

    Article • Transplantation Proceedings, June 1998, Elsevier

    Professor Christos Kroupis

  96. ATP-dependent Regulation of Sodium-Calcium Exchange in Chinese Hamster Ovary Cells Transfected with the Bovine Cardiac Sodium-Calcium Exchanger

    Article • Journal of Biological Chemistry, April 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christos Kroupis

  97. Dimerization of Thermomonospora fusca .beta.-1,4-endoglucanase E2

    Article • Biochemistry, August 1993, American Chemical Society (ACS)

    David Wilson, Professor Christos Kroupis

  98. Cloning and expression of the bovine cardiac sodium-calcium exchanger

    Article • Archives of Biochemistry and Biophysics, November 1992, Elsevier

    Professor Christos Kroupis